AuthorisedTherapeutic use (Phase IV)Interventional

Waiting on Atrial fibrillation Intervention Therapy (WAIT) Study

The WAIT Study is a research project for people with a common heart condition called atrial fibrillation, which causes an irregular and often fast heartbeat. This study is looking at whether a specific medication, Wegovy, can help prevent the return of irregular heartbeats after a procedure (called an ablation) to correct them. Researchers will continuously monitor participants for 12 months to see how many stay free from atrial fibrillation, or similar irregular heart rhythms like atrial flutter or atrial tachycardia, for 30 seconds or more. The aim is to understand if Wegovy can improve the long-term success of the ablation procedure.

At a glance

Status

Authorised

Phase

Therapeutic use (Phase IV)

Sponsor

Karolinska University Hospital

Enrolment target

200

Start

17 Dec 2025

Atrial fibrillation

What is this study about?

The WAIT Study is a research project focused on a common heart condition called atrial fibrillation. This condition makes your heart beat irregularly and sometimes very quickly, which can make you feel dizzy, tired, or short of breath. Many people with atrial fibrillation have a medical procedure called an ablation, which aims to correct these irregular heartbeats.

This study is investigating whether a specific medication, called Wegovy, can help people who have had an ablation procedure to stay free from atrial fibrillation. The researchers want to know if taking Wegovy reduces the chances of the irregular heartbeat returning after the ablation. They will be watching closely for 12 months to see if participants experience any episodes of atrial fibrillation, or similar irregular heartbeats, that last 30 seconds or longer.

Understanding if Wegovy can help maintain a regular heartbeat after an ablation is important. If successful, it could offer a new way to improve the long-term results for people living with atrial fibrillation, potentially leading to a better quality of life and fewer symptoms.

Key takeaways

The study explores if Wegovy helps prevent irregular heartbeats after a procedure.
It involves taking Wegovy and having your heart rhythm continuously monitored.
The study duration is 12 months of monitoring.
Aims to improve long-term outcomes for people with atrial fibrillation.
Open to adults aged 18 and over, both men and women.

Who may be eligible?

To be part of this study, you need to be an adult, 18 years old or older. There is no upper age limit, so people of all adult ages can be considered. Both men and women are welcome to take part in the study.

The main focus is on people who have atrial fibrillation and have recently had, or are about to have, a specific procedure to help fix their heart rhythm. The research team will check other details from your medical history to make sure the study is a good fit for you.

It's important to discuss with your doctor if this study is suitable for your personal health situation. They can help you understand all the requirements.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Do you have atrial fibrillation?
Have you recently had, or are you about to have, an ablation procedure for your heart rhythm?
Are you comfortable with potentially receiving a weekly injection and having a heart monitor placed under your skin?

Answer every question to see your result.

What does participation involve?

If you decide to join the WAIT Study, you will be given a medication called Wegovy through an injection. You will learn how to give yourself this injection, usually once a week, and it comes in a pre-filled pen. The study will involve regular check-ups with the research team to monitor your health and how you are responding to the medication.

A key part of the study is continuous monitoring of your heart rhythm. This will likely involve a small device, similar to a heart monitor, that is implanted just under your skin and can continuously record your heart's electrical activity. This device helps the researchers detect any irregular heartbeats over time without you needing to do anything.

The study will last for at least 12 months, during which time your heart rhythm will be checked. There might be some follow-up visits or phone calls after this period as well. The research team will explain all visits, tests, and how long you will be involved before you make any decisions.

Potential risks and benefits

Participating in the WAIT Study could potentially help researchers learn if Wegovy can prevent atrial fibrillation from returning after an ablation, which might improve your long-term heart health. However, like all medications, Wegovy can have side effects, and some people may experience discomfort from injections or from the heart monitoring device. Your irregular heartbeat could also return even if you are taking the study medication. You are free to withdraw from the study at any time, for any reason, without it affecting your usual medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
Sweden

Common questions

What is atrial fibrillation?

It's an irregular and often very fast heartbeat that can cause symptoms like breathlessness, dizziness, and tiredness.

What is an 'ablation' procedure?

It's a medical procedure that aims to correct irregular heartbeats by creating small scars in the heart muscle.

What is Wegovy?

Wegovy is a medication being studied to see if it can help prevent irregular heart rhythms from returning after an ablation.

How will my heart rhythm be monitored?

A small device will be placed under your skin to continuously record your heart's activity for 12 months.

How long does the study last?

The main part of the study where your heart is monitored and you take the medication will last for 12 months.