Atrial Fibrillation research hub

Preventing Stroke, Premature Death and Cognitive Decline in a Broader Community of Patients With Atrial Fibrillation

This study looks at whether newer blood thinners (DOACs) can help younger people with a heart rhythm problem called atrial fibrillation. It aims to prevent strokes, serious blood clots, and memory problems. The study uses patient health records and takes place entirely within the NHS.

Affera Global Registry

This study looks at how well a device called the Affera Platform works for people with an irregular heartbeat called Atrial Fibrillation. It aims to gather real-world information on its safety and how effective it is in different patients after it's been approved for use.

Tracking Atrial Fibrillation After Intensive Care Admission

This study looks at heart rhythm problems called atrial fibrillation (AF) in people after intensive care. It aims to see how many people develop AF and if it comes back once they leave hospital, to help prevent serious issues like strokes later on.

Outcome of Overweight AF Patients Following Ablation With a Potential Weight Loss Medication ( GOAL-AF )

This study looks at whether a weight-loss medicine called Liraglutide can help people with an irregular heartbeat (Atrial Fibrillation or AF) who are overweight. The aim is to see if losing weight before a heart procedure called ablation can improve its success and overall health.

Amplatzer Amulet LAAO vs. NOAC

This study compares a device that closes off a small pouch in the heart (Amplatzer Amulet) with standard blood-thinning medicines (NOACs). It aims to see which is safer and better at preventing strokes in people with an irregular heartbeat called atrial fibrillation.

Real World Data Collection in Subjects Treated With the FARAPULSE Pulsed Field Ablation System

This study looks at how safe and effective a new treatment called FARAPULSE is for atrial fibrillation. It collects real-world information about people treated with this system in hospitals to see how well it works and if it improves their quality of life.

CHAMPION-AF Clinical Trial

This study compares a small heart device (WATCHMAN FLX) with standard blood-thinning medicines (such as DOACs) for people with an irregular heartbeat called atrial fibrillation. It aims to see if the device can prevent strokes just as well as the medicines.

EdoxabaN foR IntraCranial Hemorrhage Survivors With Atrial Fibrillation (ENRICH-AF)

This study looks at whether a blood-thinning medicine called edoxaban can reduce the risk of stroke in people with an irregular heartbeat (atrial fibrillation) who have previously had bleeding in the brain. It compares edoxaban to not taking blood thinners.

EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality

This study aims to understand why common medicines don't work the same for everyone in the UK, especially for people from different backgrounds. It will look at many health conditions, hoping to improve how we treat them and make healthcare fairer for all.

Atrial Functional Mitral Regurgitation and Tricuspid Regurgitation

This study looks at how heart valve problems, called mitral and tricuspid regurgitation, affect people with an irregular heartbeat (atrial fibrillation). Researchers want to understand these conditions better and find out what causes them to get worse.

Hybrid Ablation of Atrial Fibrillation in Heart Failure

This study looks at a new way to treat persistent atrial fibrillation (a type of irregular heartbeat) in people who also have heart failure. It compares a combined treatment (hybrid ablation) with the usual treatment to see which works best at keeping a steady heart rhythm.

A Study to Investigate the Efficacy, Safety, Tolerability and Pharmacokinetics of PKN605 in Participants With Atrial Fibrillation

This study is testing a new medicine called PKN605 for people with an irregular heartbeat condition called atrial fibrillation. We want to see if it helps reduce how often people have irregular heartbeats and if it's safe to use.

Triple Cardiovascular Disease Detection With an Artificial Intelligence-enabled Stethoscope

This study is testing a new AI-powered stethoscope to see if it can help doctors in local clinics find heart problems like heart failure earlier. The aim is to improve heart health and reduce emergency hospital visits for these conditions.

Impact of Cardiac Prehabilitation, REhabilitation and Patient EDucation on Outcomes in Patients Undergoing First-time AF Ablation

This study looks at whether extra exercise and education before and after treatment for an irregular heartbeat (AF ablation) can lead to better results. It compares this special support to the usual care patients receive.

Adjunctive Ganglionated Plexus Ablation in Redo-Pulmonary Vein Isolation

This study looks at a new way to treat atrial fibrillation (AF) that keeps coming back after initial treatment. It focuses on disrupting specific nerve bundles in the heart that might be triggering AF, aiming to improve treatment success for people who need a second procedure.

A Study of the Acceptability and Performance of Wearables for Atrial Fibrillation Screening in Older Adults

This study looks at how well wearable devices like smartwatches and chest patches can find an irregular heartbeat called atrial fibrillation (AF) in older adults. It also checks if people find these devices easy and comfortable to use, to help prevent strokes.

Early Atrial Fibrillation Ablation for Stroke Prevention in Patients With High Comorbidity Burden (EASThigh-AFNET 11)

This study looks at whether a heart procedure called 'ablation' can better prevent serious problems like stroke or heart failure in people with an irregular heartbeat (atrial fibrillation) and other health issues, compared to standard care.

Ablate and Pace HIS Study

This study looks at a new way of fitting pacemakers for people with a heart condition called atrial fibrillation (AF) who also have signs of heart failure. It compares a standard pacemaker fitting with a newer method called His bundle pacing to see which works best.

Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

This study looks at how best to prevent blood clots and bleeding in people who develop an irregular heartbeat (atrial fibrillation) after bypass surgery. It compares different common blood-thinning treatments.

Preventing Recurrent Cardioembolic Stroke (The PRECISE Study)

This study aims to improve how we check for a heart condition called atrial fibrillation (AF) after a stroke. By finding better ways to identify who needs checking, we hope to prevent more second strokes for people in the UK.

Optimal Antiplatelet Treatment to Achieve Stroke Avoidance and Fall in Bleeding Events following Left Atrial Appendage Closure – Chronic Kidney Disease (SAFE LAAC CKD). Comparative Health Effectiveness Ancillary Study – PILOT

Optimal Antiplatelet Treatment to Achieve Stroke Avoidance and Fall in Bleeding Events following Left Atrial Appendage Closure (SAFE-LAAC). Comparative Health Effectiveness Randomized Trial – PILOT Study

An open-label, randomized clinical trial comparing Etacizin versus Propafenone in Atrial Fibrillation

Waiting on Atrial fibrillation Intervention Therapy (WAIT) Study

Effect of H2 inhalation therapy on early recurrence after atrial fibrillation ablation. Multicenter, open-label, randomized phase II controlled trial.

Future Innovations in Novel Detection for Atrial Fibrillation (FIND-AF): Pilot Study

This study is testing a new way to find an irregular heartbeat called atrial fibrillation (AF) earlier. It uses a special computer tool and remote heart monitoring for people at higher risk. The goal is to see if this helps detect AF more often and leads to better treatment to prevent strokes.

Realistic Computational Electrophysiology Simulations for the Targetted Treatment of Atrial Fibrillation

Ablation of Focal Activation in Atrial Fibrillation

This study investigates if a new mapping technique, RETRO-Mapping, can accurately find specific electrical 'drivers' of persistent atrial fibrillation (AF). We aim to see if treating these drivers, in addition to standard treatment, improves outcomes for people living with persistent AF.

High Gastrointestinal Bleed Risk Outcomes in Patients With Non-valvular Atrial Fibrillation (NVAF) in France

This study looks back at French health records to understand how different blood-thinning medicines affect people with an irregular heartbeat (atrial fibrillation) who are at higher risk of stomach bleeding. It compares older medicines like warfarin with newer ones to see how safe and effective they are.

Super-Rehab: a Novel Approach to Treat Atrial Fibrillation

This study looks at 'Super Rehab', a new lifestyle programme combining exercise, diet advice, and regular check-ups, for overweight people with a heart rhythm problem called atrial fibrillation (AF). It aims to see if Super Rehab helps improve AF symptoms when added to usual care.

The Fourth Left Atrial Appendage Occlusion Study

This study looks at whether a 'WATCHMAN device' can prevent strokes in people with atrial fibrillation who are already taking blood thinners but still have a high stroke risk. It aims to see if blocking off a small part of the heart called the left atrial appendage helps.

Stroke Prevention and Rhythm Control Therapy STEEER-AF

This study aims to improve care for people with an irregular heartbeat called atrial fibrillation (AF). It's testing if training healthcare professionals helps them better manage AF and prevent strokes, ensuring patients get the best possible treatment according to guidelines.

The Role of Right Atrial Ectopy Triggering Ganglionated Plexuses in AF

This study looks at a new way to treat atrial fibrillation (AF), a common heart rhythm problem. It explores whether targeting specific nerve endings in the right side of the heart can help people whose AF has returned after standard treatments.

Rate or Rhythm Control in CRT: the RHYTHMIC Study

This study looks at two ways to control an irregular heart rhythm called Atrial Fibrillation (AF) in people with heart failure who have a special pacemaker (CRT). It compares AF ablation (a procedure to correct the rhythm) with AV node ablation (a procedure to slow the heart rate).

A Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation

This study is comparing two medicines, milvexian and apixaban, for people with an irregular heartbeat called atrial fibrillation. We want to see if milvexian is just as good as apixaban at stopping serious problems like strokes, which can happen with this condition.

AF Ablation With High Power Short Duration RF

This study looks at a new way to treat atrial fibrillation (AF), a common heart rhythm problem. It uses a special procedure called catheter ablation to see if a high-power, short-duration approach is safe and effective in preventing AF from coming back.

PulseSelect™ PFA Global Registry

This study is observing how well a new treatment called PulseSelect™ PFA works for people with atrial fibrillation (an irregular heartbeat). It collects information on its safety and effectiveness in patients receiving this approved treatment as part of their routine care.

Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Atrial Fibrillation Occurring Transiently With Stress

This study looks at whether blood-thinning medicines (anticoagulants) can prevent strokes and other heart-related problems in people who have had temporary episodes of an irregular heartbeat called atrial fibrillation (AF) during stressful times like surgery or serious illness.

An Investigator-initiated Linked Study to OCEANIC-AF

This study aims to understand how a new blood thinner, asundexian, affects the body's natural ability to dissolve blood clots, comparing it to an existing treatment, apixaban. Researchers will use blood samples from patients already in another study.

Early Closure of Left Atrial Appendage for Patients With Atrial Fibrillation and Ischemic Stroke Despite Anticoagulation Therapy

This study looks at whether a procedure to close off a part of the heart called the left atrial appendage (LAA) in addition to blood thinners can better prevent strokes in people with atrial fibrillation who have already had a stroke despite being on blood thinners.