RecruitingNAINTERVENTIONAL

Exercise Training in Patients With Persistent or Permanent Atrial Fibrillation

This research is exploring how exercise training can help people living with atrial fibrillation (AF), a common heart rhythm problem. We're comparing two types of exercise: moderate-intensity continuous exercise (like steady jogging) and high-intensity interval training (short, intense bursts followed by rest). The study aims to find out if either of these exercise approaches, when added to standard medical care, can improve a person’s fitness levels and overall well-being. Currently, exercise isn't routinely prescribed for AF, but this study hopes to provide strong evidence that it can make a real difference in how patients feel, their ability to exercise, and their general quality of life. Finding positive results could lead to new ways of managing AF that are easy to do and appealing to patients.

At a glance

Status

Recruiting

Phase

Sponsor

Ottawa Heart Institute Research Corporation

Enrolment target

132

Start

23 Jan 2019

Estimated completion

30 Dec 2037

Atrial Fibrillation

What is this study about?

This study is about understanding if certain types of exercise can help people who have persistent or permanent atrial fibrillation (AF). AF is a common heart condition where the heart beats irregularly. While standard medical care helps manage AF, exercise isn't usually a key part of the treatment plan for improving how patients feel or their overall health.

We want to see if adding exercise to regular care can make a positive difference. We are comparing two specific ways of exercising: 1. **Moderate-intensity continuous exercise (MICE):** This is like exercising at a steady, comfortable pace for a longer period, such as brisk walking or swimming. 2. **High-intensity interval training (HIIT):** This involves short bursts of more intense exercise followed by brief periods of rest or lower-intensity activity.

The main goal is to find out if either of these exercise plans can improve how well people can exercise (their 'exercise capacity') and their overall quality of life. If we find that exercise helps, it could lead to new, simple, and effective ways for people with AF to manage their condition, feel better, and improve their health without needing special equipment.

Key takeaways

This study explores if exercise can improve health for people with ongoing atrial fibrillation.
It compares moderate steady exercise with short bursts of high-intensity exercise.
The goal is to find out if exercise improves fitness and quality of life.
Positive findings could lead to new, simple treatments for AF.
Participation involves supervised exercise and regular check-ups over a few months.

Who may be eligible?

To join this study, you need to have ongoing atrial fibrillation, either persistent or permanent. Your heart rate needs to be well-controlled, usually staying at 100 beats per minute or less when you're resting. You also need to be at least 40 years old and capable of safely doing an exercise test.

There are some reasons why you might not be able to take part. For example, if you are already exercising regularly more than twice a week, you wouldn't be suitable. Also, if you have certain other heart conditions like unstable chest pain (angina) or severe problems with your heart valves, you wouldn't be able to join.

Additionally, if you are pregnant, breastfeeding, or planning to become pregnant during the study, you cannot participate. You must also be willing and able to give your informed consent (meaning you understand and agree to join) and be available for follow-up appointments after 12 weeks.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Do you have persistent or permanent atrial fibrillation?
Is your resting heart rate usually under 100 beats per minute?
Are you able to do a physical activity test safely?
Are you 40 years old or older?
Are you not currently exercising regularly (more than twice a week)?
Are you not pregnant, breastfeeding, or planning to be during the study?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, you will be assigned to one of three groups: either standard medical care, standard care plus moderate-intensity exercise, or standard care plus high-intensity interval exercise. You'll have some initial assessments before starting, which will likely include an exercise test to check your fitness levels and questionnaires about your quality of life. The exercise programs will be supervised, and you'll be given guidance on how to perform them safely.

You won't be given any new medications specifically for this study, as it focuses on exercise. Over the course of the study, you'll have regular check-ups and follow-up assessments, including repeat exercise tests and questionnaires, to see how your body and well-being have changed. The final follow-up will be at 12 weeks from the start of the study. The total duration of your active participation, including assessments and the exercise program, will be a few months.

Potential risks and benefits

Taking part in this study may offer potential benefits, such as improved fitness, better quality of life, and learning new ways to manage your atrial fibrillation through exercise. As with any exercise program, there are some potential risks, mainly related to physical activity, though these will be closely monitored, and you will have medical supervision. You will undergo an exercise test beforehand to ensure it's safe for you to participate. Remember, your participation is voluntary, and you have the right to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (2)

London Health Sciences Network
Verified postcode
London, Canada· Recruiting
University of Ottawa Heart Insititue
Verified postcode
Ottawa, Canada· Recruiting

Common questions

What is atrial fibrillation?

Atrial fibrillation (AF) is a common heart condition that causes an irregular and often very fast heart rhythm.

What's the difference between MICE and HIIT?

MICE is a steady, gentle exercise like a brisk walk for longer, while HIIT involves short, intense bursts of activity followed by rest.

Will I have to pay to join the study?

No, you will not have to pay to participate in the study. All study-related assessments and exercise programs are provided.

Can I still take my regular AF medications?

Yes, you will continue with your standard medical care, including any prescribed medications for your atrial fibrillation.

How long will the study last for me?

Your active participation, including assessments and the exercise program, will typically last for a few months, with the main follow-up at 12 weeks.

How to find out more

Jennifer L Reed, PhD

jreed@ottawaheart.ca 613-696-7392 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.