CONTEST Study - Accuracy of contrast enhanced breast tomosynthesis: A comparison with digital mammography and breast MRI
Breast cancer is the most common cancer in the UK. Finding it early gives the best chance of successful treatment. However, dense breast tissue can make it harder for doctors to spot lumps on standard mammograms. The CONTEST study is testing a new imaging technique called Contrast Enhanced Digital Breast Tomosynthesis (CE-DBT). This test takes 3D-style X-ray pictures of the breast after a harmless dye is injected into a vein. The dye helps highlight areas of concern. The study compares this new test against standard mammograms and MRI scans in women aged 18 to 70 who have suspected breast cancer. The main goal is to find out whether the new test can show the exact size and position of a tumour more clearly, helping doctors plan the best treatment.
At a glance
What is this study about?
Breast cancer is very common in the UK, but finding it early can save lives. Most women who have breast checks receive a standard X-ray called a mammogram. However, many women have dense breast tissue, which appears white on an X-ray. Because breast tumours also look white, they can easily hide behind normal dense tissue, making them difficult to spot.
The CONTEST study is testing a new technique called Contrast Enhanced Digital Breast Tomosynthesis (CE-DBT). Before taking the X-ray, the doctor injects a special dye into your vein. Tumours often have more blood vessels than normal tissue, so the dye collects in these areas and makes them glow brighter on the scan. The scanner also takes images from several angles, creating a clearer picture.
Researchers at Ninewells Hospital in Dundee want to see if this new scan is better than standard mammograms at measuring tumour size and whether it works as well as an MRI scan. If it is successful, this test could give patients faster, clearer results without always needing a long MRI scan.
Key takeaways
- The CONTEST trial is testing a new breast X-ray scan called CE-DBT.
- The new test uses an injection of dye to make suspected tumours easier to see.
- It is designed for women aged 18 to 70 with suspected operable breast cancer.
- The goal is to see if it is better than standard mammograms and as accurate as MRI.
- Taking part is voluntary and will not delay your normal NHS treatment.
Who may be eligible?
You may be able to take part if you are a woman aged between 18 and 70, and your doctor or ultrasound scan has found a change in your breast that is strongly suspected to be operable breast cancer. You must also be able to understand the study and agree to take part.
You cannot take part if you have ever had an allergic reaction to iodine or X-ray dye, or if you have severe asthma or kidney disease. The dye used in the test can affect how kidneys work, so it is only given to people with healthy kidneys.
Women who are pregnant, breastfeeding, or who have had previous breast cancer surgery or breast implants are also not eligible. In addition, the study cannot include women who are unable to have an MRI scan or whose cancer requires chemotherapy before surgery.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- I am a woman aged between 18 and 70.
- A doctor or ultrasound scan has found a suspected breast tumour that can be treated with surgery.
- I have never had an allergic reaction to iodine or contrast dye.
- I do not have kidney problems or severe asthma.
- I do not have breast implants and have not had breast cancer surgery before.
- I am not pregnant or breastfeeding.
What does participation involve?
If you take part, you will receive all your normal NHS breast care. This includes a standard digital mammogram and an ultrasound scan. As part of the study, you will also have the new CE-DBT test. For this, a nurse will inject a contrast dye into a vein in your arm just before your breast is X-rayed.
Some women in the study will also have an MRI scan. If your doctor spots any area of concern during your visits, you may have a small sample of cells taken using a needle (a biopsy), which is part of routine care.
After your scans, you will be asked to fill in a short questionnaire about how you felt during the tests. The study procedures take place during your hospital visits, and your total time in the study will usually cover the period leading up to your planned treatment.
Potential risks and benefits
Locations (1)
- Ninewells HospitalApproximateDundee, Scotland
Common questions
What is the special dye used in the scan?
It is a liquid containing iodine that is injected into your vein. It helps abnormal areas and blood vessels stand out clearly on the X-ray.
Does the new scan hurt?
The scan feels very similar to a normal mammogram. You will feel brief pressure on your breast while the pictures are taken, and a small scratch from the injection needle.
Is the radiation safe?
Yes. While the new scan uses slightly more radiation than a standard mammogram, the dose is still very low and well within strict UK safety limits.
Will taking part delay my cancer treatment?
No. The tests are arranged alongside your normal hospital visits so that your standard diagnosis and treatment plan carry on without delay.
What happens if I change my mind?
You can leave the study at any point. You do not need to give a reason, and your doctor will continue to provide your usual NHS care.
How to find out more
Kulsam Ali
Always speak to your GP or specialist before deciding to take part in a study.
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