- recruitingNA
Integrated Short-Term Palliative Rehabilitation in Incurable Cancer
This study looks at a special support program called 'palliative rehabilitation' for people with incurable cancer. It aims to see if adding this program to usual care helps improve their quality of life more than just usual care alone.
Denmark · France · Italy - recruiting
Investigating the Tumour Immune Response of Radiotherapy
This study looks at how radiotherapy for cancer affects the body's immune system. Researchers will collect tiny tissue samples (biopsies) and blood before and after treatment to understand these changes in different cancer types.
United Kingdom - active not recruiting
BIOMARKER and IMAGING CHARACTERISATION of INFLAMMATORY ATHEROMA in PATIENTS RECEIVING IMMUNOTHERAPY and ANGIOGENESIS INHIBITORS
This study looks at how new cancer drugs, called immunotherapies and anti-angiogenesis medicines, affect your blood vessels and heart. We want to understand why some patients get heart problems or strokes when taking these important cancer treatments.
United Kingdom - authorisedTherapeutic exploratory (Phase II)
FINACCESS - Finnish National Study for Early Access to Cancer Therapies
The FINACCESS study is looking at how well new cancer medicines work and if they cause side effects. It's for adult patients with different types of cancer. Doctors want to find out more about early access treatments.
Finland - active not recruitingPHASE3
Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Osimertinib (TAGRISSO) (ROSY-T)
This study is for cancer patients who are already taking osimertinib (Tagrisso) in another AstraZeneca study and are still benefiting from it. It allows them to keep taking the drug to see if it continues to help.
China · France · Malaysia - recruiting
ORganoid GeneratioN Study for Cancer
This study aims to grow cancer cells from patient samples in the lab, like 'mini-tumours.' This helps scientists understand why some cancers respond to treatments and others don't, hopefully leading to better treatments for cancer patients in the future.
United Kingdom - enrolling by invitation
Investigating the Role of Genetics in Disease Predisposition
This study looks at how tiny changes in the sperm and eggs we inherit can affect our health, especially the risk of certain cancers and rare diseases in our children. Researchers want to understand where these changes come from and how they pass them on.
United Kingdom - active not recruiting
Mixed Methods Study to Assess Family Members Unmet Needs in an Oncology Setting
This study looks into what support family members of cancer patients might need, especially in the Swansea area. Researchers want to understand where current support falls short and how to improve it, by asking family members about their experiences.
United Kingdom - recruiting
Palliative Care and Oncology Survey on Terminology
This study asks people with cancer how they feel about words used to describe them, like 'cancer survivor'. We want to understand if these terms are helpful, especially for those receiving palliative care or active cancer treatment. Your views can help improve how care is given.
Ireland · United Kingdom - recruitingPHASE2, PHASE3
DETERMINE Trial Treatment Arm 06: Capmatinib in Adult Patients With Cancers Harbouring MET Dysregulations
This study is testing a cancer drug called capmatinib to see if it can help adults with different types of cancer that share a specific genetic change (MET mutation). It's already approved for some lung cancers, and now researchers want to know if it works for other cancers too.
United Kingdom - recruiting
Management of Immune Checkpoint Inhibition-related Hepatitis Using Low-dose Corticosteroids
This study looks at using a lower dose of steroids to treat liver problems (hepatitis) caused by cancer immunotherapy. It aims to see if this smaller dose works well, reducing side effects, and helping patients get better without needing stronger medicines.
Switzerland · United Kingdom - active not recruitingPHASE3
An Extension Study of Venetoclax for Subjects Who Have Completed a Prior Venetoclax Clinical Trial
This study is for people who have already been taking a medicine called venetoclax for their cancer in another trial. It allows them to keep taking venetoclax if it's helping them and they're not having bad side effects, so doctors can learn more about its long-term safety.
United States · Australia · Austria - recruitingPHASE2
Pan Tumor Rollover Study
This study looks at the long-term safety of different cancer treatments, including nivolumab, alone or combined with other medicines. It's for people with various types of cancer who are already receiving treatment in a related study, aiming to see how these treatments work over time.
United States · Argentina · Australia - active not recruitingPHASE1
A Study to Learn About Study Medicine ALTA2618 in Adults With AKT1 E17K-Mutant Solid Tumors
This study is looking into a new medication called ALTA2618 for adults with certain advanced cancers that have a specific genetic change (AKT1 E17K mutation). The main goal is to check its safety and find the right dose.
United States · Australia · France - enrolling by invitationPHASE3
Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Durvalumab
This study is for cancer patients who have already been in another durvalumab drug trial and are still benefiting from the treatment. It lets them continue receiving the drug to see if it keeps helping them.
United States · Argentina · Australia - active not recruitingPHASE1
AZD6244 (ARRY-142886) Solid Oral Dosage Formulation in Participants With Advanced Solid Malignancies
This study is testing a new capsule called AZD6244 for people with advanced cancers. It aims to check how safe it is, whether people can tolerate it well, and how the body handles the medicine. This is an early-stage study to understand the drug better.
United States · Netherlands · United Kingdom - active not recruiting
LEVANTIS-0093A: GAGomes for Multi-Cancer Early Detection in High-Risk Adults (LEV93A)
This study looks for early signs of many cancers in people aged 55-80 who have a history of smoking. It uses blood samples from existing screening programmes in Yorkshire to find new ways to detect cancer sooner.
United Kingdom - recruiting
Circulating Tumour DNA (ctDNA) in Patients With Colorectal Cancer and the Relationship to Imaging Features of Extramural Venous Invasion
This study looks at a new way to understand bowel cancer spread. We're taking blood samples from patients having surgery for bowel cancer to see if blood changes can tell us more about how the cancer might spread through blood vessels. This could help improve how we treat bowel cancer in the future.
United Kingdom - recruiting
Public Survey on Breath Testing for Health and Disease
This survey asks what people think about using an easy breath test to check their health and find illnesses like cancer. Your answers will help researchers understand how to make health checks better and guide future studies.
United Kingdom - recruiting
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
This study aims to understand why common medicines don't work the same for everyone in the UK, especially for people from different backgrounds. It will look at many health conditions, hoping to improve how we treat them and make healthcare fairer for all.
United Kingdom - recruitingPHASE2, PHASE3
DETERMINE Trial Treatment Arm 03: Entrectinib in Adult, Paediatric and Teenage/Young Adult Patients With ROS1 Gene Fusion-Positive Cancers.
This study is testing a drug called entrectinib for different cancers in adults and children. It focuses on cancers with a specific change in their cells, called ROS1 gene fusion, to see if entrectinib can be a new treatment option.
United Kingdom - active not recruitingPHASE3
A Study in Participants Previously Enrolled in a Genentech- and/or F. Hoffmann-La Roche Ltd-Sponsored Atezolizumab Study (IMbrella A)
This study is for people with cancer who are already receiving specific cancer treatments in another study. It allows them to continue their treatment if their original study ends and they can't get the medicine elsewhere. It's about safely extending access to these important cancer drugs.
United States · Argentina · Australia - recruiting
Met Non Small Cell Cancer Registry (MOMENT)
This study looks at how treatments for a specific type of lung cancer (NSCLC with METex14 changes) are working in real patients and how patients are doing over time. It's a way to learn more about this cancer and its treatments without testing new medicines.
United States · Austria · Belgium - recruiting
Tumour Characterisation to Guide Experimental Targeted Therapy - National
This study, called TARGET National, helps doctors understand advanced cancers better. By looking closely at your tumour, we aim to find the best experimental immune, hormone or targeted treatments suited to you. It's for people with advanced solid cancers across the UK.
United Kingdom - active not recruiting
CCP Cancer UK Companion Study
This study looks at how COVID-19 affects people with cancer in the UK. We want to understand their symptoms, treatment, and recovery, comparing them to people without cancer. This helps us learn how to better care for cancer patients during outbreaks.
United Kingdom - recruiting
RDC Biomarker Study
This study aims to find new, simple tests, like breath, blood, or saliva tests, to help doctors quickly find cancer in patients at Rapid Diagnostic Centres. It also wants to identify people at higher risk of cancer to help them get screenings or monitoring.
United Kingdom - not yet recruitingNA
Finding My Way-UK: Promoting Positive Psychological Outcomes in People Living With and Beyond Curatively Treated Cancer
This study looks at an online program, "Finding My Way-UK", for people who have finished cancer treatment. It checks if the program is easy to use and helpful for improving feelings like hope and resilience after cancer.
United Kingdom - recruitingPHASE4
The STOP-MED CTRCD Trial
This study looks at whether it's safe for cancer survivors to stop heart failure medicines if their heart has recovered well. It's for people whose hearts were affected by cancer treatment but are now working normally again.
United States · Australia · Canada - recruiting
MR-BIO: A Study to Evaluate Changes in MR Imaging and Biological Parameters
This study uses a special MRI machine to see how radiotherapy affects cancer and healthy tissues. It aims to improve treatment by understanding these changes and linking them to how well patients recover. Patients will give blood and urine samples.
United Kingdom - not yet recruiting
Validation of the European Oncology Quality of Life Toolkit
This study is testing a new set of online surveys called the EUonQoL-Kit. These surveys help understand the quality of life for people with cancer at different stages – during treatment, after treatment, and in palliative care. The goal is to make sure the surveys are accurate and helpful across Europe.
Albania · Austria · Belgium - enrolling by invitation
SMS 2: Impact of Cancer Therapy on the Somatic Mutational Landscape of Normal Tissues
This study looks at how cancer treatments, like chemotherapy or radiotherapy, affect tiny changes (mutations) in healthy body cells. We're collecting samples such as blood, cheek swabs, and urine from adult cancer patients to understand these changes better.
United Kingdom - active not recruiting
Epidemiology of Complications After Solid Organ Transplantation - EpCOT Study
This study looks at health problems, especially cancer, after organ transplants in the UK. Researchers are combining existing patient information to better understand why cancer happens and how it affects people after a transplant, to help improve care.
United Kingdom - not yet recruitingNA
Glasgow Low-dose CT and AI-based Diagnostics to Case Find Lung Cancer and Other Cardio-respiratory Long-term Conditions - Feasibility Study
This study offers a Lung Health Check for those at higher lung cancer risk. It includes a low-dose CT scan, plus heart and breathing tests, aiming to find lung cancer early and check for other conditions like heart disease and emphysema, all in one visit.
United Kingdom - recruitingNA
The PRIMROSE Trial
This study looks at how a special breathing device, used alongside standard pre-surgery exercises, can help people with lung cancer prepare for surgery. The aim is to make them fitter, reduce complications, and shorten their time in hospital.
United Kingdom - recruitingNA
Improving Radical Treatment Through MRI Evaluation of Pelvic Sigmoid Cancers
This study looks at using MRI scans for sigmoid colon cancer to see if it helps doctors plan better treatment. Half of patients get standard care (CT scan), and the other half get an additional MRI. We compare how plans change and follow up for improved care.
United Kingdom - recruiting
E²-RADIatE: EORTC-ESTRO RADiotherapy InfrAstrucTure for Europe
The E²-RADIatE study is collecting information from cancer patients across Europe who are having radiotherapy. This helps researchers better understand how radiotherapy is used and how it works alongside other treatments to improve care for people with cancer.
Austria · Belgium · Czechia - not yet recruiting
Chemotherapy-Induced Hearing Loss and Health Inequality
This study looks at how chemotherapy for cancer can cause hearing loss, especially in people from poorer backgrounds. It also checks if hearing loss affects memory and thinking, to help improve care for cancer patients in the North West of England.
United Kingdom - recruitingNA
Strategy for EArly Recognition of Cancer, COPD & Heart Failure in the Emergency Department
This study at Queen Elizabeth University Hospital checks if a computer program can help doctors find heart and lung problems like cancer earlier from chest X-rays. It aims to improve how quickly and accurately these conditions are diagnosed.
United Kingdom - recruiting
Breaking Barriers to Research Access
This study aims to understand why some cancer patients, especially those from certain backgrounds, find it hard to join research studies. By finding out what these barriers are, we hope to make sure more people can take part in research, leading to fairer and better cancer care for everyone in Cheshire and Merseyside.
United Kingdom - recruiting
Neurobehavioural and Cognitive Changes in Cancer Cachexia (CANCOG)
This study looks at how cancer, specifically weight loss due to cancer, affects the brain and body signals. Researchers want to understand changes in appetite, motivation, and brain activity to help develop new treatments for cancer-related weight loss.
United Kingdom - active not recruitingPHASE3
Add-Aspirin: A Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival After Primary Therapy in Common Non Metastatic Solid Tumours
This study looks at whether taking aspirin daily after cancer treatment can stop cancer coming back and help people live longer. It focuses on common cancers like breast, bowel, and prostate cancer.
Ireland · United Kingdom - not yet recruiting
Hair Isotope Analysis for Early Cancer Detection
This study looks at hair to find early signs of cancer. We think cancer changes how your body uses nutrients, and this might show up in your hair. By analysing hair from people with cancer, we hope to find new ways to detect the disease simply and without needles.
United Kingdom - active not recruitingPHASE3
Study to Continue Treatment With Darolutamide in Patients Who Have Been Participating in Previous Darolutamide Studies Supported by Bayer
This study is for men with cancer who are already taking darolutamide in another Bayer study and are doing well. It lets them keep taking the same medicine at the same dose, continuing their treatment journey under medical supervision.
United States · Argentina · Australia - not yet recruitingPHASE2, PHASE3
DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers.
This study looks at two drugs called dabrafenib and trametinib for various cancers with a specific gene change (BRAF V600). These drugs are already approved for some cancers and researchers want to see if they can help people with other rare cancers or cancers with this same change.
United Kingdom - recruiting
APACE - Feasibility of Using Accelerometers to Measure Physical Activity in Cancer Patients on Early Phase Clinical Trials
This study looks at how we can better measure physical activity and sleep in cancer patients using a wearable device. It helps us understand if these devices are useful for people with advanced cancer participating in early clinical trials, potentially improving care and support.
Italy · Spain · United Kingdom - active not recruitingPHASE1
Study of RP2 Monotherapy and RP2 in Combination With Nivolumab in Patients With Solid Tumors
This study is testing a new treatment called RP2, alone and with nivolumab, for adults with advanced cancers. It aims to find the safest dose and see how well it works. RP2 is a modified virus designed to fight cancer.
Spain · United Kingdom - enrolling by invitation
Retrospective WGS Study
This study looks back at records of children and young people with cancer who had a special genetic test called whole genome sequencing. The aim is to see if this test helped doctors choose better treatments for them, to understand its benefits.
United Kingdom - active not recruiting
The SUMMIT Study: A Cancer Screening Study
The SUMMIT study is looking at better ways to find cancer early. It will test a blood test for many cancers and offer special lung scans to people at higher risk in London who have smoked. The goal is to improve how we check for cancer.
United Kingdom - recruitingPHASE1
A Single- and Multiple-Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of LY4066708 in Healthy Participants
This study looks at a new medicine called LY4066708 in healthy volunteers. We want to check it's safe, how well the body handles it, and how long it stays in the system. It's a first step to see if it could help with certain health conditions later on.
United Kingdom - recruiting
A Platform Study for solId orgaN CancERs
This study aims to collect tiny samples of tissue and blood from cancer patients undergoing surgery or biopsy. These samples will help researchers understand solid organ cancers better and develop new ways to diagnose and treat them. It's designed to make it easier for researchers to get high-quality samples.
United Kingdom