Effects of Oncological Treatment During Pregnancy on Mother and Child

This study has two main parts, and you don't have to take part in both, but it's preferred if you can.

For the first part, which focuses on the mother and pregnancy, you must be a woman over 18 who has been diagnosed with cancer during pregnancy or within five years after giving birth. You must also be able to understand and sign the consent forms. If you've had certain cancer treatments like chemotherapy or radiotherapy during pregnancy, you can also join this part.

For the second part, which follows up on the children, it's for children who were exposed to cancer or cancer treatment while in the womb. Their parents will need to give permission. Once children turn 12, they'll also be asked to agree to take part. After they turn 18, they will give their own consent. The study cannot include people who have significant mental difficulties that would prevent them from understanding what's involved.

If you decide to take part in the mother's part of the study, you might be asked to provide a blood sample during or shortly after birth, as well as samples from your baby's umbilical cord and placenta. You'll also complete questionnaires about your feelings and emotional needs related to your cancer diagnosis during pregnancy.

If your child takes part in the follow-up study, they will have regular health check-ups. These happen at 6 months, 18 months, and then at ages 3, 6, 9, 12, 15, and 18 years. After they turn 18, there will be heart checks and questionnaires every five years until they are 43. Some older children might also have MRI brain scans at certain ages. These check-ups will be done by specialist doctors and psychologists.