Molecular Investigation of GENetic Factors in Cardiovascular and Immune-related Traits and Diseases Using a BIOresource of Healthy Volunteers (GENBIO)
This study, called GENBIO, aims to understand how our genes, lifestyle, and environment work together to influence the risk of heart disease. Researchers are particularly interested in two genes, SWAP70 and GMPR, which may play a role in heart health and the body's immune system. By studying these genes in healthy volunteers, scientists hope to learn more about how our bodies respond to different factors related to heart conditions. If you're already part of the NIHR BioResource and meet certain genetic criteria, you might be invited to join. Participation involves a single visit where we'll ask you some questions, take a few measurements like height and blood pressure, and collect a small blood sample. This research could lead to a better understanding of diseases, help find new treatment targets, and improve existing therapies.
At a glance
What is this study about?
Heart disease is a common problem, and it's affected by a mix of things: the genes we inherit, our daily habits, and the world around us. This study, called GENBIO, wants to explore this connection in more detail. We're focusing on healthy volunteers because their genetic makeup is already known through the NIHR BioResource, making it easier to see how specific genes might be involved.
The research looks at two genes that are potentially important for heart health. One, called SWAP70, is thought to be involved in how our immune system, which fights off illness, can affect our risk of heart disease. The other, GMPR, is important for how our red blood cells are formed. By understanding how these genes work, scientists hope to uncover the tiny, invisible processes happening in our bodies that can either protect us from heart conditions or make us more vulnerable.
Ultimately, the goal is to gain a deeper understanding of how heart diseases develop. This knowledge could help in several ways: it might lead to new ideas for medicines, show us how existing treatments could be made better, or even help doctors identify people who might be at higher risk in the future. It's all about piecing together the puzzle of heart health.
Key takeaways
- A research study looking at genes and heart health.
- Only one visit required for participants.
- Includes a questionnaire, physical measurements, and a blood test.
- Aims to improve understanding of heart disease and potential treatments.
- Not testing new medicines, but gathering knowledge.
Who may be eligible?
This study is looking for healthy volunteers who are already part of the NIHR BioResource and are aged 18 or over. You'll be invited to take part if your genetic results from the BioResource show you carry (or don't carry) particular gene variations that the researchers are interested in.
There are a few reasons why you might not be able to join. For example, if you have a long-term illness like heart disease, an autoimmune condition (where your body attacks itself), or cancer, you wouldn't be suitable. Also, if you currently smoke, drink more than a certain amount of alcohol daily, or have high blood pressure or cholesterol levels, you wouldn't be able to participate.
To keep the study results clear and accurate, you also shouldn't have a close family member with a condition that might complicate the genetic findings. Being very overweight (a BMI over 30) or being unable to fast and avoid alcohol and caffeine for 12 hours before your visit would also mean you couldn't take part.
- Are you 18 years old or older?
- Are you currently part of the NIHR BioResource?
- Do you not have any long-term illnesses like heart disease, autoimmune conditions, or cancer?
- Do you not currently smoke regularly?
- Can you fast (not eat or drink alcohol/caffeine) for 12 hours before a morning appointment?
This is a guide only — the research team will confirm whether you can take part.
What does participation involve?
If you're invited to join, taking part in this study is quite straightforward and only involves one visit. During this visit, we'll ask you to fill out a questionnaire about your health, lifestyle, and background information. We'll also take a few simple measurements, such as your height, weight, body fat, blood pressure, and heart rate.
The main part of the visit will be a blood test, which involves taking a small blood sample from your arm. This is a common and usually quick procedure. You won't be given any medication as part of this study, and there will be no follow-up visits after your initial appointment. The entire participation will be completed within this single visit.
Potential risks and benefits
Locations (1)
- Department of Public Health and Primary CareCambridge, United Kingdom
Common questions
What is the NIHR BioResource?
It's a national project where people volunteer to provide health information and blood samples for research, helping scientists understand diseases better.
What are 'genetic factors'?
These are specific parts of your DNA (your body's instruction manual) that can influence your health and how your body works.
Will I get my test results?
The study focuses on research, so individual results aren't usually shared. The findings will be used to understand health on a bigger scale.
Is this study testing new medicines?
No, this is an observational study. We're observing and collecting information to understand disease mechanisms, not testing new drugs.
How long will my visit take?
The study involves a single visit, and the team will be able to give you an estimate of how long it will take when you are invited.
How to find out more
Always speak to your GP or specialist before deciding to take part in a study.
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