Cardiovascular Diseases research hub
50 indexed studies · 33 currently recruiting
- active not recruitingNA
Computed Tomography Coronary Angiography for the Prevention of Myocardial Infarction (The SCOT-HEART 2 Trial)
This study looks at whether a special heart scan called CT coronary angiography (CTCA) can help doctors better prevent heart attacks compared to current standard methods. It involves people aged 40-70 in Scotland who are at risk of heart disease.
United Kingdom - recruiting
Low Energy Availability and Cardiovascular Disease
This study looks at how low energy in female athletes might affect their heart health. It aims to understand the link between having too little energy for daily activities and how the heart and blood vessels work.
United Kingdom - active not recruitingPHASE1
Investigation of the Effects of Dietary Nitrate and Sex on COVID-19 Vaccine Induced Vascular Dysfunction in Healthy Men and Women (DiNOVasc-COVID-19)
This study looks at how the COVID-19 vaccine affects blood vessels in healthy people. It also explores if beetroot juice, which contains natural nitrate, can help protect blood vessels. We're also checking for differences between men and women.
United Kingdom - active not recruitingNA
Screening for Asymptomatic Coronary Artery Disease in Kidney Transplant Candidates
This study looks at whether regular heart checks are really needed for people waiting for a kidney transplant. We want to see if skipping these extra checks after an initial one is just as safe as having them, focusing on preventing serious heart problems.
United States · Canada · Germany - recruiting
Real World European Investigation of Safety and Clinical Efficacy of the EVOQUE System (TRISCEND III EU)
This study looks at a new treatment called the EVOQUE system for a heart condition called tricuspid valve regurgitation. It's for people in Europe whose heart valve leaks. Doctors want to see how safe and effective this treatment is in real-life settings for up to 500 patients.
Germany · Greece · Italy - active not recruitingNA
SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN
This study looks at a treatment called renal denervation (RDN) for high blood pressure. It uses a device called Symplicity Spyral to see how well it works and if it's safe in the long term, especially for people whose blood pressure is hard to control.
United States · Australia · Belgium - active not recruitingNA
Targeted Assessment in High-Risk paTients With dIAbetes to ideNtify Undiagnosed Heart Failure
This study looks at a new way to find hidden heart failure in people with diabetes who are at higher risk. We're testing if checking a specific blood marker helps doctors discover heart problems earlier, so people can get the right care sooner.
United Kingdom - recruitingNA
A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Understanding and Management of Coronary Calcium (The Optimal Trial)
This study compares two ways to plan heart artery procedures for people with hardened arteries. It uses advanced CT scans versus a standard internal ultrasound to see which method helps doctors work better and get similar good results for patients.
United States · Belgium · Spain - active not recruiting
ADHD Remote Technology Study of Cardiometabolic Risk Factors and Medication Adherence
This study looks at how ADHD and its treatments affect heart health. We're using smartphone apps and a special watch to anonymously collect information about daily life and medication use in adults with ADHD.
Spain · United Kingdom - active not recruitingNA
Evaluation of Lifestyle Modification on Cardiovascular Risk
This study looks at how exercise, and a healthy Mediterranean diet, might help women aged 45-65 who are overweight or obese and have gone through menopause. It aims to improve heart health and metabolic health (like blood sugar and cholesterol) over 8 weeks.
United Kingdom - active not recruitingNA
Prehabilitation's Effect on Skeletal Muscle Mass in Cardiac Patients
This study looks at how a special exercise and activity programme, called 'prehabilitation', affects muscle strength in people waiting for heart surgery. Researchers want to see if doing these exercises before surgery can help patients recover better by improving their muscle mass.
United Kingdom - recruiting
Biomedical Research Informatics Centre for Cardiovascular Sciences (The BRICCS Study)
This study looks at heart and blood vessel conditions, like heart attacks or high blood pressure, in hospital patients and healthy people. Researchers will collect information and samples to better understand these conditions, improve diagnosis, and predict how they might progress.
United Kingdom - recruitingPHASE3
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
This study looks at a new medicine, vicadrostat, for people with type 2 diabetes, high blood pressure, and heart disease. It aims to see if taking vicadrostat alongside empagliflozin can help reduce heart problems. Half the participants will get the study medicine, and half will get a dummy pill.
United States · Argentina · Australia - recruitingNA
Streamlined Denervation With spYral For an Optimized Treatment (SPYRAL SWYFT) in Subjects With Uncontrolled Hypertension
This study looks at a procedure called renal denervation to treat high blood pressure. It aims to see if a simpler way of doing the procedure is just as good, and possibly quicker, than older methods. This could offer a new option for people whose blood pressure is hard to control.
Australia · Belgium · Germany - recruiting
Machine Learning in Quantitative Stress Echocardiography
This study uses advanced computer analysis on heart scans (stress echocardiograms) to find heart problems more accurately. By improving how doctors interpret these tests, it aims to help people avoid unnecessary procedures and get the right treatment faster, making heart disease diagnosis better and safer.
United Kingdom - enrolling by invitation
EuroSIDA - Clinical and Virological Outcome of European Patients Infected With HIV
The EuroSIDA study looks at how HIV affects people in Europe and how treatments work over time. It helps us understand health changes and the impact of new medicines for HIV and related conditions like hepatitis.
Argentina · Austria · Belarus - recruitingNA
Artificial Intelligence Delivered Cardiac Magnetic Resonance - Prospective Validation
This study is testing if artificial intelligence (AI) can help take detailed heart scans (CMRIs) faster and just as well as human experts. It aims to make it easier to get these important heart checks.
United Kingdom - not yet recruiting
Smart Wearable Insights to Prevent Exacerbations and Recurrence - Rehabilitation Study: SWIPER-REHAB
This study looks at how a digital heart rehabilitation program works using a smartwatch and an app. It wants to see how many people finish the program and if it saves money. It's for adults with heart conditions who are starting heart rehabilitation.
United Kingdom - active not recruiting
Future Innovations in Novel Detection for Atrial Fibrillation (FIND-AF): Pilot Study
This study is testing a new way to find an irregular heartbeat called atrial fibrillation (AF) earlier. It uses a special computer tool and remote heart monitoring for people at higher risk. The goal is to see if this helps detect AF more often and leads to better treatment to prevent strokes.
United Kingdom - recruitingNA
Smartphone Twelve-Lead ECG Utility In ST-Elevation Myocardial Infarction II
This study is testing a new smartphone device called AliveCor 12-lead ECG. It aims to see if this device can accurately detect heart attacks (STEMI and NSTEMI) in people with chest pain, just as well as the standard ECG machines used in hospitals.
United States · United Kingdom - enrolling by invitation
PDE3B in Metabolic Regulation
This study looks at how a protein called PDE3B affects how our bodies handle sugar and fat. Researchers want to understand if changes in this protein could protect people from conditions like type 2 diabetes and heart disease, potentially leading to new treatments.
United Kingdom - recruiting
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
This study aims to understand why common medicines don't work the same for everyone in the UK, especially for people from different backgrounds. It will look at many health conditions, hoping to improve how we treat them and make healthcare fairer for all.
United Kingdom - recruiting
Nutritional Screening in Cardiovascular Disease
This study looks at how a patient's diet and health before heart surgery might affect how well they recover. We'll use questionnaires, blood tests, and strength checks to understand how nutrition relates to hospital stay and recovery.
United Kingdom - recruitingPHASE3
A Study to See if Lepodisiran Can Reduce Plaque in Coronary Arteries of Adults With Elevated Lp(a) Who Have Had Heart Events or Are at High Risk
This study investigates a new medicine, lepodisiran, to reduce fatty deposits (plaque) in heart arteries. It's for adults aged 45-80 with high Lp(a), a type of cholesterol, who have heart problems or are at high risk. Researchers will use special scans to see if the medicine helps.
United States · Australia · Czechia - enrolling by invitationPHASE3
A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension
This study looks at the long-term effects and safety of a drug called Ralinepag for people with a lung condition called pulmonary arterial hypertension (PAH). It's for those who have already tried Ralinepag in a previous study.
United States · Argentina · Australia - recruitingNA
A Prospective Randomised Multi-centre Trial Comparing cArdiac MRI Guided CRT Versus Conventional CRT Implantation in Patients With Ischaemic Cardiomyopathy
This study looks at a new way to place special heart devices (CRT) in people with heart muscle damage from a lack of blood flow. We want to see if using MRI scans to guide the placement works better than the usual method for improving heart function.
United Kingdom - recruiting
Studying the Effects of Cannabis on Vasculature
This study looks at how long-term cannabis use affects your heart and blood vessels. Researchers will compare people who use cannabis regularly with those who don't, checking blood vessel health and signs of inflammation using simple tests and blood samples.
Canada - active not recruitingNA
Exercise to Prevent AnthraCycline-based Cardio-Toxicity Study 2.0 (EXACT2)
This study looks at whether a special exercise plan can help protect the hearts of women with breast cancer who are having chemotherapy. Some chemotherapy drugs can affect the heart, so we want to see if regular exercise can reduce this risk while the treatment works.
Canada - active not recruiting
Impact of a Regional Program Agir Sur Sa SantE
This study looks at a new care plan called 'Agir Sur Sa SantÉ' (meaning 'Act on Your Health') in our local area. It aims to see how well this plan works for people with conditions like diabetes, obesity, and high blood pressure, focusing on improving their overall health.
Canada - recruitingNA
Clinical Utility of a Genomic Predictor Test on the Management of Cardiorenal Complications of Type 2 Diabetes
This study looks at how a genetic test predicting heart and kidney problems in people with type 2 diabetes affects treatment. It compares people who know their risk score with those who don't, to see if knowing this information helps them reach their health goals better.
Canada - active not recruiting
Real-world Study on Dapagliflozin Usage in Patients With Heart Failure (HF) in Germany
This study looks at how a medicine called dapagliflozin is used for heart failure in Germany. Researchers want to understand how it affects people's symptoms, quality of life, and healthcare needs in everyday situations.
Germany - active not recruitingNA
Safety and Efficacy Study of reSept ASD Occluder for Treating Secundum ASD
This study looks at a new device, the reSept ASD Occluder, for treating a common heart condition called secundum Atrial Septal Defect (ASD). It aims to see if the device is safe and works well to close the hole in the heart.
United States · Canada · France - recruiting
Prospective WCD Post CABG Registry (CABG Registry)
This study looks at how well people recover their heart function after their first heart bypass surgery when they wear a special device called a WCD. It hopes to show that more people recover with modern medication use.
Germany - recruiting
The European NAFLD Registry
This study aims to understand fatty liver disease (NAFLD) better. Researchers collect information and samples from patients across Europe to find new ways to detect and monitor the disease, especially how it progresses from fatty liver to more serious conditions like fibrosis.
Belgium · Finland · France - recruiting
Retrospective Epidemiological Study of Patients in the National Cohort of the French TMA Center
This study looks back at records of over 1,200 patients in France who had a rare blood disorder called iTTP. It aims to understand how things like heart problems and specific treatments affect their long-term health and survival. It hopes to improve care for people with iTTP.
France - recruiting
Mayo AVC Registry and Biobank
This study aims to better understand a heart condition called Arrhythmogenic Ventricular Cardiomyopathy (AVC) that can lead to sudden cardiac arrest. Researchers hope to find new genetic causes and ways to predict the disease, helping to save lives in affected families.
United States · United Kingdom - active not recruiting
Exploring the Long-term Cardiovascular Effects of Vaping
This study looks at how vaping might affect your heart and blood vessels over time. We're comparing vapers who used to smoke, vapers who never smoked, people who both vape and smoke, and ex-smokers who don't vape. We'll check health over two years.
United Kingdom - active not recruitingNA
The RADIANCE II Pivotal Study: A Study of the ReCor Medical Paradise System in Stage II Hypertension
This study is testing a new device called the Paradise System for people with high blood pressure that's not too severe. It aims to see if this system, which treats kidney nerves, can safely and effectively lower blood pressure when people are taking few or no medications.
United States · Belgium · France - recruiting
Greater Manchester CARDIOvascular Pathology in Immune-Mediated Inflammatory Diseases
This study investigates the link between inflammatory conditions like rheumatoid arthritis and heart problems. Researchers aim to find early signs of heart disease in these patients to improve future treatments, focusing on understanding why and how these conditions are connected.
United Kingdom - recruiting
Patients with Coronary Artery Disease or At High Cardiovascular Risk: Measuring Compliance with Treatment for Obstructive Sleep Apnea Syndrome
This study looks at how well people with heart disease or high heart risk use treatments for sleep apnea. We're comparing two main treatments, CPAP and a mouth device, to see which is easier to stick with and works best for patients.
France - recruitingPHASE4
Effect of infLuenza vaccInation After Myocardial INfArction on Cardiac inflammaTory responsE
This study looks at how the flu vaccine affects heart inflammation in people who recently had a heart attack. Researchers want to see if the vaccine helps reduce inflammation in the arteries and throughout the body, compared to a dummy shot.
Denmark · Sweden · United Kingdom - not yet recruitingNA
A Prospective Multicenter Pivotal Study to Evaluate Safety and Effectiveness of Venus-Neo Surgical Aortic Valve
This study is testing a new heart valve called Venus-Neo to see if it's safe and works well for people needing aortic valve replacement. Researchers will follow participants for five years to understand its long-term performance.
Germany - recruiting
Registry to Assess the Safety and Feasibility of the Subpulmonary Support with the Novel Venous Cannula in Patients with Failing/Absence of the Right Heart
This study looks at how well a special device, called an EXCOR Venous Cannula, works in supporting hearts that are struggling. It aims to make sure the device is safe and helps patients get better, both in the short and long term.
Germany - recruitingNA
The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR
This study looks at a new device, the Carillon Mitral Contour System, for people with heart failure caused by a leaky heart valve. It aims to see if the device is safe and helps improve their condition, comparing it to usual care without the device.
United States · Canada · France - recruiting
Identification of New Biomarkers for the Prediction of Cardiovascular Events
This study aims to find new ways to predict heart and blood vessel problems. Researchers are collecting blood samples from patients already being looked after for heart health, hoping to discover new warning signs that help doctors understand and prevent these conditions better.
France - active not recruitingNA
Obstructive Sleep Apnoea and Cardiac Arrhythmias
This study looks at how sleep apnoea affects the heart, specifically checking for irregular heartbeats. We're using a tiny, implanted heart monitor to see if traditional methods miss important heart problems in people with sleep apnoea.
United Kingdom - recruiting
Register of Cardiovascular Complications Among People Living With HIV
This study looks at heart health in adults living with HIV who have other risk factors for heart problems. It collects information from people who have heart checks at Saint Antoine Hospital in Paris to better understand and improve their care.
France - active not recruiting
Smart Watch Insights for Prevention of Exacerbations and Enhance Rehabilitation - Movement Study
This study uses smartwatches to understand how movement affects health for people with conditions like heart disease or diabetes. Researchers hope to find ways to predict health changes and improve wellbeing programmes using the information from the watches.
United Kingdom - recruiting
Carotid Intraplaque Neovascularization Combined With Stress Echo
This study looks at a new way to predict heart attacks and strokes. It combines a standard heart stress test with a special neck ultrasound. This aims to find people at higher risk whose usual tests might miss them, by looking closely at fatty build-ups in blood vessels.
Canada - recruiting
UK CARDIOvascular Immune-Mediated Inflammatory Diseases (CARDIO-IMID) Registry Study
This study aims to understand how heart and blood vessel problems (cardiovascular diseases) are linked with conditions where the body's immune system attacks itself (immune-mediated inflammatory diseases). Researchers will collect health information from patients to find better ways to predict and manage these conditions.
United Kingdom