Aortic Valve Calcification research hub
50 indexed studies · 35 currently recruiting
- authorisedTherapeutic confirmatory (Phase III)
Does Colchicine Reduce Progression of Aortic Valve Stenosis? Colchicine and Inflammation in Aortic Stenosis (CHIANTI): A placebo-controlled, double-blind, multicenter randomized trial.
This study looks at whether a widely used medicine called colchicine can slow down the hardening of the heart's aortic valve. Researchers will compare people taking colchicine with those taking a dummy pill, to see if it helps keep the valve working better for longer. It's a big study to find out if this treatment could be useful.
Netherlands - recruiting
A Multicenter Observational Registry to Evaluate Safety and Performance of Vivo ISAR (SECURE Global Registry)
This study looks at how well a new heart stent called Vivo ISAR works and its safety for people with heart disease. It follows patients who have the stent and take blood-thinning medicines for a short time, to see their progress over a year.
India · Italy · Netherlands - active not recruitingNA
SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN
This study looks at a treatment called renal denervation (RDN) for high blood pressure. It uses a device called Symplicity Spyral to see how well it works and if it's safe in the long term, especially for people whose blood pressure is hard to control.
United States · Australia · Belgium - recruiting
The BRAVE Study- The Identification of Genetic Variants Associated With Bicuspid Aortic Valve Using a Combination of Case-control and Family-based Approaches.
The BRAVE study is looking for gene changes linked to Bicuspid Aortic Valve (BAV), a common heart condition where the heart's main valve has two flaps instead of three. Researchers hope to understand how BAV develops by studying blood samples from affected people and their families.
United Kingdom - active not recruitingPHASE1
Investigation of the Effects of Dietary Nitrate and Sex on COVID-19 Vaccine Induced Vascular Dysfunction in Healthy Men and Women (DiNOVasc-COVID-19)
This study looks at how the COVID-19 vaccine affects blood vessels in healthy people. It also explores if beetroot juice, which contains natural nitrate, can help protect blood vessels. We're also checking for differences between men and women.
United Kingdom - recruiting
The Genetics and Vascular Health Check Study (GENVASC) Aims to Help Determine Whether Gathering Genetic Information Can Improve the Prediction of Risk of Coronary Artery Disease (CAD)
The GENVASC study in Leicestershire and Northamptonshire looks at whether adding genetic information can better predict who might develop heart disease. It aims to improve early prevention for those at risk aged 40-74, especially those currently thought to be at low or medium risk.
United Kingdom - recruitingNA
Acute Impact of Whey Protein-enriched Milk Fat Globule Membrane Supplementation on Postprandial Markers of Heart and Brain Health
This study is looking at how a special milk protein supplement affects heart and brain health in middle-aged and older women after eating. It focuses on women who are overweight and have a moderate risk of heart problems.
United Kingdom - not yet recruitingPHASE4
DECODE - Haemodynamic Effects Of Semaglutide and Tirzepatide - a Series of Pilot Studies
This study looks at how new weight loss drugs, semaglutide and tirzepatide, affect blood vessels and blood pressure. Researchers want to understand if these drugs have direct benefits on the heart and blood system, beyond just helping people lose weight.
United Kingdom - recruiting
Genetic Variants and Regulation of Specialized Pro-resolving Mediator
This study looks at how tiny changes in our genes might affect how our bodies handle inflammation. We're trying to understand why some people get long-term inflammatory diseases like arthritis and heart conditions, hoping to find new ways to treat them.
United Kingdom - recruiting
The CACHE Study: Coronary Artery Care in HaEmophilia
This study uses advanced scans to look at heart health in men with haemophilia because they live longer now. We want to understand why they seem to have less heart disease and if this could help prevent heart attacks for everyone. It's about finding better ways to care for hearts.
United Kingdom - recruiting
Hypertension Explored in Long-term Postpartum Follow-up in Later Life
This study looks at why women who had high blood pressure during pregnancy might get heart and blood vessel problems later in life. Researchers want to understand these changes better to find new ways to help them.
United Kingdom - active not recruitingNA
OPTIMISation of Cardio-renal-metabolic-pulmonary Disease Guideline Adherence in High Risk Community Dwelling Individuals
This study looks at whether extra check-ups with heart specialists can help people with conditions like high blood pressure and diabetes get better treatment. The aim is to see if this extra care improves health and reduces the risk of serious problems like heart attacks.
United Kingdom - active not recruitingNA
Prehabilitation's Effect on Skeletal Muscle Mass in Cardiac Patients
This study looks at how a special exercise and activity programme, called 'prehabilitation', affects muscle strength in people waiting for heart surgery. Researchers want to see if doing these exercises before surgery can help patients recover better by improving their muscle mass.
United Kingdom - recruitingPHASE3
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
This study looks at a new medicine, vicadrostat, for people with type 2 diabetes, high blood pressure, and heart disease. It aims to see if taking vicadrostat alongside empagliflozin can help reduce heart problems. Half the participants will get the study medicine, and half will get a dummy pill.
United States · Argentina · Australia - enrolling by invitation
EuroSIDA - Clinical and Virological Outcome of European Patients Infected With HIV
The EuroSIDA study looks at how HIV affects people in Europe and how treatments work over time. It helps us understand health changes and the impact of new medicines for HIV and related conditions like hepatitis.
Argentina · Austria · Belarus - enrolling by invitation
PDE3B in Metabolic Regulation
This study looks at how a protein called PDE3B affects how our bodies handle sugar and fat. Researchers want to understand if changes in this protein could protect people from conditions like type 2 diabetes and heart disease, potentially leading to new treatments.
United Kingdom - recruiting
The Oxford Risk Factors And Non-Invasive Imaging Study
This study looks at heart and blood vessel problems using CT scans. It collects health information and blood samples to find better ways to spot and predict these conditions, helping doctors understand who is at risk and how best to help them.
United States · Australia · Belgium - recruiting
Greater Manchester CARDIOvascular Pathology in Immune-Mediated Inflammatory Diseases
This study investigates the link between inflammatory conditions like rheumatoid arthritis and heart problems. Researchers aim to find early signs of heart disease in these patients to improve future treatments, focusing on understanding why and how these conditions are connected.
United Kingdom - recruiting
Machine Learning in Quantitative Stress Echocardiography
This study uses advanced computer analysis on heart scans (stress echocardiograms) to find heart problems more accurately. By improving how doctors interpret these tests, it aims to help people avoid unnecessary procedures and get the right treatment faster, making heart disease diagnosis better and safer.
United Kingdom - active not recruitingNA
Targeted Assessment in High-Risk paTients With dIAbetes to ideNtify Undiagnosed Heart Failure
This study looks at a new way to find hidden heart failure in people with diabetes who are at higher risk. We're testing if checking a specific blood marker helps doctors discover heart problems earlier, so people can get the right care sooner.
United Kingdom - recruitingNA
Artificial Intelligence Delivered Cardiac Magnetic Resonance - Prospective Validation
This study is testing if artificial intelligence (AI) can help take detailed heart scans (CMRIs) faster and just as well as human experts. It aims to make it easier to get these important heart checks.
United Kingdom - active not recruiting
Smart Watch Insights for Prevention of Exacerbations and Enhance Rehabilitation - Movement Study
This study uses smartwatches to understand how movement affects health for people with conditions like heart disease or diabetes. Researchers hope to find ways to predict health changes and improve wellbeing programmes using the information from the watches.
United Kingdom - active not recruiting
Genetic Determinants of Kidney Disease in People of African Ancestry With HIV
This study looks at why kidney problems are more common in people of African heritage living with HIV in the UK. It found that certain genes can increase this risk. The research aims to better understand these factors to improve care.
United Kingdom - recruiting
The European NAFLD Registry
This study aims to understand fatty liver disease (NAFLD) better. Researchers collect information and samples from patients across Europe to find new ways to detect and monitor the disease, especially how it progresses from fatty liver to more serious conditions like fibrosis.
Belgium · Finland · France - recruitingNA
Screening for earlY Heart Failure Diagnosis and Management in Primary Care or at HOme Using Natriuretic Peptides and echocardiographY "SYMPHONY-HF"
This study, called SYMPHONY-HF, is looking at better ways to find and manage heart failure early in people at risk. It compares standard care to a new approach using a blood test and heart scan to spot the condition sooner.
United States · Canada · Denmark - not yet recruiting
Smart Wearable Insights to Prevent Exacerbations and Recurrence - Rehabilitation Study: SWIPER-REHAB
This study looks at how a digital heart rehabilitation program works using a smartwatch and an app. It wants to see how many people finish the program and if it saves money. It's for adults with heart conditions who are starting heart rehabilitation.
United Kingdom - active not recruiting
Future Innovations in Novel Detection for Atrial Fibrillation (FIND-AF): Pilot Study
This study is testing a new way to find an irregular heartbeat called atrial fibrillation (AF) earlier. It uses a special computer tool and remote heart monitoring for people at higher risk. The goal is to see if this helps detect AF more often and leads to better treatment to prevent strokes.
United Kingdom - recruitingNA
Smartphone Twelve-Lead ECG Utility In ST-Elevation Myocardial Infarction II
This study is testing a new smartphone device called AliveCor 12-lead ECG. It aims to see if this device can accurately detect heart attacks (STEMI and NSTEMI) in people with chest pain, just as well as the standard ECG machines used in hospitals.
United States · United Kingdom - recruitingPHASE4
Effect of infLuenza vaccInation After Myocardial INfArction on Cardiac inflammaTory responsE
This study looks at how the flu vaccine affects heart inflammation in people who recently had a heart attack. Researchers want to see if the vaccine helps reduce inflammation in the arteries and throughout the body, compared to a dummy shot.
Denmark · Sweden · United Kingdom - recruiting
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
This study aims to understand why common medicines don't work the same for everyone in the UK, especially for people from different backgrounds. It will look at many health conditions, hoping to improve how we treat them and make healthcare fairer for all.
United Kingdom - recruiting
Nutritional Screening in Cardiovascular Disease
This study looks at how a patient's diet and health before heart surgery might affect how well they recover. We'll use questionnaires, blood tests, and strength checks to understand how nutrition relates to hospital stay and recovery.
United Kingdom - recruiting
Cardiovascular Longitudinal ALSPAC Research Investigations Following Hypertensive Pregnancy in Young Adulthood
This study looks at young adults (30-40 years old) who were born to mothers with high blood pressure during pregnancy. Researchers want to understand why these individuals might have higher risks of heart and blood vessel problems later in life and how to prevent them.
United Kingdom - recruiting
UK CARDIOvascular Immune-Mediated Inflammatory Diseases (CARDIO-IMID) Registry Study
This study aims to understand how heart and blood vessel problems (cardiovascular diseases) are linked with conditions where the body's immune system attacks itself (immune-mediated inflammatory diseases). Researchers will collect health information from patients to find better ways to predict and manage these conditions.
United Kingdom - recruiting
Mayo AVC Registry and Biobank
This study aims to better understand a heart condition called Arrhythmogenic Ventricular Cardiomyopathy (AVC) that can lead to sudden cardiac arrest. Researchers hope to find new genetic causes and ways to predict the disease, helping to save lives in affected families.
United States · United Kingdom - enrolling by invitationPHASE3
A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension
This study looks at the long-term effects and safety of a drug called Ralinepag for people with a lung condition called pulmonary arterial hypertension (PAH). It's for those who have already tried Ralinepag in a previous study.
United States · Argentina · Australia - active not recruiting
ADHD Remote Technology Study of Cardiometabolic Risk Factors and Medication Adherence
This study looks at how ADHD and its treatments affect heart health. We're using smartphone apps and a special watch to anonymously collect information about daily life and medication use in adults with ADHD.
Spain · United Kingdom - active not recruitingNA
Obstructive Sleep Apnoea and Cardiac Arrhythmias
This study looks at how sleep apnoea affects the heart, specifically checking for irregular heartbeats. We're using a tiny, implanted heart monitor to see if traditional methods miss important heart problems in people with sleep apnoea.
United Kingdom - recruitingNA
The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR
This study looks at a new device, the Carillon Mitral Contour System, for people with heart failure caused by a leaky heart valve. It aims to see if the device is safe and helps improve their condition, comparing it to usual care without the device.
United States · Canada · France - active not recruiting
Exploring the Long-term Cardiovascular Effects of Vaping
This study looks at how vaping might affect your heart and blood vessels over time. We're comparing vapers who used to smoke, vapers who never smoked, people who both vape and smoke, and ex-smokers who don't vape. We'll check health over two years.
United Kingdom - active not recruitingNA
The RADIANCE II Pivotal Study: A Study of the ReCor Medical Paradise System in Stage II Hypertension
This study is testing a new device called the Paradise System for people with high blood pressure that's not too severe. It aims to see if this system, which treats kidney nerves, can safely and effectively lower blood pressure when people are taking few or no medications.
United States · Belgium · France - recruiting
Cardiovascular Risk Assessment For Kidney Transplantation - Utility of Computed Tomography Coronary Angiography in the Assessment of Patients Awaiting Kidney Transplantation
This study looks at using a special heart scan, called a CT coronary angiogram, to find out which kidney transplant patients might be at higher risk of heart problems later on. The goal is to improve how we check hearts before a kidney transplant.
United Kingdom - recruiting
Biomedical Research Informatics Centre for Cardiovascular Sciences (The BRICCS Study)
This study looks at heart and blood vessel conditions, like heart attacks or high blood pressure, in hospital patients and healthy people. Researchers will collect information and samples to better understand these conditions, improve diagnosis, and predict how they might progress.
United Kingdom - recruitingNA
A Prospective Randomised Multi-centre Trial Comparing cArdiac MRI Guided CRT Versus Conventional CRT Implantation in Patients With Ischaemic Cardiomyopathy
This study looks at a new way to place special heart devices (CRT) in people with heart muscle damage from a lack of blood flow. We want to see if using MRI scans to guide the placement works better than the usual method for improving heart function.
United Kingdom - recruiting
Low Energy Availability and Cardiovascular Disease
This study looks at how low energy in female athletes might affect their heart health. It aims to understand the link between having too little energy for daily activities and how the heart and blood vessels work.
United Kingdom - recruitingNA
Streamlined Denervation With spYral For an Optimized Treatment (SPYRAL SWYFT) in Subjects With Uncontrolled Hypertension
This study looks at a procedure called renal denervation to treat high blood pressure. It aims to see if a simpler way of doing the procedure is just as good, and possibly quicker, than older methods. This could offer a new option for people whose blood pressure is hard to control.
Australia · Belgium · Germany - recruitingNA
Study on Optimal Temperature During Cardiopulmonary Bypass (THERMIC-4)
This study looks at the best body temperature during heart surgery using a heart-lung machine. Some doctors cool patients, while others keep them at normal temperature. We want to see if a normal temperature is a safe option for adult heart patients and if this type of study can be run effectively.
United Kingdom - active not recruiting
The UHSM Cardiovascular Magnetic Resonance Study
This study looks at how a special type of MRI scan, called a cardiovascular magnetic resonance (CMR) scan, can help doctors understand and predict heart problems. It involves patients who are already having a CMR scan for their heart condition, with a little extra scanning and some health checks.
United Kingdom - active not recruiting
Molecular Investigation of GENetic Factors in Cardiovascular and Immune-related Traits and Diseases Using a BIOresource of Healthy Volunteers (GENBIO)
This study looks at how your genes and lifestyle affect heart health. We're inviting healthy volunteers from the NIHR BioResource to help scientists understand important genetic factors, like the SWAP70 and GMPR genes, that might protect against or lead to heart problems.
United Kingdom - recruiting
Inherited Cardiac cONditions In Kids
This study looks at inherited heart conditions in children and their families. It uses an online platform called The Heart Hive to gather information about diagnoses, genes, and how the condition changes over time. The goal is to find better and more personalised treatments.
United Kingdom - not yet recruitingPHASE3
A Study to See if Lepodisiran Can Reduce Plaque in Coronary Arteries of Adults With Elevated Lp(a) Who Have Had Heart Events or Are at High Risk
This study investigates a new medicine, lepodisiran, to reduce fatty deposits (plaque) in heart arteries. It's for adults aged 45-80 with high Lp(a), a type of cholesterol, who have heart problems or are at high risk. Researchers will use special scans to see if the medicine helps.
United States · Australia · Czechia