- enrolling by invitationPHASE3
A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension
This study looks at the long-term effects and safety of a drug called Ralinepag for people with a lung condition called pulmonary arterial hypertension (PAH). It's for those who have already tried Ralinepag in a previous study.
United States · Argentina · Australia - recruitingPHASE3
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
This study looks at a new medicine, vicadrostat, for people with type 2 diabetes, high blood pressure, and heart disease. It aims to see if taking vicadrostat alongside empagliflozin can help reduce heart problems. Half the participants will get the study medicine, and half will get a dummy pill.
United States · Argentina · Australia - recruitingNA
A Prospective Randomised Multi-centre Trial Comparing cArdiac MRI Guided CRT Versus Conventional CRT Implantation in Patients With Ischaemic Cardiomyopathy
This study looks at a new way to place special heart devices (CRT) in people with heart muscle damage from a lack of blood flow. We want to see if using MRI scans to guide the placement works better than the usual method for improving heart function.
United Kingdom - recruiting
Studying the Effects of Cannabis on Vasculature
This study looks at how long-term cannabis use affects your heart and blood vessels. Researchers will compare people who use cannabis regularly with those who don't, checking blood vessel health and signs of inflammation using simple tests and blood samples.
Canada - active not recruitingNA
Exercise to Prevent AnthraCycline-based Cardio-Toxicity Study 2.0 (EXACT2)
This study looks at whether a special exercise plan can help protect the hearts of women with breast cancer who are having chemotherapy. Some chemotherapy drugs can affect the heart, so we want to see if regular exercise can reduce this risk while the treatment works.
Canada - active not recruiting
Impact of a Regional Program Agir Sur Sa SantE
This study looks at a new care plan called 'Agir Sur Sa SantÉ' (meaning 'Act on Your Health') in our local area. It aims to see how well this plan works for people with conditions like diabetes, obesity, and high blood pressure, focusing on improving their overall health.
Canada - recruitingNA
Clinical Utility of a Genomic Predictor Test on the Management of Cardiorenal Complications of Type 2 Diabetes
This study looks at how a genetic test predicting heart and kidney problems in people with type 2 diabetes affects treatment. It compares people who know their risk score with those who don't, to see if knowing this information helps them reach their health goals better.
Canada - active not recruiting
Real-world Study on Dapagliflozin Usage in Patients With Heart Failure (HF) in Germany
This study looks at how a medicine called dapagliflozin is used for heart failure in Germany. Researchers want to understand how it affects people's symptoms, quality of life, and healthcare needs in everyday situations.
Germany - active not recruitingNA
Safety and Efficacy Study of reSept ASD Occluder for Treating Secundum ASD
This study looks at a new device, the reSept ASD Occluder, for treating a common heart condition called secundum Atrial Septal Defect (ASD). It aims to see if the device is safe and works well to close the hole in the heart.
United States · Canada · France - recruiting
Prospective WCD Post CABG Registry (CABG Registry)
This study looks at how well people recover their heart function after their first heart bypass surgery when they wear a special device called a WCD. It hopes to show that more people recover with modern medication use.
Germany - recruiting
The European NAFLD Registry
This study aims to understand fatty liver disease (NAFLD) better. Researchers collect information and samples from patients across Europe to find new ways to detect and monitor the disease, especially how it progresses from fatty liver to more serious conditions like fibrosis.
Belgium · Finland · France - recruiting
Retrospective Epidemiological Study of Patients in the National Cohort of the French TMA Center
This study looks back at records of over 1,200 patients in France who had a rare blood disorder called iTTP. It aims to understand how things like heart problems and specific treatments affect their long-term health and survival. It hopes to improve care for people with iTTP.
France - recruiting
Mayo AVC Registry and Biobank
This study aims to better understand a heart condition called Arrhythmogenic Ventricular Cardiomyopathy (AVC) that can lead to sudden cardiac arrest. Researchers hope to find new genetic causes and ways to predict the disease, helping to save lives in affected families.
United States · United Kingdom - active not recruiting
Exploring the Long-term Cardiovascular Effects of Vaping
This study looks at how vaping might affect your heart and blood vessels over time. We're comparing vapers who used to smoke, vapers who never smoked, people who both vape and smoke, and ex-smokers who don't vape. We'll check health over two years.
United Kingdom - active not recruitingNA
The RADIANCE II Pivotal Study: A Study of the ReCor Medical Paradise System in Stage II Hypertension
This study is testing a new device called the Paradise System for people with high blood pressure that's not too severe. It aims to see if this system, which treats kidney nerves, can safely and effectively lower blood pressure when people are taking few or no medications.
United States · Belgium · France - recruiting
Greater Manchester CARDIOvascular Pathology in Immune-Mediated Inflammatory Diseases
This study investigates the link between inflammatory conditions like rheumatoid arthritis and heart problems. Researchers aim to find early signs of heart disease in these patients to improve future treatments, focusing on understanding why and how these conditions are connected.
United Kingdom - recruiting
Patients with Coronary Artery Disease or At High Cardiovascular Risk: Measuring Compliance with Treatment for Obstructive Sleep Apnea Syndrome
This study looks at how well people with heart disease or high heart risk use treatments for sleep apnea. We're comparing two main treatments, CPAP and a mouth device, to see which is easier to stick with and works best for patients.
France - recruitingPHASE4
Effect of infLuenza vaccInation After Myocardial INfArction on Cardiac inflammaTory responsE
This study looks at how the flu vaccine affects heart inflammation in people who recently had a heart attack. Researchers want to see if the vaccine helps reduce inflammation in the arteries and throughout the body, compared to a dummy shot.
Denmark · Sweden · United Kingdom - not yet recruitingNA
A Prospective Multicenter Pivotal Study to Evaluate Safety and Effectiveness of Venus-Neo Surgical Aortic Valve
This study is testing a new heart valve called Venus-Neo to see if it's safe and works well for people needing aortic valve replacement. Researchers will follow participants for five years to understand its long-term performance.
Germany - recruiting
Registry to Assess the Safety and Feasibility of the Subpulmonary Support with the Novel Venous Cannula in Patients with Failing/Absence of the Right Heart
This study looks at how well a special device, called an EXCOR Venous Cannula, works in supporting hearts that are struggling. It aims to make sure the device is safe and helps patients get better, both in the short and long term.
Germany - recruitingNA
The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR
This study looks at a new device, the Carillon Mitral Contour System, for people with heart failure caused by a leaky heart valve. It aims to see if the device is safe and helps improve their condition, comparing it to usual care without the device.
United States · Canada · France - recruiting
Identification of New Biomarkers for the Prediction of Cardiovascular Events
This study aims to find new ways to predict heart and blood vessel problems. Researchers are collecting blood samples from patients already being looked after for heart health, hoping to discover new warning signs that help doctors understand and prevent these conditions better.
France - active not recruitingNA
Obstructive Sleep Apnoea and Cardiac Arrhythmias
This study looks at how sleep apnoea affects the heart, specifically checking for irregular heartbeats. We're using a tiny, implanted heart monitor to see if traditional methods miss important heart problems in people with sleep apnoea.
United Kingdom - recruiting
Register of Cardiovascular Complications Among People Living With HIV
This study looks at heart health in adults living with HIV who have other risk factors for heart problems. It collects information from people who have heart checks at Saint Antoine Hospital in Paris to better understand and improve their care.
France - active not recruiting
Smart Watch Insights for Prevention of Exacerbations and Enhance Rehabilitation - Movement Study
This study uses smartwatches to understand how movement affects health for people with conditions like heart disease or diabetes. Researchers hope to find ways to predict health changes and improve wellbeing programmes using the information from the watches.
United Kingdom - recruiting
Carotid Intraplaque Neovascularization Combined With Stress Echo
This study looks at a new way to predict heart attacks and strokes. It combines a standard heart stress test with a special neck ultrasound. This aims to find people at higher risk whose usual tests might miss them, by looking closely at fatty build-ups in blood vessels.
Canada - recruiting
UK CARDIOvascular Immune-Mediated Inflammatory Diseases (CARDIO-IMID) Registry Study
This study aims to understand how heart and blood vessel problems (cardiovascular diseases) are linked with conditions where the body's immune system attacks itself (immune-mediated inflammatory diseases). Researchers will collect health information from patients to find better ways to predict and manage these conditions.
United Kingdom - recruiting
The Oxford Risk Factors And Non-Invasive Imaging Study
This study looks at heart and blood vessel problems using CT scans. It collects health information and blood samples to find better ways to spot and predict these conditions, helping doctors understand who is at risk and how best to help them.
United States · Australia · Belgium - active not recruitingNA
TRISCEND II Pivotal Trial
This study is testing a new device called the Edwards EVOQUE system for people with severe tricuspid valve disease. It compares the device plus regular care to regular care alone, aiming to see if the device is safe and effective.
United States · Germany - active not recruitingPHASE2
ETA and AT1 Antagonism in ANCA-vasculitis (SPARVASC)
This study looks at a new drug, sparsentan, for people with ANCA-associated vasculitis. It aims to see if blocking certain chemicals can help improve blood vessel health, which is important for preventing heart attacks and strokes in these patients.
United Kingdom - active not recruiting
Molecular Investigation of GENetic Factors in Cardiovascular and Immune-related Traits and Diseases Using a BIOresource of Healthy Volunteers (GENBIO)
This study looks at how your genes and lifestyle affect heart health. We're inviting healthy volunteers from the NIHR BioResource to help scientists understand important genetic factors, like the SWAP70 and GMPR genes, that might protect against or lead to heart problems.
United Kingdom - recruiting
Inherited Cardiac cONditions In Kids
This study looks at inherited heart conditions in children and their families. It uses an online platform called The Heart Hive to gather information about diagnoses, genes, and how the condition changes over time. The goal is to find better and more personalised treatments.
United Kingdom - active not recruitingNA
2019-06 TRISCEND Study
This study looks at a new heart valve replacement called Edwards EVOQUE for people with a leaky tricuspid valve. It aims to see how safe and well this new treatment works for those whose current medicines aren't enough to help their symptoms.
United States · Canada · France - recruitingNA
Is Post-exertional Symptom Exacerbation Specific to Patients With Myalgic Encephalomyelitis / Chronic Fatigue Syndrome? A Study Comparing Patients With Myalgic Encephalomyelitis / Chronic Fatigue Syndrome and Patients With Cardiac Diseases Who Underwent an Exercise Test.
This study compares how exercise affects people with ME/CFS and those with heart conditions. We're looking at why ME/CFS causes extreme tiredness and other symptoms after effort, and if this is different for people with heart problems, using a special exercise test.
France - recruiting
The BRAVE Study- The Identification of Genetic Variants Associated With Bicuspid Aortic Valve Using a Combination of Case-control and Family-based Approaches.
The BRAVE study is looking for gene changes linked to Bicuspid Aortic Valve (BAV), a common heart condition where the heart's main valve has two flaps instead of three. Researchers hope to understand how BAV develops by studying blood samples from affected people and their families.
United Kingdom - recruitingNA
Screening for earlY Heart Failure Diagnosis and Management in Primary Care or at HOme Using Natriuretic Peptides and echocardiographY "SYMPHONY-HF"
This study, called SYMPHONY-HF, is looking at better ways to find and manage heart failure early in people at risk. It compares standard care to a new approach using a blood test and heart scan to spot the condition sooner.
United States · Canada · Denmark - recruitingNA
Developing a Brief Intervention to Communicate Cardiovascular Risk to Patients Presenting to the Emergency Department With Chest Pain: a Co-Production Approach. Phase 2.
This study helps patients who come to the emergency room with chest pain but haven't had a heart attack. We want to find better ways to tell them about their heart health risks and how to make changes to stay healthy.
United Kingdom - active not recruitingNA
OPTIMISation of Cardio-renal-metabolic-pulmonary Disease Guideline Adherence in High Risk Community Dwelling Individuals
This study looks at whether extra check-ups with heart specialists can help people with conditions like high blood pressure and diabetes get better treatment. The aim is to see if this extra care improves health and reduces the risk of serious problems like heart attacks.
United Kingdom - recruiting
A Multicenter Observational Registry to Evaluate Safety and Performance of Vivo ISAR (SECURE Global Registry)
This study looks at how well a new heart stent called Vivo ISAR works and its safety for people with heart disease. It follows patients who have the stent and take blood-thinning medicines for a short time, to see their progress over a year.
India · Italy · Netherlands - recruitingNA
Effects of Milk-based Drinks on Gut Microbiome, Sleep and Cardiometabolic Markers
This study looks at how kefir, a fermented milk drink, affects sleep, gut health, and heart health markers like cholesterol in adults aged 40-70 who struggle with sleep. Participants will drink either kefir or milk for four weeks.
United Kingdom - active not recruitingPHASE3
A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease
This study is looking into a new medication called retatrutide for people living with obesity and heart problems. We want to see if it's safe and helps with weight loss when taken once a week, compared to a dummy medicine.
United States · Argentina · Australia - recruitingNA
Study on Optimal Temperature During Cardiopulmonary Bypass (THERMIC-4)
This study looks at the best body temperature during heart surgery using a heart-lung machine. Some doctors cool patients, while others keep them at normal temperature. We want to see if a normal temperature is a safe option for adult heart patients and if this type of study can be run effectively.
United Kingdom - recruitingPHASE3
Aggressive Smoking Cessation Trial (ASAP)
This study looks at new ways to help people with heart conditions quit smoking. It compares combining a stop-smoking medicine with e-cigarettes against the medicine alone. The goal is to find the most effective and safest way to help you stop smoking for good.
Canada - recruitingPHASE4
Clinical Surveillance vs. Anticoagulation for Low-risk Patients With Isolated Subsegmental Pulmonary Embolism
This study looks at the best way to treat small blood clots in the lungs (isolated subsegmental pulmonary embolism) in people at low risk. It compares watching carefully without treatment to giving blood-thinning medicine to reduce bleeding risks.
Belgium · Canada · France - active not recruitingNA
SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN
This study looks at a treatment called renal denervation (RDN) for high blood pressure. It uses a device called Symplicity Spyral to see how well it works and if it's safe in the long term, especially for people whose blood pressure is hard to control.
United States · Australia · Belgium - recruitingNA
A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Understanding and Management of Coronary Calcium (The Optimal Trial)
This study compares two ways to plan heart artery procedures for people with hardened arteries. It uses advanced CT scans versus a standard internal ultrasound to see which method helps doctors work better and get similar good results for patients.
United States · Belgium · Spain - recruitingPHASE3
A Study to See if Lepodisiran Can Reduce Plaque in Coronary Arteries of Adults With Elevated Lp(a) Who Have Had Heart Events or Are at High Risk
This study investigates a new medicine, lepodisiran, to reduce fatty deposits (plaque) in heart arteries. It's for adults aged 45-80 with high Lp(a), a type of cholesterol, who have heart problems or are at high risk. Researchers will use special scans to see if the medicine helps.
United States · Australia · Czechia - not yet recruitingNA
Effects of a Legume-rich Diet in the Context of the Planetary Health Diet Compared to a Western-oriented Dietary Pattern in Participants with Increased Cardiometabolic Risk
This study is looking at how a diet rich in peas, beans, and lentils (legumes) affects the health of people aged 50-75 who are at higher risk of heart problems. It compares this special 'Planetary Health Diet' to a typical Western diet over six weeks.
Germany - recruiting
Clinical Study for the Investigation and Validation of a Therapy Procedure for the Adjustment of Risk Factors in Patients With Coronary Heart Disease by Means of Digital Therapy Control
This study is testing a new digital health app called iATROS. It aims to help people with heart disease manage their health better by tracking risk factors on their smartphone. We want to see if it works as well as, or better than, standard care.
Germany - active not recruiting
Defining the Genetics, Biomarkers and Outcomes for Dilated Cardiomyopathy
This study aims to discover better ways to diagnose and treat Dilated Cardiomyopathy (DCM) and other inherited heart conditions. It involves genetic tests and heart scans to understand the disease better and potentially lead to more personalised treatments.
United Kingdom