RecruitingOBSERVATIONAL

UK CARDIOvascular Immune-Mediated Inflammatory Diseases (CARDIO-IMID) Registry Study

This study, called CARDIO-IMID, is creating a detailed registry for people in the UK who have both heart/blood vessel conditions and immune system conditions like rheumatoid arthritis or lupus. The main goal is to understand the strong link between these two types of diseases and find out if a simple blood test could help predict future heart problems. Researchers will gather a lot of health information, including test results and images, from patients already being treated. This will help them learn more about how and why heart problems develop in people with immune conditions, ultimately leading to better care for everyone with these health challenges.

At a glance

Status

Recruiting

Sponsor

University of Manchester

Enrolment target

600

Start

04 Feb 2026

Estimated completion

01 Aug 2028

Cardiovascular Diseases Immune-Mediated Inflammatory Diseases

What is this study about?

Imagine your body's immune system as its protector, fighting off germs and illnesses. But sometimes, this system can get confused and start attacking healthy parts of your own body – these are called immune-mediated inflammatory diseases (IMIDs). Examples include conditions like rheumatoid arthritis, lupus, or Crohn's disease. We also know a lot about heart and blood vessel conditions, known as cardiovascular diseases (CVD), such as heart attacks or strokes.

Doctors and researchers have noticed that people with IMIDs seem to have a higher chance of also developing CVD. This study, called the UK CARDIO-IMID Registry, wants to investigate this connection much more closely. It's like building a very detailed map of patients' health journeys. The main idea is to collect information from many patients across the UK who have both types of conditions. This will help them understand how common heart problems are in people with IMIDs, what might cause them, and how they show up. They're especially interested in whether certain blood tests, called cardiac biomarkers, can help predict heart problems early on.

The information collected in this registry will be a valuable resource for future research. By gathering data on symptoms, test results (like blood tests and scans), and treatments, researchers hope to find new ways to spot heart problems sooner, develop better treatments for people with IMIDs, and ultimately improve the health of many. This study is an important step towards better understanding and managing these complex health challenges.

Key takeaways

This study aims to understand the link between immune conditions and heart health.
It will collect health data from adults across the UK with both types of conditions.
The goal is to find better ways to predict and manage heart problems in people with immune diseases.
Participation involves sharing existing medical information from your routine care.
It's an observational study, meaning no new medicines or treatments are given.
Your involvement helps improve future care for many patients.

Who may be eligible?

This study is looking for adults aged 18 or older who have an immune-mediated inflammatory disease (IMID).

Specifically, they are interested in people who: have an IMID and are at a higher risk of developing heart problems but haven't had one yet; have an IMID and have just been diagnosed with a new heart event (like a heart attack, stroke, or severe chest pain); or have an IMID and have a history of heart problems.

You would need to be diagnosed with an IMID by a specialist doctor (a rheumatologist) and, for those with heart problems, have that diagnosis confirmed by a heart specialist (a cardiologist).

Quick self-check

Are you 18 years old or older?
Have you been diagnosed with an immune-mediated inflammatory disease (IMID) by a rheumatologist?
Do you either have a higher risk of heart problems, have recently experienced a new heart event, or have a history of heart problems?
Are you willing to provide your written consent to participate?

This is a guide only — the research team will confirm whether you can take part.

What does participation involve?

Taking part in this study primarily involves allowing researchers to collect and review your routine health information. This includes details from your regular check-ups, blood tests, scans, and other assessments that are already part of your usual care for your immune condition and any heart problems. You will continue to have your appointments as normal, usually every 3-6 months when first diagnosed then 6-12 monthly, as decided by your doctors.

Optionally, some participants may be asked if they would like to take part in additional sub-studies. These might involve extra questionnaires, specific tests (like more detailed blood tests or imaging scans) that are not part of your usual care, or providing extra samples for research. These additional parts would be clearly explained to you, and it would be entirely your choice whether to participate in them. There are no specific medications or interventions given as part of the main registry study, as it focuses on observing your standard care. Your participation will last as long as you continue to receive care for your conditions, allowing researchers to track changes over time.

Potential risks and benefits

The main benefit of taking part is contributing to a better understanding of how immune conditions affect heart health, which could lead to improved care for future patients. As this is an observational study using your existing health information, there are very few direct risks. Any optional extra tests would be fully explained beforehand. You have the right to withdraw from the study at any time without this affecting your medical care.

Locations (2)

Royal Infirmary of Edinburgh
Edinburgh, United Kingdom· Recruiting
Countess of Chester Hospital NHS Foundation Trust
Chester, United Kingdom· Recruiting

Common questions

What is an Immune-Mediated Inflammatory Disease (IMID)?

An IMID is a condition where your immune system, which usually fights off germs, mistakenly attacks healthy parts of your own body, causing inflammation.

What is Cardiovascular Disease (CVD)?

CVD refers to conditions affecting your heart and blood vessels, such as heart attacks, strokes, or problems with blood flow.

Will I receive any new treatments in this study?

No, this study is about collecting information from your existing medical care. You won't receive new treatments as part of this registry.

What kind of information will be collected about me?

Researchers will collect details from your routine doctor visits, blood tests, scans, and other health assessments you already have.

Can I leave the study if I change my mind?

Yes, you can decide to stop participating at any time, and this will not affect the medical care you receive.

How to find out more

Georgia Reeves

georgia.reeves@manchester.ac.uk +44 161 306 5600 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.