A Research Study to Look at How Well Zenagamtide Works Compared to Placebo in People With Established Atherosclerotic Cardiovascular Disease and Either Overweight or Obesity

To join this study, you need to be aged 45 or over. You must also have a history of certain heart and blood vessel problems. This includes having had a heart attack, a stroke, or specific circulation issues in your legs (peripheral artery disease). If you have type 2 diabetes, you might still be able to join, but your diabetes treatment needs to have been stable for at least 3 months, and you can't be on certain types of diabetes medicines that work in a similar way to Zenagamtide.

There are also reasons why you might not be able to join. For example, if you've had a recent heart attack, stroke, or severe heart failure within the last month, or if you've had certain heart or blood vessel procedures recently. You also can't take part if you have certain types of severe heart failure, or if you've had frequent severe low blood sugar episodes, type 1 diabetes, or certain severe eye problems related to diabetes.

If you decide to take part in this study, you'll be assigned by chance to either receive Zenagamtide or a dummy medicine (placebo). Neither you nor your study doctor will know which one you are receiving. You will need to attend several visits to the study clinic where you'll have various health checks, such as blood tests, blood pressure measurements, and heart checks. You will be given the study medicine to take regularly. The doctors and nurses will monitor your health closely throughout the study to see how you are responding and if you experience any side effects. This is a 'Phase 3' study, which means it's one of the final steps before a medicine might be approved, and these studies often last for a significant period.