- recruitingPHASE3
A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2)
This study looks at a medicine called tirzepatide for teenagers aged 12-17 who are overweight and have related health problems. Researchers want to see if it helps with weight and heart health when combined with healthy eating and exercise.
United States · Argentina · Australia - recruitingPHASE3
A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)
This study is for children and teenagers aged 6-17 who are overweight or have obesity. It's testing a new medication called Orforglipron to see if it's safe and helps with weight management, compared to a dummy medicine. It aims to find better ways to help young people manage their weight.
United States · Belgium · Brazil - recruitingPHASE3
A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities
This study is looking at a new once-a-day tablet, orforglipron, for teenagers (12-17 years old) with obesity or who are overweight with other health issues. It will check if the medicine helps with weight and if it's safe to use.
United States · Israel · Italy - recruitingPHASE3
Efficacy and Safety of KAI-9531 in Participants Living With Obesity or Overweight With Weight-Related Comorbidities Who Do Not Have Diabetes
This study is looking at a new medicine called KAI-9531. It aims to see if weekly injections of this medicine can help people who are overweight or obese, and have other health issues related to their weight, lose weight. We want to know if it's safe and effective.
United States · Argentina · Australia - not yet recruitingNA
Glycaemic Response of Arabic Bread
This study is looking at how different types of Arabic bread, made with chickpea, pea, or lentil flour, affect blood sugar levels. They want to see if these breads can help keep blood sugar more steady compared to regular wheat bread in people who are overweight or have obesity.
United Kingdom - recruitingPHASE3
A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight
This study looks at new treatments, CagriSema and cagrilintide, for children and teenagers aged 8-18 who are overweight. It compares these new drugs to an existing medicine (semaglutide) or a dummy drug (placebo) to see how well they help with weight loss.
United States · Australia · Austria - active not recruitingPHASE3
A Research Study to See How Well CagriSema Helps People With Excess Body Weight Lose Weight
This study looks at how a new medicine called CagriSema helps people who are overweight lose weight. It compares CagriSema to other medicines and a dummy medicine. Participants will take a weekly injection, and the study will last about 3 and a half years.
United States · Argentina · Australia - recruitingPHASE3
A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes
This study is looking into a new medication called Eloralintide for people who are overweight or have obesity but don't have type 2 diabetes. It aims to see how well it works and if it's safe to help with weight management.
United States · Argentina · Australia - ongoing, recruitingTherapeutic confirmatory (Phase III)
I8F-MC-GPHJ: A Phase 3b, Randomized Controlled Study to Evaluate the Efficacy and Safety of Tirzepatide Compared to Semaglutide 2.4 mg in Adults Who Have Obesity or Overweight with Weight-Related Comorbidities
This study is comparing two medicines, Tirzepatide and Semaglutide, to see which is more effective and safer for helping adults with obesity or overweight, who also have other health issues, to lose weight. It's looking at how much weight people lose and other health changes.
Germany · Belgium · Poland - authorisedTherapeutic confirmatory (Phase III)
The effect of semaglutide therapy on hepatic fat content and on the acute reponse of liver fat to high-fat load in obese MASLD patients
This study looks at how a medicine called semaglutide affects fat in the liver of men with obesity and a condition called MASLD. We want to see if it reduces liver fat and how the liver responds to fatty foods after taking the medicine.
Czechia - recruitingNA
Intensive Weight Loss Intervention Versus Bariatric Surgery for Adults With Severe and Complex Obesity: the LightBAR Randomised Trial
This study compares an intensive diet and lifestyle programme with weight-loss surgery for adults with severe obesity. We want to see which method works best and is safest, to help improve future treatment options.
Denmark · United Kingdom - recruitingPHASE4
Metformin for Antipsychotic-induced Weight Gain in Adults With Intellectual Disability
This study looks at whether a medicine called metformin can help adults with learning disabilities who've gained weight from antipsychotic medicines. These medicines are important, but weight gain can lead to other health problems.
Canada - active not recruiting
Meta-Analyses of the Effect of Plant Protein Versus Animal Protein on Cardiometabolic Risk
This study looks at lots of past research to see if swapping animal protein for plant protein makes a difference to health conditions like diabetes, heart problems, and kidney issues. They want to understand if eating more plant-based protein, like from beans or nuts, can be better for our health.
Canada - recruitingPHASE3
Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea on Positive Airway Pressure Therapy
This study is testing a new medicine, Maridebart Cafraglutide, for adults with sleep apnea who use a CPAP machine and are also overweight or have obesity. We want to see if the medicine helps improve their sleep apnea and is safe to use over 52 weeks.
United States · Australia · Brazil - recruitingEARLY_PHASE1
Akkermansia Muciniphilia and Metabolic Side Effects of ADT
This study looks at whether apple cider vinegar can increase beneficial gut bacteria in men with prostate cancer starting hormone therapy. Researchers want to see if this helps reduce side effects like weight gain and diabetes, which can be linked to their treatment.
Canada - active not recruiting
Impact of a Regional Program Agir Sur Sa SantE
This study looks at a new care plan called 'Agir Sur Sa SantÉ' (meaning 'Act on Your Health') in our local area. It aims to see how well this plan works for people with conditions like diabetes, obesity, and high blood pressure, focusing on improving their overall health.
Canada - recruitingPHASE3
AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
This study looks at a new medicine, NNC0487-0111, for people who are overweight and have knee pain from arthritis. It wants to see if this medicine helps with losing weight and reducing pain compared to a dummy medicine.
United States · Australia · Bulgaria - recruitingPHASE3
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain
This study looks at a new medicine called retatrutide for people who are overweight or have obesity and suffer from long-term lower back pain. It aims to see if the medicine helps ease their pain and if it's safe to use.
United States · Argentina · Canada - recruiting
Safety and Effectiveness of Orbera365™ Intragastric Balloon System
This study looks at how safe and effective the Orbera365™胃内バルーン [Orbera365™ Intragastric Balloon] is for people wanting to lose weight. It's for adults already choosing this balloon, and it helps doctors understand its safety when kept in for a longer time.
Czechia · France · Spain - recruitingPHASE3
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
This study looks at a new medicine, NNC0487-0111, for people with heart failure and obesity. It compares the medicine to a dummy treatment (placebo) to see if it's safe and helps improve heart health.
United States · Argentina · Australia - active not recruitingPHASE1
A Study to Evaluate the Effect of RO7204239 on Insulin Sensitivity and Muscle Composition in Participants With Type 2 Diabetes Mellitus (T2DM) and Overweight or Obesity
This study looks at a new drug, RO7204239, for people with type 2 diabetes who are overweight or have obesity. It aims to see if the drug can improve how the body uses insulin and affects muscle health. This is an early stage study.
Germany - not yet recruitingNA
Multicentric Approval Study Trans-Duodenal Barrier for Typ 2 Diabetes With Obesity
This study checks a new internal device, the Trans-Duodenal Barrier, for safety and effectiveness in adults with type 2 diabetes and obesity. It's a temporary implant to see if it helps lower blood sugar and reduce weight.
Germany - not yet recruitingNA
Financial Incentives and Weight Loss in Failed Bariatric Surgery
This study looks at whether financial rewards can help people who have regained weight after weight-loss surgery. It explores if a reward system encourages people to achieve and maintain their weight loss goals, and if it's a good way for the health service to help in the future.
France - recruiting
Deep Phenotyping of Peripheral Blood Cells and Circulating Factors in Metabolic Diseases
This study looks at blood cells and other substances in people with obesity, diabetes, and fatty liver disease. Researchers want to understand how these differ in people with and without these conditions to learn more about how they develop.
Germany - recruiting
The European NAFLD Registry
This study aims to understand fatty liver disease (NAFLD) better. Researchers collect information and samples from patients across Europe to find new ways to detect and monitor the disease, especially how it progresses from fatty liver to more serious conditions like fibrosis.
Belgium · Finland · France - recruitingNA
Exercise Training on Brain Insulin Responsiveness
This study looks at how different types of exercise affect brain's response to insulin in people with and without obesity. Researchers compare moderate exercise, intense interval exercise, and no exercise to see which might be best for brain health. It's about understanding how exercise impacts brain signals related to insulin.
Germany - active not recruitingPHASE1
A Study in Healthy People or Otherwise Healthy With Overweight or Obesity to Compare 2 Formulations of Survodutide Given in Different Ways, Either as a Pre-filled Syringe or a Pen-like Injector
This study looks at a new medicine called survodutide for people who are healthy or have overweight/obesity. We want to see if two different versions of the medicine, given with different types of injectors, work similarly in the body. It's an early-stage study.
Germany - recruitingPHASE3
AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss
This study is looking into a new medicine, NNC0487-0111, to help people who have lost weight keep it off. Participants will get either the new medicine or a dummy medicine by injection once a week to see if it's safe and effective for weight management.
United States · Argentina · Australia - recruiting
Global Research Initiative for Patients Screening on MASH
This study aims to improve how doctors find serious liver conditions like MASH in people with health problems like diabetes or obesity. It brings together healthcare providers across Europe to use new care guidelines and raise awareness about these liver diseases.
Belgium · Czechia · France - recruitingNA
Personalized Responses to Dietary Composition Trial 3
This study, PREDICT 3, aims to understand how different foods affect individuals. By looking at how people respond to meals in their everyday life, it helps create more personalised eating advice to improve health for conditions like diabetes and heart problems.
United States · United Kingdom - recruitingNA
PROTeIn-rich Meals to Control Glucose
This study looks at how different eating patterns might help people with prediabetes or type 2 diabetes manage their blood sugar. Researchers are comparing two diets to see which is better for controlling sugar levels and body inflammation.
Germany - recruitingPHASE3
AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea
This study looks at a new medicine, NNC0487-0111, for people who are overweight or obese and have sleep apnoea. We want to see if it helps with weight loss and improves sleep apnoea. Participants will take weekly injections, either the new medicine or a dummy medicine.
United States · Australia · China - active not recruitingPHASE4
STEP TEENS Weight Maintenance: A Research Study on How Well Semaglutide Helps Teenagers With Excess Body Weight to Lose Weight and Maintain Weight Loss
This study looks at how a weekly injection, semaglutide, helps teenagers aged 12-15 with obesity to lose weight and keep it off. All participants will receive the treatment for at least three years, aiming to understand its effectiveness for weight management.
United States · Belgium · Canada - not yet recruitingNA
Study Assessing the Contribution of Telemedicine Monitoring in Addition to Standard Follow-up of an Obesity Program
This study in France looks at whether adding regular phone or video calls (telemedicine) to standard obesity care helps people stick with their treatment and keeps them from dropping out. It's for adults aged 18-60 who have completed an obesity management program.
France - recruitingNA
Health-economic Assessment of Robot-assisted Bariatric Surgery
This study compares two ways to do weight-loss surgery for people with obesity: using a robot or standard keyhole surgery. It aims to see which method is better and more cost-effective for the UK healthcare system, looking at complication rates and quality of life.
France - active not recruiting
Weight Loss Surgery in Adolescents With Extreme Obesity
This study looks at weight-loss surgery for teenagers and young adults with severe obesity in Germany. It aims to understand the benefits and risks of surgery, compared to other weight management methods, as part of a careful support programme.
Germany - recruiting
Impact of Semaglutide (Ozempic/Wegovy®) on Heart and Muscle Mass
This study looks at how a medicine called semaglutide (Ozempic/Wegovy®) affects your heart and muscles over a year. Researchers use special scans and tests to understand if it helps keep your muscles healthy, especially if you have type 2 diabetes or obesity.
Canada - active not recruitingPHASE3
A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Type 2 Diabetes
This study is looking at a new medicine called orforglipron for people with obesity or who are overweight and have type 2 diabetes. It wants to see how well it helps control blood sugar compared to a dummy medicine, called a placebo.
United States · Argentina · China - active not recruiting
Obesity Intervention "Obeldicks" for Obese Children, Adolescents and Their Parents
This study looks at a 12-month programme called "Obeldicks" for children and teenagers aged 6-18 who are very overweight. It combines healthy eating, behaviour support, and exercise to help them manage their weight and improve their health.
Germany - active not recruitingPHASE2
A Study to Assess Efficacy, Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7204239 in Combination With Tirzepatide in Participants With Obesity or Overweight With At Least One Weight-related Comorbidity
This study looks at a new medicine, RO7204239, combined with an existing medicine, tirzepatide, for adults who are overweight or have obesity. It aims to see if this combination helps with weight loss and is safe for people without diabetes.
United States · Poland · Spain - active not recruitingNA
ARIADNE: A Study of Weight Loss for Diabetes Treatment and Wellbeing
This study looks at how a special low-calorie diet affects people with type 2 diabetes and concerns about their eating habits. We want to see if this diet helps with diabetes without causing problems with their relationship with food. It will help us understand if this diet is safe for everyone.
United Kingdom - recruiting
Who Will Benefit From Bariatric Surgery for Diabetes?
This study looks at why some people with type 2 diabetes benefit from weight-loss surgery (Roux-en-Y gastric bypass) more than others. Researchers want to understand if things like body fat, genes, and gut hormones play a role in putting type 2 diabetes into remission after surgery.
United Kingdom - active not recruitingPHASE3
A Research Study on How Well Semaglutide Helps Children and Teenagers With Excess Body Weight Lose Weight
This study looks at how a medicine called semaglutide helps children and teenagers lose weight. Participants get weekly injections of either semaglutide or a dummy medicine. All also receive healthy lifestyle advice. The study lasts about 2.5 years.
United States · Austria · Belgium - enrolling by invitationNA
Real-world Exploration of Digital iNnovation in the Management of Excess Weight
This study looks at a new digital programme to help people in South East London manage their weight. It checks if this online approach improves health, saves money, and makes weight management services better for everyone, especially those with obesity.
United Kingdom - active not recruitingPHASE3
A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and at Least One Weight-Related Comorbidity
This study is looking at a new medicine called orforglipron to help people who are overweight or have obesity lose weight. It's for adults with at least one other health condition linked to their weight, but not diabetes. It will last about 18 months.
United States · Argentina · China - recruitingNA
The Effect of Time-Restricted Eating in Cardiometabolic Health
This study looks at how eating only within a 9-hour window affects health in people who are overweight and have prediabetes. We want to see if this eating pattern can improve important health markers related to heart and metabolic health, without changing body weight.
United Kingdom - active not recruitingPHASE3
A Study of Retatrutide (LY3437943) in the Maintenance of Weight Reduction in Individuals With Obesity
This study is investigating a new medication called Retatrutide for people living with obesity. It aims to see how well this medication helps people maintain their weight loss over a long period.
United States · Canada · United Kingdom - recruitingPHASE3
Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity
Researchers are studying a new drug called Maridebart Cafraglutide to see if it can help people with heart disease and who are overweight or obese. The goal is to find out if this drug can lower the risk of heart attacks, strokes, and other serious heart problems.
United States · Argentina · Australia - recruitingPHASE3
A Study to Learn About the Study Medicine (PF-08653944) in People With Obesity or Overweight and Type 2 Diabetes (T2D)
This study looks at a new medicine for adults with overweight or obesity and type 2 diabetes. It aims to see if the medicine helps with weight loss and is safe. The medicine is given as a weekly injection under the skin.
United States · Argentina · Bulgaria - recruitingNA
The Effect of Obesity and Weight Loss in Heart Failure With Preserved Ejection Fraction
This study investigates if losing weight can help people with a specific type of heart failure called HFpEF. It aims to see if diet-led weight loss improves heart function, exercise ability, and quality of life in overweight or obese patients.
United Kingdom