- recruiting
Deep Phenotyping of Peripheral Blood Cells and Circulating Factors in Metabolic Diseases
This study looks at blood cells and other substances in people with obesity, diabetes, and fatty liver disease. Researchers want to understand how these differ in people with and without these conditions to learn more about how they develop.
Germany - recruiting
The European NAFLD Registry
This study aims to understand fatty liver disease (NAFLD) better. Researchers collect information and samples from patients across Europe to find new ways to detect and monitor the disease, especially how it progresses from fatty liver to more serious conditions like fibrosis.
Belgium · Finland · France - recruitingNA
Exercise Training on Brain Insulin Responsiveness
This study looks at how different types of exercise affect brain's response to insulin in people with and without obesity. Researchers compare moderate exercise, intense interval exercise, and no exercise to see which might be best for brain health. It's about understanding how exercise impacts brain signals related to insulin.
Germany - active not recruitingPHASE1
A Study in Healthy People or Otherwise Healthy With Overweight or Obesity to Compare 2 Formulations of Survodutide Given in Different Ways, Either as a Pre-filled Syringe or a Pen-like Injector
This study looks at a new medicine called survodutide for people who are healthy or have overweight/obesity. We want to see if two different versions of the medicine, given with different types of injectors, work similarly in the body. It's an early-stage study.
Germany - recruitingPHASE3
AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss
This study is looking into a new medicine, NNC0487-0111, to help people who have lost weight keep it off. Participants will get either the new medicine or a dummy medicine by injection once a week to see if it's safe and effective for weight management.
United States · Argentina · Australia - recruiting
Global Research Initiative for Patients Screening on MASH
This study aims to improve how doctors find serious liver conditions like MASH in people with health problems like diabetes or obesity. It brings together healthcare providers across Europe to use new care guidelines and raise awareness about these liver diseases.
Belgium · Czechia · France - recruitingNA
Personalized Responses to Dietary Composition Trial 3
This study, PREDICT 3, aims to understand how different foods affect individuals. By looking at how people respond to meals in their everyday life, it helps create more personalised eating advice to improve health for conditions like diabetes and heart problems.
United States · United Kingdom - recruitingNA
PROTeIn-rich Meals to Control Glucose
This study looks at how different eating patterns might help people with prediabetes or type 2 diabetes manage their blood sugar. Researchers are comparing two diets to see which is better for controlling sugar levels and body inflammation.
Germany - recruitingPHASE3
AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea
This study looks at a new medicine, NNC0487-0111, for people who are overweight or obese and have sleep apnoea. We want to see if it helps with weight loss and improves sleep apnoea. Participants will take weekly injections, either the new medicine or a dummy medicine.
United States · Australia · China - active not recruitingPHASE4
STEP TEENS Weight Maintenance: A Research Study on How Well Semaglutide Helps Teenagers With Excess Body Weight to Lose Weight and Maintain Weight Loss
This study looks at how a weekly injection, semaglutide, helps teenagers aged 12-15 with obesity to lose weight and keep it off. All participants will receive the treatment for at least three years, aiming to understand its effectiveness for weight management.
United States · Belgium · Canada - not yet recruitingNA
Study Assessing the Contribution of Telemedicine Monitoring in Addition to Standard Follow-up of an Obesity Program
This study in France looks at whether adding regular phone or video calls (telemedicine) to standard obesity care helps people stick with their treatment and keeps them from dropping out. It's for adults aged 18-60 who have completed an obesity management program.
France - recruitingNA
Health-economic Assessment of Robot-assisted Bariatric Surgery
This study compares two ways to do weight-loss surgery for people with obesity: using a robot or standard keyhole surgery. It aims to see which method is better and more cost-effective for the UK healthcare system, looking at complication rates and quality of life.
France - active not recruiting
Weight Loss Surgery in Adolescents With Extreme Obesity
This study looks at weight-loss surgery for teenagers and young adults with severe obesity in Germany. It aims to understand the benefits and risks of surgery, compared to other weight management methods, as part of a careful support programme.
Germany - recruiting
Impact of Semaglutide (Ozempic/Wegovy®) on Heart and Muscle Mass
This study looks at how a medicine called semaglutide (Ozempic/Wegovy®) affects your heart and muscles over a year. Researchers use special scans and tests to understand if it helps keep your muscles healthy, especially if you have type 2 diabetes or obesity.
Canada - active not recruitingPHASE3
A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Type 2 Diabetes
This study is looking at a new medicine called orforglipron for people with obesity or who are overweight and have type 2 diabetes. It wants to see how well it helps control blood sugar compared to a dummy medicine, called a placebo.
United States · Argentina · China - active not recruiting
Obesity Intervention "Obeldicks" for Obese Children, Adolescents and Their Parents
This study looks at a 12-month programme called "Obeldicks" for children and teenagers aged 6-18 who are very overweight. It combines healthy eating, behaviour support, and exercise to help them manage their weight and improve their health.
Germany - active not recruitingPHASE3
A Research Study to See How Well CagriSema Helps People With Excess Body Weight Lose Weight
This study looks at how a new medicine called CagriSema helps people who are overweight lose weight. It compares CagriSema to other medicines and a dummy medicine. Participants will take a weekly injection, and the study will last about 3 and a half years.
United States · Argentina · Australia - active not recruitingPHASE2
A Study to Assess Efficacy, Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7204239 in Combination With Tirzepatide in Participants With Obesity or Overweight With At Least One Weight-related Comorbidity
This study looks at a new medicine, RO7204239, combined with an existing medicine, tirzepatide, for adults who are overweight or have obesity. It aims to see if this combination helps with weight loss and is safe for people without diabetes.
United States · Poland · Spain - active not recruitingNA
ARIADNE: A Study of Weight Loss for Diabetes Treatment and Wellbeing
This study looks at how a special low-calorie diet affects people with type 2 diabetes and concerns about their eating habits. We want to see if this diet helps with diabetes without causing problems with their relationship with food. It will help us understand if this diet is safe for everyone.
United Kingdom - recruiting
Who Will Benefit From Bariatric Surgery for Diabetes?
This study looks at why some people with type 2 diabetes benefit from weight-loss surgery (Roux-en-Y gastric bypass) more than others. Researchers want to understand if things like body fat, genes, and gut hormones play a role in putting type 2 diabetes into remission after surgery.
United Kingdom - active not recruitingPHASE3
A Research Study on How Well Semaglutide Helps Children and Teenagers With Excess Body Weight Lose Weight
This study looks at how a medicine called semaglutide helps children and teenagers lose weight. Participants get weekly injections of either semaglutide or a dummy medicine. All also receive healthy lifestyle advice. The study lasts about 2.5 years.
United States · Austria · Belgium - enrolling by invitationNA
Real-world Exploration of Digital iNnovation in the Management of Excess Weight
This study looks at a new digital programme to help people in South East London manage their weight. It checks if this online approach improves health, saves money, and makes weight management services better for everyone, especially those with obesity.
United Kingdom - active not recruitingPHASE3
A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and at Least One Weight-Related Comorbidity
This study is looking at a new medicine called orforglipron to help people who are overweight or have obesity lose weight. It's for adults with at least one other health condition linked to their weight, but not diabetes. It will last about 18 months.
United States · Argentina · China - recruitingNA
The Effect of Time-Restricted Eating in Cardiometabolic Health
This study looks at how eating only within a 9-hour window affects health in people who are overweight and have prediabetes. We want to see if this eating pattern can improve important health markers related to heart and metabolic health, without changing body weight.
United Kingdom - active not recruitingPHASE3
A Study of Retatrutide (LY3437943) in the Maintenance of Weight Reduction in Individuals With Obesity
This study is investigating a new medication called Retatrutide for people living with obesity. It aims to see how well this medication helps people maintain their weight loss over a long period.
United States · Canada · United Kingdom - recruitingPHASE3
Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity
Researchers are studying a new drug called Maridebart Cafraglutide to see if it can help people with heart disease and who are overweight or obese. The goal is to find out if this drug can lower the risk of heart attacks, strokes, and other serious heart problems.
United States · Argentina · Australia - recruiting
Safety and Effectiveness of Orbera365™ Intragastric Balloon System
This study looks at how safe and effective the Orbera365™胃内バルーン [Orbera365™ Intragastric Balloon] is for people wanting to lose weight. It's for adults already choosing this balloon, and it helps doctors understand its safety when kept in for a longer time.
Czechia · France · Spain - recruitingPHASE3
A Study to Learn About the Study Medicine (PF-08653944) in People With Obesity or Overweight and Type 2 Diabetes (T2D)
This study looks at a new medicine for adults with overweight or obesity and type 2 diabetes. It aims to see if the medicine helps with weight loss and is safe. The medicine is given as a weekly injection under the skin.
United States · Argentina · Bulgaria - recruitingNA
The Effect of Obesity and Weight Loss in Heart Failure With Preserved Ejection Fraction
This study investigates if losing weight can help people with a specific type of heart failure called HFpEF. It aims to see if diet-led weight loss improves heart function, exercise ability, and quality of life in overweight or obese patients.
United Kingdom - authorisedTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of KAI-9531 Administered Once Weekly in Participants Living with Obesity or Overweight and Diabetes
This study is looking into a new treatment called KAI-9531 for people who are overweight or have obesity and also have diabetes. Researchers want to see if this new medicine can help people lose weight and improve their blood sugar over about a year and a half.
Hungary · Poland · Bulgaria - active not recruitingNA
Impact of an Integrated Obesity Management System on Patient's Care
This study looks at how a special training program for doctors and nurses might help people with obesity. It aims to see if better-trained healthcare teams can help patients manage their weight and related health problems like high blood pressure and type 2 diabetes more effectively.
Canada - recruitingPHASE1
A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD1043 in Healthy Adult Participants Living With Overweight and/or Obesity.
This study is looking into a new medication called AZD1043 for people who are overweight or have obesity. Researchers want to understand if it's safe, how the body handles it, and how it affects the body.
United States · United Kingdom - recruitingNA
Intragastric Balloon in Obese Patients With Uncontrolled Asthma
This study looks at how an intragastric balloon, plus diet and exercise, helps people with obesity and uncontrolled asthma. We want to see if it improves asthma control compared to just diet and exercise.
France - not yet recruiting
Endoscopic Sleeve Gastroplasty (ESG) Prospective Trial for Obesity (EGO-Trial)
This study, called EGO-Trial, is looking into a new, less invasive treatment called Endoscopic Sleeve Gastroplasty (ESG) for people living with obesity in France. It aims to see how well it works and how safe it is in real-life healthcare settings.
France · Guadeloupe - enrolling by invitationNA
Cities for Better Health Childhood Obesity Prevention Initiative
This project aims to help children aged 6-13 in several cities globally live healthier lives by preventing childhood obesity. It looks at how community programs in schools and neighbourhoods can improve healthy eating, physical activity, and overall well-being.
Australia · Brazil · Canada - active not recruitingNA
Fit-for-Fertility Multicenter Randomized Controlled Trial
This study looks into how a healthy lifestyle program, called Fit-for-Fertility, can help women with obesity and infertility. It compares this program to standard fertility treatments to see if it improves chances of pregnancy and having a healthy baby.
Canada - active not recruitingPHASE3
A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease
This study is looking into a new medication called retatrutide for people living with obesity and heart problems. We want to see if it's safe and helps with weight loss when taken once a week, compared to a dummy medicine.
United States · Argentina · Australia - recruitingPHASE3
A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight
This study looks at new and existing medicines (CagriSema and Semaglutide) to help people with obesity, sometimes with type 2 diabetes, lose weight. Researchers want to see how safe and effective these medicines are. It lasts about 83 weeks.
United States · Argentina · Australia - not yet recruitingPHASE1
A Study to Evaluate ALN-6222 in Participants With Obesity
This study is looking into a new medication called ALN-6222 for adults who are overweight. It's a first step to see if it's safe, how the body uses it, and if it could help with weight management.
Canada - active not recruitingPHASE3
Semaglutide 2.4 mg in Patients With Poor Weight-loss
This study is looking at whether a medicine called semaglutide, given as a 3mg injection, can help people who haven't lost enough weight after weight-loss surgery. It compares semaglutide to a dummy treatment over 68 weeks to see if it helps with weight loss and overall health.
United Kingdom - active not recruitingPHASE3
A Research Study to Look Into the Long-term Effect on Weight Loss of CagriSema in People With Obesity
This study is looking at a new medicine called CagriSema to help people with obesity lose weight. It compares CagriSema to a dummy medicine over three years. Participants won't know if they're getting the active medicine or the dummy medicine. The aim is to see how well it works long-term.
United States · Belgium · Canada - active not recruitingPHASE3
Weight Loss in People Living With Overweight or Obesity and Type 2 Diabetes Following Treatment With Cagrilintide
This study looks at a new medicine called cagrilintide for people with overweight or obesity and type 2 diabetes. It aims to see how well cagrilintide helps people lose weight. Participants will receive either the new medicine or a dummy medicine.
United States · Argentina · Canada - authorisedTherapeutic use (Phase IV)
A neuropsychobiological approach to optimize patient selection for GLP-1-based pharmacotherapy for weight management across the binge eating spectrum
This study looks at how a weight loss injection, Wegovy, affects people with obesity, especially those who also experience binge eating. Researchers want to see changes in weight and binge eating habits after six months of treatment. It's investigating if certain body and brain signals can help pick the best candidates for this treatment.
Belgium - recruitingPHASE3
A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes
This study is looking into a new medication called Eloralintide for people who are overweight or have obesity but don't have type 2 diabetes. It aims to see how well it works and if it's safe to help with weight management.
United States · Argentina · Australia - recruitingNA
Gut Hormones and Roux en Y Gastric Bypass
This study looks at how weight-loss surgery (gastric bypass) changes natural body chemicals called 'gut hormones'. We want to see if these changes help people with obesity and type 2 diabetes by burning more energy, eating less, losing weight, and changing how they react to food.
United Kingdom - recruitingNA
Optimal Cardiopulmonary Bypass and Anticoagulation Management Strategies in Obese Patients Undergoing Cardiac Surgery
This study looks at the best way to manage heart bypass surgery for people who are overweight. It's testing if using your lean body weight, rather than total weight, helps decide the right amount of medication and machine settings, making the surgery safer and more effective.
Canada - recruitingPHASE3
A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities
This study is looking at a new once-a-day tablet, orforglipron, for teenagers (12-17 years old) with obesity or who are overweight with other health issues. It will check if the medicine helps with weight and if it's safe to use.
United States · Israel · Italy - recruitingNA
Endoscopic Sutured Gastroplasty with Endomina® Device Versus Standard of Care in Patients with Type 2 Diabetes and Class I Obesity: a Multi-center, Randomized Controlled Trial
This study looks at a new stomach-reduction procedure for people with type 2 diabetes and obesity. It compares this procedure, called endoscopic gastroplasty using the Endomina device, with standard care to see if it helps put diabetes into remission.
France - recruitingNA
Effect of Agonist GLP1 on Adipose Tissue in Patients Undergoing Bariatric Surgery
This study looks at how a medicine called GLP-1 (used for weight loss) affects body fat in people having weight-loss surgery. Researchers want to see if GLP-1 changes levels of a hormone called oxytocin, which might help understand how these treatments work.
France - active not recruitingNA
A Behavioural Weight Loss Intervention Delivered in Cardiac Rehabilitation for Patients With Atrial Fibrillation and Obesity
This study looks at how adding weight loss classes to heart rehabilitation helps people with atrial fibrillation (an irregular heartbeat) and obesity. It compares whether combined treatment helps more with losing weight and improving heart rhythm than heart rehabilitation alone.
Canada