- ongoing, recruitingHuman Pharmacology (Phase I)- Other
A research study of how safe a new medicine called NNC0519‑0130 is and to test its effect in people living with excess body weight with or without type 2 diabetes
This study is looking at a new medicine called NNC0519-0130. It's for adults who are overweight or have obesity, including those with type 2 diabetes. Researchers want to see if the medicine is safe and how it affects the body.
Germany - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Study to Learn if the Study Medicines Called Itraconazole and Cyclosporine Change How the Body Processes the Other Study Medicine Called Danuglipron in Healthy Adults
This study is looking at how two medicines, itraconazole and cyclosporine, might affect how your body uses another new medicine called Danuglipron. It's for healthy adults and is an early-stage study to understand how these drugs interact.
Belgium - active not recruitingNA
Evaluation of Lifestyle Modification on Cardiovascular Risk
This study looks at how exercise, and a healthy Mediterranean diet, might help women aged 45-65 who are overweight or obese and have gone through menopause. It aims to improve heart health and metabolic health (like blood sugar and cholesterol) over 8 weeks.
United Kingdom - authorisedTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of KAI-9531 Administered Once Weekly in Participants Living with Obesity or Overweight with Weight-Related Comorbidities Who Do Not Have Diabetes
This study is testing a new medicine, KAI-9531, for people who are overweight or have obesity and other health issues, but don't have diabetes. We want to see if it helps with weight loss and is safe to use over about 18 months.
Bulgaria · Hungary · Spain - recruitingPHASE4
Fibrosis Lessens After Metabolic Surgery
This study looks at how well weight-loss surgery compares to new medicines for treating liver disease. It focuses on a condition called MASH, which is linked to being overweight and can cause liver damage.
United States · Brazil · Canada - not yet recruitingPHASE3
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
This study looks at a new medicine, NNC0487-0111, for people with heart failure and obesity. It compares the medicine to a dummy treatment (placebo) to see if it's safe and helps improve heart health.
United States · Argentina · Australia - enrolling by invitation
A Study to Evaluate Safety of Exposure to Wegovy During Pregnancy
This study looks at how babies and mothers are doing when the mother has taken Wegovy for obesity or being overweight during pregnancy. It compares their health outcomes with mothers who didn't take Wegovy but had similar health conditions.
United States · Spain · United Kingdom - not yet recruitingNA
Group Skills Training for Body Awareness and Managing Emotions
This study aims to help people with obesity improve their awareness of body signals and manage emotions better. It tests a new group program, based on polyvagal theory, to see if it helps people understand their body's messages and respond in healthier ways.
United Kingdom - recruiting
Safety and Effectiveness of Orbera365™ Intragastric Balloon System
This study looks at how safe and effective the Orbera365™胃内バルーン [Orbera365™ Intragastric Balloon] is for people wanting to lose weight. It's for adults already choosing this balloon, and it helps doctors understand its safety when kept in for a longer time.
Czechia · France · Spain - recruitingNA
Intensive Weight Loss Intervention Versus Bariatric Surgery for Adults With Severe and Complex Obesity: the LightBAR Randomised Trial
This study compares an intensive diet and lifestyle programme with weight-loss surgery for adults with severe obesity. We want to see which method works best and is safest, to help improve future treatment options.
Denmark · United Kingdom - recruiting
A UK Registry for Metabolic and Bariatric Endoscopic Interventions
This UK study is collecting information on new, less invasive procedures using a camera on a thin tube (endoscope) to help people with obesity and type 2 diabetes lose weight. It aims to see how safe and effective these treatments are in real-life settings.
United Kingdom - active not recruitingPHASE3
A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity
This study is looking at how a medication called Tirzepatide might help people living with obesity. Researchers want to see if it can reduce serious health problems and improve overall health in adults.
United States · Argentina · Australia - authorisedPhase III and phase IV (Integrated)
Applying Mysimba in patients with weight regain after bariatric surgery
This study looks at whether a medication called Mysimba, combined with usual healthy lifestyle advice, can help people who have put some weight back on after weight-loss surgery. It compares this combination to just the healthy lifestyle advice alone, to see if it helps achieve further weight loss.
Netherlands - recruitingNA
The Effect of Obesity and Weight Loss in Heart Failure With Reduced Ejection Fraction.
This study explores if losing weight can improve the heart's health and quality of life for people with a specific type of heart failure. Participants will follow a supervised diet plan or continue their usual care.
Jersey · United Kingdom - recruitingNA
The Effect of Exercise in Patients Awaiting Bariatric Surgery
This study looks at how a 4-week online exercise programme helps people preparing for weight-loss surgery. It aims to see if exercise before surgery can improve fitness and how the body uses energy, compared to not exercising.
United Kingdom - authorisedTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Active- and Placebo-Controlled, Partially-Blinded Study to Compare the Efficacy and Safety of KAI-9531 Administered Once Weekly Versus Semaglutide and Placebo in Participants Living with Obesity Who Do Not Have Diabetes
This study is looking at a new medicine, KAI-9531, to help people living with obesity who don't have diabetes. It compares KAI-9531 with an existing medicine (Wegovy) and a dummy treatment to see how well it helps with weight loss and if it's safe.
Poland · Bulgaria - recruitingPHASE3
A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes
This study is looking into a new medication called Eloralintide for people who are overweight or have obesity but don't have type 2 diabetes. It aims to see how well it works and if it's safe to help with weight management.
United States · Argentina · Australia - active not recruitingPHASE3
Evaluation of Maridebart Cafraglutide in Adult Participants Without Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight
This study is looking at a new medicine called Maridebart Cafraglutide to see if it helps adults who are overweight or have obesity lose weight. It compares the medicine to a dummy treatment (placebo) to find out if it's more effective.
United States · Argentina · Australia - active not recruitingPHASE3
A Study of Retatrutide (LY3437943) in the Maintenance of Weight Reduction in Individuals With Obesity
This study is investigating a new medication called Retatrutide for people living with obesity. It aims to see how well this medication helps people maintain their weight loss over a long period.
United States · Canada · United Kingdom - recruitingPHASE3
AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss
This study is looking into a new medicine, NNC0487-0111, to help people who have lost weight keep it off. Participants will get either the new medicine or a dummy medicine by injection once a week to see if it's safe and effective for weight management.
United States · Argentina · Australia - recruitingNA
Bariatric Surgery and Exercise Interventions: Effects on Muscle
This study looks at how weight loss surgery affects muscles. It also checks if a special exercise programme after surgery can help improve muscle strength. We're inviting people having weight loss surgery at Royal Derby Hospital to take part.
United Kingdom - active not recruitingPHASE3
Weight Loss in People Living With Overweight or Obesity Following Treatment With Cagrilintide
This study is testing a new medicine called Cagrilintide to see if it helps people living with overweight or obesity to lose weight. Some people will get the new medicine, and others will get a dummy treatment. The study will last about 18 months for each person.
United States · Argentina · Australia - recruiting
Weight Loss in Adults Using Semaglutide (Real-world Study)
This study looks at how a medicine called semaglutide helps adults lose weight in real-life settings. Doctors decide who receives the treatment. It aims to see how effective semaglutide is for people who are overweight or obese, following their usual healthcare.
United States · United Kingdom - recruitingPHASE3
A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2)
This study looks at a medicine called tirzepatide for teenagers aged 12-17 who are overweight and have related health problems. Researchers want to see if it helps with weight and heart health when combined with healthy eating and exercise.
United States · Argentina · Australia - recruiting
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
This study aims to understand why common medicines don't work the same for everyone in the UK, especially for people from different backgrounds. It will look at many health conditions, hoping to improve how we treat them and make healthcare fairer for all.
United Kingdom - recruitingNA
Intensive Weight Loss Intervention Versus Usual Care for Adults With Severe and Complex Obesity
This study compares an intensive weight loss programme, including special diets and support, with standard NHS weight management for adults with severe obesity. It aims to see which works best for health and cost.
Denmark · United Kingdom - recruitingPHASE1
A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD1043 in Healthy Adult Participants Living With Overweight and/or Obesity.
This study is looking into a new medication called AZD1043 for people who are overweight or have obesity. Researchers want to understand if it's safe, how the body handles it, and how it affects the body.
United States · United Kingdom - active not recruitingNA
ARIADNE: A Study of Weight Loss for Diabetes Treatment and Wellbeing
This study looks at how a special low-calorie diet affects people with type 2 diabetes and concerns about their eating habits. We want to see if this diet helps with diabetes without causing problems with their relationship with food. It will help us understand if this diet is safe for everyone.
United Kingdom - recruitingPHASE3
A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities
This study is looking at a new once-a-day tablet, orforglipron, for teenagers (12-17 years old) with obesity or who are overweight with other health issues. It will check if the medicine helps with weight and if it's safe to use.
United States · Israel · Italy - recruitingNA
Comorbid Obesity and Depression With an Anti-inflammatory Medication
This study looks into using a medicine called minocycline for people who have both obesity and depression. It's for those with signs of body inflammation. The aim is to see if this treatment can help improve depression symptoms by reducing inflammation.
United Kingdom - active not recruitingPHASE3
A Research Study to Look Into the Long-term Effect on Weight Loss of CagriSema in People With Obesity
This study is looking at a new medicine called CagriSema to help people with obesity lose weight. It compares CagriSema to a dummy medicine over three years. Participants won't know if they're getting the active medicine or the dummy medicine. The aim is to see how well it works long-term.
United States · Belgium · Canada - enrolling by invitationNA
Real-world Exploration of Digital iNnovation in the Management of Excess Weight
This study looks at a new digital programme to help people in South East London manage their weight. It checks if this online approach improves health, saves money, and makes weight management services better for everyone, especially those with obesity.
United Kingdom - active not recruitingPHASE3
A Research Study on How Well Semaglutide Helps Children and Teenagers With Excess Body Weight Lose Weight
This study looks at how a medicine called semaglutide helps children and teenagers lose weight. Participants get weekly injections of either semaglutide or a dummy medicine. All also receive healthy lifestyle advice. The study lasts about 2.5 years.
United States · Austria · Belgium - recruitingPHASE3
A Study to Learn About the Study Medicine (PF-08653944) in People With Obesity or Overweight and Type 2 Diabetes (T2D)
This study looks at a new medicine for adults with overweight or obesity and type 2 diabetes. It aims to see if the medicine helps with weight loss and is safe. The medicine is given as a weekly injection under the skin.
United States · Argentina · Bulgaria - recruitingNA
Gut Hormone LEAP2 in Metabolism and Eating Behaviour: Fixed Meal Testing
This study looks at how different sized liquid meals affect hunger hormones and feelings of fullness in healthy adults, both with and without obesity. We want to see if meal size changes these hormones and how much people eat afterwards.
United Kingdom - recruiting
Who Will Benefit From Bariatric Surgery for Diabetes?
This study looks at why some people with type 2 diabetes benefit from weight-loss surgery (Roux-en-Y gastric bypass) more than others. Researchers want to understand if things like body fat, genes, and gut hormones play a role in putting type 2 diabetes into remission after surgery.
United Kingdom - recruitingNA
Gut Hormones and Roux en Y Gastric Bypass
This study looks at how weight-loss surgery (gastric bypass) changes natural body chemicals called 'gut hormones'. We want to see if these changes help people with obesity and type 2 diabetes by burning more energy, eating less, losing weight, and changing how they react to food.
United Kingdom - recruiting
Nottingham Community Liver Biomarkers Cohort
This study in Nottingham looks at improving how we find liver disease early in the community. It involves people with risk factors like heavy alcohol use, obesity, or diabetes, to see if new blood and scan tests can help identify liver problems before they become serious.
United Kingdom - recruitingPHASE3
Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity
Researchers are studying a new drug called Maridebart Cafraglutide to see if it can help people with heart disease and who are overweight or obese. The goal is to find out if this drug can lower the risk of heart attacks, strokes, and other serious heart problems.
United States · Argentina · Australia - recruiting
Periodontal Assessment of a Bariatric Care Population
This study looks at gum health in people considering weight-loss surgery. It explores the link between obesity, gum disease, and genetic factors, and examines bacteria in the mouth to understand these connections better.
United Kingdom - recruiting
Biomarkers in Patients With Suspected HFpEF
This study looks for better ways to spot heart failure, especially in people with obesity or low levels of a common blood test. Researchers hope to find new blood markers to help doctors diagnose heart failure more accurately and earlier.
United Kingdom - recruitingPHASE3
A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight
This study looks at new treatments, CagriSema and cagrilintide, for children and teenagers aged 8-18 who are overweight. It compares these new drugs to an existing medicine (semaglutide) or a dummy drug (placebo) to see how well they help with weight loss.
United States · Australia · Austria - recruitingPHASE4
A Study of Tirzepatide (LY3298176) Compared With Standard of Care in Adult Participants With Obesity and Without Diabetes (SURMOUNT-REAL UK)
This study looks at a new medicine called tirzepatide for adults with obesity but not diabetes. It compares it to standard care to see how well it helps with weight loss and if it can prevent type 2 diabetes over about five years.
United Kingdom - authorisedTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of KAI-9531 Administered Once Weekly in Participants Living with Obesity or Overweight and Diabetes
This study is looking into a new treatment called KAI-9531 for people who are overweight or have obesity and also have diabetes. Researchers want to see if this new medicine can help people lose weight and improve their blood sugar over about a year and a half.
Hungary · Poland · Bulgaria - authorisedHuman Pharmacology (Phase I)- Other
A research study to see how NNC0487-0111 affects the body’s energy use after a weight loss in adults living with obesity, compared to a low-calorie diet or placebo
This study looks at a new treatment, NNC0487-0111, for adults who have lost weight but are still living with obesity. It compares this treatment to a low-calorie diet or a dummy medicine, to see how it affects the body's energy use after weight loss.
Netherlands · Denmark - authorisedHuman Pharmacology (Phase I)- Other
A Study of Eloralintide (LY3841136) in Participants With Overweight or Obesity
This study is looking into a new medication called Eloralintide (LY3841136) for adults who are overweight or obese. It's an early-stage study to understand how the medicine works in the body and if it's safe.
Germany - active not recruitingNA
Adults Regulating Their Weight Everyday With Mobile Internet Support
This study, called ARTEMIS, is exploring if a mobile app can help adults in the UK manage their weight. It focuses on using the app to help people make daily healthy choices and build lasting habits for weight control, without needing in-person meetings.
United Kingdom - recruiting
Effect of Obesity, Diabetes and Bariatric Surgery on Pregnancy Outcomes
This study looks at how being overweight or having diabetes affects mothers and babies during pregnancy in the UK. Researchers are also comparing mums who've had weight loss surgery with those who haven't, to understand the different effects on pregnancy.
United Kingdom - recruitingPHASE3
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
This study looks at a new medicine, Maridebart cafraglutide, for people with heart failure and obesity. It aims to see if the medicine can reduce heart-related problems like hospital stays, improve symptoms, and help people live longer, alongside their usual heart failure care.
United States · Argentina · Australia - active not recruitingPHASE3
A Research Study to See How Well CagriSema Helps People With Excess Body Weight Lose Weight
This study looks at how a new medicine called CagriSema helps people who are overweight lose weight. It compares CagriSema to other medicines and a dummy medicine. Participants will take a weekly injection, and the study will last about 3 and a half years.
United States · Argentina · Australia