- active not recruitingNA
Intensive Weight Loss Intervention Versus Usual Care for Adults With Severe and Complex Obesity
This study compares an intensive weight loss programme, including special diets and support, with standard NHS weight management for adults with severe obesity. It aims to see which works best for health and cost.
Denmark · United Kingdom - recruitingPHASE3
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
This study looks at a new medicine, Maridebart cafraglutide, for people with heart failure and obesity. It aims to see if the medicine can reduce heart-related problems like hospital stays, improve symptoms, and help people live longer, alongside their usual heart failure care.
United States · Argentina · Australia - recruitingNA
Gut Hormone LEAP2 in Metabolism and Eating Behaviour: Fixed Meal Testing
This study looks at how different sized liquid meals affect hunger hormones and feelings of fullness in healthy adults, both with and without obesity. We want to see if meal size changes these hormones and how much people eat afterwards.
United Kingdom - authorisedTherapeutic exploratory (Phase II)
Weight management with orismilast alone or in combination with s.c. semaglutide (WELOSITI)
This study looks at a new medicine called orismilast, sometimes with semaglutide, to help adults aged 18 and over manage their weight. Researchers want to see how much weight people lose over 16 weeks.
Denmark - recruitingPHASE1
A Study in People With Overweight or Obesity to Compare How 2 Different Formulations of Survodutide Are Taken up by the Body
This study is looking at how two different forms of a new medicine, survodutide, are taken up by the body in healthy people who are overweight or have obesity. It aims to see if both forms work in a similar way.
United Kingdom - ongoing, recruitingTherapeutic exploratory (Phase II)
Dapiglutide for the treatment of obesity (DREAM): a randomised, double-blind, placebo-controlled, investigator-initiated trial
This study, called DREAM, is looking into a new medication called dapiglutide for treating obesity. It's in an early stage (Phase II) and aims to see how much dapiglutide can help people lose weight, compared to a dummy pill. Researchers will also check its effects on gut health and inflammation.
Denmark - authorisedHuman Pharmacology (Phase I)- Other
A Study of Eloralintide (LY3841136) in Participants With Overweight or Obesity
This study is looking into a new medication called Eloralintide (LY3841136) for adults who are overweight or obese. It's an early-stage study to understand how the medicine works in the body and if it's safe.
Germany - active not recruitingPHASE3
A Study to Test the Effect of Survodutide (BI 456906) on Cardiovascular Safety in People With Overweight or Obesity (SYNCHRONIZE™ - CVOT)
This study looks at a new medicine called survodutide for people who are overweight or obese. It checks if survodutide helps with heart health problems. Participants take the medicine weekly for up to 2 years, alongside diet and exercise advice.
United States · Argentina · Australia - recruitingPHASE3
A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight
This study looks at new treatments, CagriSema and cagrilintide, for children and teenagers aged 8-18 who are overweight. It compares these new drugs to an existing medicine (semaglutide) or a dummy drug (placebo) to see how well they help with weight loss.
United States · Australia · Austria - enrolling by invitation
A Two-year Prospective, Observational Study of Wegovy in Real-world Clinical Practice
This study looks at how a medicine called Wegovy (semaglutide) is used in real life to help people with obesity. It will follow participants for two years to see how it affects weight, body size, and quality of life.
Spain · Switzerland · United Kingdom - recruiting
Weight Loss in Adults Using Semaglutide (Real-world Study)
This study looks at how a medicine called semaglutide helps adults lose weight in real-life settings. Doctors decide who receives the treatment. It aims to see how effective semaglutide is for people who are overweight or obese, following their usual healthcare.
United States · United Kingdom - recruitingPHASE3
A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2)
This study looks at a medicine called tirzepatide for teenagers aged 12-17 who are overweight and have related health problems. Researchers want to see if it helps with weight and heart health when combined with healthy eating and exercise.
United States · Argentina · Australia - authorisedTherapeutic use (Phase IV)
Efficacy and safety of pharmacological therapy of obesity in liver transplant candidates
This study looks at how a medicine called Mounjaro helps people with obesity who are waiting for a liver transplant. Researchers want to see if it helps them lose weight and if it's safe to use, carefully checking for any side effects and how it affects their health after a transplant.
Czechia - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A research study to look at how CagriSema influences food intake, appetite and emptying of the stomach in people with excess body weight
This study is looking at a new medicine called CagriSema to see how it affects eating, hunger, and how quickly your stomach empties if you are overweight. It's an early study to understand how it works in the body.
Germany - active not recruitingNA
Evaluation of Lifestyle Modification on Cardiovascular Risk
This study looks at how exercise, and a healthy Mediterranean diet, might help women aged 45-65 who are overweight or obese and have gone through menopause. It aims to improve heart health and metabolic health (like blood sugar and cholesterol) over 8 weeks.
United Kingdom - recruitingPHASE3
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
This study looks at a new medicine, NNC0487-0111, for people with heart failure and obesity. It compares the medicine to a dummy treatment (placebo) to see if it's safe and helps improve heart health.
United States · Argentina · Australia - recruitingPHASE4
Fibrosis Lessens After Metabolic Surgery
This study looks at how well weight-loss surgery compares to new medicines for treating liver disease. It focuses on a condition called MASH, which is linked to being overweight and can cause liver damage.
United States · Brazil · Canada - authorisedTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of KAI-9531 Administered Once Weekly in Participants Living with Obesity or Overweight with Weight-Related Comorbidities Who Do Not Have Diabetes
This study is testing a new medicine, KAI-9531, for people who are overweight or have obesity and other health issues, but don't have diabetes. We want to see if it helps with weight loss and is safe to use over about 18 months.
Bulgaria · Hungary · Spain - active not recruitingPHASE3
A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity
This study is looking at how a medication called Tirzepatide might help people living with obesity. Researchers want to see if it can reduce serious health problems and improve overall health in adults.
United States · Argentina · Australia - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Control Of BioEquivalence with Xenical (COBEX): A Phase I, randomized, active-control study to evaluate EMP22 pharmacodynamics and EMP16 pharmacokinetics versus Xenical® in healthy volunteers.
This study is comparing two new medicines (EMP22 and EMP16) for obesity with an existing one (Xenical). We want to see how much fat is passed in your poo when taking these medicines. It's a first step to understand how they work in healthy adults.
Sweden - recruiting
A UK Registry for Metabolic and Bariatric Endoscopic Interventions
This UK study is collecting information on new, less invasive procedures using a camera on a thin tube (endoscope) to help people with obesity and type 2 diabetes lose weight. It aims to see how safe and effective these treatments are in real-life settings.
United Kingdom - recruiting
Support for weight loss for adults from the dental team when attending routine appointments at dental practices
This study looks at whether dental teams can help adults with weight management. If you join, your height and weight will be measured at your dental check-up, and you'll discuss healthy habits with your dental team to see if this helps improve health.
United Kingdom - not yet recruitingNA
Group Skills Training for Body Awareness and Managing Emotions
This study aims to help people with obesity improve their awareness of body signals and manage emotions better. It tests a new group program, based on polyvagal theory, to see if it helps people understand their body's messages and respond in healthier ways.
United Kingdom - enrolling by invitation
A Study to Evaluate Safety of Exposure to Wegovy During Pregnancy
This study looks at how babies and mothers are doing when the mother has taken Wegovy for obesity or being overweight during pregnancy. It compares their health outcomes with mothers who didn't take Wegovy but had similar health conditions.
United States · Spain · United Kingdom - recruitingPHASE2
A Study to Test Whether BI 3034701 Helps People to Lose Weight Who Live With Obesity or Overweight
This study is testing a new medicine, BI 3034701, to see if it helps adults with obesity or overweight lose weight. Participants will get either the medicine or dummy medicine, plus advice on diet and exercise.
United States · Australia · Canada - recruitingPHASE3
Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity
Researchers are studying a new drug called Maridebart Cafraglutide to see if it can help people with heart disease and who are overweight or obese. The goal is to find out if this drug can lower the risk of heart attacks, strokes, and other serious heart problems.
United States · Argentina · Australia - recruitingPHASE3
Efficacy and Safety of Ribupatide in Participants Living With Obesity or Overweight With Weight-Related Comorbidities Who Do Not Have Diabetes
This study is looking at a new medicine called KAI-9531. It aims to see if weekly injections of this medicine can help people who are overweight or obese, and have other health issues related to their weight, lose weight. We want to know if it's safe and effective.
United States · Argentina · Australia - active not recruitingPHASE3
A Study of Retatrutide (LY3437943) in Participants With Obesity or Overweight
This study is looking into a new medication called retatrutide for people who are overweight or have obesity. It aims to see how well it helps with weight loss and if it's safe, compared to a dummy treatment.
United States · United Kingdom - active not recruitingPHASE3
Weight Loss in People Living With Overweight or Obesity Following Treatment With Cagrilintide
This study is testing a new medicine called Cagrilintide to see if it helps people living with overweight or obesity to lose weight. Some people will get the new medicine, and others will get a dummy treatment. The study will last about 18 months for each person.
United States · Argentina · Australia - recruitingPHASE3
AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight
This study, AMAZE 1, is testing a new medicine called NNC0487-0111 to see if it helps people with excess body weight lose weight. It involves weekly injections, with some participants receiving the active medicine and others a dummy treatment (placebo).
United States · Argentina · Australia - recruiting
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
This study aims to understand why common medicines don't work the same for everyone in the UK, especially for people from different backgrounds. It will look at many health conditions, hoping to improve how we treat them and make healthcare fairer for all.
United Kingdom - recruitingPHASE3
A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)
This study is for children and teenagers aged 6-17 who are overweight or have obesity. It's testing a new medication called Orforglipron to see if it's safe and helps with weight management, compared to a dummy medicine. It aims to find better ways to help young people manage their weight.
United States · Belgium · Brazil - recruitingPHASE3
Efficacy and Safety of Ribupatide Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes
This study is looking at a new medicine called Ribupatide for people living with obesity. It compares Ribupatide with another medicine, Semaglutide, and a dummy treatment, to see how well it helps with weight loss. We want to find out if Ribupatide is more effective and safe.
United States · Australia · Bulgaria - recruitingPHASE3
A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes
This study is looking into a new medication called Eloralintide for people who are overweight or have obesity but don't have type 2 diabetes. It aims to see how well it works and if it's safe to help with weight management.
United States · Argentina · Australia - active not recruitingPHASE3
A Research Study to See How Well CagriSema Helps People With Excess Body Weight Lose Weight
This study looks at how a new medicine called CagriSema helps people who are overweight lose weight. It compares CagriSema to other medicines and a dummy medicine. Participants will take a weekly injection, and the study will last about 3 and a half years.
United States · Argentina · Australia - not yet recruitingNA
Weight and Metabolic Management Study
This study is testing if a nutritional supplement, elénzia CONTROL®, can help adults manage their weight. It looks at people who haven't used certain weight-loss medications (GLP-1s) or who recently stopped them. Researchers want to see if it helps reduce weight or stops weight regain.
United Kingdom - recruitingPHASE3
AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss
This study is looking into a new medicine, NNC0487-0111, to help people who have lost weight keep it off. Participants will get either the new medicine or a dummy medicine by injection once a week to see if it's safe and effective for weight management.
United States · Argentina · Australia - active not recruitingPHASE3
A Study to Learn About the Study Medicine (PF-08653944) in People With Obesity or Overweight and Type 2 Diabetes (T2D)
This study looks at a new medicine for adults with overweight or obesity and type 2 diabetes. It aims to see if the medicine helps with weight loss and is safe. The medicine is given as a weekly injection under the skin.
United States · Argentina · Bulgaria - active not recruitingPHASE4
STEP TEENS Weight Maintenance: A Research Study on How Well Semaglutide Helps Teenagers With Excess Body Weight to Lose Weight and Maintain Weight Loss
This study looks at how a weekly injection, semaglutide, helps teenagers aged 12-15 with obesity to lose weight and keep it off. All participants will receive the treatment for at least three years, aiming to understand its effectiveness for weight management.
United States · Belgium · Canada - recruitingPHASE3
A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities
This study is looking at a new once-a-day tablet, orforglipron, for teenagers (12-17 years old) with obesity or who are overweight with other health issues. It will check if the medicine helps with weight and if it's safe to use.
United States · Israel · Italy - recruitingNA
Intensive Weight Loss Intervention Versus Bariatric Surgery for Adults With Severe and Complex Obesity: the LightBAR Randomised Trial
This study compares an intensive diet and lifestyle programme with weight-loss surgery for adults with severe obesity. We want to see which method works best and is safest, to help improve future treatment options.
Denmark · United Kingdom - not yet recruitingNA
Glycaemic Response of Arabic Bread
This study is looking at how different types of Arabic bread, made with chickpea, pea, or lentil flour, affect blood sugar levels. They want to see if these breads can help keep blood sugar more steady compared to regular wheat bread in people who are overweight or have obesity.
United Kingdom - ongoing, recruitingTherapeutic confirmatory (Phase III)
I8F-MC-GPHJ: A Phase 3b, Randomized Controlled Study to Evaluate the Efficacy and Safety of Tirzepatide Compared to Semaglutide 2.4 mg in Adults Who Have Obesity or Overweight with Weight-Related Comorbidities
This study is comparing two medicines, Tirzepatide and Semaglutide, to see which is more effective and safer for helping adults with obesity or overweight, who also have other health issues, to lose weight. It's looking at how much weight people lose and other health changes.
Germany · Belgium · Poland - authorisedTherapeutic confirmatory (Phase III)
The effect of semaglutide therapy on hepatic fat content and on the acute reponse of liver fat to high-fat load in obese MASLD patients
This study looks at how a medicine called semaglutide affects fat in the liver of men with obesity and a condition called MASLD. We want to see if it reduces liver fat and how the liver responds to fatty foods after taking the medicine.
Czechia - recruitingPHASE4
Metformin for Antipsychotic-induced Weight Gain in Adults With Intellectual Disability
This study looks at whether a medicine called metformin can help adults with learning disabilities who've gained weight from antipsychotic medicines. These medicines are important, but weight gain can lead to other health problems.
Canada - active not recruiting
Meta-Analyses of the Effect of Plant Protein Versus Animal Protein on Cardiometabolic Risk
This study looks at lots of past research to see if swapping animal protein for plant protein makes a difference to health conditions like diabetes, heart problems, and kidney issues. They want to understand if eating more plant-based protein, like from beans or nuts, can be better for our health.
Canada - recruitingPHASE3
Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea on Positive Airway Pressure Therapy
This study is testing a new medicine, Maridebart Cafraglutide, for adults with sleep apnea who use a CPAP machine and are also overweight or have obesity. We want to see if the medicine helps improve their sleep apnea and is safe to use over 52 weeks.
United States · Australia · Brazil - recruitingEARLY_PHASE1
Akkermansia Muciniphilia and Metabolic Side Effects of ADT
This study looks at whether apple cider vinegar can increase beneficial gut bacteria in men with prostate cancer starting hormone therapy. Researchers want to see if this helps reduce side effects like weight gain and diabetes, which can be linked to their treatment.
Canada - active not recruiting
Impact of a Regional Program Agir Sur Sa SantE
This study looks at a new care plan called 'Agir Sur Sa SantÉ' (meaning 'Act on Your Health') in our local area. It aims to see how well this plan works for people with conditions like diabetes, obesity, and high blood pressure, focusing on improving their overall health.
Canada - recruitingPHASE3
AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
This study looks at a new medicine, NNC0487-0111, for people who are overweight and have knee pain from arthritis. It wants to see if this medicine helps with losing weight and reducing pain compared to a dummy medicine.
United States · Australia · Bulgaria