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Clinimetric Properties of Muscle Mass and Stiffness Measurements of the Quadriceps in Patients With COPD

This study aims to discover better ways to check the leg muscles of people living with Chronic Obstructive Pulmonary Disease (COPD). Many individuals with COPD experience weaker leg muscles, specifically in their thighs, which can impact their daily lives and overall health. We're investigating two methods: a simple tape measure around the thigh, and a special scan called ShearWave elastography that checks muscle stiffness. The goal is to see how accurate and helpful these measurements are for monitoring muscle health, especially when someone starts a pulmonary rehabilitation programme. This could lead to earlier detection of muscle changes, helping doctors provide better support and care.

At a glance

Status
Recruiting
Sponsor
Groupe Hospitalier du Havre
Enrolment target
30
Start
30 May 2025
Estimated completion
01 Dec 2026

What is this study about?

If you have COPD, you might find that your muscles, especially in your legs, aren’t as strong as they used to be. This is quite common and can affect how you move around, your quality of life, and even your overall health. Doctors know that losing muscle in the thighs (a group of muscles called the quadriceps) can be a sign of future health problems in people with COPD, so keeping an eye on muscle health is really important.

This study wants to find easier and more effective ways to check on these leg muscles. Currently, there isn't one perfect way for doctors to reliably track muscle changes over time. We're looking at two different methods. The first is very simple: using a tape measure around the thigh to see how big the muscle is. This is quick and cheap, but we need to check how accurate and dependable it is for tracking changes in people with COPD, especially when they exercise or start rehabilitation.

The second method uses a special scanning technique called ShearWave elastography. This scan measures how stiff your muscles are. Muscle stiffness can give us clues about muscle quality, which might be different from just measuring size or strength. This is a newer method, and we want to see if it provides useful information that current tests don't, helping doctors understand the muscle health of people with COPD even better. Ultimately, finding better ways to monitor muscle health could help doctors provide more targeted care and support.

Key takeaways

  • COPD can affect leg muscle strength and size.
  • The study aims to find better ways to monitor thigh muscle health.
  • It uses a tape measure and a special scan (ShearWave elastography).
  • Participation involves simple measurements before and after rehabilitation.
  • This research could help doctors provide better care for people with COPD.

Who may be eligible?

This study is looking for adults aged 18 or over who have COPD and are just beginning a pulmonary rehabilitation programme. Pulmonary rehabilitation is a supervised exercise and education programme designed to help people with lung conditions breathe easier and improve their quality of life.

You wouldn't be able to join this study if you are already taking part in another research study, are pregnant, or are under the care of a guardian. Also, if you've had a leg amputation, suffer from certain nerve or muscle conditions, or if your heart health means you shouldn't do pulmonary rehabilitation, then this study wouldn't be suitable for you.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

  1. Do I have COPD?
  2. Am I 18 years old or older?
  3. Am I about to start a pulmonary rehabilitation programme?
  4. Am I not involved in any other research studies?
  5. Do I not have any conditions that stop me from doing pulmonary rehabilitation?
Answer every question to see your result.

What does participation involve?

If you join this study, we will be measuring your thigh muscles both before you start your pulmonary rehabilitation programme and again after you finish. These measurements will involve using a simple tape measure around your thigh to check its size, and a special scan called ShearWave elastography to see how stiff your muscle is. There are no new medications involved in this study; you will follow your usual pulmonary rehabilitation programme. The length of your involvement will depend on the duration of your pulmonary rehabilitation programme.

Potential risks and benefits

By taking part, you will help us learn more about muscle health in people with COPD, which could lead to better ways for doctors to support patients in the future. The measurements we are taking are simple and generally low-risk. The tape measure is harmless, and the ShearWave elastography scan is similar to a regular ultrasound and doesn't involve radiation or discomfort. The main time commitment is having these measurements done before and after your rehabilitation programme. You are free to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (1)

  • Groupe Hospitalier du Havre
    Verified postcode
    Le Havre, France· Recruiting

Common questions

What muscles are you studying?

We are focusing on the quadriceps, which are the large muscles at the front of your thighs.

What is pulmonary rehabilitation?

It's a programme of exercise and education designed to help people with lung conditions like COPD manage their symptoms and improve their overall health.

Will I have to take any new medicines?

No, this study does not involve any new medicines. You will continue with your usual medical care.

What is ShearWave elastography?

It's a special type of scan, similar to an ultrasound, that measures how stiff your muscles are. It's painless and doesn't use radiation.

How long will I be in the study?

Your participation will last for the duration of your pulmonary rehabilitation programme, as we take measurements at the start and end of it.

How to find out more

Claire Dubois, PT

Always speak to your GP or specialist before deciding to take part in a study.

Interested in taking part?

Register your interest

Share your details and the research team for "Clinimetric Properties of Muscle Mass and Stiffness Measurem…" will contact you if you may be eligible. Always speak to your GP before agreeing to take part.

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