The Minimally Invasive Coronary Surgery Compared to STernotomy Coronary Artery Bypass Grafting Trial
This study is looking at two ways to do heart bypass surgery for blocked arteries in your heart. One is called MICS CABG, which uses a small cut on your chest, and the other is traditional open-chest surgery, called sternotomy CABG. Doctors want to find out if the keyhole surgery helps people get back to their normal activities quicker and feel better in the months after their operation. They will compare how good patients' lives feel and how well they recover at different times after surgery, like after 1 month, 3 months, 6 months, and a year. This research could help decide which surgery is best for patients with blocked heart arteries.
At a glance
What is this study about?
This study is about a common heart problem called coronary artery disease, where the blood vessels supplying your heart become narrowed or blocked. When this happens, doctors sometimes recommend a surgery called coronary artery bypass grafting (CABG). This operation helps create new routes for blood to flow around the blockages.
Traditionally, this surgery involves a larger cut down the middle of your chest. However, a newer method, called Minimally Invasive Coronary Surgery (MICS CABG), uses a much smaller cut, usually on the left side of the chest. This new approach might mean a quicker recovery and getting back to your normal life sooner, but doctors want to be sure.
That's why this study, called the MIST Trial, is being done. Researchers want to properly compare these two types of surgery. They will carefully look at how patients feel and recover after each type of surgery, using questionnaires about their quality of life. The goal is to see if MICS CABG truly offers better recovery and quality of life in the first year after surgery compared to the traditional method, and this could help surgeons decide the best way to operate in the future.
Key takeaways
- Compares traditional open-chest heart bypass with a keyhole method.
- Aims to find out if keyhole surgery helps patients recover faster and feel better.
- Participation involves being randomly assigned to one of the two surgery types.
- You'll complete quality of life questionnaires over 12 months.
- Helps doctors understand the best surgical options for blocked heart arteries.
Who may be eligible?
To join this study, you must be 18 years old or older and have blockages in several of the important arteries around your heart. Your doctor will need to agree that both the traditional and the keyhole surgery methods are suitable options for you.
There are also some reasons why you wouldn't be able to join. For example, if you've already had heart surgery or certain chest treatments, or if you have other serious health problems that might shorten your life significantly. Also, if you need other heart procedures at the same time as your bypass surgery, or if you can't come to all the follow-up appointments, you wouldn't be able to participate.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you 18 or older?
- Do you have blockages in several major heart arteries?
- Has your doctor said both traditional and keyhole bypass surgery might be suitable for you?
- Are you able to attend follow-up appointments for a year after surgery?
- Have you not had previous heart surgery or certain chest treatments?
What does participation involve?
If you join this study, you will be randomly assigned to have either the traditional bypass surgery (sternotomy CABG) or the keyhole bypass surgery (MICS CABG). This is like flipping a coin, so neither you nor your doctor can choose which type of surgery you will have for the study. After your surgery, you will be asked to complete some questionnaires about your health and quality of life. These will be done at 1 month, 3 months, 6 months, and 12 months after your operation. This helps the study team understand how you are recovering and feeling. You won't be given any new or experimental medications as part of this study; it's about comparing surgical techniques. The total duration of your active participation, including follow-up, will be 12 months.
Potential risks and benefits
Locations (13)
- University of Pittsburgh Medical CenterVerified postcodePittsburgh, United States
- Gundersen Lutheran Medical CenterVerified postcodeLa Crosse, United States
- Universitaire Ziekenhuizen LeuvenVerified postcodeLeuven, Belgium
- Division of Cardiac Surgery, University of Ottawa Heart InstituteVerified postcodeOttawa, Canada
- University Health NetworkVerified postcodeToronto, Canada
- Jilin Heart HospitalVerified postcodeJilin City, China
- Leipzig Heart Institute GmbHVerified postcodeLeipzig, Germany
- Robert-Bosch-HospitalVerified postcodeStuttgart, Germany
- Apollo Hospital, BangaloreVerified postcodeBangalore, India
- Manipal HospitalsVerified postcodeNew Delhi, India
- Tokyo Bay Urayasu Ichikawa Medical CenterVerified postcodeUrayasu, Japan
- National University Hospital (NUH) - SingaporeVerified postcodeSingapore, Singapore
Common questions
What is the main purpose of this study?
To compare two types of heart bypass surgery (traditional vs. keyhole) to see which leads to a better recovery and quality of life.
What does 'randomly assigned' mean?
It means you will be chosen by chance, like a lottery, to receive either one type of surgery or the other for the study.
Will I get special medicine in this study?
No, this study is about comparing surgical methods, not new medicines. You will receive standard post-operative care.
How long will I be involved in the study?
You will be followed up for 12 months after your surgery, with questionnaires at specific times during that year.
Can I change my mind and leave the study?
Yes, you can leave the study at any time, and it won't affect your ongoing medical care.
How to find out more
Always speak to your GP or specialist before deciding to take part in a study.
Discussion
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