Coronary Artery Disease research hub

Coronary Computed Tomography Study to Assess the Effect of Inclisiran in Addition to Maximally Tolerated Statin Therapy on Atherosclerotic Plaque Progression in Participants With a Diagnosis of Non-obstructive Coronary Artery Disease Without Previous Cardiovascular Events

This study looks at whether a new medicine called inclisiran, taken with your usual statin, can help slow down or stop the build-up of fatty deposits (plaque) in the arteries around your heart. We're studying people with early heart disease who haven't had a heart attack or stroke.

Effect of the SCOT-HEART 2 Trial on Lifestyle.

This study looks at how information from heart scans or risk scores affects lifestyle choices like diet and exercise. It's part of a bigger study (SCOT-HEART 2) to prevent heart attacks. We want to find the best way to share scan results with patients.

ALPHA LONG Study- BioMatrix AlphaTM Stent Study in Patients With CAD

This study looks at new sizes of the BioMatrix Alpha™ stent for people with heart artery disease. It aims to see if these new sizes work as safely and effectively as the ones already approved, helping doctors treat more patients.

Liquid Biopsy System Intracoronary Blood Sampling and Analysis to Characterise Disease Biomarkers in Patients With Coronary Disease

This study aims to improve treatments for coronary artery disease. Researchers are testing a new device to collect blood samples from inside heart arteries. This will help them find disease markers and develop more personalised treatments.

High Frame Rate Ultrasound in Heart Disease Assessment

This study compares new high-speed heart scans with standard ones to see if they give doctors more information about heart disease. It involves people with known heart problems and those at low risk, using ultrasound and a special dye.

Equity in Modifying Plaque Of WomEn With UndeRtreated Calcified Coronary Artery Disease

This study is looking at how a new treatment for narrowed heart arteries, called coronary IVL, works in women. It aims to see how well it clears blockages caused by hardening of the arteries and if it helps them in the long term.

Troponin in Acute Chest Pain to Risk Stratify and Guide EffecTive Use of Computed Tomography Coronary Angiography

This study looks at people who had chest pain but weren't having a heart attack. We want to see if a special heart scan, called a CT scan, can help find hidden heart problems in these patients, especially if they have certain troponin levels.

Precise Procedural and PCI Plan (P4)

This study compares two ways to guide heart stent procedures: one using detailed CT scans beforehand, and another using tiny cameras inside the artery during the procedure. We want to see which method works best and is safest for treating blocked heart arteries.

Drug-Coated Balloon in Anticoagulated and Bleeding Risk Patients Undergoing PCI

This study compares two treatments for blocked heart arteries in people at high risk of bleeding: a special drug-coated balloon and a drug-eluting stent. It checks if the balloon, with a shorter medicine course, is as good as the stent, which needs longer medication.

Controlled Trial of High-risk Coronary Intervention With Percutaneous Left Ventricular Unloading

This study looks at a small heart pump used during a common heart procedure called a stent. It aims to see if this pump helps high-risk patients avoid serious complications and if it's good value for money.

Sirolimus-coated Balloon Versus Drug-eluting Stent in Native Coronary Vessels - TRANSFORM II

This study compares two treatments for blocked heart arteries: a special balloon (Magic Touch) and a tiny mesh tube called a stent. It aims to see which works better for people with heart artery disease.

Accelerated Stress CMR in Coronary Artery Disease

This study compares a new, faster MRI heart scan with the standard one for diagnosing heart artery disease. It aims to see if the quicker scan is as accurate as the usual method, using advanced X-rays as a benchmark.

SECURE Trial: Stress Echocardiography With Carotid Ultrasound vs Routine CT Coronary Angiography in Chronic Coronary Syndrome for Endpoints

The SECURE trial compares two ways of checking for heart problems: a CT scan or an ultrasound of the heart and neck arteries. It aims to find the best way to detect heart disease early and improve treatment, following participants for 5 years.

Low-dose Interleukin-2 After Myocardial Infarction to Investigate Effects on Tissue-resident Regulatory T Cells

This study looks at how a drug called Interleukin-2 might help your body repair heart tissue after a heart attack. We want to see how it affects special 'repair' cells in and around your heart, compared to those in your blood.

Product Surveillance Registry

This study keeps track of how well Medtronic medical devices, like those for heart problems or other conditions, work in real life. It aims to make sure these devices are safe and effective for patients.

Coronary Flow During Rapid Heart Rates

This study looks at how the heart's blood supply copes during very fast heartbeats, like those in Ventricular Tachycardia (VT). Researchers want to understand why some people tolerate VT better than others, especially if they have heart artery disease. The goal is to improve treatments and potentially reduce the need for devices like ICDs.

Leg Ischaemia Management Collaboration

This study looks at how many people with severe leg circulation problems need an amputation within a year. It compares care before and after a new special clinic was set up to help save limbs.

A Study to Evaluate the Safety and Pharmacokinetics of Regadenoson in Pediatric Patients

This study looks at a medicine called regadenoson in children, from babies to teenagers. It checks how safe it is and how it works in their bodies during a heart scan to help doctors understand heart conditions better.

Barts Sex-CAD Database - Sex Hormones and Inflammatory Status in Coronary Artery Disease

This study looks at how hormones and inflammation affect heart artery disease in men and women, especially for women after menopause. Researchers at Barts Heart Centre hope to find better ways to treat heart conditions by understanding these differences.

Objective Risk Assessment in Patients With Possible Anginal Chest Pain Using Leading Technology

This study looks at new ways to quickly check people with chest pain that might be angina (heart pain). It uses a mix of online forms, home heart checks, and quick blood tests to work out if someone is at low, medium, or high risk of heart problems.

PeRcutaneous cOronary Intervention of Native Coronary arTery Versus Venous Bypass Graft in Patients With Prior CABG

This study compares two ways to fix blocked heart arteries in people who have had bypass surgery. Researchers are looking at whether fixing the original artery or the bypass graft works better in the long run for patients with coronary artery disease.

Predicting the Risk of Non-culprit Coronary Artery Disease After a Heart Attack

The SELUTION DeNovo Study

This study compares two ways to treat blocked heart arteries: a special balloon (SELUTION SLR) with optional supportive stents, versus standard stents. It aims to see which method is better at keeping arteries open and healthy long-term.

Correlation of FFR CT With Invasive FFR in Multi-ethnic Cohort- a Retrospective Study

This study looks at how well a non-invasive heart scan (FFR CT) compares to a more invasive test (FFR) for coronary artery disease. We're using existing patient data to see if the scan can help reduce the need for invasive procedures and improve care.

Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function

This study looks at using a small heart pump called Impella during a common heart procedure (PCI) for people with serious heart disease and weak heart muscles. It compares this approach to standard care to see if Impella improves recovery and long-term health.

Modification of Coronary Calcium With Laser Based Intravascular Lithotripsy for Coronary Artery Disease (FRACTURE)

This study looks at a new way to treat hardened arteries in the heart. It uses special sound waves to gently break up calcium buildup, making it easier for doctors to open the artery and improve blood flow. The aim is to see how well this treatment works.

iCorMicA - Stratified Medicine in Angina

This study looks at how best to treat chest pain (angina) when blockages aren't found in the main heart arteries. It tests if personalised treatment, guided by special heart tests, improves symptoms and health for people with this condition.

Artificial Intelligence Stress Echo (FINESSE) Project

The FINESSE project uses existing heart scan results and health records from Milton Keynes University Hospital to predict heart problems better. It aims to see if combining these records with smart computer programs can more accurately spot who might get a heart attack, stroke, or need heart surgery.

Coronary Microvascular Angina Cardiac Magnetic Resonance Imaging (CorCMR) Trial

This study investigates better ways to diagnose and treat chest pain in people whose heart arteries don't show major blockages. It uses a special MRI scan to understand if tiny blood vessel problems are causing the pain and tests if knowing this helps improve treatment.

CMR Versus CT in Coronary Artery Disease

This study compares different scans (MRI and CT) to see which is best at finding heart problems in people with chest pain. It uses a special heart test as a standard to check how accurate the scans are.

Development of Novel Physiological CMR Methods in Health and Disease

This study uses special MRI scans to understand how the heart works in healthy people and those with heart conditions. It looks at how the heart responds to small challenges, like a fluid boost, to find better ways to spot and treat heart problems.

MiECC Versus Conventional Cardiopulmonary Bypass in Cardiac Surgery (MiECS)

This study compares two types of heart-lung machines used in heart surgery: the standard one and a newer, smaller version. It aims to see if the smaller machine leads to fewer serious problems after surgery for conditions like coronary artery disease and aortic valve issues.

iFR Guided Coronary Artery Bypass Grafting Surgery

This study looks at a new way to help guide heart bypass surgery. It compares whether using special measurements inside the heart's arteries (called iFR) leads to better long-term results for the bypass grafts compared to just looking at X-ray pictures.

The PIONEER-IV Study is Comparing Clinical Outcomes Between Angiography-derived Physiology Guidance to Usual Care in an All-comers PCI Population With Unrestrictive Use of the HT Supreme Sirolimus-eluting Stent

This study compares different ways to guide heart stent procedures for people with heart disease. It looks at using advanced imaging compared to standard care, aiming to find the best approach for better patient outcomes.

Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women

This study looks at two types of heart bypass surgery for women: using one or multiple healthy arteries. Researchers want to see if using more arteries leads to better long-term health, quality of life, and fewer future heart problems for women.

Physiology-guided vs Angiography-guided Non-culprit Lesion Complete Revascularization for Acute MI & Multivessel Disease

This study compares two ways of treating extra narrowed arteries after a heart attack. It looks at whether using special measurements or just X-ray pictures to guide treatment leads to better outcomes, like preventing future heart attacks or death.

Telehealth Interventions for Cardiac Surgery

This study looks at whether checking on heart surgery patients from home, using technology like apps and devices (telehealth), can improve their well-being before their operation and help prevent serious health issues that might lead to a hospital visit.

Decision Support Tool for Revascularisation Options in Coronary Artery Disease

This study aims to create a helpful online tool for people with heart disease. It will help them understand treatments like stents or bypass surgery, so they can choose the best option with their doctor, making sure their personal preferences are included in the decision.

Residual Inflammation and Plaque Progression Long-term Evaluation

This study looks at how inflammation in blood vessels after a heart attack might lead to future problems. We use special scans to see inflammation and track changes in blood vessels over time. The goal is to understand how to better prevent future heart issues.

ULTRA LONG: BioFreedom Ultra

This study is looking at a new type of heart stent, called BioFreedom Ultra, for people with heart artery disease who are at a high risk of bleeding. It aims to check if new, larger sizes of this stent are as safe and effective as the sizes already approved.

A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Understanding and Management of Coronary Calcium (The Optimal Trial)

This study compares two ways to plan heart artery procedures for people with hardened arteries. It uses advanced CT scans versus a standard internal ultrasound to see which method helps doctors work better and get similar good results for patients.

Antibiotic Treatment Trial in Acute Coronary Syndrome

This study is looking at whether common antibiotics could help people who have had a heart attack. It will check if these medicines can reduce serious heart and brain problems over time. Both men and women over 18 can take part.

Changes in plaque characteristics after short-term statin therapy assessed with coronary CT

This study looks at how a short course of statin medication affects the fatty build-up (plaque) in heart arteries. Researchers use special CT scans to measure these changes, aiming to improve heart health understanding.

(22597) A study to learn about how safe nitroglycerin is and how it affects the body when taken along with nurandociguat in people with coronary artery disease.

This study is looking at how a new drug, nurandociguat, works with a common heart medicine, nitroglycerin, in people with heart artery disease. The main goal is to check if this combination is safe and how it affects the body.

An International, Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase III Trial on the Effects of EA-230 on the Length of Hospital Stay Following On-Pump Coronary Artery Bypass Grafting Surgery

This study is testing a new medicine, EA-230, to see if it helps people recover faster after heart bypass surgery. Doctors want to know if it can shorten the time people need to stay in hospital after their operation.

Colchicine Assessment of Low-grade Inflammation and Biomarker Response in Atherosclerosis with Targeted Evaluation

This study is looking at whether a common medicine called colchicine can reduce inflammation in the blood vessels of people with heart disease. We want to see if it helps improve heart health by using special scans to check for changes.

Coronary Artery Stents in Heart Failure With Preserved Ejection Fraction

This study looks at whether fitting tiny tubes called stents into narrowed heart arteries can improve the quality of life for people with a common heart problem called HFpEF. Researchers want to see if this procedure helps them feel better.

Distal Evaluation of Functional Performance with Intravascular Sensors to Assess the Narrowing Effect: Guided Physiologic Stenting

This study compares different ways to guide treatments for blocked heart arteries. It looks at whether using special wires that measure blood flow inside the heart's arteries helps doctors place stents better than traditional X-ray pictures. It aims to improve how we treat heart disease.