Coronary artery disease research hub
50 indexed studies · 27 currently recruiting
- completed
A feasibility study of using a novel lifestyle change programme (Super Rehab) to reverse coronary artery disease
This UK study looks at whether an intensive lifestyle programme called 'Super Rehab' can help reverse heart disease. Researchers want to see if combining personal exercise training and healthy eating advice can clear furred-up arteries in adults who also have metabolic issues like high blood pressure or raised blood sugar.
United Kingdom · England - authorisedTherapeutic confirmatory (Phase III)
An International, Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase III Trial on the Effects of EA-230 on the Length of Hospital Stay Following On-Pump Coronary Artery Bypass Grafting Surgery
This study is testing a new medicine, EA-230, to see if it helps people recover faster after heart bypass surgery. Doctors want to know if it can shorten the time people need to stay in hospital after their operation.
Belgium · Netherlands - recruiting
Product Surveillance Registry
This study keeps track of how well Medtronic medical devices, like those for heart problems or other conditions, work in real life. It aims to make sure these devices are safe and effective for patients.
United States · Argentina · Australia - active not recruitingNA
Physiology-guided vs Angiography-guided Non-culprit Lesion Complete Revascularization for Acute MI & Multivessel Disease
This study compares two ways of treating extra narrowed arteries after a heart attack. It looks at whether using special measurements or just X-ray pictures to guide treatment leads to better outcomes, like preventing future heart attacks or death.
United States · Australia · Austria - completed
The extent of intimal hyperplasia and atherogenesis in bypass vein grafts following different surgical preparation techniques
During heart bypass surgery, doctors often use a vein taken from your leg. Over time, these veins can become blocked. This study compares four gentle ways surgeons prepare leg veins during surgery. The goal is to see if changing these techniques helps bypass grafts stay open and healthy for longer.
United Kingdom · England - recruitingPHASE2
Dose-finding Study of YMI024 to Assess Efficacy, Safety, and Tolerability in Adults With Stable Coronary Artery Disease and Elevated hsCRP
This study is testing a new medication, YMI024, for people with stable heart artery disease. It aims to see if the medicine can reduce inflammation and if different doses are safe and effective.
United States · Australia · Germany - active not recruitingNA
Modification of Coronary Calcium With Laser Based Intravascular Lithotripsy for Coronary Artery Disease (FRACTURE)
This study looks at a new way to treat hardened arteries in the heart. It uses special sound waves to gently break up calcium buildup, making it easier for doctors to open the artery and improve blood flow. The aim is to see how well this treatment works.
United States · Belgium · Denmark - active not recruiting
Residual Inflammation and Plaque Progression Long-term Evaluation
This study looks at how inflammation in blood vessels after a heart attack might lead to future problems. We use special scans to see inflammation and track changes in blood vessels over time. The goal is to understand how to better prevent future heart issues.
United Kingdom - active not recruitingNA
An Evaluation of the Talk Test for Exercise Prescription for Home-Based Cardiac Rehabilitation
This study looks at a simple \"talk test\" to guide exercise for people with heart disease recovering at home. It compares it to a more complex test to see if it's safe and effective for helping people exercise after heart surgery or procedures.
Canada - active not recruiting
BIOFLOW-VIII All-comers Orsiro Mission Safety and Performance Registry
This study is looking at how a special type of heart stent, called Orsiro Mission, works in everyday treatment for people with heart artery problems. It will check its safety and how well it performs over time in many different patients across France.
France - recruiting
Correlation of FFR and iFR With Cardiac PET Perfusion in Patients With Severe Aortic Valve Stenosis
This study looks at how well two common heart tests, FFR and iFR, work in people with a severe heart valve problem called aortic stenosis. It compares their results to another type of heart scan (PET) to see if these tests accurately show blockages in the heart's arteries.
Germany - recruiting
Essen Coronary Artery Disease Registry
This study, called ECAD, is looking at people in Germany who have a common heart condition called coronary artery disease. It aims to understand what factors lead to different health outcomes after they have a special heart test called a coronary angiogram.
Germany - recruiting
Post-Operative Myocardial Incident & Atrial Fibrillation
This study looks at why some people have heart problems like a heart attack or an irregular heartbeat after heart surgery. Researchers are keen to understand what part of your blood, fat, or heart health might lead to these issues.
France - recruitingNA
Optimal Strategy to Correct Stent underexpAnsion in Resistant Lesions
This study looks at new ways to treat narrowed heart arteries, especially when previous treatments haven't fully opened them. It compares a new method called intravascular lithotripsy (IVL) with standard balloon treatments to see which works best and is safest for patients.
France - recruitingNA
FANTOM Post Market Clinical Trial
This study is looking at a new type of dissolvable support (called Fantom) for blocked heart arteries in people with coronary artery disease. It's a follow-up study to see how well it works and if it's safe after it's been used in patients for a while.
Austria · Germany · Switzerland - recruiting
iFR Guided Coronary Artery Bypass Grafting Surgery
This study looks at a new way to help guide heart bypass surgery. It compares whether using special measurements inside the heart's arteries (called iFR) leads to better long-term results for the bypass grafts compared to just looking at X-ray pictures.
United Kingdom - recruitingPHASE2
Coronary Artery Stents in Heart Failure With Preserved Ejection Fraction
This study looks at whether fitting tiny tubes called stents into narrowed heart arteries can improve the quality of life for people with a common heart problem called HFpEF. Researchers want to see if this procedure helps them feel better.
United Kingdom - recruiting
MAIN-IMAGE Registry
This study looks at heart scans from people with heart artery disease. We want to see if specific details in these scans can predict future heart problems like heart attacks or if the disease gets worse. It helps us understand heart disease better.
Germany - recruiting
Evaluation of the Benefit of Exercise Testing for the Diagnosis of Obstruction in the Coronary Arteries of the Heart
This study looks at whether a special exercise test can spot blocked heart arteries. We want to see if this test can tell us if you have heart problems without always needing more invasive scans, aiming to make diagnosis simpler.
France - recruiting
Correlation of FFR CT With Invasive FFR in Multi-ethnic Cohort- a Retrospective Study
This study looks at how well a non-invasive heart scan (FFR CT) compares to a more invasive test (FFR) for coronary artery disease. We're using existing patient data to see if the scan can help reduce the need for invasive procedures and improve care.
United Kingdom - active not recruitingNA
Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function
This study looks at using a small heart pump called Impella during a common heart procedure (PCI) for people with serious heart disease and weak heart muscles. It compares this approach to standard care to see if Impella improves recovery and long-term health.
United States · Canada · Germany - active not recruitingNA
The SELUTION DeNovo Study
This study compares two ways to treat blocked heart arteries: a special balloon (SELUTION SLR) with optional supportive stents, versus standard stents. It aims to see which method is better at keeping arteries open and healthy long-term.
Austria · Czechia · Finland - recruitingNA
Development of Novel Physiological CMR Methods in Health and Disease
This study uses special MRI scans to understand how the heart works in healthy people and those with heart conditions. It looks at how the heart responds to small challenges, like a fluid boost, to find better ways to spot and treat heart problems.
United Kingdom - recruitingNA
Time Restricted Eating and Cardiac Rehabilitation
This study looks at a special eating plan called time-restricted eating (TRE) alongside standard heart rehabilitation. We want to see if TRE is safe and helps people with heart conditions get even better results from their rehabilitation.
Canada - recruitingNA
Implementing Individualized Patient Reported Outcome Measures in Routine Care of Patients With Coronary Artery Disease
This study looks at a new online survey system for heart patients in the UK. It checks if patients and doctors find it easy to use and helpful for discussing heart health. The goal is to improve how patients and doctors talk about and manage coronary artery disease.
Canada - active not recruitingPHASE3
Coronary Computed Tomography Study to Assess the Effect of Inclisiran in Addition to Maximally Tolerated Statin Therapy on Atherosclerotic Plaque Progression in Participants With a Diagnosis of Non-obstructive Coronary Artery Disease Without Previous Cardiovascular Events
This study looks at whether a new medicine called inclisiran, taken with your usual statin, can help slow down or stop the build-up of fatty deposits (plaque) in the arteries around your heart. We're studying people with early heart disease who haven't had a heart attack or stroke.
United States · Argentina · Australia - recruitingNA
Drug-Coated Balloon in Anticoagulated and Bleeding Risk Patients Undergoing PCI
This study compares two treatments for blocked heart arteries in people at high risk of bleeding: a special drug-coated balloon and a drug-eluting stent. It checks if the balloon, with a shorter medicine course, is as good as the stent, which needs longer medication.
Finland · France · Germany - recruitingNA
Feasibility and Pilot Testing of "My Heart and CKD" Online Shared Decision Aid
This study is testing a new online tool called 'My Heart and CKD'. It helps people with kidney and heart disease, and their doctors, make important decisions about heart treatments. It aims to make sure choices match what's best for each person.
Canada - active not recruiting
Multimodal Epicardial and Endocardial COronary PHYsiological Evaluation in Pathological Situations (PHYCO)
This study looks at how we check for heart problems when arteries are partly blocked. We use a method called FFR, but it might not always show the full picture. This research aims to improve how we diagnose and treat these blockages, making treatments more personal for each patient.
France - active not recruiting
PRE-DETERMINE Cohort Study
This study looks at people with heart artery disease and some heart muscle weakness. It aims to find new ways, like blood tests and ECGs, to predict who might be at risk of a sudden heart problem (sudden cardiac death) and how to prevent it.
United States · Canada · Puerto Rico - recruiting
CMR Versus CT in Coronary Artery Disease
This study compares different scans (MRI and CT) to see which is best at finding heart problems in people with chest pain. It uses a special heart test as a standard to check how accurate the scans are.
United Kingdom - active not recruitingNA
Physiology as Guidance to Evaluate the Direct Impact of Coronary Lesion Treatment: The PREDICT Study
This study looks at whether using special measurements of blood flow during heart procedures helps patients more than just looking at X-ray pictures. It aims to see if this leads to fewer problems and less chest pain after treatment for blocked heart arteries.
Canada - recruiting
Mainz Intracoronary Database. The Coronary Slow-flow and Microvascular Diseases Registry
This study looks at people having heart scans in Mainz, Germany. It gathers information about their heart health, especially conditions like coronary artery disease and microvascular dysfunction, to help doctors understand these problems better.
Germany - recruitingNA
Randomization of Single vs Multiple Arterial Grafts
This study compares using one main artery graft to two or more in heart bypass surgery. It aims to see if using more grafts improves survival, reduces heart attacks, strokes, or the need for more procedures for people with coronary artery disease.
United States · Austria · Brazil - active not recruitingNA
The Minimally Invasive Coronary Surgery Compared to STernotomy Coronary Artery Bypass Grafting Trial
This study compares two types of heart bypass surgery for blocked arteries: keyhole surgery (MICS CABG) and traditional open-chest surgery (sternotomy CABG). It aims to see which one helps patients recover faster and have a better quality of life afterwards.
United States · Belgium · Canada - active not recruitingNA
COMBINE-INTERVENE: COMBINEd Ischemia and Vulnerable Plaque Percutaneous INTERVENtion to Reduce Cardiovascular Events
This study looks at a new way to treat blocked heart arteries. It compares two methods for deciding where to place stents: one using blood flow measurements, and another adding detailed artery scans. The aim is to see if combining these methods leads to better heart health.
Australia · Canada · Denmark - active not recruitingNA
The TEACH (Texting After ACS Discharge) Pilot Randomized Trial
This study looks at whether sending text messages can help people who have recently had a heart attack. It aims to see if texting can support their recovery, encourage them to take their medicines, and reduce how often they need to go back to hospital.
Canada - active not recruitingNA
Feasibility of High-Intensity Interval Nordic Walking in Patients With Coronary Artery Disease
This study looks at a new type of exercise called "High-Intensity Interval Nordic Walking" (HIIT-NoW) for people with heart artery disease. It compares it to standard exercise to see if it helps improve physical and mental health after heart procedures like bypass surgery or stents.
Canada - not yet recruiting
Clinical Information System Impact on Hospitalized Patients With Chronic Disease
This study looks at how a new computer system in hospitals, called Connect Care, affects patients with ongoing health problems like diabetes or heart disease. Researchers are checking if the system helps reduce hospital readmissions or deaths within 30 days of leaving the hospital.
Canada - active not recruitingNA
Functional Assessment by Virtual Online Reconstruction. The FAVOR III Europe Trial
This study compares a new, simpler way to check heart artery blockages (QFR) against the usual method (FFR). We want to see if QFR is just as good at guiding treatment for chest pain, aiming to improve patient care.
Denmark · France · Germany - recruiting
Resorbable Magnesium Scaffolds Registry
This study looks at how new heart devices called Resorbable Magnesium Scaffolds (Magmaris, Freesolve) work in people with coronary artery disease. It checks their safety and how well they perform in everyday situations, following standard medical guidelines.
Australia · Germany · Italy - recruitingNA
IVUS Guided PCI in Patients With Chronic Kidney Disease
This study looks at a new way to treat heart blockages in people with serious kidney problems. Instead of using a special dye that can harm kidneys, doctors will use sound waves to guide the treatment, hoping to make it safer and avoid further kidney damage.
France - active not recruitingPHASE3
Ischemic and Bleeding Outcomes After Angiolite Stent Implantation and an Abbreviated Dual Antiplatelet Therapy
This study looks at new ways to treat coronary artery disease. It compares two types of stents (Angiolite and Xience) and two different durations of anti-clotting medication (1 month vs. 12 months) to see which is safest and most effective for patients.
Belgium · France · Spain - recruiting
Clinical Study for the Investigation and Validation of a Therapy Procedure for the Adjustment of Risk Factors in Patients With Coronary Heart Disease by Means of Digital Therapy Control
This study is testing a new digital health app called iATROS. It aims to help people with heart disease manage their health better by tracking risk factors on their smartphone. We want to see if it works as well as, or better than, standard care.
Germany - recruitingNA
iCorMicA - Stratified Medicine in Angina
This study looks at how best to treat chest pain (angina) when blockages aren't found in the main heart arteries. It tests if personalised treatment, guided by special heart tests, improves symptoms and health for people with this condition.
Ireland · Netherlands · Poland - active not recruitingNA
Effect of the SCOT-HEART 2 Trial on Lifestyle.
This study looks at how information from heart scans or risk scores affects lifestyle choices like diet and exercise. It's part of a bigger study (SCOT-HEART 2) to prevent heart attacks. We want to find the best way to share scan results with patients.
United Kingdom - active not recruiting
Artificial Intelligence Stress Echo (FINESSE) Project
The FINESSE project uses existing heart scan results and health records from Milton Keynes University Hospital to predict heart problems better. It aims to see if combining these records with smart computer programs can more accurately spot who might get a heart attack, stroke, or need heart surgery.
United Kingdom - active not recruiting
Equity in Modifying Plaque Of WomEn With UndeRtreated Calcified Coronary Artery Disease
This study is looking at how a new treatment for narrowed heart arteries, called coronary IVL, works in women. It aims to see how well it clears blockages caused by hardening of the arteries and if it helps them in the long term.
United States · France · Germany - enrolling by invitationNA
Distal Evaluation of Functional Performance with Intravascular Sensors to Assess the Narrowing Effect: Guided Physiologic Stenting
This study compares different ways to guide treatments for blocked heart arteries. It looks at whether using special wires that measure blood flow inside the heart's arteries helps doctors place stents better than traditional X-ray pictures. It aims to improve how we treat heart disease.
United States · Australia · Austria - recruiting
Barts Sex-CAD Database - Sex Hormones and Inflammatory Status in Coronary Artery Disease
This study looks at how hormones and inflammation affect heart artery disease in men and women, especially for women after menopause. Researchers at Barts Heart Centre hope to find better ways to treat heart conditions by understanding these differences.
United Kingdom