Functional Assessment by Virtual Online Reconstruction. The FAVOR III Europe Trial

This study is looking for adults aged 18 or older, both men and women, who are scheduled to have a heart angiogram. You might be suitable if you experience stable chest pain (angina) or if you're having a check-up for other blockages after a mild heart attack. You'll need to be able to understand the study and agree to take part in writing. Your heart arteries should have a narrowing between 40% and 90% and be at least 2.5 mm wide, and it's okay if you've had a narrowing return in a natural artery.

You cannot take part if you have very severe kidney problems, a life expectancy of less than a year, or are very unwell due to heart issues. Also, you're not eligible if you've had a certain type of heart attack very recently, have bypass grafts that are being studied, or certain heart rhythm problems. If you are pregnant, breastfeeding, planning to become pregnant, or have other specific heart conditions like very poor heart pumping ability, this study won't be right for you. It's also not suitable if you're allergic to the dye used in angiograms or can't take certain medications.

If you join the study, you'll still have your planned heart angiogram as usual. During this procedure, depending on which group you're in, your doctor will use either the standard FFR method (with the pressure wire) or the new QFR method (which uses the angiogram images) to assess your heart blockages. The treatment decisions for your narrowed arteries will then be guided by the results of that specific diagnostic method.

You will have follow-up evaluations to check on your health and any heart-related events over the course of one year. This will involve appointments where doctors will ask about your well-being and might do some routine checks. The total duration of your active participation in the study, including all follow-ups, will be 12 months.