Active not recruitingOBSERVATIONAL

Accelerated Stress CMR in Coronary Artery Disease

This research is looking into a new, faster way of performing a special heart scan called a stress Cardiovascular Magnetic Resonance (CMR), sometimes known as an MRI scan of the heart. The aim is to see if this quicker scan is just as good at finding blockages in the heart's arteries as the standard, longer version. We're comparing both types of scans against a very accurate X-ray procedure that checks blood flow in the heart arteries. The study also wants to find out if the faster scan is more comfortable for patients and how long each scan takes. If successful, this could mean patients get accurate diagnoses more quickly and with less discomfort.

At a glance

Status

Active not recruiting

Sponsor

University of Leicester

Enrolment target

167

Start

01 Jul 2021

Estimated completion

30 Nov 2025

Coronary Artery Disease

What is this study about?

This study is investigating a new, quicker way to perform a heart scan called a Cardiovascular Magnetic Resonance (CMR). This type of scan uses strong magnets and radio waves to create detailed pictures of your heart and blood vessels. In this research, we're particularly interested in how well this faster scan, which we call an 'accelerated' stress CMR, can detect coronary artery disease. This is a condition where the blood vessels supplying your heart become narrowed or blocked, which can lead to chest pain (angina).

The main goal is to find out if this accelerated scan is as accurate as the standard, longer CMR scan. To do this, we'll compare both types of scans in patients who are already scheduled for another procedure called an invasive coronary angiography. This angiography is a very precise X-ray test that uses a thin tube inserted into an artery to look directly at the heart's blood flow, and it will be our benchmark for accuracy. We'll also be looking at how comfortable patients find each scanning method and how long they actually take.

Ultimately, if the accelerated scan proves to be both accurate and more comfortable, it could become a valuable tool for doctors. It might mean patients can get a clear diagnosis of coronary artery disease faster and with a more comfortable experience, helping them get the right treatment sooner. This research is about improving how we diagnose heart conditions for everyone.

Key takeaways

Compares a new, faster heart MRI scan with the standard version.
Aims to see if the quicker scan is as accurate for diagnosing artery disease.
Patients will undergo two types of heart MRI scans before a planned X-ray procedure.
Looks at patient comfort and scan duration for both methods.
Could lead to faster, more comfortable heart disease diagnosis.

Who may be eligible?

This study is looking for adults aged 18 or over who are being considered for an imaging procedure called an invasive coronary angiography because they're experiencing chest pain that might be related to their heart. You'll need to be happy and able to give your full agreement to take part, and be able to understand the study's information written in English. You also need to be willing to allow your GP and other consultants to be informed about your participation.

There are certain reasons why someone might not be able to join. For example, if you've recently had a heart attack (in the last six months), or if you have severe claustrophobia (a fear of enclosed spaces) which would make an MRI scan difficult. Also, if you have certain heart rhythm problems, severe lung conditions like COPD or asthma, or serious kidney issues, you wouldn't be able to take part. Women who are pregnant, breastfeeding, or could become pregnant are also excluded. Lastly, if you have any medical devices that aren't compatible with an MRI, or if you can't have certain contrast dyes, you wouldn't be eligible.

Quick self-check

Are you 18 years old or older?
Are you having an invasive coronary angiography for chest pain?
Can you understand written English?
Have you had a heart attack in the last 6 months (if yes, you may not be eligible)?
Do you have severe claustrophobia (if yes, you may not be eligible)?
Are you pregnant or breastfeeding (if yes, you may not be eligible)?

This is a guide only — the research team will confirm whether you can take part.

What does participation involve?

If you decide to take part, you'll undergo two types of heart MRI scans: the new, faster one and the standard one, all before your planned invasive coronary angiography. The order of these scans will be decided randomly, like flipping a coin. Afterwards, you'll complete a short questionnaire about your comfort, any symptoms you experienced, and how long you felt the scans took. The total duration of your involvement will depend on when your planned angiography is scheduled, as all study-related scans happen before this procedure. There's no specific medication prescribed as part of this study, as it focuses on scans and patient experience.

Potential risks and benefits

Participating in this study might offer some potential benefits, such as contributing to medical knowledge that could improve heart diagnostics for future patients. You will also receive advanced heart scans. Potential risks are generally low for MRI scans but include discomfort from lying still in an enclosed space, and, for some, possible mild reactions to the contrast dye used. You have the right to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Glenfield Hospital
Leicester, United Kingdom

Common questions

What is a stress CMR?

A stress CMR is a special MRI scan of your heart which is done while your heart is gently stressed, usually medicine, to see how your heart muscle and blood flow respond.

Is an MRI scan safe?

Yes, MRI scans are generally very safe. They use magnets and radio waves, not X-rays, and are harmless for most people. Your medical team will check for anything that might make it unsafe for you.

Will I feel anything during the scan?

You might feel a warming sensation or hear loud tapping noises during the scan, which is normal. You may also feel a flushing sensation or mild chest discomfort from the stress medication, which is temporary.

What is contrast dye?

Contrast dye is a special liquid given through a vein during the scan to help certain parts of your body show up more clearly in the images. It's usually well-tolerated.

How long will the scans take?

The study aims to compare the length of the new accelerated scan with the standard scan. We'll be asking you about your perceived scan duration as part of the study.