Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)

To join this study, you need to be an adult (18 or older) with Type 2 Diabetes. Your current diabetes treatment should include metformin (at least 1500mg daily), and you might also be taking another medicine called an SGLT2 inhibitor. Crucially, your blood sugar levels (measured by a test called HbA1c) should be between 7.0% and 10.5%, meaning your diabetes isn't fully controlled by your current medicines. You also need to have a Body Mass Index (BMI) of 25 or higher and your weight should have been stable for at least three months.

However, there are reasons why you might not be able to join. For example, if you have Type 1 Diabetes, or if you've had severe low blood sugar or certain serious diabetes problems in the last six months. Other reasons include having severe kidney or heart problems, a history of certain cancers, or if you've had surgery for weight loss. Also, if you've recently taken medicines to lose weight, you might not be able to participate. The study team will carefully check all these details with you.

If you join this study, it will involve regular visits to the clinic over roughly two years, which is about 26 months. You might have up to 24 appointments in total. During these visits, doctors and nurses will check your health, take blood samples, and ask about your general well-being. You would be given one of the two study medicines, either retatrutide or semaglutide, to help manage your blood sugar. The medical team will closely monitor you to see how the medicine is working and if you have any side effects. You are free to withdraw from the study at any time, for any reason, without it affecting your medical care.