Diabetic Polyneuropathy research hub

Driving with Neuropathy

This study looks at how training with visual feedback can help drivers with diabetes and nerve damage (neuropathy) to use their accelerator pedal safely. It aims to see if this training can reduce how much they press the pedal, making driving safer.

A Study Looking to Improve Sleep and Reduce Sedentary Behaviour in Those Living With Type 2 Diabetes Mellitus

This study aims to help people with Type 2 diabetes who struggle with sleep and are not very active. It explores how a special talking therapy and advice on being more active can improve sleep and overall health in this group.

Prevalence and Determinants of Subclinical Cardiovascular Dysfunction in Adults With Type 2 Diabetes Mellitus

This study looks at how heart problems start in people with type 2 diabetes. We want to understand what causes these problems early on, before they cause symptoms. This could help us find new ways to treat or prevent heart disease in the future.

EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease

This study looks at a new medicine, vicadrostat, for people with type 2 diabetes, high blood pressure, and heart disease. It aims to see if taking vicadrostat alongside empagliflozin can help reduce heart problems. Half the participants will get the study medicine, and half will get a dummy pill.

A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes

This study investigates how a medicine called semaglutide affects eye problems in people with type 2 diabetes over five years. Participants will get either semaglutide or a dummy medicine, injected once a week, along with their usual diabetes treatments.

The Poor Responders Study

This study aims to understand why some people don't lose as much weight as expected after weight-loss surgery, despite having the same operation. Researchers want to identify factors that predict who will lose the most weight and who might struggle, before the surgery takes place.

A Randomised, Controlled Trial of a Low-energy Diet for Improving Functional Status in Heart Failure With PRESERVED Ejection Fraction Preserved Ejection Fraction

This study looks at how a special low-calorie diet might help people with a type of heart failure where the heart struggles to relax properly. It aims to see if diet can improve heart function, symptoms, and exercise ability.

Identification of New Biomarkers of Insulin Resistance

This study looks for new ways to spot insulin resistance early, a step before type 2 diabetes. We'll check how a special protein called Rab3 changes with diet and exercise, and also look at gut health. This helps us understand and prevent type 2 diabetes.

A Research Study to Investigate the Effects of CagriSema Compared to Placebo in People With Type 2 Diabetes and Painful Diabetic Peripheral Neuropathy

This study looks at a new medicine called CagriSema for people with type 2 diabetes and pain from nerve damage. It compares CagriSema to a dummy medicine to see if it helps reduce pain and manage diabetes.

Heart Failure in Patients With Diabetes: Cells, Crosstalk and Consequences

This study looks at how diabetes and heart failure affect each other, focusing on body cells and communication between different tissues like fat and muscle. We'll compare people with and without these conditions to better understand their causes.

Digoxin and Senolysis in Heart Failure and Diabetes Mellitus

This study looks at how a common heart medicine, Digoxin, might help people with both heart failure and type 2 diabetes. We are exploring if Digoxin can improve how fat tissue works in these patients by clearing out certain old, 'tired' cells.

A Study of Cardiovascular Events iN Diabetes Plus

This study is for people with type 2 diabetes who haven't had a heart attack or stroke. It checks if a tablet called semaglutide can safely lower risks of heart problems, strokes, and death from heart issues over about 5 years, all done from home.

CGM Use in Adults With Type 2 Diabetes on Basal Insulin

This study looks at how a continuous glucose monitor (FreeStyle Libre 3) compares to regular finger-prick tests for managing type 2 diabetes. It aims to see if the monitor helps adults with type 2 diabetes better control their blood sugar over 16 weeks.

A UK Registry for Metabolic and Bariatric Endoscopic Interventions

This UK study is collecting information on new, less invasive procedures using a camera on a thin tube (endoscope) to help people with obesity and type 2 diabetes lose weight. It aims to see how safe and effective these treatments are in real-life settings.

A Study to Follow Paediatric Participants With Growth Hormone Deficiency Treated With Somapacitan for Long Term Safety Information and Clinical Parameters

Who Will Benefit From Bariatric Surgery for Diabetes?

This study looks at why some people with type 2 diabetes benefit from weight-loss surgery (Roux-en-Y gastric bypass) more than others. Researchers want to understand if things like body fat, genes, and gut hormones play a role in putting type 2 diabetes into remission after surgery.

NT-proBNP Selected Prevention of Cardiac Events in Diabetic Patients

This study looks at how high doses of certain heart medicines (RAS-antagonists and beta-blockers) might help prevent heart problems in people with Type 2 diabetes who haven't had heart disease before. It also checks a blood marker called NT-proBNP.

NT-proBNP Selected PreventiOn of cardiac eveNts in a populaTion of dIabetic patients without A history of Cardiac disease; a prospective randomized trial

This study looks at how certain blood pressure and heart medications might help people with type 2 diabetes, who haven't had heart problems before, to avoid future heart issues. It focuses on a specific blood marker (NT-proBNP) to guide treatment.

A study to test how insulin NNC0471-0119 works in the body in participants with type 2 diabetes when given by an insulin pump.

This study is looking at a new type of insulin, called NNC0471-0119, for people with type 2 diabetes. Researchers want to understand how it works in the body when given through an insulin pump. It's an early-stage study to gather basic information about the new insulin.

Rebalancing the Fat Content of the Heart and Muscles

This study looks at a new diabetes medicine called Semaglutide, combined with diet or exercise. We want to see how it affects the amount of fat in the heart and leg muscles of people with type 2 diabetes. It's about finding better ways to manage diabetes beyond just blood sugar.

Chronotype of Patients With Diabetes and Effect on Glycaemic Control

This study looks at how your natural sleep patterns, called chronotype, are linked to managing diabetes and your overall heart health. We want to understand how different sleep timings affect blood sugar levels and other health factors in people with type 1 and type 2 diabetes.

A research study of a new medicine (NNC0650-0013) in healthy men