Assessing Durvalumab and FLOT Chemotherapy in Resectable Gastric and Gastroesophageal Junction Cancer

To join this study, you would need to have stomach or food pipe cancer that doctors believe can be fully removed with an operation. This would be confirmed by special tests and a sample of your tumour. You shouldn't have started any other cancer treatment for your current cancer yet.

You would need to be well enough to take part, meaning you can carry out most of your daily activities without too much difficulty. Your body's organs, like your kidneys and liver, would also need to be working properly. The medical team would take a look at your general health to make sure it's safe for you to join.

There are also some reasons why you might not be able to join. For example, if your cancer has spread widely to other parts of your body, or if you have certain other types of cancer. You also couldn't take part if you've recently used medicines that suppress your immune system, or if any of the study drugs would be unsafe for you due to other health conditions. Having had an organ transplant in the past would also prevent you from joining.

If you decide to join this study, you would receive treatment both before and after your cancer surgery. This involves getting injections of either durvalumab or a placebo, combined with FLOT chemotherapy, in cycles. You will have regular visits to the clinic for these treatments, as well as for various tests like blood tests, scans, and physical exams to monitor your health and how the treatment is working.

After your surgery, you will continue with follow-up appointments and may receive more study treatment. The total duration of active treatment and close monitoring will depend on your individual response and how long you remain on the study, but participation could last for several months to a couple of years. Even after your treatment ends, there will be a follow-up period to check on your long-term health.