A Study to Test the Safety and Effectiveness of GSK5764227, Alone or With Other Treatments, in Participants With Advanced Gastrointestinal Cancers That Cannot be Surgically Removed

To join this study, you need to be at least 18 years old and have advanced bowel (colorectal) or pancreatic cancer that cannot be removed by surgery. If you have bowel cancer, you must have tried one or two previous treatments that weren't successful. If you have pancreatic cancer, you must have tried one previous treatment that didn't work. The doctors will also need a sample of your cancer tissue, either from a recent biopsy or an older sample.

Your general health will be assessed to ensure you are well enough to take part, including having active cancer that can be measured. You should also be willing to use effective birth control if there's a chance of pregnancy. Before joining, you'll need to understand and agree to all the study requirements by signing a consent form.

There are also some reasons why you might not be able to join. For example, if you have another type of cancer that has recently progressed or needed active treatment (unless it's a very common skin cancer or a completely removed early-stage cancer). You also can't have had major surgery recently, typically within the last month.

If you decide to take part in this study, the specific details of what's involved will be explained clearly by the study team. Generally, you would receive the study medicine, GSK5764227. This might be given on its own or alongside other standard cancer treatments. You would have regular appointments for check-ups, which include tests to see how you are responding to the treatment and to monitor your general health. These could involve blood tests, scans, and physical examinations.

The study would involve visits to the clinic for treatments and assessments. The exact number and frequency of visits will be outlined in the detailed study plan. You would be monitored closely for any side effects. After the main treatment period, there would likely be a follow-up phase to continue monitoring your health and the long-term effects of the treatment. The total duration of your participation would be fully explained before you join.