Thromboprophylaxis in Good and Intermediate Prognosis Advanced Germ Cell Tumors

To join this study, you need to be a man over 18 years old who has been diagnosed with a germ cell tumour that has responded well to treatment in the past, or has a moderate outlook. You must be suitable for a specific type of first-time chemotherapy that uses the drug cisplatin, and you shouldn't have had any other chemotherapy before.

If you're considered to be at a higher risk of developing blood clots, you might be asked to join the main part of the study where we compare two groups. This higher risk could be due to factors like certain levels of a substance in your blood (called lactate dehydrogenase), your body size, or the size of any lymph nodes in your abdomen. You'd also need to be able to understand and sign the consent forms and be willing to come to all the study appointments.

However, you wouldn't be able to join if you have cancer that has spread to your brain, a history of blood clots, or if you're already taking blood-thinning medicines. Other reasons you might not be able to join include kidney problems, if you've recently had major surgery, have very high blood pressure, or a low number of blood cells called platelets. Also, if you have a high risk of bleeding, you would not be able to take part.

If you decide to take part, you would be involved in the study for about 14 to 17 weeks. This period depends on how many cycles of chemotherapy your doctor plans for you. During this time, the researchers will carefully monitor your health. If you are in the high-risk group, you would either receive the blood clot prevention medicine or not, depending on which group you are randomly assigned to. You would have regular visits and assessments, which would likely include blood tests and physical examinations to check on your health and any side effects. You'll need to follow the study's instructions carefully and attend all scheduled appointments.