A Study of Tislelizumab in Combination With Investigational Agents in Participants With Head and Neck Squamous Cell Carcinoma

To be considered for this study, you would need to have head and neck squamous cell carcinoma that has come back or spread and cannot be cured by local treatments like surgery or radiotherapy. The cancer must be in specific areas like your throat, mouth, or voice box. You should not have received any previous treatment for your cancer that has returned or spread, although prior treatment for earlier stages of the disease is allowed.

Your cancer cells must also show a certain level of a marker called PD-L1, which helps us understand how the treatment might work. You must also be generally well enough to participate, able to carry out your normal daily activities with little difficulty, and have a healthy enough blood count and organ function. If you are female and able to get pregnant, or male with a female partner who could get pregnant, you would need to agree to use effective birth control during and for several months after the study.

There are also some reasons why you might not be able to join. For example, if your cancer started in your nose (nasopharynx), skin, or salivary glands, or if it's not the squamous cell type. If you've previously had similar immunotherapy treatments, or if you have another active cancer or certain serious lung conditions, you would likely not be eligible. The study is open to both men and women aged 18 and older.

If you decide to take part in this study, you will be randomly assigned to receive either tislelizumab on its own or tislelizumab combined with one of the other experimental medicines. This is like flipping a coin to decide your treatment group. The treatments will be given through a drip into a vein at regular, scheduled times. You will need to attend regular clinic visits for these infusions and for monitoring.

Throughout the study, the research team will carry out various tests and assessments to see how you are responding to the treatment and to check for any side effects. This will involve blood tests, scans, and physical examinations. You will continue to receive the study treatment for as long as it is helping you, as long as you don't experience too many side effects, or until you choose to stop participating. The precise duration of your involvement will depend on your individual response to treatment.