Only patients with oncologic locally advanced or metastatic tumour (lung cancer research hub

MOIO_Randomized phase III trial of standard immunotherapy (IO) by checkpoint inhibitors, versus reduced dose intensity of IO in patients with locally advanced or metastatic cancer in response after 6 months of standard IO

This study compares standard immunotherapy with a reduced dose for people whose cancer responded well after 6 months. It looks at how long they stay well and their quality of life. The aim is to see if a lower dose can be just as effective.

Phase II Randomized Controlled Study Aiming to Evaluate the Interest of Qutenza in Patients With ORL Cancer in Remission and With Sequellae Neuropathic Pain.

This study looks into whether a skin patch called Qutenza can help people who have had head and neck cancer and are left with nerve pain. It compares Qutenza with another medicine, Laroxyl, to see if either can reduce pain by a significant amount over nine months.

Study of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors

This study is testing two anti-cancer drugs, cabozantinib and atezolizumab, alone and together, for various advanced cancers. It aims to find a safe combination dose and see how well it works and any side effects.

Exploratory Study of Early Biomarkers Allowing Dynamic Assessment of Response to Treatment in Cancers of the Head and Neck

This study looks at head and neck cancer that can't be cured with surgery or radiotherapy. Researchers want to find early signs in blood and saliva that show if treatments, especially immunotherapy, are working. This could help doctors understand which treatments are best for each person.

Evorpacept (ALX148) in Combination With Pembrolizumab and Chemotherapy in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-04)

This study looks at a new drug, evorpacept, combined with pembrolizumab and chemotherapy for advanced head and neck cancer. It aims to see if this new combination is effective for patients who haven't had treatment for their advanced disease.

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

This study is looking at a new treatment called HER3-DXd for people with certain advanced solid tumours that haven't responded to other treatments. It aims to see how well it works and if it's safe for different types of cancer, like melanoma, lung cancer, and breast cancer.

Stereotactic Body Radiotherapy in Patients With Rare Oligometastatic Cancers (OligoRARE)

This study looks at adding special radiation to standard care for rare cancers that have spread a little. It wants to see if this addition helps people live longer compared to standard care alone.

A Clinical Study to Investigate the Efficacy of Tigilanol Tiglate Directly in Head and Neck Cancer

This study is testing a new medicine, Tigilanol Tiglate, for head and neck cancer. Doctors will inject the medicine directly into tumours to see how well it works at shrinking them and if it's safe. It's for patients who have recurring cancer or whose previous treatments haven't worked.

A Study of Tislelizumab in Combination With Investigational Agents in Participants With Head and Neck Squamous Cell Carcinoma

This study is looking at a new treatment called tislelizumab, sometimes combined with other medicines, for head and neck cancer that has come back or spread. The aim is to see if it can shrink tumours and if it's safe for patients.

The RESCUE Study: Survival and Functional Outcomes Following Salvage Surgery for RESidual or reCurrent sqUamous cEll Carcinoma of the Head and Neck

The RESCUE study looks at how well people do after surgery for head and neck cancer that has come back or stayed. It also checks if past treatments or a person's genes can affect this.

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

This study is testing a new drug, rezatapopt, for advanced cancers with a specific gene change (TP53 Y220C). It's also looking at rezatapopt with another drug, pembrolizumab, to see how safe and effective they are. It’s for people who have already had cancer treatment.

Exploratory Study of Clonal Evolution in Cancer for Patients Undergoing Transoral Robotic Surgery for Radiation Exposed Residual/reCurrent Tumours of the Upper Aerodigestive Tract

This study looks at how head and neck cancers change after radiotherapy. We want to understand why some cancers come back or new ones appear, which could help doctors choose better treatments for patients.

Preservation of Swallowing in Respected Oral Cavity Squamous Cell Carcinoma: Examining Radiation Volume Effects (PRESERVE): A Randomized Trial

This study compares different ways of giving radiotherapy after surgery for a type of mouth cancer. We want to see which method best protects swallowing and improves quality of life for patients with certain lymph node clear areas.

A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors

This study is looking at a new medicine called PF-08046876 for people with advanced cancers like bladder, lung, head & neck, oesophageal, or pancreatic cancer. It checks how safe the medicine is and how well it works. The medicine is given through a drip.

The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study

The MOMENTUM Study is tracking how a new type of advanced radiotherapy, called MR-Linac, works for people with different cancers. It aims to see if this treatment improves survival, controls cancer better, and enhances quality of life by using highly precise radiation guidance.

Study of EOS-448 With Standard of Care and/or Investigational Therapies in Participants With Advanced Solid Tumors

This study is testing different combinations of new drugs, including EOS-448, with or without standard treatments for advanced cancers like lung and head & neck cancer, and melanoma. Researchers want to see if these combinations are safe and effective.

Study BT5528-100 in Patients With Advanced Solid Tumors Associated With EphA2 Expression

This study is testing a new drug, BT5528, for advanced cancers like ovarian, lung, and breast cancer. We want to find a safe dose, understand side effects, and see how well it works, sometimes given with another drug called nivolumab.

Ixovex-1 Single Agent and Combination Therapy

This study is testing a new virus treatment, Ixovex-1, for advanced solid tumours and head and neck cancer. It aims to find a safe dose, alone and with Pembrolizumab, for patients who have limited other treatment options.

Head and Neck Early Relapse Detection Study (HERD)

This study aims to find better ways to detect head and neck cancer coming back early after treatment. We're looking at different body tests to create a warning system so doctors can act quickly and improve chances of successful treatment.

A Study to Test the Safety, Tolerability and Effect of ZI-MA4-1 for Patients With Locally Advanced or Metastatic Solid Malignancies

DENTOFACIAL-PBT Stage 2 - Feasibility Study

This study looks at how proton beam therapy for childhood head and neck cancer might affect teeth and jaws. Researchers want to understand these side effects better to improve future care for young patients in the UK.

Ex VIvo DEtermiNed Cancer Therapy

This study, called EVIDENT, wants to see if we can test a tiny piece of your tumour in the lab to predict how well cancer treatments will work for you. It's for people with various solid cancers, like bladder or kidney cancer, who are having surgery or a biopsy.

Phase 2, open-label, multicentre, single-arm study to evaluate the activity of the combination of EGFR inhibitors and c-MET inhibitors in patients with platinum-resistant head and neck squamous cell carcinoma after relapse to immunotherapy.

This study is for people in the UK with head and neck cancer that has come back after other treatments. It's testing a new combination of two drugs, cetuximab and tepotinib, to see if they can shrink the cancer. It's called a 'Phase 2' study, meaning it's an early look at how well the treatment works.

PANACEA : Effect of PrehAbilitation by NutritionAl supplementation with Cannabidiol on skeletal muscle mass and mitochondrial function in hEad and neck cAncer : a proof of concept controlled randomized trial

This study looks into how nutritional support, including a cannabis-derived product (CBD), might help people with head and neck cancer. Researchers want to see if it improves muscle health and energy production in cells. It's a small, early-stage study to see if the idea has promise.

A randomized, open-label, Phase III trial to assess the efficacy and safety of BupiZenge compared to lidocaine for pain associated with oral mucositis in head and neck cancer

This study is looking at a new lozenge, BupiZenge, to see if it's better than standard medicine (lidocaine) at reducing mouth pain for people with head and neck cancer. This pain, called oral mucositis, can be very uncomfortable during and after radiotherapy.

Comparing intraoperative indocyanine green fluorescence imaging with standard clinical assessment for flap perfusion in head and neck reconstruction: A randomised controlled Trial (VISION Trial)

This study looks at a new way to check blood flow during surgery for head and neck cancer. It compares a special dye injection with the usual methods to see if it helps reduce problems with tissue flaps used for reconstruction.

Evorpacept (ALX148) in Combination With Pembrolizumab in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-03)

This study looks at a new drug, evorpacept, combined with an existing one, pembrolizumab, for advanced head and neck cancer. It aims to see if this combination works better than pembrolizumab alone for patients who haven't had treatment for advanced stages of their cancer. It's a Phase 2 trial, meaning it's still in earlier stages of testing.

A Phase 2a, double-blind, placebo-controlled, multi-center, randomized study evaluating LSTA1 when added to standard of care (SoC) versus standard of care alone in subjects with advanced solid tumors (BOLSTER)