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Ongoing, recruitingHuman Pharmacology (Phase I)- OtherInterventional

A study to investigate the bioavailability of the SAR444656 test formulation and the food effect on the SAR444656 test formulation in healthy adult participants

This research study is for healthy adult volunteers and is designed to learn more about a new medicine called SAR444656. Specifically, we want to see how much of the medicine your body absorbs and how quickly it does this. We also want to find out if eating food before or after taking the medicine changes how it works inside your body. This type of study is an early step in testing new medicines to make sure they are safe and work as expected. Your participation would help scientists understand SAR444656 better, which is crucial for its future development. We are looking for healthy people over 18 years old.

At a glance

Status
Ongoing, recruiting
Phase
Human Pharmacology (Phase I)- Other
Sponsor
Sanofi-Aventis Recherche & Developpement
Enrolment target
80
Start
25 Mar 2025

What is this study about?

This study is a really important early step in developing a new medicine called SAR444656. When a new medicine is created, lots of tests have to be done to make sure it's safe and effective before it can be given to patients. One of the first things scientists need to understand is how the medicine behaves inside the human body.

In this study, we're focusing on two main things. First, we want to see how much of the SAR444656 medicine actually gets into your bloodstream after you take it. This is important because it tells us how well your body absorbs the drug. Second, we want to understand if eating food changes this process. Sometimes, taking a medicine with food can change how much of it your body absorbs, or how quickly it works.

By taking part, you would be helping researchers gather vital information about SAR444656. This information will help them decide the best way to give this medicine to people in the future, for example, whether it should be taken with or without food. Your contribution is key to the early development of this potential new treatment.

Key takeaways

  • This study helps understand a new medicine, SAR444656.
  • It checks how your body absorbs the medicine and if food changes this.
  • You need to be a healthy adult, 18 or over.
  • There are no direct health benefits to you, but you help future medical research.
  • You can leave the study at any time.
  • Participation involves clinic visits and blood tests.

Who may be eligible?

This study is looking for healthy adults. You might be suitable if you are 18 years old or over, with no upper age limit. We welcome both men and women to take part.

Being 'healthy' for this study means you don't have any major medical conditions that could affect how the medicine works in your body or make it unsafe for you to participate. The study team will check your health carefully to make sure it's safe for you.

If you have any long-term health problems, or regularly take other medicines, it's very important to discuss this with the study team. They will be able to tell you if you're still eligible to join.

Quick self-check
  • Are you 18 years old or older?
  • Do you consider yourself generally healthy?
  • Are you able to attend several clinic appointments?
  • Are you willing to have blood tests?
  • Are you happy to try a new, unapproved medicine?
  • Do you understand that you won't get direct health benefits from this study?

This is a guide only — the research team will confirm whether you can take part.

What does participation involve?

Taking part in this study will involve several visits to a clinic. During these visits, you will be given the SAR444656 medicine, sometimes with food and sometimes without, to see how your body reacts. You'll have blood samples taken at different times to measure how much of the medicine is in your system. We will also check your general health, such as blood pressure and heart rate, to make sure you're doing well. The total time you'll spend involved in the study, including all visits and any follow-up, will be explained in detail by the study team before you decide to join.

Potential risks and benefits

While this study helps us understand a new medicine, there are no direct health benefits to you from taking part, as it's an early-stage study in healthy people. However, you will be contributing to medical research that could help others in the future. As with any medicine, there's always a chance of side effects, which the study team will explain fully. They will monitor you closely throughout. You are free to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (1)

  • Belgium

Common questions

What is SAR444656?

SAR444656 is a new medicine that is being investigated. This study aims to understand how your body handles it.

What does 'bioavailability' mean?

Bioavailability means how much of the medicine your body absorbs and how quickly it gets into your bloodstream to have an effect.

Why do you need healthy volunteers?

Early studies like this often use healthy volunteers to understand how a new medicine works in a typical body before testing it in ill patients.

Will I be paid for taking part?

Information about any payment or compensation for your time and travel will be provided by the study team.

How long will the study last for me?

The exact duration for your participation, including visits and follow-up, will be clearly explained by the study team.

How to find out more

Always speak to your GP or specialist before deciding to take part in a study.

Discussion

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