AuthorisedHuman Pharmacology (Phase I)- OtherInterventional

Thorough QT/QTc study with GLPG3667, placebo, and active comparator in healthy subjects

This study is looking into a new medicine called GLPG3667. We want to understand how it affects the electrical signals in the heart, specifically a measurement called the QT interval. This is a very important safety check because some medicines can cause problems with the heart's rhythm. Healthy volunteers will take either GLPG3667, a dummy pill (placebo), or a known medicine (active comparator) that has similar effects on the heart. By comparing these, doctors can see if GLPG3667 is safe for the heart. This is a very early study, meaning it’s one of the first times this medicine is being given to people. It's a crucial step before it can be tested in patients who might benefit from it.

At a glance

Status

Authorised

Phase

Human Pharmacology (Phase I)- Other

Sponsor

Galapagos

Enrolment target

Start

22 May 2026

Healthy volunteers

What is this study about?

This study is all about a new medicine called GLPG3667. Before any new medicine can be given to people who are ill, doctors need to be very sure it's safe. One of the most important safety checks is to see how the medicine affects the heart. Sometimes, medicines can change the heart's electrical activity, which could lead to problems with its rhythm. This study focuses on a specific electrical measurement in the heart called the QT interval. Think of it like a signal that shows how long it takes for your heart to recharge between beats.

In this study, healthy volunteers will help us understand if GLPG3667 changes this QT interval. Participants will be given GLPG3667, or a 'dummy' pill (called a placebo, which has no medicine in it), or another medicine that we know affects the QT interval (called an active comparator). By comparing what happens with all three, doctors can clearly see if GLPG3667 has any unusual or concerning effects on the heart's electrical system. This helps us work out if it's safe enough to move on to the next stages of testing.

This is a 'Phase I' study, which means it's an early-stage test in a small group of people. It's not about treating a specific illness yet, but purely about safety and understanding how the body handles the medicine. The information we gain from studies like this is vital. It helps researchers decide if a new medicine has the potential to be a safe and effective treatment in the future for people who really need it. Without these early safety checks, new medicines couldn't be developed.

Key takeaways

This study tests a new medicine (GLPG3667) in healthy people.
It checks how the medicine affects the heart's electrical activity.
This is an early safety check (Phase I) for potential new treatments.
Participants will receive the new medicine, a dummy pill, or a known medicine.
Both men and women aged 18 and over can be considered.
The main goal is to ensure the medicine is safe for the heart.

Who may be eligible?

To join this study, you need to be a healthy volunteer. This means you generally feel well and don't have any major ongoing health problems or illnesses that could affect the study results or your safety.

Anyone aged 18 years or older can be considered for this study, as there is no upper age limit. Both men and women are welcome to take part. After expressing your interest, the study team will ask you more detailed questions about your health and medical history to make sure the study is a good fit for you and that it's safe for you to participate.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Do you generally consider yourself healthy?
Are you able to attend regular appointments at a clinic?
Are you comfortable potentially receiving a placebo (dummy pill)?
Are you willing to have your heart activity monitored with an ECG?

Answer every question to see your result.

What does participation involve?

If you decide to take part, you would receive either the new medicine (GLPG3667), a dummy pill (placebo), or another known medicine. The study team will explain exactly what this means for you and how it will be given. You would have regular appointments at the study clinic or hospital. These visits would include check-ups, having your heart's electrical activity monitored (like with an ECG, which is quick and painless), and possibly giving blood or urine samples.

These checks are important so the doctors can carefully watch how the medicine is affecting your body and ensure your safety. While the exact total duration isn't specified here, early-stage studies often involve a few visits over several weeks, with regular follow-up. You will be told the complete schedule before you agree to join.

Potential risks and benefits

Taking part in a study like this helps advance medical research, which could eventually lead to new treatments for others. However, like all medicines, GLPG3667 might have side effects, even in healthy people. These could be mild, but there's always a possibility of more serious ones, especially related to heart rhythm, which is exactly what the study is designed to monitor very closely. You have the right to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
Netherlands

Common questions

What is a 'healthy volunteer'?

A healthy volunteer is someone who does not have any serious ongoing health conditions and generally feels well. You'll have a health check to make sure you're suitable.

What does a 'dummy pill' (placebo) mean?

A dummy pill looks exactly like the study medicine but contains no active ingredients. It helps doctors see if any effects are truly from the medicine or just from expectation.

Will I know which treatment I'm getting?

Usually, in studies like this, neither you nor the doctors will know who is getting which treatment until the study is over. This is to keep the results fair and unbiased.

What is the 'QT interval' they are measuring?

The QT interval is a measurement from an ECG (heart tracing) that shows how long it takes your heart's electrical system to reset between beats. It's an important safety check for certain medicines.

Will I get paid for taking part?

Some studies offer payment for your time and expenses. This would be clearly explained by the study team before you agree to participate.