- recruitingNA
Evaluation of the Biomechanics of Crowding and the Energetic Cost of Endurance Runners Unilateral Transtibial Amputees.
This study looks at how running blades work for people with one leg amputation. We want to understand how different blades affect running, energy use, and injury risk, especially for long-distance running. The aim is to help amputee runners perform better and stay safe.
France - recruitingPHASE1
A Study to Evaluate Novel KarX and KarT Prototypes Versus the KarXT and KarX-EC Reference Following Single Doses, and to Explore the Effect of Food After Multiple Doses of Selected Prototypes in Healthy Adult Participants
This study is testing new versions of a medicine called KarXT and KarX-EC in healthy adults. Researchers want to see how these new versions work after a single dose and if food changes how they act after several doses. It's about finding out how medicines are absorbed by the body.
United Kingdom - completedPhase I
Phase I trial: CA47303
This early-stage study, called CA47303, is looking for healthy women aged 18 to 45. It's designed to understand how a new investigational treatment works in the body and if it's safe. Details about the treatment will be made public later.
United Kingdom · Northern Ireland - recruitingNA
Evaluation of Adding Nitrate Into Foods for Regulating Nitric Oxide Bioavailability in Healthy Individuals
This study looks at whether adding a natural ingredient called nitrate to common foods like biscuits and porridge can help improve heart health and lower blood pressure in healthy people. Researchers want to see if these nitrate-enriched foods work as well as existing supplements.
United Kingdom - active not recruitingPHASE3
Study of a 21-valent Pneumococcal Conjugate Vaccine in Healthy Infants From Approximately 2 Months of Age
This study is testing a new vaccine (PCV21) for healthy babies aged 2 to 4 months. It aims to see if it's safe and helps babies make germ-fighting antibodies against pneumococcal disease, comparing it to an existing vaccine alongside their routine immunisations.
Belgium · Czechia · Estonia - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
A Phase 1 relative bioavailability study in 14 healthy adult participants investigating the Arvisol® tablets to see whether its pharmacokinetic properties are similar to the reference drug which is a marketed oral soliton cannabidiol, named Epidiolex® CBD oral solution.
This study is looking at a new tablet form of a medicine called Arvisol®. We want to see if it works in the body in the same way as an existing liquid medicine, Epidiolex®, which contains CBD. It's for healthy adults.
Hungary - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of loperamide.
This study is looking at how two different versions of a common medicine for tummy troubles, called loperamide, are absorbed by the body. We need healthy volunteers to help us understand if they work in the same way. It's an early-stage study to check the medicine's behaviour.
Spain - completedPhase I
An open-label mass balance study of [14C]EIK1001 in healthy male subjects
This study is looking into how the body handles a new cancer drug, EIK1001. We need healthy men to take a single dose to see how the body breaks it down and gets rid of it. This helps doctors create more effective cancer treatments for the future.
United Kingdom · England - authorisedHuman Pharmacology (Phase I)- Other
A PHASE 1, OPEN-LABEL STUDY TO ASSESS THE ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION, INCLUDING THE MASS BALANCE, OF A SINGLE ORAL DOSE OF [14C]-VAFIDEMSTAT IN HEALTHY MALE PARTICIPANTS
This early-stage study is looking at a new medicine called Vafidemstat in healthy men. Researchers want to understand how the body takes in, uses, and gets rid of this medicine after one dose. It helps them learn important basic information about how the drug works.
Netherlands - recruitingPHASE1, PHASE2
Study Evaluating ABCL635 for Vasomotor Symptoms of Menopause
This study is looking into a new medication called ABCL635 for hot flashes and night sweats caused by menopause. It aims to see if it's safe, how it works in the body, and if it helps with these symptoms in both healthy people and women experiencing moderate to severe symptoms.
Canada - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A trial to learn how much [11C]savolitinib enters the brains of healthy participants
This study looks at how a new medicine, called [11C]savolitinib, gets into the brains of healthy adults. It's a very early stage of research to understand how the medicine works in the body.
Sweden - completedPhase I
Phase I trial HMR code: 25-001
This early-stage study is looking for healthy volunteers. It's a 'Phase 1' trial, which usually means researchers are testing a new treatment or medicine for the first time in people. More details about the study will be shared later.
United Kingdom · England - completedPhase I
A study to compare how the body takes in and gets rid of sefaxersen when given by an injection device or a regular syringe in healthy adults
This study looks at a new way to give sefaxersen, a drug being developed for a kidney condition. It compares an injection device to a standard syringe in healthy adults to see if both methods deliver the drug equally well and if the device makes it easier to use.
United Kingdom · England - ongoing, recruitingTherapeutic use (Phase IV)
Hypoxic ventilatory response (HVR): Effect of Esketamine
This study looks at how a medicine called esketamine affects breathing when there's not much oxygen. It's for healthy volunteers and will help us understand the drug's effects on the body, including any side effects and how much stays in the blood.
Netherlands - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Randomised, crossover bioequivalence clinical trial of ezetimibe/atorvastatin 10 mg/80 mg tablets versus ezetimibe/atorvastatin 10 mg/80 mg film-coated tablets, after a single oral dose administration to healthy volunteers under fasting conditions
This study is comparing two versions of a combined heart medication (ezetimibe and atorvastatin) to see if they work the same way in the body. We're looking for healthy volunteers to help us understand if a new version of the tablet is just as effective as the existing one.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study to evaluate how the body absorbs, breaks down and removes drug as well as safety and tolerability when two drugs are administered together as an injection under the skin to healthy participants.
This study is looking at two new medicines given together as a jab under the skin. We want to see how your body handles them and if they cause any side effects in healthy people. This helps us understand how the drugs work safely.
Belgium - completedPhase I
Phase 1 trial HMR code: 25-006
This early-stage study, called HMR 25-006, is looking for healthy female volunteers. The main goal is to test a new treatment for the first time in people. More detailed information about the study will be shared later, within 30 months after it has finished.
United Kingdom · England - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
KF2024#1 trial: Esketamine interaction study
This study is looking at how a new drug called esketamine works in healthy people. It's a very early stage of research to understand how the body uses and gets rid of the medicine, and if it's the same as another known version of the drug.
Finland - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Randomised, bioequivalence clinical trial of ezetimibe/atorvastatin 10 mg/80 mg tablets versus ezetimibe/atorvastatin 10 mg/80 mg film-coated tablets, after a single oral dose administration to healthy volunteers under fasting conditions in crossover replicated design.
This study is looking at how two versions of a common cholesterol-lowering medicine are absorbed by healthy people. It wants to see if a new generic version works the same way as an existing one.
Spain - recruitingNA
Preparation and Feasibility of Exams for Expected Studies
This study helps us get ready for future medical research. We’re testing how well our brain and heart scanning equipment works with healthy people and those with Parkinson's disease or paralysis. This helps us plan better studies later on.
France - ongoing, recruitingPhase I and Phase II (Integrated)- Bioequivalence Study
A study in two groups of healthy male adult participants to assess how much test medicine (SAR441566) is taken up, degraded and removed by the body and to assess the extent to which SAR441566 becomes available to the body when given by mouth
This study is looking at a new medicine called SAR441566 in healthy male volunteers. We want to understand how the body uses and gets rid of this medicine when it's taken by mouth. This helps us ensure it's safe and works well.
Netherlands - recruiting
Multimodal Cardiovascular and Hepatic Population Imaging
This study uses advanced scans like MRI to look at hearts and livers in healthy people. It aims to improve how we spot early signs of disease and understand how different factors affect our health, helping us work towards more personalised medicine.
France - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of loperamide.
This study is looking at how two different versions of a common medicine for tummy troubles, called loperamide, work in healthy people. We want to check if they act in the same way in your body.
Spain - recruitingNA
A Technical Innovation of Prismatic Adaptation Test in Healthy Subject, in Favour of Autonomy and Independence in Daily Life Following a Brain Injury
This study is testing new ways to help people with a brain injury condition called unilateral neglect, which affects how they notice and react to things on one side. We're looking at virtual reality and imagining movements to see if these methods could make therapies easier to do at home.
France - recruitingPHASE1
Safety, Tolerability, and Pharmacokinetics of RCS-21 in Healthy Volunteers.
This study is testing a new medicine, RCS-21, in healthy volunteers to see if it's safe and how it acts in the body. Participants will inhale a single dose and be carefully monitored.
Germany - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Randomized, open-label, three-period crossover study on the palatability of oral dispersible formulations of Zonisamide in healthy volunteers.
This study is looking at how different forms of a medicine called Zonisamide taste. It involves healthy adult volunteers trying out different versions of the medicine to see which is easiest and most pleasant to take. This helps make future medicines better for patients.
Spain - active not recruitingNA
Effect of Transcranial Near InfraRed Light on Cerebral Function in Young and Healthy Older Subjects: a FMRI Study (TIROC)
This study looks at whether shining a special light on the head can improve brain function in healthy people. We're comparing younger and older adults by looking at their brain activity during a finger-tapping task before and after the treatment.
France - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
A study to learn how zilucoplan moves throughout the body over time when given in 2 different ways in healthy adults
This study looks at a new medicine called zilucoplan in healthy adults. Researchers want to see how the medicine moves through the body over time when given in two different ways. It's an early-stage study to understand the medicine better.
Netherlands - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of linagliptin
This study is looking at how two different versions of a medicine called linagliptin work in the body. We need healthy volunteers to help us understand if the new version is just as good as an existing one. This is an early-stage study to check the medicine's effects.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence study of the oral suspension of netupitant/palonosetron combination product versus the hard capsules of netupitant/palonosetron combination product after a single dose administration to healthy male and female volunteers in an open-label, randomised, single centre, 2-treatment, 4-period, 2 sequence replicative design
This study is testing if a new liquid form of a medicine called netupitant/palonosetron works the same way in the body as the capsule form. We're looking for healthy adults to help us find out if both forms deliver the medication equally.
Germany - authorisedTherapeutic exploratory (Phase II)
A Mechanistic Study to Evaluate Impact of Afamelanotide in Aqueous Solution on Ultraviolet Radiation-Induced DNA Damage and DNA Repair Capacity in Healthy Volunteers
This study is looking at how a trial medicine called PRENUMBRA, containing afamelanotide, might protect healthy skin from sun damage. Researchers want to see if it helps reduce harm from UV rays and improves skin's ability to fix itself after sun exposure.
Germany - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Physiologically based pharmacokinetic modelling of intravenous and intranasal formulations of naloxone in healthy volunteers
This study is looking at how two different ways of giving a medicine called naloxone work in healthy people. Naloxone is used to reverse the effects of opioid overdose. We want to see how the body handles naloxone when it's given through a drip or as a nasal spray.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Study with healthy volunteers to investigate the safety, tolerability, blood concentration and some effects of various amounts of the pharmaceutical substance SR-878
This study is looking for healthy volunteers to test a new medicine called SR-878. Researchers want to see if it's safe, how well people tolerate it, and how much of it stays in the blood. They'll also check for any early effects.
Austria - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Randomized, crossover, two-period, two-treatment, comparative bioavailability study of ibuprofen (arginine) granules for oral solution, developed by Farmalider, S.A., and Espidifen® granules for oral solution, administered in single dose of 600 mg to healthy subjects under fasting conditions.
This study compares two types of ibuprofen — one new, one already available — to see how well they're absorbed by your body. It involves healthy volunteers taking a single dose of each in liquid form, to check if the new ibuprofen works just as well as the existing one.
Spain - recruitingNot Applicable
Investigating the effects of oral scopolamine on cognition and emotion processing
This study looks at how a low dose of scopolamine, a common travel sickness medicine, affects emotions and thinking in healthy people. The findings could help us understand how to develop new, faster-acting treatments for depression.
United Kingdom · England - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
A Randomized, Double-blind, Controlled, Parallel-group, Single Dose, Three arm Study to Compare the Pharmacokinetic Similarity of MAB-22 Versus Prolia® Sourced from the European Union and United States in Healthy Male Participants
This study is looking at a new version of a medicine for bone conditions, called MAB-22. We want to see if it works the same way in the body as an existing medicine, Prolia®. Healthy men will take a single dose of one of these medicines.
Hungary · Netherlands - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of linagliptin/metformin
This study is checking if two different versions of a medicine for type 2 diabetes, containing linagliptin and metformin, work in the same way in healthy people. It's a first step to make sure any new version is just as good as the original.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of linagliptin/metformin.
Researchers are comparing two versions of a blood sugar lowering medicine. This study is for healthy volunteers to see if the body uses these two versions in the same way. It helps ensure new medicines work as expected.
Spain - recruiting
EarMetrics®-Oximeter - a targeted oxygenation observation study
This study tests a new ear device, the EarMetrics®-Oximeter, to measure blood oxygen levels. It aims to be more accurate for people with darker skin. Healthy adults will have their oxygen levels monitored during a temporary, controlled reduction of oxygen.
United Kingdom · England - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Randomized, open-label clinical trial (Phase 1) to evaluate safety, tolerability, pharmacokinetics and food effects of a single dose of IM-250 in healthy volunteers
This early-stage study is looking for healthy volunteers to test a new medicine called IM-250. We want to see if it's safe, how well the body handles it, and if food changes how it works. This is the first time it will be given to people.
Bulgaria - authorisedHuman Pharmacology (Phase I)- Other
A study investigating the safety, absorption, and elimination of RO7795068, a new compound that may potentially be used in the treatment of obesity
This study is looking into a new medicine, RO7795068, which might help treat obesity. We want to understand how safe it is and how the body takes it in and gets rid of it. We're inviting healthy volunteers to take part.
Netherlands - completedPhase I
A 2-part study to investigate the safety, tolerability and effect of MB272 in healthy volunteers
This study, called MB272, looked at a new drug (GS-0272) in healthy volunteers. It checked if the drug was safe, how well people tolerated it, and how it acted in the body when given in different ways and doses. The goal was to gather early information about this potential new medicine.
United Kingdom · Wales - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Study on Oral and Intranasal Forms in Healthy Volunteers using Pharmacokinetic Modeling
This study is looking at how two different ways of taking a medicine – by mouth and through the nose – work in healthy people. It's an early-stage study to understand how the body handles the medicine.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of linagliptin
This study is looking at two versions of a diabetes medicine called linagliptin to see if they work the same way in healthy people. It's a very early-stage study to check how the medicines are absorbed by the body.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Randomised, crossover bioequivalence clinical trial of edoxaban 60 mg tablets versus edoxaban 60 mg film-coated tablets, after a single oral dose administration to healthy volunteers under fasting conditions.
This study is checking if a new version of the edoxaban 60 mg tablet works the same way as the current one. Healthy volunteers take a single dose of each tablet on different days to see if they are medically equivalent.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
Investigation of Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Subcutaneous Injections of NNC0582-0001 in Healthy Adults
This study is looking at a new medicine called NNC0582-0001, given as a single injection under the skin. It aims to check if it's safe and how the body handles it in healthy adults. This is the very first time this medicine is being tested in people.
Austria - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of loperamide.
This study is testing if two different versions of a common medicine, loperamide, work the same way in the body. We need healthy volunteers to help us understand how the medicine is absorbed.
Spain - recruitingPHASE1
Multiple Dose Study for a New Medication to Potentially Treat Liver Diseases
This study looks at a new medicine for liver conditions, including fatty liver disease. It checks if the medicine, given as an injection, is safe and how the body handles it. Participants will either get the new medicine or a dummy treatment over 3 months.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
OPEN-LABEL PALATABILITY STUDY OF A NOVEL ORODISPERSIBLE PARACETAMOL/IBUPROFEN FORMULATION AFTER A SINGLE ORAL ADMINISTRATION IN HEALTHY SUBJECTS
This study is testing a new type of painkiller that mixes paracetamol and ibuprofen in one easy-to-take form. Researchers want to find out how it tastes and how pleasant it is to take for healthy adults. It's an early-stage study to gather initial feedback.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of edoxaban.
This study is looking at two versions of a medicine called edoxaban in healthy volunteers. It wants to see if both versions act the same way in the body. This helps ensure new medicines work just as well as existing ones.
Spain