Healthy volunteers research hub

A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, PHASE I STUDY TO ASSESS THE SAFETY, TOLERABILITY, AND PHARMACOKINETICS OF SINGLE ANDMULTIPLE ASCENDING DOSES OF THN391 IN HEALTHY SUBJECTS

This early-stage study is looking for healthy volunteers to test a new medicine called THN391. We want to see if it's safe, how well the body handles it, and how it moves through the body after single and repeated doses. It's the first time this medicine will be given to people.

A Single Dose, Non-randomised, Open-label, Parallel Group Study to Assess the Pharmacokinetics, Safety, and Tolerability of AZD4144 in Participants with Severe Renal Impairment, End-stage Kidney Disease, and in Healthy Participants

This study looks at a new medicine called AZD4144 in people with severe kidney problems, those on dialysis, and healthy volunteers. It checks how the body handles the medicine, if it's safe, and if it causes any side effects. It's an early-stage study.

Bioequivalence clinical trial of two formulations of linagliptin/metformin.

Researchers are comparing two versions of a blood sugar lowering medicine. This study is for healthy volunteers to see if the body uses these two versions in the same way. It helps ensure new medicines work as expected.

Bioequivalence clinical trial of two formulations of loperamide.

This study is looking at how two different versions of a common medicine for tummy troubles, called loperamide, are absorbed by the body. We need healthy volunteers to help us understand if they work in the same way. It's an early-stage study to check the medicine's behaviour.

KF2024#1 trial: Esketamine interaction study

This study is looking at how a new drug called esketamine works in healthy people. It's a very early stage of research to understand how the body uses and gets rid of the medicine, and if it's the same as another known version of the drug.

A randomized, triple-blind, placebo-controlled study on the effect of rifaximin on psychobiological functions in healthy men.

This study is looking at how a medicine called Targaxan might affect how healthy men deal with stress. Researchers will check things like stress levels and gut health to understand its effects.

(ROAR) Reversal of opioid-induced respiratory depression with opioid antagonists - a pharmacokinetic pharmacodynamic modeling study in opioid naïve individuals and chronic opioid users under real-life conditions

This study looks at how medicines called opioid antagonists can reverse breathing problems caused by strong painkillers (opioids). We're testing these medicines in healthy people and those who use opioids, to understand how quickly and effectively they work to help breathing.

A randomized, open-label, two-period, two-sequence crossover trial to investigate the effect of food on the pharmacokinetics of Silexan 80 mg in healthy participants

This study is looking at how a medicine called Silexan 80mg is absorbed by the body when taken with food, compared to when it's taken without food. Healthy adults are taking part to help us understand this better.

A Phase I, Randomised, Open Label, Single Center, Single Oral Dose, Three Treatment, Three Period, Three Sequence, Change-over Bioequivalence Study of Paracetamol Orodispersible Tablet 500 mg (Haleon) to assess Bioequivalence with Alvedon 500 mg Film-Coated Tablet (Haleon, Sweden) and Panadol 500 mg Film-Coated Tablet (Haleon, Australia) in Healthy Adult Subjects Under Fasting Conditions

This study tested a new type of paracetamol (like Panadol) that dissolves in your mouth. It compared how well your body absorbed it compared to standard paracetamol tablets. The aim was to see if they worked in a similar way in healthy adults.

Identifying Wearable Biomarkers to Monitor Dietary Intake

This study explores if wearable devices can accurately measure what people eat. Researchers will monitor healthy volunteers after high and low-calorie meals to see how their bodies react, hoping to create a better way to track diet than current methods.

Pharmacokinetics of GH001 Delivered Via a Proprietary Aerosol Delivery Device in Healthy Subjects

This study is looking at a new way to deliver a medicine called GH001 through an inhaler. We want to see how the body handles the medicine and if it's safe for healthy people. It's a first step to understand this new treatment.

A Study to Evaluate ALN-4915 in Adult Healthy Volunteers

This study is looking into a new medicine called ALN-4915. It's for healthy adults aged 18-65. The main aim is to check if the medicine is safe and how it affects the body.

A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease

This study is testing a new medicine, BMS-986470, for people with sickle cell disease and healthy volunteers. Researchers want to see if it's safe, how it works in the body, and if it helps with sickle cell symptoms. It's an early-stage study.

A Study to Evaluate ALN-4285 in Adult Healthy Volunteers

This study is looking into a new medication called ALN-4285. It aims to see how safe it is and what happens to it in the body when given to healthy adults. Some participants will receive the medication, others a dummy treatment.

A Study to Evaluate Novel KarX and KarT Prototypes Versus the KarXT and KarX-EC Reference Following Single Doses, and to Explore the Effect of Food After Multiple Doses of Selected Prototypes in Healthy Adult Participants

This study is testing new versions of a medicine called KarXT and KarX-EC in healthy adults. Researchers want to see how these new versions work after a single dose and if food changes how they act after several doses. It's about finding out how medicines are absorbed by the body.

Artificial Intelligence Delivered Cardiac Magnetic Resonance - Prospective Validation

This study is testing if artificial intelligence (AI) can help take detailed heart scans (CMRIs) faster and just as well as human experts. It aims to make it easier to get these important heart checks.

Evaluation of Adding Nitrate Into Foods for Regulating Nitric Oxide Bioavailability in Healthy Individuals

This study looks at whether adding a natural ingredient called nitrate to common foods like biscuits and porridge can help improve heart health and lower blood pressure in healthy people. Researchers want to see if these nitrate-enriched foods work as well as existing supplements.

Multiple Dose Study for a New Medication to Potentially Treat Liver Diseases

This study looks at a new medicine for liver conditions, including fatty liver disease. It checks if the medicine, given as an injection, is safe and how the body handles it. Participants will either get the new medicine or a dummy treatment over 3 months.

Bioequivalence study of GP-IMP-001 with regards to reference product

This study is looking at how a new drug called GP-IMP-001 is absorbed by the body compared to an existing drug. We need healthy male volunteers aged 18 and over to help us. It's an early-stage study to make sure the new drug works similarly.

Bioequivalence clinical trial of two formulations of vortioxetine.

This study is looking at two versions of a medicine called vortioxetine to see if they work the same way in the body. It’s for healthy adults and is an early-stage study to check how the medicine is absorbed.

Dosimetry, kinetics and test-retest properties of a novel norepinephrine transporter radiotracer [18F]NS12137

This early-stage study looks at a new tracing substance called [18F]NS12137. Researchers are testing it in healthy men to understand how it moves through the body and if it gives consistent results. It's the first time this substance is being given to people.

Randomized, open-label clinical trial (Phase 1) to evaluate safety, tolerability, pharmacokinetics and food effects of a single dose of IM-250 in healthy volunteers

This early-stage study is looking for healthy volunteers to test a new medicine called IM-250. We want to see if it's safe, how well the body handles it, and if food changes how it works. This is the first time it will be given to people.

Bioequivalence clinical trial of two formulations of ezetimibe/atorvastatin

This study is looking at how well two different versions of a medicine called ezetimibe/atorvastatin are absorbed by the body. This medicine is used to help lower cholesterol. We need healthy volunteers to take part and help us understand if the new version works the same as the established one.

Randomized, crossover, comparative bioavailability study of two Paracetamol-Ibuprofen 25-20 mg/ml oral suspension, administered in single dose to healthy subjects under fasting conditions.

This study is looking at two different liquid medicines that contain paracetamol and ibuprofen. We want to see how well and how quickly your body absorbs each medicine. It's for healthy adults and involves taking a single dose of each medicine on separate occasions.

Phase 1 Safety and Tolerability Study of REGN9533 in Healthy Adults.

This study is looking for healthy adults to test a new medicine called REGN9533 for the very first time in people. The main goal is to check if it's safe to use and how well the body handles it. It's an early-stage study to gather important information.

A study investigating the safety, absorption, and elimination of RO7795068, a new compound that may potentially be used in the treatment of obesity

This study is looking into a new medicine, RO7795068, which might help treat obesity. We want to understand how safe it is and how the body takes it in and gets rid of it. We're inviting healthy volunteers to take part.

Phase I clinical trial to evaluate the pharmacokinetics, safety and tolerability of repeated topical application of PARENTIDE in healthy volunteers

This study is testing a new cream called PARENTIDE on healthy people. We want to see how the cream is absorbed, if it's safe, and if people can tolerate it when used repeatedly. It's an early-stage study to understand the new treatment better.

RANDOMIZED, CROSSOVER, TWO-PERIOD, COMPARATIVE BIOAVAILABILITY STUDY OF TWO IBUPROFEN FORMULATIONS, AFTER A SINGLE ORAL DOSE OF 400 MG IN SOLUTION FORM TO HEALTHY SUBJECTS UNDER FASTING CONDITIONS

This study compares two different ibuprofen medicines to see how well they are absorbed by healthy people. Participants will take a single dose of ibuprofen on two separate occasions to help researchers understand which one gets into the body best.

Drug-Drug Interaction Study With BIA 28-6156 and Clarithromycin, Midazolam, and Dabigatran Etexilate in Healthy Participants

This study is looking at how a new drug, BIA 28-6156, reacts with three common medicines: clarithromycin (an antibiotic), midazolam (a sedative), and dabigatran etexilate (a blood thinner). We want to see if they affect each other when taken together, to make sure future patients can take them safely.

A Study on Oral and Intranasal Forms in Healthy Volunteers using Pharmacokinetic Modeling

This study is looking at how two different ways of taking a medicine – by mouth and through the nose – work in healthy people. It's an early-stage study to understand how the body handles the medicine.

Phase 1 clinical trial to evaluate the safety, tolerability and pharmacokinetics of multiple daily doses of IM-250 in healthy volunteers.

This study is testing a new medicine called IM-250 in healthy adult volunteers for the first time. We want to see if it's safe, how well people tolerate it, and what happens to the medicine in the body after taking multiple doses. It's an early-stage study.

A trial to learn about how multiple doses of itraconazole change how AZD5004 moves throughout the body over time in healthy adults and how multiple doses of AZD5004 change how ethinyl estradiol and levonorgestrel move throughout the body overtime in healthy female adults

This study looks at how a new drug, AZD5004, interacts with a common anti-fungal medicine (itraconazole) and with common birth control pills (ethinyl estradiol and levonorgestrel). It's for healthy adults and helps us understand how these medicines work together in the body.

Bioequivalence clinical trial of two formulations of dapagliflozin/metformin

This study is looking at two different versions of a common diabetes medicine, dapagliflozin/metformin. We want to see if they work the same way in healthy people. This helps make sure new medicines are just as good as existing ones.

A study to assess the safety of ARGX-121 in Healthy Adult Participants

This study is looking into a new medication called ARGX-121 to see if it's safe for healthy adults. It's one of the very first times this medicine will be given to people. Researchers want to make sure it doesn't cause any serious problems.

Randomised, crossover bioequivalence clinical trial of edoxaban 60 mg tablets versus edoxaban 60 mg film-coated tablets, after a single oral dose administration to healthy volunteers under fasting conditions.

This study is checking if a new version of the edoxaban 60 mg tablet works the same way as the current one. Healthy volunteers take a single dose of each tablet on different days to see if they are medically equivalent.

Jim Beam Cumulative Irritation Patch Test

This study is looking at how skin reacts to a product called Jim Beam when applied repeatedly. It's a very early-stage trial, just testing on healthy volunteers to see if it causes any irritation. They're checking skin responses to make sure it's safe for people.

Bioequivalence clinical trial of two formulations of loperamide.

This study is looking at how two different versions of a common medicine for tummy troubles, called loperamide, work in healthy people. We want to see if these two versions are absorbed in the body in the same way, to make sure they'll have the same effect.

Bioequivalence clinical trial of two formulations of dapagliflozin/metformin

This study is looking at how two different versions of a common medicine, dapagliflozin/metformin, are absorbed and used by the body. It involves healthy adults and aims to check if they work in the same way.

Randomized, open-label, three-period crossover study on the palatability of oral dispersible formulations of Zonisamide in healthy volunteers.

This study is looking at how different forms of a medicine called Zonisamide taste. It involves healthy adult volunteers trying out different versions of the medicine to see which is easiest and most pleasant to take. This helps make future medicines better for patients.

Bioequivalence clinical trial of two formulations of linagliptin

This study is looking at two versions of a diabetes medicine called linagliptin to see if they work the same way in healthy people. It's a very early-stage study to check how the medicines are absorbed by the body.

Bioequivalence clinical trial of two formulations of loperamide.

This study is testing if two different versions of a common medicine, loperamide, work the same way in the body. We need healthy volunteers to help us understand how the medicine is absorbed.

OPEN-LABEL PALATABILITY STUDY OF A NOVEL ORODISPERSIBLE PARACETAMOL/IBUPROFEN FORMULATION AFTER A SINGLE ORAL ADMINISTRATION IN HEALTHY SUBJECTS

This study is testing a new type of painkiller that mixes paracetamol and ibuprofen in one easy-to-take form. Researchers want to find out how it tastes and how pleasant it is to take for healthy adults. It's an early-stage study to gather initial feedback.

A study understanding how much CDR132L enters the bloodstream after injection under the skin compared to injection into a vein in healthy participants

This study looks at how a new medicine, CDR132L, gets into the body. We want to see if giving it as a jab under the skin works as well as giving it into a vein. This helps us understand the best way to give this medicine in the future.

A PHASE 1, OPEN-LABEL STUDY TO ASSESS THE ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION, INCLUDING THE MASS BALANCE, OF A SINGLE ORAL DOSE OF [14C]-VAFIDEMSTAT IN HEALTHY MALE PARTICIPANTS

This early-stage study is looking at a new medicine called Vafidemstat in healthy men. Researchers want to understand how the body takes in, uses, and gets rid of this medicine after one dose. It helps them learn important basic information about how the drug works.

Thorough QT/QTc study with GLPG3667, placebo, and active comparator in healthy subjects

This study is testing a new medicine, GLPG3667, in healthy people to see how it affects the heart's electrical activity. This is an early-stage study to check for any heart-related side effects before the medicine can be tested in people with the actual illness it’s designed to treat.

ELE-101 Safety & Tolerability Study in Healthy Participants and Patients With Depression

This study is looking at a new drug called ELE-101 for depression. It checks how safe it is and how it works in healthy people first, then in people with depression, to see if it could be a helpful new treatment.

Safety and Immunogenicity of an Investigational Pentavalent Meningococcal ABCYW Vaccine Against Meningococcal Disease in Children, Toddlers, and Infants

This study is testing a new vaccine to protect children, toddlers, and babies against meningococcal disease. Researchers want to see if the new vaccine is safe and works well compared to existing vaccines, sometimes given alongside other routine childhood shots.

Randomised, crossover bioequivalence clinical trial of pregabalin 300 mg tablets versus pregabalin 300 mg hard capsules, after a single oral dose administration to healthy volunteers under fasting conditions.

Randomised, crossover bioequivalence clinical trial of rosuvastatin/ezetimibe 20 mg/ 10 mg film-coated tablets versus rosuvastatin/ezetimibe 20 mg/ 10 mg hard capsules, after a single oral dose administration to healthy volunteers under fasting conditions.

Hypoxic ventilatory response (HVR): Effect of Esketamine