RecruitingPHASE1INTERVENTIONAL

A Study to Evaluate ALN-4915 in Adult Healthy Volunteers

This study is testing a new investigational medicine called ALN-4915. It involves healthy adult volunteers between 18 and 65 years old. The main purpose is to see if the medicine is safe and well-tolerated when given to people. Researchers will also learn how the body handles the medicine and what effects it has. Some volunteers will receive ALN-4915, while others will receive a placebo, which looks like the medicine but has no active ingredients. This helps researchers understand the true effects of ALN-4915. This is an early-stage study, meaning it's one of the first times this medicine is being tested in humans.

At a glance

Status

Recruiting

Phase

PHASE1

Sponsor

Alnylam Pharmaceuticals

Enrolment target

Start

02 Mar 2026

Estimated completion

31 Jul 2027

Healthy Volunteers

What is this study about?

This study is designed to learn more about a new medicine called ALN-4915. Think of it as a first step in understanding how this potential new treatment might work. Researchers want to find out if it's safe for people to take and if it causes any unwanted side effects.

They will also look at how the medicine moves through and is processed by the body, and what effects it might have on different body systems. This early information is really important because it helps scientists decide if the medicine should be studied further for specific health conditions in the future.

By taking part, healthy volunteers help gather vital information that could one day lead to new treatments. It's a way of contributing to medical science without having a specific illness.

Key takeaways

This study is testing a new medicine called ALN-4915 in healthy adults.
It aims to check the medicine's safety and how it works in the body.
Participation involves receiving either the medicine or a placebo.
You must be 18-65 years old and healthy to join.
Your contribution helps advance medical research.

Who may be eligible?

To join this study, you need to be a healthy adult between 18 and 65 years old. You must also be willing and able to attend all study appointments and complete any required tests.

There are some reasons why you might not be able to join. For example, if you have certain abnormal liver test results that are higher than what's considered normal, or if you've had an infection caused by certain types of germs that can invade the body. Also, if you know you have problems with your immune system or certain parts of your body's defence mechanisms, you wouldn't be able to take part.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you between 18 and 65 years old?
Are you generally healthy, with no major ongoing medical problems?
Do you have normal liver test results (or within acceptable limits)?
Have you ever had an invasive infection by certain types of bacteria?
Do you have a healthy immune system?

Answer every question to see your result.

What does participation involve?

If you decide to take part, you would receive either the new medicine, ALN-4915, or a placebo (which looks like the medicine but has no active drug). You wouldn't know which one you're getting, and neither would the research team, until the study is over.

Throughout the study, you would attend several visits to the clinic where you might have health check-ups, blood tests, and other assessments to monitor your well-being and see how the medicine is affecting your body. The total number of visits and the overall duration of your participation would be explained in detail by the study team.

Potential risks and benefits

Because this is an early study of a new medicine, the main benefit for you would be helping medical science and potentially contributing to new treatments in the future, rather than a direct health benefit for yourself. As with any medicine, there's always a chance of side effects, even in healthy people. The research team will explain all known or potential risks to you. Remember, you have the right to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

Clinical Trial Site
Verified postcode
London, United Kingdom· Recruiting

Common questions

What is a 'healthy volunteer'?

A healthy volunteer is someone who does not have any significant medical conditions that would affect the study's results or put them at higher risk.

What is a 'placebo'?

A placebo looks exactly like the study medicine but doesn't contain any active ingredients. It helps researchers compare the effects of the actual medicine.

Will I know if I'm getting the medicine or the placebo?

No, neither you nor the study team will know during the study. This is called 'blinding' and helps ensure fair and accurate results.

What are 'pharmacodynamics (PD) and pharmacokinetics (PK)'?

These are simply terms for how the medicine affects your body (PD) and how your body handles the medicine (PK) – how it's absorbed, distributed, and removed.

How long does a study like this usually last?

The full duration of your involvement, including all visits and follow-ups, would be fully explained by the study team if you express interest.

How to find out more

Clinical Trial Information Line

clinicaltrials@alnylam.com 1-877-ALNYLAM Official trial record

Always speak to your GP or specialist before deciding to take part in a study.