A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation

To join this study, your doctor will need to check some things. You must be at least 18 years old. You'll need to have a diagnosis of heart failure, and doctors will look at your heart's pumping ability (called 'ejection fraction') to make sure it's over a certain level. They'll also check for signs of inflammation in your blood and look at specific measurements related to your heart's structure.

Your recent health history is also important. For example, doctors will check if you've had a recent hospital stay or urgent visit for worsening heart failure. They will use blood tests to measure certain substances that indicate heart strain or inflammation.

These checks are important to make sure the study includes people who could benefit most from the treatment being tested and that the results are as clear as possible. Everyone who takes part needs to fit specific health requirements, which your study doctor will explain in detail.

If you decide to take part in this study, it's a commitment that could last up to four years. You would need to attend about 20 clinic visits during this time. At these visits, doctors and nurses will carry out various health checks and tests. You would receive the study medicine, either ziltivekimab or a placebo, as a monthly injection.

You'll be taught how to give yourself these injections either using a pre-filled syringe (which you'd inject into a skinfold) or a pen-injector (which goes into flatter skin). You'll also be asked to use a special app on your smartphone to regularly record when you've taken your injections and to answer questions about how you're feeling and your general health. This helps the study team keep track of your progress and monitor the effects of the treatment.