- active not recruitingNA
REDUCE LAP-HF RANDOMIZED TRIAL I
This study looks at a new small device for people with heart failure. It aims to see if this device can lower high pressure in the heart's upper left chamber, which could help reduce symptoms.
United States · Australia · Belgium - ongoing, recruitingPhase I and Phase II (Integrated)- Other
Safety and Tolerability of AC01 in patients with heart failure
This study is looking at a new medicine called AC01 for people with heart failure. It's an early-stage trial checking if the medicine is safe and if people can take it without too many problems. Both men and women aged 18 and over can take part.
Sweden · Italy · Netherlands - active not recruitingNA
Effects of Telemonitoring on the Outcome of Heart Failure Patients After an Incidence of Acute Decompensation
This study is looking at how a smartphone app called Medly can help people with heart failure manage their condition after leaving hospital. It aims to see if Medly improves their self-care, quality of life, and helps prevent them from needing to be readmitted to hospital soon after discharge.
Canada - recruitingNA
Breast cancEr, FITness and ExeRcise for Heart Health: The BE-FITTER Study
This study looks at how exercise or yoga helps older women who've had breast cancer and chemotherapy. It checks if these activities can improve heart and muscle health and make daily tasks easier.
Canada - recruitingNA
Surgical Ablation of AF Efficacy Trial
This study looks at whether a surgical procedure to treat an irregular heartbeat (atrial fibrillation) during heart surgery can help prevent future heart problems, especially heart failure. It compares adding this procedure to not adding it, in people already having heart surgery.
Canada - recruitingPHASE3
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
This study looks at a new medicine, NNC0487-0111, for people with heart failure and obesity. It compares the medicine to a dummy treatment (placebo) to see if it's safe and helps improve heart health.
United States · Argentina · Australia - recruitingPHASE4
The STOP-MED CTRCD Trial
This study looks at whether it's safe for cancer survivors to stop heart failure medicines if their heart has recovered well. It's for people whose hearts were affected by cancer treatment but are now working normally again.
United States · Australia · Canada - recruitingPHASE3
A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
This study investigates if a new drug, vicadrostat, combined with empagliflozin, can help adults with heart failure and a weakened heart pump. Participants will take study medications for up to 3.5 years, alongside their usual care.
United States · Argentina · Belgium - recruitingNA
BIO|CONCEPT.BIOMONITOR-HF Collect Clinical Data From Heart Failure Patients Using BIOMONITOR Devices With a Study Specific Research Software
This study looks at heart failure patients without special heart devices. We want to understand irregular heartbeats and develop a tool to predict when heart failure might get worse, helping doctors intervene sooner to improve care.
Belgium · Germany - active not recruiting
Real-world Study on Dapagliflozin Usage in Patients With Heart Failure (HF) in Germany
This study looks at how a medicine called dapagliflozin is used for heart failure in Germany. Researchers want to understand how it affects people's symptoms, quality of life, and healthcare needs in everyday situations.
Germany - recruiting
The PAtients pResenTing With COngenital HeaRt DIseAse Register (ARTORIA-R)
This study, called ARTORIA-R, is collecting information from many countries about adults with heart conditions they were born with (congenital heart disease) who need a heart transplant. It aims to understand why some need transplants and how they do afterwards.
Germany - recruiting
IMPRoving Cardiovascular RiSk Stratification Using T1 Mapping in General populatION
This study looks at new ways to spot heart problems early using special MRI scans, especially in people who might have had heart inflammation from things like COVID-19. We want to see how these scans can help improve heart health predictions.
Germany - recruitingNA
Bioimpedance Integration for Optimized Fluid Management in Decompensated Heart Failure
This study looks at whether a special fluid measurement tool, Bioimpedance Analysis (BIA), can help doctors better manage fluid in people with heart failure who are in the hospital. The goal is to see if using BIA reduces readmissions and the need for extra treatment.
United Kingdom - active not recruitingNA
HF-TRACK: A UK RCT of an Passive Heart Failure Monitoring and Tracking Device
This study tests a new device called Heartfelt for people with heart failure. It helps spot early signs of worsening heart failure by checking changes in leg size, aiming to prevent hospital stays. It's for adults aged 18 and over.
United Kingdom - not yet recruitingNA
AV Nodal Ablation With Conduction System Pacing Versus Cardiac Resynchronization for Symptomatic Heart Failure Patients With Atrial Fibrillation
This study compares two ways to help hearts in people with heart failure and a fast, irregular heartbeat (atrial fibrillation). It looks at whether a new pacing method works as well as a standard one after a procedure to control the heart's rhythm, hoping to improve symptoms and quality of life.
France · Germany · Italy - recruiting
Non-interventional Study on Guideline Directed Medical Therapy for Patients With Heart Failure (HF) in Germany
This study in Germany looks at how well hospitals apply the latest guidelines for treating heart failure. It checks if specialist training helps doctors start and adjust heart medications quickly for patients with a specific type of heart failure before they leave the hospital.
Germany - not yet recruitingNA
Resistance Exercise With Blood Flow Restriction by Vascular Occlusion on Myocardial Function in Heart Failure With Reduced Ejection Fraction
This study looks at a special type of exercise called 'blood flow restriction training' for people with heart failure. It aims to see if adding this training to regular resistance exercise helps the heart and muscles more than resistance exercise alone, especially for those unable to do high-intensity workouts.
France - recruiting
Registry to Assess the Safety and Feasibility of the Subpulmonary Support with the Novel Venous Cannula in Patients with Failing/Absence of the Right Heart
This study looks at how well a special device, called an EXCOR Venous Cannula, works in supporting hearts that are struggling. It aims to make sure the device is safe and helps patients get better, both in the short and long term.
Germany - recruitingNA
Perioperative Interdisciplinary, Intersectoral Process Optimization in Heart Failure
This study looks at how a team approach can help older patients (over 65) with or at risk of heart failure having non-heart surgery. It aims to reduce complications after their operation by improving their care before and after surgery.
Germany - not yet recruiting
The PICM Risk Prediction Study - Application of AI to Pacing
This study uses artificial intelligence to find out which people with pacemakers might develop a heart problem called pacemaker-induced cardiomyopathy (PICM). By looking at past patient information, researchers hope to improve how pacemakers are used and prevent this heart issue before it starts.
United Kingdom - recruiting
Intensive Care Unit-acquired Heart Failure in Critically Ill: the ICU-HF Study
This study looks into how a stay in intensive care might affect heart muscle and whether this could lead to heart failure, a condition where the heart struggles to pump blood effectively. Researchers will use special scans to check participants' hearts.
Austria · Germany - active not recruiting
Multivariate Biomarker Study for Sarcopenia in Heart Failure
This study looks at muscle weakness (sarcopenia) in people with heart failure. Researchers want to understand why it happens by checking body measures, blood samples, and how well muscles work. This could help find better ways to diagnose and treat muscle weakness in heart failure.
United Kingdom - recruiting
The Force Frequency Relationship in Heart Failure and Diabetes Mellitus: a Metabolic Aetiology?
This study looks at how your heart's pumping power changes with heart rate, especially if you have heart failure and/or diabetes. We want to understand if problems with how your body uses energy (metabolism) are involved, hoping to find better treatments.
United Kingdom - recruitingNA
The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR
This study looks at a new device, the Carillon Mitral Contour System, for people with heart failure caused by a leaky heart valve. It aims to see if the device is safe and helps improve their condition, comparing it to usual care without the device.
United States · Canada · France - not yet recruitingNA
A Study Testing a New Heart Scan Method to Improve Pacemaker Treatment for Heart Failure
This study looks at a new heart scan measurement, called EF1, to see if it can better predict who will benefit from a pacemaker treatment called Cardiac Resynchronisation Therapy (CRT) for heart failure. We hope this helps more people get the right treatment.
United Kingdom - active not recruiting
Future Innovations in Novel Detection of Heart Failure FIND-HF
This study aims to find new ways to spot heart failure early using computer programmes. It will look at health records to identify people at risk, so they can get help sooner and avoid hospital stays. It's an observational study, meaning no new treatments are given.
United Kingdom - recruitingPHASE3
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
This study looks at a new drug, omecamtiv mecarbil, for people with severe heart failure. It aims to see if the drug can help reduce hospital stays, the need for transplants, or the risk of death compared to a dummy pill.
United States · Canada · China - recruitingPHASE2
Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
This study is looking into a new medication called BMS-986435/MYK-224 for people with a type of heart failure called HFpEF. Researchers want to see if it's safe, how well people tolerate it, and how much of the medicine stays in the body.
United States · Argentina · Canada - recruitingPHASE3
Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin
This study looks at how two medicines, Baxdrostat and dapagliflozin, might help people with heart failure. We're testing if this combination can reduce hospital stays for heart failure or prevent death from heart problems in people with type 2 diabetes and high blood pressure.
United States · Argentina · Australia - recruitingPHASE2, PHASE3
Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
This study is looking at a new medicine called vericiguat for children and young people aged 29 days to 17 years with heart failure. We want to see if it can improve their heart health compared to a dummy medicine.
United States · Belgium · Brazil - recruiting
Study to Collect High-Resolution ECG Data and Patient Insights on Heart Failure Care
This study is gathering heart rhythm data and patient opinions to improve future heart disease research and care. It aims to understand patients' experiences with current heart failure treatments and diagnostic tests, helping to design better studies in the future.
United Kingdom - recruitingNA
Stereotactic Ablative Radiotherapy for the Treatment of Refractory Ventricular Tachycardia
This study looks at a new way to treat a fast, abnormal heart rhythm called ventricular tachycardia (VT). We're testing a special type of radiation, usually used for cancer, to see if it can safely stop VT in people who can't have other treatments or for whom other treatments haven't worked.
United Kingdom - active not recruiting
Impact of Peripheral Vascular Stiffness Assessment on Risk Prediction in Patients With Myocardial Infarction
This study looks at people who have had a heart attack to see how stiff their blood vessels are. We want to find out if this stiffness helps predict future heart problems, especially a type of heart failure, and improve how we look after patients.
France - active not recruitingNA
Cardiac Resynchronization Therapy in Previously Untreatable and High Risk Upgrade Patients
This study looks at a new wireless heart pacing system called WiSE-CRT for people with heart failure who haven't responded to standard treatments or couldn't get them. It aims to see if this new system is safe and effective in improving heart function.
United States · Australia · France - recruiting
Assessment of Physical Activity and Cardiovascular Outcomes in Patients With Chronic Heart Failure
This study looks at how physical activity affects people with heart failure. We want to understand if being active helps improve heart health and reduce hospital stays for heart failure patients in the UK.
Germany · Italy - active not recruitingNA
Pilot Testing of an Online Rehabilitation Intervention for People With Heart Failure (PORIAS-HF).
This study tests a new online exercise program for people with heart failure. We want to see if it's practical and helpful for improving health and independence, especially when in-person programs aren't available.
United Kingdom - ongoing, recruitingTherapeutic exploratory (Phase II)
A multi-center, randomized, placebo- and active-controlled, parallel-group, 24-week proof of concept and dose-finding study to evaluate efficacy, safety, and tolerability of XXB750 in patients with heart failure
This study is looking into a new medication called XXB750 for people with heart failure. It hopes to see how well it works, what dose is best, and if it's safe compared to a dummy treatment or existing medicines.
Netherlands · Italy · Bulgaria - recruitingNA
Development of Novel Physiological CMR Methods in Health and Disease
This study uses special MRI scans to understand how the heart works in healthy people and those with heart conditions. It looks at how the heart responds to small challenges, like a fluid boost, to find better ways to spot and treat heart problems.
United Kingdom - active not recruitingNA
TRISCEND II Pivotal Trial
This study is testing a new device called the Edwards EVOQUE system for people with severe tricuspid valve disease. It compares the device plus regular care to regular care alone, aiming to see if the device is safe and effective.
United States · Germany - recruitingNA
Monitoring Oedema in Heart Failure to Improve Function and Reduce Hospitalisation Risk
This study looks at a new device called Heartfelt for people with heart failure. It helps spot early signs of fluid build-up (swelling) by taking pictures of legs. We want to see if it improves life and reduces hospital stays compared to usual care.
United Kingdom - not yet recruiting
Screening, Characterization, and Longitudinal Follow-up of Patients With Cardiac Amyloidosis
This study looks at people with heart amyloidosis to understand how the condition develops and how treatments work. It involves tests like MRI scans and blood tests over two years to help doctors learn more and improve care for this heart disease.
Germany - enrolling by invitation
Global Utilization And Registry Database for Improved heArt preservatioN
This study looks at how well heart transplants work when donor hearts are carried in a special system called SherpaPak CTS. Researchers will compare outcomes of patients who received hearts using this system to those who received hearts transported in the old way, aiming for better heart preservation.
United States · Austria · Spain - not yet recruitingNA
Remote Monitoring and Optimization of Heart Failure Therapy
This study looks at whether a wearable device can help people with heart failure after a hospital stay. It monitors vital signs to help doctors manage their care better, aiming to reduce future hospital visits and improve well-being.
France · Germany · Italy - active not recruiting
Personalized Therapy Study - Attain Stability Quad Post-Approval Study
This study looks at how well a specific heart device (Model 4798 lead) works over a long time in people with heart failure. It helps doctors understand its performance in everyday life and is required by health regulators.
United States · France · Greece - recruiting
QUAD-HF - Prospective Registry of Patients With Incident Heart Failure and Left Ventricular Ejection Fraction <50%
This study looks at people in the UK recently diagnosed with heart failure, where the heart's main pumping chamber doesn't squeeze as strongly as it should. We want to see how their condition develops, what treatments they receive, and how well hospitals follow national guidance in everyday practice.
United Kingdom - recruitingNA
Screening for earlY Heart Failure Diagnosis and Management in Primary Care or at HOme Using Natriuretic Peptides and echocardiographY "SYMPHONY-HF"
This study, called SYMPHONY-HF, is looking at better ways to find and manage heart failure early in people at risk. It compares standard care to a new approach using a blood test and heart scan to spot the condition sooner.
United States · Canada · Denmark - recruitingNA
Acute Reno-Cardiac Action of Dapagliflozin In Advanced Heart Failure Patients on Heart Transplant Waiting List
This study looks at how a drug called dapagliflozin affects the heart and kidneys in people with severe heart failure waiting for a transplant. Researchers will measure a protein in the blood to see how these organs are doing over six months.
France - recruitingNA
Preventive Catheter Ablation for Ventricular arrhythmiaS in Patients With End-sTage Heart faiLure
This study looks at a procedure called catheter ablation for people with severe heart failure and irregular heartbeats. It aims to see if doing this procedure early can help prevent serious heart problems, reduce needing a heart transplant, or improve overall health.
Germany - recruiting
Retrospective Natural History Study of RASopathy-associated Cardiomyopathy (RAS-CM)
This study looks at past health records of children with a heart condition called RASopathy-associated cardiomyopathy (RAS-CM). We want to learn more about how this condition affects patients over time and gather information that could help develop new treatments for it in the future.
Germany - active not recruiting
REDUCE LAP-HF III Corvia Protocol 1701
This study looks at a new treatment called the IASD System II for people with heart failure. It checks how well it works and if it's safe in everyday use, and if it improves quality of life. It's happening in Germany.
Germany · Switzerland