- recruiting
Preparatory Work for a Trial of Adjuncts to Diuretic Treatment in Patients Hospitalised With Heart Failure: Addressing Uncertainties and Building Consensus
This study is preparing for a future trial about new treatments for heart failure. Researchers are asking doctors, nurses, and heart failure patients and their carers to help design the best way to test these treatments.
United Kingdom - recruitingPHASE2
A Research Study Comparing CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Reduced/Mildly Reduced Ejection Fraction and Left Ventricular Hypertrophy
This study is testing a new medicine, CDR132L, for people with heart failure. It aims to see how the medicine affects the heart's structure and function. Some people will get the new medicine, others a dummy pill, to compare the results over about 60 weeks.
Australia · Czechia · Germany - recruiting
The Force Frequency Relationship in Heart Failure and Diabetes Mellitus: a Metabolic Aetiology?
This study looks at how your heart's pumping power changes with heart rate, especially if you have heart failure and/or diabetes. We want to understand if problems with how your body uses energy (metabolism) are involved, hoping to find better treatments.
United Kingdom - recruiting
Lifestyle Behaviours of Women Newly Diagnosed With Heart Failure
This study looks at the daily activities, sleep, and overall well-being of women newly diagnosed with heart failure. We want to understand what helps or hinders them in staying active, as women have often been overlooked in heart failure research.
United Kingdom - active not recruiting
Multi-morbidity Screening in People With Type 2 Diabetes and Pre Diabetes
This study checks for other health issues often linked with Type 2 diabetes and pre-diabetes, like problems with your heart, liver, or sleep. It's testing a new, more thorough health check-up to find these problems earlier.
United Kingdom - recruitingNA
Bioimpedance Integration for Optimized Fluid Management in Decompensated Heart Failure
This study looks at whether a special fluid measurement tool, Bioimpedance Analysis (BIA), can help doctors better manage fluid in people with heart failure who are in the hospital. The goal is to see if using BIA reduces readmissions and the need for extra treatment.
United Kingdom - recruitingPHASE1
A Research Study on the Effects of NNC0537-1482 in Participants With Heart Failure
This study is testing a new medicine called NNC0537-1482 for people with heart failure. We're looking at its safety and how it works. Some will get the new medicine, others a dummy medicine. It lasts about two months, plus a check-up period.
United Kingdom - authorisedTherapeutic use (Phase IV)
Discontinuation or Continuation of SGLT-2 Inhibitors Before Cardiac Surgery: Impact on Postoperative Cardiovascular Outcomes – DISCO Study
This study looks at whether continuing or stopping certain heart failure medications (SGLT-2 inhibitors) before heart surgery affects how well patients recover. It aims to improve outcomes for people with heart failure having surgery.
France - recruitingPHASE2
Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
This study is looking into a new medication called BMS-986435/MYK-224 for people with a type of heart failure called HFpEF. Researchers want to see if it's safe, how well people tolerate it, and how much of the medicine stays in the body.
United States · Argentina · Canada - active not recruitingNA
HF-TRACK: A UK RCT of an Passive Heart Failure Monitoring and Tracking Device
This study tests a new device called Heartfelt for people with heart failure. It helps spot early signs of worsening heart failure by checking changes in leg size, aiming to prevent hospital stays. It's for adults aged 18 and over.
United Kingdom - active not recruitingNA
REDUCE LAP-HF TRIAL II
This study looks at a new tiny device, the IASD System II, for people with heart failure. It aims to see if this implant can improve symptoms and quality of life by helping the heart manage pressure better. Half the people get the implant, and half get a check-up without it.
United States · Australia · Austria - recruitingNA
Stereotactic Ablative Radiotherapy for the Treatment of Refractory Ventricular Tachycardia
This study looks at a new way to treat a fast, abnormal heart rhythm called ventricular tachycardia (VT). We're testing a special type of radiation, usually used for cancer, to see if it can safely stop VT in people who can't have other treatments or for whom other treatments haven't worked.
United Kingdom - recruiting
IRONHEART: Intravenous Iron in Non-ischaemic Heart Failure
This study looks at how giving iron through a drip (intravenous iron) affects people with a specific type of heart failure and iron deficiency. It aims to see if it improves heart function and overall well-being.
United Kingdom - recruitingNA
Smartphone Twelve-Lead ECG Utility In ST-Elevation Myocardial Infarction II
This study is testing a new smartphone device called AliveCor 12-lead ECG. It aims to see if this device can accurately detect heart attacks (STEMI and NSTEMI) in people with chest pain, just as well as the standard ECG machines used in hospitals.
United States · United Kingdom - recruiting
A Prospective, Observational, Single Centre Study to Assess the Feasibility of the Data Harvested by the Acorai Intracardiac Pressure Monitoring (ICPM) System in Predicting Prognosis in Patients Discharged From Hospital After Treatment for Acute Decompensated Heart Failure
This study is testing a new, easy-to-use device called the Acorai Heart Monitor. It hopes to measure heart pressures from outside your body, helping doctors understand heart failure better and predict how patients might do after leaving the hospital. This could make monitoring safer and simpler.
United Kingdom - recruiting
Utilising AI Analysis of Sounds To prEdict heaRt failurE decOmpensation
This study is looking into a new way to spot early signs of worsening heart failure using AI to listen to changes in sounds like your voice and breathing. This could help doctors treat you sooner and potentially reduce hospital visits.
United Kingdom - recruitingNA
Development of Novel Physiological CMR Methods in Health and Disease
This study uses special MRI scans to understand how the heart works in healthy people and those with heart conditions. It looks at how the heart responds to small challenges, like a fluid boost, to find better ways to spot and treat heart problems.
United Kingdom - enrolling by invitation
Global Utilization And Registry Database for Improved heArt preservatioN
This study looks at how well heart transplants work when donor hearts are carried in a special system called SherpaPak CTS. Researchers will compare outcomes of patients who received hearts using this system to those who received hearts transported in the old way, aiming for better heart preservation.
United States · Austria · Spain - active not recruitingNA
Targeted Assessment in High-Risk paTients With dIAbetes to ideNtify Undiagnosed Heart Failure
This study looks at a new way to find hidden heart failure in people with diabetes who are at higher risk. We're testing if checking a specific blood marker helps doctors discover heart problems earlier, so people can get the right care sooner.
United Kingdom - not yet recruitingNA
Remote Monitoring and Optimization of Heart Failure Therapy
This study looks at whether a wearable device can help people with heart failure after a hospital stay. It monitors vital signs to help doctors manage their care better, aiming to reduce future hospital visits and improve well-being.
France · Germany · Italy - recruiting
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
This study aims to understand why common medicines don't work the same for everyone in the UK, especially for people from different backgrounds. It will look at many health conditions, hoping to improve how we treat them and make healthcare fairer for all.
United Kingdom - recruitingNA
pErsonalised Nocebo Assessment of Beta-blockEr Symptoms in Heart Failure
This study looks into why some people with heart failure stop taking important beta-blocker medicines. We want to find out if their symptoms are real side effects or if worries about side effects play a role, helping more people stay on effective treatment.
United Kingdom - recruitingNA
The Effect of Obesity and Weight Loss in Heart Failure With Reduced Ejection Fraction.
This study explores if losing weight can improve the heart's health and quality of life for people with a specific type of heart failure. Participants will follow a supervised diet plan or continue their usual care.
Jersey · United Kingdom - recruitingPHASE3
A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation
This study is looking into a new medicine called ziltivekimab for people with heart failure and inflammation. It compares ziltivekimab to a dummy medicine (placebo) to see if it can help. The treatment you receive is chosen by chance, and the study will last up to 1 year and 4 months.
United States · Argentina · Australia - recruitingNA
Hybrid Ablation of Atrial Fibrillation in Heart Failure
This study looks at a new way to treat persistent atrial fibrillation (a type of irregular heartbeat) in people who also have heart failure. It compares a combined treatment (hybrid ablation) with the usual treatment to see which works best at keeping a steady heart rhythm.
United Kingdom - recruiting
Biomarkers in Patients With Suspected HFpEF
This study looks for better ways to spot heart failure, especially in people with obesity or low levels of a common blood test. Researchers hope to find new blood markers to help doctors diagnose heart failure more accurately and earlier.
United Kingdom - not yet recruiting
Left Bundle Branch Area Pacing 3D Guidance System
This study is developing a smart computer system to improve how pacemakers are fitted for people with certain heart conditions. It aims to help doctors place the pacemaker lead more accurately, potentially leading to better results for patients.
United Kingdom - recruitingPHASE4
The STOP-MED CTRCD Trial
This study looks at whether it's safe for cancer survivors to stop heart failure medicines if their heart has recovered well. It's for people whose hearts were affected by cancer treatment but are now working normally again.
United States · Australia · Canada - active not recruitingNA
Evaluate the Safety and Performance of the AccuCinch® Ventricular Repair System - The CorCinch-EU Study
This study is testing a new device, the AccuCinch® system, for people with severe heart failure. It aims to see how safe and effective it is at improving heart function and symptoms, especially for those whose heart is enlarged and not pumping well.
Belarus · Belgium · Czechia - active not recruiting
Outcomes of Patients Who Survived Treatment on an Intensive Care Unit for COVID-19 in England and Wales
This study looks at the health of people in England and Wales one year after they left intensive care for COVID-19. Researchers will compare their health to people who were in intensive care for other reasons. The aim is to understand long-term health effects.
United Kingdom - active not recruitingNA
Cardiac Resynchronization Therapy in Previously Untreatable and High Risk Upgrade Patients
This study looks at a new wireless heart pacing system called WiSE-CRT for people with heart failure who haven't responded to standard treatments or couldn't get them. It aims to see if this new system is safe and effective in improving heart function.
United States · Australia · France - recruiting
POWER Myocardial Fatigue Study: a Biomechanical Assessment of Contractility of Human Myocardium
This study aims to understand why hearts get tired in heart failure. Researchers will look at human heart tissue to learn how it works under different conditions and stress, hoping to find new ways to help hearts recover and reduce fatigue.
United Kingdom - recruitingPHASE3
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
This study looks at a new drug, omecamtiv mecarbil, for people with severe heart failure. It aims to see if the drug can help reduce hospital stays, the need for transplants, or the risk of death compared to a dummy pill.
United States · Canada · France - recruitingNA
Monitoring Oedema in Heart Failure to Improve Function and Reduce Hospitalisation Risk
This study looks at a new device called Heartfelt for people with heart failure. It helps spot early signs of fluid build-up (swelling) by taking pictures of legs. We want to see if it improves life and reduces hospital stays compared to usual care.
United Kingdom - active not recruiting
Epidemiology of Complications After Solid Organ Transplantation - EpCOT Study
This study looks at health problems, especially cancer, after organ transplants in the UK. Researchers are combining existing patient information to better understand why cancer happens and how it affects people after a transplant, to help improve care.
United Kingdom - active not recruitingNA
Triple Cardiovascular Disease Detection With an Artificial Intelligence-enabled Stethoscope
This study is testing a new AI-powered stethoscope to see if it can help doctors in local clinics find heart problems like heart failure earlier. The aim is to improve heart health and reduce emergency hospital visits for these conditions.
United Kingdom - recruiting
The Sarcopenia Study
This study looks at muscle weakness, called sarcopenia, in people with heart failure. Researchers want to see if different types of heart failure affect how common sarcopenia is, comparing heart failure patients to healthy people and those with type 2 diabetes.
United Kingdom - active not recruiting
Personalized Therapy Study - HFRS (TriageHF) Post Approval Study
This study looks at how a special feature called TriageHF on Medtronic heart devices helps people with heart failure. Researchers will watch how these devices are used in everyday care to see how well they work after being released for general use.
United States · France · Greece - recruitingPHASE2, PHASE3
Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
This study is looking at a new medicine called vericiguat for children and young people aged 29 days to 17 years with heart failure. We want to see if it can improve their heart health compared to a dummy medicine.
United States · Belgium · Brazil - not yet recruiting
The PICM Risk Prediction Study - Application of AI to Pacing
This study uses artificial intelligence to find out which people with pacemakers might develop a heart problem called pacemaker-induced cardiomyopathy (PICM). By looking at past patient information, researchers hope to improve how pacemakers are used and prevent this heart issue before it starts.
United Kingdom - recruitingPHASE4
Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure
This study compares a drug called acalabrutinib with other standard treatments for people with chronic leukaemia and heart problems. It aims to see how safe and well acalabrutinib works in this group, particularly focusing on its effects on the heart.
United States · Czechia · Italy - not yet recruiting
Detecting the Undetected: Heart Failure Screening at the Lymphoedema Point of Care
This study looks for undiagnosed heart failure in people with leg swelling (lymphoedema). It uses a quick test at the clinic to find heart problems early, aiming to prevent serious complications and improve care without extra trips to the GP.
United Kingdom - active not recruiting
Multivariate Biomarker Study for Sarcopenia in Heart Failure
This study looks at muscle weakness (sarcopenia) in people with heart failure. Researchers want to understand why it happens by checking body measures, blood samples, and how well muscles work. This could help find better ways to diagnose and treat muscle weakness in heart failure.
United Kingdom - recruitingPHASE2
Sotagliflozin in Patients With Heart Failure Symptoms and Type 1 Diabetes
This study looks at whether a tablet called sotagliflozin can help people with type 1 diabetes and heart failure feel better. We're testing if it improves their quality of life and is safe, compared to a dummy pill.
United Kingdom - recruiting
QUAD-HF - Prospective Registry of Patients With Incident Heart Failure and Left Ventricular Ejection Fraction <50%
This study looks at people in the UK recently diagnosed with heart failure, where the heart's main pumping chamber doesn't squeeze as strongly as it should. We want to see how their condition develops, what treatments they receive, and how well hospitals follow national guidance in everyday practice.
United Kingdom - enrolling by invitationNA
Pacing in Heart Failure With Preserved LVEF
This study looks at how a special pacemaker might help people with heart failure. Researchers will try different settings on the pacemaker in 10 volunteers to see if it improves their hearts' function and symptoms.
United Kingdom - recruitingNA
Atrial Fibrillation Ablation Versus Atrioventricular Nodal Ablation with Conduction System Pacing in Heart Failure
This study compares two treatments for people with long-term atrial fibrillation and heart failure: one uses a pacemaker and a procedure to block faulty signals, the other uses a procedure to reset the heart's rhythm. It aims to see which is better at improving health.
Austria · Belgium · Bulgaria - not yet recruiting
Biomarkers for the Assessment of Congestion in Patients With Ambulatory and Hospitalised Heart Failure
This study is testing new blood and urine tests for people with heart failure. It hopes these new tests will better spot when fluid is building up in the body, which can help doctors treat patients sooner and potentially prevent hospital stays.
United Kingdom - recruiting
Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
This study looks at how well Medtronic heart devices, like pacemakers and defibrillators, perform over a long time. It helps ensure these devices are reliable and safe for people with heart conditions such as irregular heartbeats or heart failure.
United States · Australia · Austria - recruitingPHASE2
A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)
This study is testing a new medicine, PF-07328948, for adults with heart failure. We want to see if it's safe and helps improve symptoms when taken alongside existing treatments. Volunteers will take the medicine or a dummy pill for 36 weeks.
United States · Brazil · Bulgaria