- recruitingPHASE3
A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients With Heart Failure (CONFIRMATION-HF)
This study looks at combining two medicines, Finerenone and Empagliflozin, for people in the hospital with heart failure. We want to see if this combination works better and is safe compared to usual care for managing their condition.
United States · Brazil · Canada - authorisedTherapeutic exploratory (Phase II)
A Phase 2, randomized, double-blind, placebo-controlled trial to evaluate the efficacy, safety, and tolerability of CRD-4730 in patients with heart failure with reduced ejection fraction (HFREF) (CALIBRATE-HF)
This study is testing a new tablet called CRD-4730 for adults with heart failure. Researchers want to see if the medicine can help the heart pump blood better, ease everyday symptoms, and improve quality of life. Participants will take either the study drug or a dummy pill for 24 weeks.
Latvia · Slovakia · Lithuania - recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Pharmacokinetics of inhaled levosimendan: a pilot study
This early-stage study looks at a heart medicine called levosimendan. Doctors usually give it through a drip, but this trial tests breathing it in as a mist. Researchers want to see how safely and quickly the body absorbs the inhaled medicine in adults with heart failure.
Belgium - authorisedTherapeutic confirmatory (Phase III)
Achieve - ACetazolamide in patients with Heart failure, to decrease weight and relIEVE symptoms
Heart failure can cause fluid to build up in the body, leading to breathlessness and swollen legs. The Achieve study tests whether an extra water tablet called acetazolamide (Diamox) helps patients safely lose excess fluid weight over five days, alongside their usual heart medicines, to help them feel better faster.
France - recruitingTherapeutic exploratory (Phase II)
A Phase 2 Proof-of-Concept clinical trial to quantify myocardial manganese uptake rate by cardiovascular magnetic resonance imaging following mangafodipir trisodium administration in healthy volunteers and heart failure patients with preserved ejection fraction caused by hypertrophic cardiomyopathy or cardiac amyloidosis.
This study looks at how a special scan can show how much manganese goes into the heart, comparing healthy people with those who have heart failure due to specific conditions. The aim is to see if this method can help us understand these heart problems better.
Norway - recruitingTherapeutic use (Phase IV)
Effects of Digoxin in Modern Heart Failure Treatment
This study looks at how well the medicine Digoxin works for people with heart failure. It checks how much oxygen your body uses during exercise and how well your heart pumps, to understand its effects in modern treatments.
Portugal - recruitingTherapeutic confirmatory (Phase III)
Hydralazine-ISDN in Patients With Chronic Heart Failure - Hydralazine Heart Failure Trial (H-HeFT) Metformin in Patients with Chronic Heart Failure and Diabetes or Insulin Resistance - Metformin Heart Failure Trial (Met-HeFT) A randomized, 2 x 2 factorial designed, double-blind, placebo controlled study (DANHEART).
This study looks at two different treatments, BiDil and Metformin, for people with long-term heart failure. Researchers want to see if these treatments can reduce serious events like hospital stays, heart transplants, or heart attacks, and improve overall health.
Denmark - recruitingHuman Pharmacology (Phase I)- First administration to humans
A research study on the effects of NNC0537-1482 in healthy individuals when injected under the skin.
This study is looking at a new medicine, NNC0537-1482, for heart failure. It's the first time it’s being given to people. Healthy adults will receive an injection under their skin to see how safe it is and how it works in the body.
Netherlands - recruitingTherapeutic use (Phase IV)
DECISION; Digoxin Evaluation in Chronic heart failure: Investigational Study In Outpatients in the Netherlands
This study, called DECISION, is looking at digoxin, a common medicine, for people with heart failure in the Netherlands. It wants to see if digoxin helps reduce hospital visits for heart failure and prevent heart-related deaths in patients who are not in the hospital.
Netherlands - recruitingHuman Pharmacology (Phase I)- Other
A study to Learn If Study Medicines Called Cyclosporine and Clarithromycin Affect How the Body Processes the Other Study Medicine Called PF-07328948 in Healthy Adults.
This study is looking at how two medicines, Cyclosporine and Clarithromycin, might change how your body handles a new medicine called PF-07328948. It's for healthy adults and aims to understand if these medicines interact with each other.
Belgium - recruitingPHASE3
A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
This study investigates if a new drug, vicadrostat, combined with empagliflozin, can help adults with heart failure and a weakened heart pump. Participants will take study medications for up to 3.5 years, alongside their usual care.
United States · Argentina · Belgium - recruiting
Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
This study looks at how well Medtronic heart devices, like pacemakers and defibrillators, perform over a long time. It helps ensure these devices are reliable and safe for people with heart conditions such as irregular heartbeats or heart failure.
United States · Australia · Austria - recruitingPHASE3
Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin
This study looks at how two medicines, Baxdrostat and dapagliflozin, might help people with heart failure. We're testing if this combination can reduce hospital stays for heart failure or prevent death from heart problems in people with type 2 diabetes and high blood pressure.
United States · Argentina · Australia - recruitingPHASE3
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
This study looks at a new medicine, NNC0487-0111, for people with heart failure and obesity. It compares the medicine to a dummy treatment (placebo) to see if it's safe and helps improve heart health.
United States · Argentina · Australia - recruitingPHASE2, PHASE3
Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
This study is looking at a new medicine called vericiguat for children and young people aged 29 days to 17 years with heart failure. We want to see if it can improve their heart health compared to a dummy medicine.
United States · Belgium · Brazil - active not recruitingPHASE2
Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
This study is looking into a new medication called BMS-986435/MYK-224 for people with a type of heart failure called HFpEF. Researchers want to see if it's safe, how well people tolerate it, and how much of the medicine stays in the body.
United States · Argentina · Canada - recruitingPHASE3
A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
This study looks into a new treatment for adults with heart failure. It combines two medicines, vicadrostat and empagliflozin, to see if they can improve heart health in people with a specific type of heart failure. Participants take tablets daily and are closely monitored.
United States · Argentina · Australia - recruiting
Using handheld ultrasound in community centres to help diagnose heart failure earlier
This study tests whether handheld heart scans in local community centres can help diagnose heart failure earlier. Using small ultrasound devices with artificial intelligence, trained healthcare staff will scan patients closer to home. The goal is to see if this speeds up care compared to waiting for hospital tests.
United Kingdom · England - recruitingPhase I and Phase II (Integrated)- Other
Safety and Tolerability of AC01 in patients with heart failure
This study is looking at a new medicine called AC01 for people with heart failure. It's an early-stage trial checking if the medicine is safe and if people can take it without too many problems. Both men and women aged 18 and over can take part.
Sweden · Italy · Netherlands - recruitingTherapeutic exploratory (Phase II)
A multi-center, randomized, placebo- and active-controlled, parallel-group, 24-week proof of concept and dose-finding study to evaluate efficacy, safety, and tolerability of XXB750 in patients with heart failure
This study is looking into a new medication called XXB750 for people with heart failure. It hopes to see how well it works, what dose is best, and if it's safe compared to a dummy treatment or existing medicines.
Netherlands · Italy · Bulgaria - recruitingHuman Pharmacology (Phase I)- Other
A Study to Learn How Different Amounts of the Study Medicine Called PF-07328948 are Tolerated and Act in the Body in Healthy Adults
This study is looking at a new medicine called PF-07328948 in healthy adults. We want to find out what doses are safe and how the medicine works in the body. It's an early stage study to understand the drug better, and is not for people with heart failure.
Belgium - recruitingTherapeutic exploratory (Phase II)
C3651011 - A PHASE 2, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, 4-ARM STUDY TO INVESTIGATE SYMPTOMS, FUNCTION, HEALTH-RELATED QUALITY OF LIFE AND SAFETY WITH REPEATED SUBCUTANEOUS ADMINISTRATION OF PONSEGROMAB VERSUS PLACEBO IN ADULT PARTICIPANTS WITH HEART FAILURE
This study is testing a new medicine, ponsegromab, for people with heart failure. We want to see if it improves symptoms like breathlessness and tiredness, how well people can do daily activities, and their overall quality of life, compared to a dummy medicine.
Germany · Poland · Hungary - active not recruitingNA
Cardiac Resynchronization Therapy in Previously Untreatable and High Risk Upgrade Patients
This study looks at a new wireless heart pacing system called WiSE-CRT for people with heart failure who haven't responded to standard treatments or couldn't get them. It aims to see if this new system is safe and effective in improving heart function.
United States · Australia · France - enrolling by invitation
Global Utilization And Registry Database for Improved heArt preservatioN
This study looks at how well heart transplants work when donor hearts are carried in a special system called SherpaPak CTS. Researchers will compare outcomes of patients who received hearts using this system to those who received hearts transported in the old way, aiming for better heart preservation.
United States · Austria · Spain - active not recruitingNA
REDUCE LAP-HF RANDOMIZED TRIAL I
This study looks at a new small device for people with heart failure. It aims to see if this device can lower high pressure in the heart's upper left chamber, which could help reduce symptoms.
United States · Australia · Belgium - active not recruitingNA
Effects of Telemonitoring on the Outcome of Heart Failure Patients After an Incidence of Acute Decompensation
This study is looking at how a smartphone app called Medly can help people with heart failure manage their condition after leaving hospital. It aims to see if Medly improves their self-care, quality of life, and helps prevent them from needing to be readmitted to hospital soon after discharge.
Canada - recruitingNA
Breast cancEr, FITness and ExeRcise for Heart Health: The BE-FITTER Study
This study looks at how exercise or yoga helps older women who've had breast cancer and chemotherapy. It checks if these activities can improve heart and muscle health and make daily tasks easier.
Canada - recruitingNA
Surgical Ablation of AF Efficacy Trial
This study looks at whether a surgical procedure to treat an irregular heartbeat (atrial fibrillation) during heart surgery can help prevent future heart problems, especially heart failure. It compares adding this procedure to not adding it, in people already having heart surgery.
Canada - active not recruiting
Real-world Study on Dapagliflozin Usage in Patients With Heart Failure (HF) in Germany
This study looks at how a medicine called dapagliflozin is used for heart failure in Germany. Researchers want to understand how it affects people's symptoms, quality of life, and healthcare needs in everyday situations.
Germany - recruitingPHASE4
The STOP-MED CTRCD Trial
This study looks at whether it's safe for cancer survivors to stop heart failure medicines if their heart has recovered well. It's for people whose hearts were affected by cancer treatment but are now working normally again.
United States · Australia · Canada - recruitingNA
BIO|CONCEPT.BIOMONITOR-HF Collect Clinical Data From Heart Failure Patients Using BIOMONITOR Devices With a Study Specific Research Software
This study looks at heart failure patients without special heart devices. We want to understand irregular heartbeats and develop a tool to predict when heart failure might get worse, helping doctors intervene sooner to improve care.
Belgium · Germany - recruiting
The PAtients pResenTing With COngenital HeaRt DIseAse Register (ARTORIA-R)
This study, called ARTORIA-R, is collecting information from many countries about adults with heart conditions they were born with (congenital heart disease) who need a heart transplant. It aims to understand why some need transplants and how they do afterwards.
Germany - recruiting
IMPRoving Cardiovascular RiSk Stratification Using T1 Mapping in General populatION
This study looks at new ways to spot heart problems early using special MRI scans, especially in people who might have had heart inflammation from things like COVID-19. We want to see how these scans can help improve heart health predictions.
Germany - recruitingNA
Bioimpedance Integration for Optimized Fluid Management in Decompensated Heart Failure
This study looks at whether a special fluid measurement tool, Bioimpedance Analysis (BIA), can help doctors better manage fluid in people with heart failure who are in the hospital. The goal is to see if using BIA reduces readmissions and the need for extra treatment.
United Kingdom - active not recruitingNA
HF-TRACK: A UK RCT of an Passive Heart Failure Monitoring and Tracking Device
This study tests a new device called Heartfelt for people with heart failure. It helps spot early signs of worsening heart failure by checking changes in leg size, aiming to prevent hospital stays. It's for adults aged 18 and over.
United Kingdom - not yet recruitingNA
AV Nodal Ablation With Conduction System Pacing Versus Cardiac Resynchronization for Symptomatic Heart Failure Patients With Atrial Fibrillation
This study compares two ways to help hearts in people with heart failure and a fast, irregular heartbeat (atrial fibrillation). It looks at whether a new pacing method works as well as a standard one after a procedure to control the heart's rhythm, hoping to improve symptoms and quality of life.
France · Germany · Italy - recruitingPHASE3
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
This study looks at a new drug, omecamtiv mecarbil, for people with severe heart failure. It aims to see if the drug can help reduce hospital stays, the need for transplants, or the risk of death compared to a dummy pill.
United States · Canada · China - recruiting
Non-interventional Study on Guideline Directed Medical Therapy for Patients With Heart Failure (HF) in Germany
This study in Germany looks at how well hospitals apply the latest guidelines for treating heart failure. It checks if specialist training helps doctors start and adjust heart medications quickly for patients with a specific type of heart failure before they leave the hospital.
Germany - not yet recruitingNA
Resistance Exercise With Blood Flow Restriction by Vascular Occlusion on Myocardial Function in Heart Failure With Reduced Ejection Fraction
This study looks at a special type of exercise called 'blood flow restriction training' for people with heart failure. It aims to see if adding this training to regular resistance exercise helps the heart and muscles more than resistance exercise alone, especially for those unable to do high-intensity workouts.
France - recruiting
Registry to Assess the Safety and Feasibility of the Subpulmonary Support with the Novel Venous Cannula in Patients with Failing/Absence of the Right Heart
This study looks at how well a special device, called an EXCOR Venous Cannula, works in supporting hearts that are struggling. It aims to make sure the device is safe and helps patients get better, both in the short and long term.
Germany - recruitingNA
Perioperative Interdisciplinary, Intersectoral Process Optimization in Heart Failure
This study looks at how a team approach can help older patients (over 65) with or at risk of heart failure having non-heart surgery. It aims to reduce complications after their operation by improving their care before and after surgery.
Germany - active not recruiting
Multivariate Biomarker Study for Sarcopenia in Heart Failure
This study looks at muscle weakness (sarcopenia) in people with heart failure. Researchers want to understand why it happens by checking body measures, blood samples, and how well muscles work. This could help find better ways to diagnose and treat muscle weakness in heart failure.
United Kingdom - not yet recruiting
The PICM Risk Prediction Study - Application of AI to Pacing
This study uses artificial intelligence to find out which people with pacemakers might develop a heart problem called pacemaker-induced cardiomyopathy (PICM). By looking at past patient information, researchers hope to improve how pacemakers are used and prevent this heart issue before it starts.
United Kingdom - recruiting
Intensive Care Unit-acquired Heart Failure in Critically Ill: the ICU-HF Study
This study looks into how a stay in intensive care might affect heart muscle and whether this could lead to heart failure, a condition where the heart struggles to pump blood effectively. Researchers will use special scans to check participants' hearts.
Austria · Germany - recruiting
The Force Frequency Relationship in Heart Failure and Diabetes Mellitus: a Metabolic Aetiology?
This study looks at how your heart's pumping power changes with heart rate, especially if you have heart failure and/or diabetes. We want to understand if problems with how your body uses energy (metabolism) are involved, hoping to find better treatments.
United Kingdom - not yet recruitingNA
A Study Testing a New Heart Scan Method to Improve Pacemaker Treatment for Heart Failure
This study looks at a new heart scan measurement, called EF1, to see if it can better predict who will benefit from a pacemaker treatment called Cardiac Resynchronisation Therapy (CRT) for heart failure. We hope this helps more people get the right treatment.
United Kingdom - recruitingNA
The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR
This study looks at a new device, the Carillon Mitral Contour System, for people with heart failure caused by a leaky heart valve. It aims to see if the device is safe and helps improve their condition, comparing it to usual care without the device.
United States · Canada · France - active not recruiting
Future Innovations in Novel Detection of Heart Failure FIND-HF
This study aims to find new ways to spot heart failure early using computer programmes. It will look at health records to identify people at risk, so they can get help sooner and avoid hospital stays. It's an observational study, meaning no new treatments are given.
United Kingdom - recruiting
Study to Collect High-Resolution ECG Data and Patient Insights on Heart Failure Care
This study is gathering heart rhythm data and patient opinions to improve future heart disease research and care. It aims to understand patients' experiences with current heart failure treatments and diagnostic tests, helping to design better studies in the future.
United Kingdom - recruitingNA
Stereotactic Ablative Radiotherapy for the Treatment of Refractory Ventricular Tachycardia
This study looks at a new way to treat a fast, abnormal heart rhythm called ventricular tachycardia (VT). We're testing a special type of radiation, usually used for cancer, to see if it can safely stop VT in people who can't have other treatments or for whom other treatments haven't worked.
United Kingdom