A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy

To join this study, you would need to be between 40 and 84 years old. You should have been diagnosed with ongoing heart failure that causes symptoms for at least three months, and you need to be taking daily water tablets (diuretics). Your heart failure should be stable, and you should be on your usual heart failure medicines without recent changes.

An important part of this study is that your heart's main pumping chamber (left ventricle) needs to be able to pump blood effectively, which doctors will check with a scan. However, this pumping chamber also needs to show signs of being thicker than normal, which will also be measured. Your Body Mass Index (BMI), a measure of weight in relation to height, needs to be between 18.5 and 40, and your total weight should be no more than 140 kg.

There are also some reasons you might not be able to participate. For example, if you have severe kidney problems, or if you've recently had a heart attack or an episode of acute kidney failure. The study doctors will carefully review all your medical information to see if you are a good fit.

If you decide to take part in this study, you would be involved for approximately 60 weeks, which is about a year and three months. During this time, you would have regular visits to the clinic for check-ups and assessments. The study involves taking either the new medicine, CDR132L, or a placebo, which means a dummy pill with no active ingredients. You won't know which one you're receiving, and it will be decided randomly, like flipping a coin.

At these visits, doctors and nurses will monitor your health closely. This will involve physical examinations, providing blood and urine samples, and having heart scans (like an echocardiogram) to see how your heart's structure and function are changing. These tests help the researchers understand how the potential new medicine is working. You will receive clear instructions on how to take the study medication and what to expect at each appointment.