A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)
This research study, called BRANCH-HF, is looking into a new medicine named PF-07328948 for adults living with heart failure. The main goal is to find out if this new medicine is safe to use and if it can help improve heart failure symptoms when added to the usual treatments people are already taking. Participants will be given either the new medicine or a 'dummy' pill (placebo) to take once a day for 36 weeks. We’ll be comparing the effects to understand how well it works and if it has any side effects. Involvement in the study lasts about 48 weeks in total, with a mix of clinic and home visits.
At a glance
What is this study about?
You might be interested in this study if you have heart failure and are looking for information about new treatments. This study is testing a new medicine called PF-07328948. It's designed to see if this medicine can improve your heart's health and help you feel better. The research is in an early stage, which means we are trying to get a better understanding of how the medicine works, how safe it is, and what effects it has on people with heart failure.
Heart failure is a condition where your heart struggles to pump enough blood around your body. Even if you're already taking medicines for heart failure, this study is looking at whether adding PF-07328948 could offer more benefits. This new medicine is being compared to a 'placebo', which looks exactly like the study medicine but contains no active ingredients. This helps doctors tell if any changes in your health are due to the new medicine or something else.
By taking part, you'd be helping doctors learn more about heart failure and potentially find new ways to help people living with this condition. Every participant's experience is important in building a complete picture of the medicine's effects.
Key takeaways
- Tests a new medicine (PF-07328948) for heart failure.
- Compares the new medicine against a 'dummy' pill (placebo).
- Participation lasts about 48 weeks, with 15 clinic or phone visits.
- You continue your current heart failure medicines.
- Aims to understand safety and how well the medicine works.
- Suitable for adults aged 18-79 with a confirmed heart failure diagnosis.
Who may be eligible?
To join this study, you generally need to be an adult between 18 and 79 years old and have a confirmed diagnosis of heart failure for at least three months. Your heart failure symptoms should fall within a certain range, meaning you may experience some impact on your daily life but not be severely limited. Doctors will also check that your heart's pumping ability is above a certain level.
There are also reasons why you might not be able to join. For example, if you have Type 1 diabetes, certain liver problems, or other conditions that might affect how your body uses the medicine. If you've had a heart transplant, are waiting for one, or have certain other serious heart conditions, you wouldn't be able to take part. Also, if you know you're allergic to or can't take certain existing heart failure medicines (called SGLT2 inhibitors), this study might not be right for you.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you between 18 and 79 years old?
- Have you been diagnosed with heart failure for at least 3 months?
- Do you have some symptoms of heart failure that affect your daily life?
- Are you currently taking standard heart failure medicines, including SGLT2 inhibitors?
- Do you *not* have Type 1 diabetes, serious liver problems, or have you *not* had a heart transplant?
What does participation involve?
If you join this study, you'll be involved for about 48 weeks in total. For the main part of the study, you'll take tablets by mouth once a day for 36 weeks. You'll either receive the new study medicine (PF-07328948) or a dummy pill (placebo); neither you nor your study doctor will know which you are taking. You will continue to take your regular heart failure medicines at the same time.
During these 48 weeks, you'll have 15 appointments. About 10 of these will be at the study clinic, where doctors and nurses will check your health, ask about your symptoms, and do tests to see how you're responding to the treatment. The other 5 appointments might be done over the phone, which could be more convenient for you. These visits are important for keeping track of your health and the medicine's effects.
Potential risks and benefits
Locations (142)
- National Heart InstituteVerified postcodeBeverly Hills, United States· Recruiting
- Orange County Research CenterVerified postcodeLake Forest, United States· Recruiting
- Comprehensive Cardiovascular CareVerified postcodeSanta Maria, United States· Recruiting
- FOMAT Medical ResearchVerified postcodeSanta Maria, United States· Recruiting
- FWD Clinical ResearchVerified postcodeBoca Raton, United States· Active not recruiting
- Jacksonville Center for Clinical ResearchVerified postcodeJacksonville, United States· Recruiting
- Infinite Clinical ResearchVerified postcodeMiami, United States· Recruiting
- Flourish Research Acquisition, LLC dba Flourish Research - North MiamiVerified postcodeMiami, United States· Recruiting
- Amavita Research ServicesVerified postcodeNorth Miami Beach, United States· Recruiting
- Clinical Site Partners, LLC dba Flourish ResearchVerified postcodeWinter Park, United States· Recruiting
- NMH Clinical Research UnitVerified postcodeChicago, United States· Recruiting
- Northwestern Memorial HealthCare - Arkes PavilionVerified postcodeChicago, United States· Recruiting
Common questions
What is heart failure?
Heart failure means your heart isn't pumping blood as well as it should. It doesn't mean your heart has stopped, but it can make you feel tired or breathless.
What is a 'placebo'?
A placebo is a 'dummy' pill that looks just like the real medicine but contains no active ingredients. It helps doctors see if the real medicine is truly making a difference.
Will I know if I'm getting the actual medicine or the placebo?
No, during the study, neither you nor your study doctor will know whether you are taking the study medicine or the placebo. This helps make the study as fair and accurate as possible.
Can I continue my regular heart failure medicines?
Yes, you will continue taking your standard heart failure medicines, including SGLT2 inhibitors, as part of this study.
How long will I be involved in the study?
Your total involvement in the study will be about 48 weeks, which includes 36 weeks of taking the study medicine or placebo.
How to find out more
Pfizer CT.gov Call Center
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
Discussion
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