RecruitingNAINTERVENTIONAL

Anti-hypertensive Therapy and Exercise Treatment to Improve Vascular Health in Patients With Hypertension.

This study wants to find the best ways to treat high blood pressure and improve the health of your blood vessels. Researchers are looking at how a combination of blood pressure medication and a personal exercise plan might help. They also want to understand the body changes that happen when people get healthier. For a year, participants with high blood pressure who haven't taken medication before will receive standard blood pressure drugs, with some also doing personalised exercise. Doctors will check blood pressure and blood vessels regularly. The aim is to achieve healthy blood pressure levels and explore long-term benefits of treatment. This helps us make treatment decisions more personal and effective for everyone.

At a glance

Status

Recruiting

Phase

Sponsor

Heinrich-Heine University, Duesseldorf

Enrolment target

Start

01 Apr 2025

Estimated completion

31 Dec 2028

Hypertension Vascular Function Fitness Testing Metabolism Changes

What is this study about?

This research is looking into better ways to manage high blood pressure, also known as hypertension. High blood pressure is a common health problem that can affect your blood vessels, both large and small, and can lead to damage in important organs over time. Often, exercise is suggested as a way to help lower blood pressure and reduce some of this damage.

In this study, doctors want to see how standard blood pressure medication, either on its own or combined with a special exercise plan tailored just for you, affects blood pressure and the health of your blood vessels. They will carefully check your blood pressure and how your blood vessels are working. They also want to understand the smaller changes happening in your body and cells that contribute to better blood vessel health, which could lead to more personalised ways of treating high blood pressure in the future.

Over one year, the study will involve people who have recently been diagnosed with high blood pressure and haven't started medication yet. They will receive guideline-based blood pressure medication, and some will also follow an individualised exercise programme. Regular check-ups will help the researchers understand how these treatments affect your blood pressure and blood vessel health over time. This will help doctors make more informed decisions about the best treatments for each person, aiming for better long-term health.

Key takeaways

This study explores how medication and exercise affect high blood pressure.
It aims to improve blood vessel health and personalise treatments.
Participants will have regular health checks for one year.
You must have high blood pressure but not be on medication currently.
The study helps us understand long-term benefits for people with high blood pressure.

Who may be eligible?

To join this study, you generally need to be an adult, aged 18 or older. You should have been diagnosed with high blood pressure (specifically, a type called 'systolic hypertension grade I-II', which means your top blood pressure number is between 140 and 179 mmHg) and not currently be taking any medication for your blood pressure.

However, there are reasons why you might not be able to take part. For example, if you have certain existing health conditions, such as chronic eye diseases (like advanced macular degeneration or glaucoma) or very high pressure in your eyes, or if you have specific medical issues that would make exercise unsafe for you (like serious heart problems picked up during an exercise test, or bone/joint problems). Also, if your high blood pressure is only in your bottom number (diastolic hypertension), or if you are unable to give your written permission to join, you wouldn't be able to participate.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Do you have high blood pressure (top number 140-179 mmHg) but are not taking medication for it?
Do you have any serious chronic eye conditions such as glaucoma or macular degeneration?
Do you have any medical problems that make exercise unsafe for you?
Are you willing and able to provide written consent to take part?

Answer every question to see your result.

What does participation involve?

If you decide to take part, you'll be involved in the study for a total of one year. This includes getting regular check-ups every two months at the study centre. During these visits, your blood pressure will be carefully measured, and various tests will be done to check the health of your blood vessels. You'll also have assessments of your fitness and how your body uses energy.

Throughout the study, you'll be given blood pressure medication following standard guidelines, if you are in that group. If you are also in the exercise group, you'll receive a personalised exercise plan to follow. The goal is to reach your target blood pressure within the first six months. After that, there will be another six months of follow-up visits to see how the treatment is working in the long term. You can withdraw from the study at any time.

Potential risks and benefits

Taking part in this study could offer you the benefit of close medical monitoring for your high blood pressure and, for some, a personalised exercise plan. This might help you achieve healthier blood pressure and improve your blood vessel health. However, as with any medical study or exercise programme, there could be some risks, such as side effects from medication or potential strains from exercise, though these will be carefully monitored. You will be fully informed about any known risks before you agree to participate, and importantly, you have the right to withdraw from the study at any point without giving a reason, and this will not affect your usual medical care.

Locations (1)

Universitätsklinik Düsseldorf
Verified postcode
Düsseldorf, Germany· Recruiting

Common questions

What is 'high blood pressure'?

High blood pressure (hypertension) means the force of your blood pushing against your artery walls is consistently too high, which can lead to health problems.

What does 'vascular health' mean?

'Vascular health' refers to the health of your blood vessels (arteries, veins, and capillaries), which carry blood around your body. Good vascular health means they are strong and flexible.

Will I have to do exercise?

Some participants in the study will be asked to follow a personalised exercise plan, while others will not. You will be assigned to a group at random.

How long will the study last for me?

If you join the study, you will be involved for a total of one year, with regular check-ups every two months.

What if I feel unwell during the study?

Your health will be closely monitored throughout the study. If you feel unwell, you should always inform the study team immediately.

How to find out more

Johannes Stegbauer, Prof. Dr.

studienzentrum-nephrologie@med.uni-duesseldorf.de +49 211 81 080 74 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.