- recruiting
Evaluation of the Clinical Benefit of the Aktiia Blood Pressure Monitoring for Early Awareness of Hypertension and Prediction of Cardiovascular Risk
This study looks at how a new type of blood pressure monitor (Aktiia G1) can help people with high blood pressure. It aims to see if continuous monitoring, combined with lifestyle information, can improve how we manage high blood pressure and predict heart health risks.
Switzerland · United Kingdom - active not recruitingPHASE3
Open-Label Extension (OLE) Study to Assess Safety, Efficacy, and Tolerability of Lorundrostat in Subjects With Hypertension
This study looks at a new medicine called lorundrostat for high blood pressure. It checks how safe and effective it is over a longer period in people who have already taken part in a related study.
United States · Australia · Bulgaria - ongoing, recruitingTherapeutic exploratory (Phase II)
The COlchicine HypERtENsion Trial
This study is looking at whether a medicine called Colchicine can help people with high blood pressure and heart problems. Researchers will check changes in how stiff people's arteries are after taking the medicine for six months, compared to a dummy pill.
Denmark - not yet recruitingNA
Effects of a Brown Seaweed Tart Cherry Blend in Mild-moderate Hypertension
This study is looking at whether a blend of brown seaweed and tart cherry can help people with slightly high blood pressure. These natural ingredients are thought to have good effects on the heart and blood vessels, and researchers want to see if they can reduce blood pressure without needing traditional medicines.
United Kingdom - recruitingPHASE3
Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease
This study looks at a new medicine called zilebesiran for people with high blood pressure that isn't well controlled, especially if they also have heart problems or are at high risk of developing them. The aim is to see if zilebesiran can reduce serious heart-related events like heart attacks or strokes.
United States · Argentina · Australia - recruiting
Cardiovascular Longitudinal ALSPAC Research Investigations Following Hypertensive Pregnancy in Young Adulthood
This study looks at young adults (30-40 years old) who were born to mothers with high blood pressure during pregnancy. Researchers want to understand why these individuals might have higher risks of heart and blood vessel problems later in life and how to prevent them.
United Kingdom - recruiting
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
This study aims to understand why common medicines don't work the same for everyone in the UK, especially for people from different backgrounds. It will look at many health conditions, hoping to improve how we treat them and make healthcare fairer for all.
United Kingdom - not yet recruitingNA
Personalised Pharmacometabolomic-guided Strategy Trial to Optimise Treatment for Hypertension
This study explores a 'smart approach' to choosing high blood pressure medication. By analysing blood tests and clinical information, doctors aim to find the best treatment for you, potentially reducing side effects and improving blood pressure control.
Germany · Netherlands · Spain - enrolling by invitationPHASE3
A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension
This study looks at the long-term effects and safety of a drug called Ralinepag for people with a lung condition called pulmonary arterial hypertension (PAH). It's for those who have already tried Ralinepag in a previous study.
United States · Argentina · Australia - active not recruitingNA
The RADIANCE II Pivotal Study: A Study of the ReCor Medical Paradise System in Stage II Hypertension
This study is testing a new device called the Paradise System for people with high blood pressure that's not too severe. It aims to see if this system, which treats kidney nerves, can safely and effectively lower blood pressure when people are taking few or no medications.
United States · Belgium · France - recruitingNA
Controlling and Lowering Blood Pressure With the MobiusHD™
This study looks at how well a device called MobiusHD™ works for people with high blood pressure that’s hard to treat. It checks if the device is safe and helps lower blood pressure after it’s been used in patients.
Germany · Netherlands · United Kingdom - recruitingNA
Streamlined Denervation With spYral For an Optimized Treatment (SPYRAL SWYFT) in Subjects With Uncontrolled Hypertension
This study looks at a procedure called renal denervation to treat high blood pressure. It aims to see if a simpler way of doing the procedure is just as good, and possibly quicker, than older methods. This could offer a new option for people whose blood pressure is hard to control.
Australia · Belgium · Germany - recruitingNA
Hypertension Management in Young Adults Personalised by Echocardiography and Clinical Outcome.
This study looks at how heart scans and clinic information can help doctors better manage high blood pressure in young adults (18-40). It aims to improve how we predict their risk of heart problems.
United Kingdom - active not recruitingNA
A Study of the ReCor Medical Paradise System in Clinical Hypertension
This study looks at a new ultrasound system, called Paradise®, to treat high blood pressure. It compares this new treatment with a pretend procedure to see how safe and effective it is for people with different types of high blood pressure.
United States · Belgium · France - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
A single-dose, randomized, two-period, two-sequence, crossover comparative bioavailability study on formulations containing ramipril, amlodipine and indapamide in combination product versus Triatec® 10 mg capsules (Sanofi - Produtos Farmacêuticos, Lda., Portugal), containing ramipril, Norvasc® 10 mg, tablets (Upjohn EESV, the Netherlands), containing amlodipine and Natrilix® 2.5 mg film-coated tablets (Les Laboratoires Servier, France), containing indapamide co-administered together as reference in healthy male and female volunteers under fasting conditions.
This study is comparing how well a new combination medicine for high blood pressure works in healthy adults. It's looking at whether the new medicine is absorbed in the body in the same way as taking the individual ingredients separately.
Czechia - not yet recruitingNA
Effect of Beetroot Juice on Cardiovascular and Autonomic Responses to Exercise in Adults With Type 2 Diabetes
This study looks at whether beetroot juice can help adults with Type 2 Diabetes recover better after exercise. It checks how exercise affects blood pressure and heart rate, as well as how helpful beetroot juice might be with these effects.
United Kingdom - recruitingNA
The Man Van Project
The Man Van project offers mobile health checks at workplaces and communities for men, especially those from ethnic minority groups, to find health problems like prostate cancer early. The goal is to make healthcare easier to access and improve men's health outcomes.
United Kingdom - recruitingNA
Real World Evaluation of Lifelight®: A Contactless Vital Signs Monitor for Self-monitoring Blood Pressure and Its Comparison to Standard of Care
This study compares a new contactless blood pressure monitor, Lifelight, with traditional cuffs for people with uncontrolled high blood pressure. It aims to see how well Lifelight works in real life and if it helps manage blood pressure.
United Kingdom - recruiting
The European NAFLD Registry
This study aims to understand fatty liver disease (NAFLD) better. Researchers collect information and samples from patients across Europe to find new ways to detect and monitor the disease, especially how it progresses from fatty liver to more serious conditions like fibrosis.
Belgium · Finland · France - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
A randomized, open-label, single dose, 2-way crossover bioequivalence study comparing apixaban 5 mg hard capsules (PG412 [Celon Pharma]) vs apixaban 5 mg film-coated tablets (Eliquis [Bristol-Myers Squibb]) under fasting conditions in healthy volunteers
This study compares two different versions of a medicine called apixaban (one is PG412, the other is Eliquis). Both help prevent blood clots. We want to see if the new version works in the body in the same way as the established one.
Poland - recruiting
Optical Coherence Tomography And NEphropathy: The OCTANE Study
This study looks at changes in eye blood vessels in people with high blood pressure and kidney disease, compared to healthy individuals. It uses a simple eye scan (OCT) to see if these changes happen and if treatments help improve them.
United Kingdom - active not recruitingNA
SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN
This study looks at a treatment called renal denervation (RDN) for high blood pressure. It uses a device called Symplicity Spyral to see how well it works and if it's safe in the long term, especially for people whose blood pressure is hard to control.
United States · Australia · Belgium - recruiting
The "Global Paradise System" Registry
This study looks at a treatment called renal denervation using the Paradise Ultrasound system for high blood pressure. It tracks how well it works and if it's safe over time in people who have already had the treatment. It also checks blood pressure readings at home and quality of life.
Austria · Belgium · France - recruitingNA
BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT
This study looks at whether a special feature in a Medtronic pacemaker can help lower high blood pressure. It compares having this feature on versus off in people who either need a pacemaker or already have one and also have high blood pressure.
United States · Australia · Belgium - recruitingPHASE3
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
This study looks at a new medicine, vicadrostat, for people with type 2 diabetes, high blood pressure, and heart disease. It aims to see if taking vicadrostat alongside empagliflozin can help reduce heart problems. Half the participants will get the study medicine, and half will get a dummy pill.
United States · Argentina · Australia - recruiting
Hypertension Explored in Long-term Postpartum Follow-up in Later Life
This study looks at why women who had high blood pressure during pregnancy might get heart and blood vessel problems later in life. Researchers want to understand these changes better to find new ways to help them.
United Kingdom - recruitingNA
Blood Pressure Following Isometric Exercise in Inactive Adults
This study looks at how a special type of exercise, called isometric exercise, affects blood pressure in adults who don't exercise much. It could help us understand if this exercise can lower blood pressure.
United Kingdom - authorisedTherapeutic use (Phase IV)
Comparative study of eplerenone-based treatment strategy versus irbesartan-based blood pressure lowering in obese hypertensive patients (HEBRO Study)
This study compares two common strategies for lowering blood pressure in obese patients. It looks at whether treatments based on eplerenone or irbesartan are better at controlling blood pressure over 24 weeks. The aim is to find effective ways to manage high blood pressure in this group.
Greece - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
A study comparing the new drug PG413 produced by Celon Pharma SA with the drug Eliquis available on the market in healthy volunteers.
This study is testing a new medicine, PG413, to see how it compares to an existing medicine called Eliquis. Both medicines are used to prevent strokes and treat blood clots. This early study helps us understand how PG413 works in healthy people.
Poland - recruitingNA
A Trial Within Cohort Feasibility Study Design Comparing Standard of Care Versus Weight Loss (Achieved Through Tirzepatide) for Obesity-related Hypertension in Young Adults
This study looks at how a new weight loss medicine, Tirzepatide, affects high blood pressure in young adults who are overweight or obese. We want to see if losing weight can help lower blood pressure more effectively than usual care.
United Kingdom