Active not recruitingPHASE3INTERVENTIONAL

A Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL2

This research study, called ATTAIN-Hypertension, is investigating a new medication, orforglipron, for adults who have high blood pressure and are also overweight or living with obesity. The main goal is to find out if orforglipron is effective in lowering blood pressure and to check how safe it is for people to use. Participants will be randomly assigned to either receive the new medicine or a 'dummy' pill (placebo) that looks the same but contains no active drug. This is a common way to test new treatments, helping researchers understand the medicine's true effects. It's part of a larger research programme looking into orforglipron.

At a glance

Status

Active not recruiting

Phase

PHASE3

Sponsor

Eli Lilly and Company

Enrolment target

487

Start

30 Apr 2025

Estimated completion

01 Sep 2027

Hypertension

What is this study about?

This study, known as ATTAIN-Hypertension, is a clinical trial focused on a new medicine called orforglipron (which has a code name LY3502970). The main purpose of this research is to see if orforglipron can help people who have high blood pressure, especially if they are also overweight or living with obesity. High blood pressure can lead to serious health problems like heart attacks and strokes, so finding effective treatments is very important.

Researchers want to understand two key things: first, if orforglipron actually works to lower blood pressure in this group of people (this is called its 'efficacy'), and second, whether it is safe to use and what side effects it might have (this is called its 'safety'). To do this, some people in the study will receive orforglipron, while others will receive a 'placebo', which looks identical but doesn't contain any active medicine. This allows doctors to compare the results and see if the new medicine is having a real effect.

This specific study is part of a bigger research effort investigating orforglipron. By participating, you would be helping medical science learn more about how to treat high blood pressure in people who also struggle with their weight, potentially leading to new treatment options in the future.

Key takeaways

The study is testing a new medicine, orforglipron, for high blood pressure.
It's for adults who also have obesity or are overweight.
The goal is to check how well the medicine works and if it's safe.
Some participants will get the actual medicine, others a dummy pill.
Participation involves regular clinic visits and health checks.
You can leave the study at any time if you change your mind.

Who may be eligible?

To be considered for this study, you must be 18 years old or older. The study is open to both men and women.

Since this study is part of a larger research programme, there are specific guidelines that decide who can and cannot take part. These guidelines are carefully considered to make sure the study is safe for everyone involved and that the results are clear.

If you are interested, a member of the research team will explain these guidelines in detail and check if you meet all the necessary requirements for screening. They will ask questions about your health and medical history.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Do you have high blood pressure?
Are you currently overweight or living with obesity?
Are you able to attend regular clinic appointments?

Answer every question to see your result.

What does participation involve?

Taking part in this study would involve a series of visits to the clinic over a period of time. During these visits, you would have various health checks, such as measurements of your blood pressure, weight, and blood tests. You would be given either the study medicine (orforglipron) or a dummy pill (placebo) to take regularly, as instructed by the study team.

The specific number of visits and the total length of your participation would be explained fully by the study team during your initial conversations. There will also be follow-up appointments to monitor your health and how you are responding to the medication. All procedures, including medication doses and the duration of the study, will be carefully set out in the study plan.

Potential risks and benefits

Potential benefits of taking part could include closer monitoring of your blood pressure and general health, and possibly experiencing an improvement in your blood pressure if you receive the active medicine. However, like all medicines, orforglipron may have side effects, and some people might not improve or could even feel worse. All possible risks will be fully explained before you agree to participate. Remember, joining a clinical trial is always your choice, and you are free to withdraw at any time without giving a reason, and it will not affect your usual medical care.

Locations (99)

Elite Clinical Studies, LLC
Verified postcode
Phoenix, United States
Valley Clinical Trials, Inc.
Verified postcode
Covina, United States
Valley Clinical Trials, Inc.
Verified postcode
Northridge, United States
Chase Medical Research, LLC
Verified postcode
Waterbury, United States
Excel Medical Clinical Trials
Verified postcode
Boca Raton, United States
Care Access - Brandon
Verified postcode
Brandon, United States
Northeast Research Institute - Downtown Office
Verified postcode
Jacksonville, United States
Peace River Cardiovascular Center
Verified postcode
Port Charlotte, United States
East-West Medical Research Institute
Verified postcode
Honolulu, United States
Sinai Hospital Of Baltimore
Verified postcode
Baltimore, United States
Ascension Saint Agnes Heart Care
Verified postcode
Baltimore, United States
Lucida Clinical Trials
Verified postcode
New Bedford, United States

Common questions

What is high blood pressure?

High blood pressure, or hypertension, means your blood is pushing too hard against the walls of your arteries. Over time, this can damage your blood vessels and lead to serious health problems like heart disease or stroke.

What is 'obesity or overweight' in this study?

This refers to having a body weight that is higher than what is considered healthy for your height. The study will use specific measurements, like Body Mass Index (BMI), to determine this.

What is a 'placebo'?

A placebo is a 'dummy' pill or treatment that looks exactly like the real medicine but contains no active drug. It helps researchers see if the real medicine is actually working or if improvements are due to other factors.

Will I know if I'm getting the real medicine or the placebo?

No, neither you nor the study team will know whether you are receiving the active medicine or the placebo. This is to ensure the study results are fair and unbiased. This is called 'blinding'.

Can I stop participating in the study if I want to?

Yes, absolutely. Your participation is completely voluntary, and you can choose to leave the study at any time, for any reason, without it affecting your future medical care.