Not yet recruitingOBSERVATIONAL

Oral 'Breath Test' to Measure Anabolic Sensitivity to a Protein Meal Across the Age and Physical Activity Spectrum

This study is looking at how our bodies use protein to build muscle, which is called 'anabolic sensitivity'. We want to see if this ability changes as we get older, if it's different for men and women, and how much our physical activity levels affect it. Traditionally, this was only measured using complicated methods like muscle biopsies. However, this study uses a new, simple 'breath test' to check how efficiently our bodies use protein from a liquid meal. Understanding anabolic sensitivity is important because it can help us learn more about maintaining muscle mass and overall health throughout our lives.

At a glance

Status

Not yet recruiting

Sponsor

University of Toronto

Enrolment target

Start

20 Dec 2024

Estimated completion

31 Aug 2025

Inactivity, Physical Aging Healthy Aging Growth & Development Sex Differences Anabolic Sensitivity Protein Metabolism Physical Activity

What is this study about?

Imagine your muscles are like a house being built – they constantly need building blocks, and protein is a key one. This study is all about understanding how well our bodies use the protein we eat to build and repair muscles. This process is called 'anabolic sensitivity'.

We know that as people get older, or if they aren't very active, their bodies might not be as good at using protein to build muscle. This can mean they lose muscle more easily over time. Current ways to measure this often involve uncomfortable procedures, like taking a small piece of muscle (a biopsy).

This study uses a new, much simpler approach: a 'breath test'. You'll have a liquid protein meal, and then researchers will measure certain things in your breath to see how your body processes that protein – whether it's used to build new muscle or burned for energy. By doing this, we can better understand how muscle health changes throughout life, and what factors, like age, sex, and activity, play a role.

Key takeaways

The study uses a new, simple breath test.
It aims to understand how our bodies use protein to build muscle.
Researchers are interested in how age, sex, and activity affect this.
Participation involves having a liquid protein meal and giving breath samples.
It helps us learn more about keeping muscles healthy throughout life.

Who may be eligible?

This study is looking for healthy volunteers. This includes children aged 8 to 16, and adults aged 18 to 35, or 60 to 80. Your weight should generally be in a healthy range (not underweight or very overweight).

You wouldn't be able to join if you regularly use certain pain medications (like most anti-inflammatory drugs) or blood thinners. We also can't include you if you use a walking aid, have certain ongoing health problems like digestive issues, heart disease, or diabetes, or if you are pregnant or taking hormone replacement therapy. Smokers and those using recreational drugs are also not eligible.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you between 8-16, 18-35, or 60-80 years old?
Do you consider yourself generally healthy?
Do you not regularly use certain strong pain relievers or blood thinners?
Are you able to follow study instructions, like tracking your diet if asked?
Are you not pregnant or on hormone replacement therapy?
Do you not have chronic conditions like diabetes or heart disease?

Answer every question to see your result.

What does participation involve?

If you take part, you'll have a liquid protein meal. Afterwards, researchers will collect samples of your breath at different times over a short period. This will help them see how your body uses the protein. This is a non-invasive test, meaning nothing will be put into your body, and it shouldn't be uncomfortable. You'll also complete some questionnaires about your activity levels and health.

Potential risks and benefits

There are no significant risks associated with this breath test, as it's a very gentle procedure. You might find the liquid protein meal a bit unusual, but it's safe. While there aren't direct health benefits to you personally, your participation will greatly help scientists understand more about muscle health as we age and how different people respond to protein, which could lead to better advice for maintaining muscle in the future. You are free to withdraw from the study at any time without giving a reason.

Locations (1)

Goldring Center for High Performance Sport
Verified postcode
Toronto, Canada

Common questions

What is 'anabolic sensitivity'?

It's basically how well your body uses protein to build and repair muscles.

What is the 'breath test' like?

It's a simple test where you breathe into a special device after having a protein drink. It's painless.

Will I have to exercise for this study?

No, you don't need to exercise as part of the study. Your current activity levels will be discussed.

How long will the study take?

The information doesn't say exactly how long each visit is, but it involves a breath test after a meal.

Do I get paid for taking part?

The information provided doesn't mention payment for participation.

How to find out more

Daniel R Moore, PhD

dr.moore@utoronto.ca 4169464088 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.