Not yet recruitingOBSERVATIONAL

SURgical Registry of ENDocarditis EuRope

This study, called SURRENDER, is a European registry collecting information from adult patients who have a serious heart infection, known as infective endocarditis, and are undergoing heart surgery. Researchers want to understand more about the people affected, the treatments they receive during surgery, and how they recover. They will follow patients for up to five years to see the long-term results of the surgery. This information will help doctors improve care and outcomes for future patients with this condition, which can be very serious and costly for healthcare systems.

At a glance

Status

Not yet recruiting

Sponsor

University Hospital, Essen

Enrolment target

10,000

Start

01 Sep 2023

Estimated completion

01 Apr 2033

Infective Endocarditis Cardiac Surgery Outcomes

What is this study about?

Heart infections, called infective endocarditis, are thankfully quite rare, but they are becoming more common, especially in Western countries. This type of infection can be very serious, leading to long hospital stays, a high chance of getting re-infected, and a significantly lower quality of life for those affected. When people with this infection need heart surgery, they can be very unwell and face a high risk of complications during and after the operation.

Because of these challenges, doctors across Europe have started a study called SURRENDER. The main goal is to create a detailed collection of information (a registry) about patients who have infective endocarditis and need heart surgery. They want to track different aspects of their care, from the type of person affected, their medical details, and the specific treatments they receive around the time of surgery.

By gathering this information from many different hospitals over several years, the researchers hope to get a clearer picture of which surgical approaches and treatments work best. They will also look at how well patients recover, not just immediately after surgery but also over the next few years. This will help doctors understand and potentially improve the care for people with this serious heart condition.

Key takeaways

This is a European study looking at heart infections and surgery.
It aims to improve care for patients with infective endocarditis.
Information from your medical records will be collected over several years.
You must be an adult having heart surgery for this infection to join.
No new treatments or tests are involved in this study.
You can withdraw from the study at any time.

Who may be eligible?

To be part of this study, you would need to be an adult, aged 18 or over, who has been diagnosed with infective endocarditis (a heart infection) and is going to have heart surgery for it. You would also need to give your written permission (consent) to take part.

However, you wouldn't be able to join if you are under 18 years old, or if you are already taking part in a different study that involves a specific treatment or intervention. Also, if you don't wish to give your consent, you wouldn't be included.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Am I 18 years old or older?
Do I have infective endocarditis (a heart infection)?
Am I going to have heart surgery for this infection?
Am I NOT currently in another study that involves specific treatments?
Am I willing to give written permission to share my medical information?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, the doctors and nurses will collect information about you and your health during your hospital stay for heart surgery. This will include details about your age, general health, test results from your blood, and information about the heart surgery itself. They will also keep track of how you are doing at 30 days and 90 days after your surgery, and then once a year for up to five years. This follow-up might involve reviewing your medical records or speaking with your doctors during your routine check-ups.

Potential risks and benefits

There are no direct medical risks from taking part in this study, as it only involves collecting existing medical information and does not involve new treatments or procedures. The potential benefits are for future patients, as the information collected will help doctors understand and improve care for people with infective endocarditis needing heart surgery. You are, of course, free to withdraw your consent and stop participating at any time without affecting your medical care.

Locations (2)

Department of Cardiac Surgery, Hospital Nürnberg, Paracelsus Medical University
Verified postcode
Nuremberg, Germany
University Hospital Essen, Department of Thoracic and Cardiovascular Surgery, West-German Heart and Vascular Center, University Duisburg-Essen
Verified postcode
Essen, Germany

Common questions

What is infective endocarditis?

It's a serious infection of the inner lining of your heart, often involving the heart valves.

What does 'cardiac surgery' mean?

It means an operation on your heart, often to repair or replace a damaged heart valve because of the infection.

Why is this study being done?

To understand how different treatments for heart infections work and to improve care for future patients.

Will I have extra tests if I join?

No, this study only collects information from your existing medical records; you won't have any additional tests.

Can I change my mind about taking part?

Yes, you can decide to stop participating at any time without it affecting your medical care.

How to find out more

Matthias Thielmann, Prof. Dr.

matthias.thielmann@uk-essen.de +49-201-723-84908 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.