Active not recruitingOBSERVATIONAL

SCOOT: Sample Collection for DART

The SCOOT study aims to improve how we find and diagnose lung health problems, especially lung cancer, early on. We will use a blood sample from people aged 55 to 75 who have had a CT scan showing a spot (pulmonary nodule) on their lung as part of a Lung Health Check. The information from these blood samples will be used to develop new computer programs, sometimes called Artificial Intelligence (AI). These AI tools will help doctors analyse medical results faster and more accurately, leading to quicker diagnoses and better treatment plans for lung conditions. Finding lung cancer early means treatments are often more successful.

At a glance

Status

Active not recruiting

Sponsor

University of Oxford

Enrolment target

872

Start

11 Aug 2022

Estimated completion

30 Sep 2027

Lung Cancer

What is this study about?

The SCOOT study is looking at how we can use new technology to improve the detection and diagnosis of lung health problems, particularly lung cancer. We want to make it easier to find these problems early, so that people can get the right treatment as quickly as possible. When lung cancer is spotted early, the treatments available are often more effective.

To do this, we are collecting a blood sample from people who are already having further tests for a spot on their lung, found during a routine Lung Health Check. This blood sample, along with information from another study called DART, will be used to develop special computer programs, also known as Artificial Intelligence (AI). These programs are taught to look at medical results and find important patterns.

Once these AI programs are developed, they could help doctors in the future. They would be used to support doctors by quickly and accurately looking at scans and test results. This means people could be diagnosed faster, need fewer tests, and start the most suitable treatment sooner, leading to better health outcomes.

Key takeaways

Aims to improve early diagnosis of lung health problems, including lung cancer.
Uses a blood sample to develop new smart computer tools (AI).
Focuses on people aged 55-75 with lung spots discovered during a Lung Health Check.
Could help doctors diagnose problems faster and choose better treatments sooner.
Participation involves giving one blood sample during routine appointments.
Your medical care will not be affected by taking part.

Who may be eligible?

This study is looking for people aged between 55 and 75 years old.

You might be able to take part if you've recently had a CT scan as part of a Lung Health Check, and that scan showed a small spot or spots on your lung (which doctors call a pulmonary nodule). For the study, you would also need to be having more tests, such as another special scan called a PET-CT, or a biopsy (where a tiny piece of tissue is taken for examination), or surgery to remove the spot.

It's also very important that you are happy and able to understand what taking part means and give your permission (informed consent) to join the study. There are no other reasons why you wouldn't be able to join.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you between 55 and 75 years old?
Have you recently had a CT scan from a Lung Health Check?
Did that scan show a spot (pulmonary nodule) on your lung?
Are you having further tests (like a PET-CT, biopsy, or surgery) for this lung spot?
Are you willing and able to understand the study and give your permission to join?

Answer every question to see your result.

What does participation involve?

If you decide to take part in the SCOOT study, the main thing you would need to do is provide a blood sample. This sample would be collected at the same time as some of your other routine tests, so it shouldn't require an extra visit. The blood sample will be used to help develop new computer tools for finding lung health problems. There are no other visits, assessments, or medications involved directly with this study. The total duration of your direct participation would be very short – just the time it takes to give the blood sample.

Potential risks and benefits

There are no direct benefits to you from taking part in this study, but your contribution will help improve the diagnosis and treatment of lung conditions for future patients. The main risk is the slight discomfort and small chance of bruising when giving a blood sample, which is a very common and safe procedure. You are free to withdraw from the study at any time without giving a reason, and this will not affect your medical care.

Locations (11)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

Lung Health Check: Oxford - Churchill Hospital, OUH
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Oxford, United Kingdom
Lung Health Check Centre: Royal Sussex
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Brighton, United Kingdom
Lung Health Check Centre: North Bristol
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Bristol, United Kingdom
Lung Health Check Centre: Gateshead
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Gateshead, United Kingdom
Lung Health Check Centre: Corby & Kettering
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Kettering, United Kingdom
Lung Health Check Centre: Cheshire & Merseyside
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Liverpool, United Kingdom
Lung Health Check Centre: RM Partners
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London, United Kingdom
Lung Health Check Centre: Newcastle & Gateshead
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Newcastle, United Kingdom
Lung Health Check Centre: Plymouth
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Plymouth, United Kingdom
Lung Health Check Centre: Stoke
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Stoke, United Kingdom
Lung Health Check Centre: South Tyneside and Sunderland
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Sunderland, United Kingdom

Common questions

What is a 'pulmonary nodule'?

A pulmonary nodule is a small spot or growth that shows up on a lung scan. Most are harmless, but some can be an early sign of lung cancer, which is why they are often investigated further.

What is Artificial Intelligence (AI) in this study?

AI in this study refers to clever computer programs that can be trained to look at medical information, like blood tests, to help doctors find health problems more quickly and accurately.

Will taking part affect my current treatment?

No, taking part in this study will not affect any of your current or future medical care or treatment decisions. It's about collecting an extra blood sample at the same time as other tests.

How long will my blood sample be used?

Your blood sample will be used to develop and test the new computer tools for as long as the research is ongoing, to ensure the tools are effective and accurate.

Who will have access to my information?

Only authorised research staff will have access to your information, which will be protected to ensure your privacy. Your name will not be linked to the study data shared with the AI developers.