- recruitingPHASE1, PHASE2
Evaluation of IRDye800CW-nimotuzumab in Lung Cancer Surgery
This study looks at a new way to help surgeons find lung cancer during operations. It uses a special dye, IRDye800CW-nimotuzumab, that glows near cancer cells. Doctors want to see if it's safe, how much to use, and when to use it to help surgery be more accurate.
Canada - recruitingPHASE1, PHASE2
Evaluation of 89Zr-DFO-nimotuzumab for Non-invasive Imaging of EGFR+ Cancers by Positron Emission Tomography (PET)
This study looks for a better way to find specific cancer cells (EGFR-positive) in lung and bowel cancers. We use a special scan (PET) after giving a small amount of a test medicine to see if it lights up these cancer cells, helping doctors choose the best treatments.
Canada - recruitingPHASE3
The Thoracic Peri-Operative Integrative Surgical Care Evaluation Trial - Stage III
This study looks at new ways to help people having surgery for lung, stomach, or food pipe cancer. It aims to reduce problems after surgery, improve quality of life, and explore how natural health approaches might help alongside standard care.
Canada - recruitingNA
Endobronchial Ultrasound-guided Transbronchial Needle Aspiration for Lymph Node Staging in Patients With Non-small Cell Lung Cancer Pursuing Stereotactic Body Radiotherapy (SBRT)
This study looks at a special test called EBUS-TBNA for people with early lung cancer who can't have surgery. The test helps doctors understand if the cancer has spread to nearby glands, which helps decide if a modern radiation treatment (SBRT) is suitable.
Canada - recruitingNA
Joint Thoracic Oncology Research Unit of LYon: Lung cancerS DatabaSE (ULYSSE)
This study in Lyon, France, is collecting information and samples from people with lung cancer and similar chest cancers. Researchers want to learn more about these cancers to help improve treatments in the future. It involves giving blood and answering questionnaires.
France - active not recruiting
Radiograph Accelerated Detection and Identification of Cancer in the Lung
This study looks at how a new computer program called qXR, which uses artificial intelligence (AI), can help doctors find lung cancer earlier. It checks chest X-rays to spot possible problems, aiming to improve diagnosis and treatment for people in the UK.
United Kingdom - recruiting
DOLCE: Determining the Impact of Optellum's Lung Cancer Prediction Solution
This study checks if an AI tool helps doctors decide the best care for lung lumps. It aims to see if using AI improves patient health and saves money compared to current methods for managing these lumps.
United Kingdom - recruiting
AI & Radiomics for Stratification of Lung Nodules After Radically Treated Cancer
This study uses computers to analyse scans of new lung spots in people who've had cancer. It aims to help doctors tell if these spots are harmless, a new cancer, or cancer spread, to improve diagnosis and care.
United Kingdom - recruitingPHASE4
PROspective Master-protocol for Evaluation of Systemic THErapeutics in Elderly With Thoracic Malignancies
This study looks at how well older people (70+) with specific lung cancer are treated with standard medicines. It collects real-world information about their health, treatments, safety, and how their quality of life is affected.
France - recruiting
An Observational Study of Predictors and Outcomes of Lung Cancer in Never-smokers in the UK
This study looks at lung cancer in people in the UK who have never smoked. Researchers want to understand why non-smokers get lung cancer and find ways to diagnose it earlier and improve treatment. Taking part won't change your usual medical care.
United Kingdom - recruiting
A Feasibility Study of MRI Guided Stereotactic Ablative Radiotherapy (MIDSECTION)
This study looks at treating abdominal and lung cancers using a new type of radiotherapy machine, called an MR-Linac. It aims to see if this machine can deliver very precise radiation to tumours while better protecting healthy tissues, and how it affects the patient experience.
United Kingdom - active not recruitingPHASE3
A Clinical Study of Pembrolizumab (+) Berahyaluronidase Alfa (MK-3475A) to Treat Newly-diagnosed Metastatic Non-small Cell Lung Cancer (MK-3475A-F84)
This study looks at a new way to give a lung cancer medicine called pembrolizumab. It compares giving it through a drip in your arm (IV) versus a new injection under the skin (SC) for people with advanced non-small cell lung cancer. Researchers want to see how the injection works.
United States · China · Germany - active not recruiting
Bronchoscopic Microwave Ablation of Lung Tissue
This study looks at a new way to treat lung cancer using a special tool to heat and remove small growths (nodules) in the lungs. It aims to see how safe and effective this treatment is for patients.
Netherlands · United Kingdom - recruitingNA
Prospective Multicenter Cohort Study to Validate Four Groups of Biomarkers for Assessing Lung Cancer Risk Among Patients With Atheromatous Cardiovascular Disease in a Screening Pathway
This study looks for early signs of lung cancer in people at risk, especially those with heart disease linked to smoking. They'll use blood and stool samples, along with special X-rays, to find new ways to detect cancer sooner and help people stop smoking.
France - recruitingNA
First in Human Study for the Assessment of Safety and Initial Performance of the EAS1 System
This study is testing a new system called EAS1 to treat lung cancer. It's the first time this system is being used in humans. Doctors want to see if it's safe and if it works well for people with early-stage lung cancer who could also have surgery.
Israel · Spain · United Kingdom - recruitingPHASE2
APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
This study is testing a new oral medicine, APL-101, for people with advanced cancers. It focuses on lung cancer and other solid tumours where specific genetic changes linked to a protein called MET are found. Researchers want to see how well it works and if it's safe.
United States · Australia · Canada - recruiting
Should low-dose CT be used instead of chest X-ray to screen patients for lung cancer when they have possible symptoms?
This study looks at whether a special type of X-ray called a low-dose CT scan is better than a regular chest X-ray for finding lung cancer early in people with symptoms. Finding cancer earlier often means better treatment outcomes, but CT scans have some downsides.
United Kingdom · England - active not recruiting
SCOOT: Sample Collection for DART
This study helps find lung health problems, especially lung cancer, earlier. We use a blood sample to create new computer tools. These tools aim to speed up diagnosis and help doctors choose the best treatment faster for people aged 55-75 with certain lung findings.
United Kingdom - recruitingPHASE2
Adjunctive Intravenous Ascorbic Acid for Advanced Non-Small Cell Lung Cancer
Researchers are studying if high-dose vitamin C given into the veins, alongside standard chemotherapy for advanced lung cancer, can be helpful. This study will compare vitamin C to a dummy treatment in people with advanced non-small cell lung cancer.
Canada - active not recruiting
Resistance to the Tyrosine Kinase Inhibitor Osimertinib and Pharmacokinetics in Non-small Cell Lung Cancer
This study looks at how a lung cancer drug called osimertinib works in the body and why it sometimes stops being effective. Researchers want to understand if different drug levels in the blood affect how well it works and if this could help prevent the cancer from coming back.
France - recruiting
European Real-World Registry for Use of the Ion Endoluminal System
This study looks at how well a device called the Ion Endoluminal System works in real patients. It's for people having tests for lung growths (nodules) to see if they're cancerous or to help locate them for treatment.
France · Germany · Switzerland - ongoing, recruitingPhase I and Phase II (Integrated)- Other
CA209-8KX Phase I/II pharmacokinetic multi-tumor study of subcutaneous formulation of nivolumab monotherapy
This study is looking at a new way to give nivolumab, a cancer medicine, through an injection under the skin. It's for people with various advanced cancers like lung, kidney, and liver cancer, to see how the body handles the medicine and if it's safe.
Spain · Netherlands · Italy - recruitingNA
Modulation of Anti-tumor T Cell Responses in Cancer Patients Treated by Concomitant Radiochemotherapy
This study looks at how combined radiation and chemotherapy for lung or head and neck cancers affects the body's natural cancer-fighting cells. Researchers hope to understand these immune responses better to improve future treatments.
France - recruitingPHASE1
Study to Determine the Safety and Pharmacokinetics of DO-2 in Patients With Advanced or Refractory Solid Tumours
This study is testing a new medicine, DO-2, for people with advanced solid tumours, especially lung cancer, that have specific genetic changes and where other treatments haven't worked. It aims to see if DO-2 is safe and how it moves through the body.
Belgium · France · Netherlands - recruitingPHASE2
Investigating the Effects of Atezolizumab in People Whose Tumour DNA or RNA Indicates Possible Sensitivity
This study looks at a medicine called atezolizumab for different cancers. We want to see if a special test of your cancer cells can predict if the medicine will work well for you. This helps us learn more about tailoring treatments.
Canada - recruitingNA
Clinico-biological Data Collection Study of Metastatic Lung Cancer
This study is gathering information from people with advanced lung cancer. We want to understand why treatments work for some and not others by looking at different pieces of information like health, lifestyle, and tumour details. This could help doctors choose better treatments in the future.
France - recruiting
LIVInG With chrONic Cancer TrEatments (LONGEVITI) Study
This study looks at how new cancer treatments affect daily life for people with long-term cancer. It aims to understand how to best support them while they are on these treatments, often for many months or years.
Canada - recruitingPHASE2
Reducing Respiratory Symptoms of Pulmonary Irradiation in Interstitial Lung Disease
This study looks at new ways to help people with lung cancer and a lung condition called Interstitial Lung Disease (ILD) who are having radiotherapy. It tests if two medicines, NAC and a short course of steroids, can reduce breathing problems after treatment.
Canada - active not recruitingNA
HANSE - Holistic Implementation Study Assessing a Northern German Interdisciplinary Lung Cancer Screening Effort
This study, called HANSE, is looking at how to set up a lung cancer screening programme in Germany. It uses special X-ray scans (low-dose CT) to find lung cancer early in people at higher risk, like smokers. The aim is to see if this type of screening can work well within existing hospital services.
Germany - recruiting
Study of High-Precision Evaluation of Molecular ResiduaL Disease Through a PlatfOrm for Cancer TracKing and Interception (SHERLOCK)
The SHERLOCK study aims to find tiny bits of cancer DNA in your blood after treatment. This helps doctors spot if cancer might return early, hoping to improve long-term health. We're looking for new ways to track different types of cancer.
Canada - recruitingPHASE1, PHASE2
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
This study is testing a new drug, rezatapopt, for advanced cancers with a specific gene change (TP53 Y220C). It's also looking at rezatapopt with another drug, pembrolizumab, to see how safe and effective they are. It’s for people who have already had cancer treatment.
United States · Australia · France - recruitingPHASE2
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
This study is looking at a new treatment called HER3-DXd for people with certain advanced solid tumours that haven't responded to other treatments. It aims to see how well it works and if it's safe for different types of cancer, like melanoma, lung cancer, and breast cancer.
United States · Australia · Belgium - recruitingNA
Tumor Rebiopsy During Progression Under Immunotherapy for Patients With Lung Cancer
This study collects new tumour samples from lung cancer patients whose immunotherapy has stopped working. Researchers will use these samples to understand why the treatment failed and to find new ways to help patients in the future. It aims to improve future lung cancer care.
France - not yet recruitingNA
Totally Robotic Versus Surgeon-Assisted Robotic Lung Resection For Early-Stage NSCLC
This study compares two ways of doing keyhole surgery for early-stage lung cancer using robots. We want to see if performing the whole operation with robots is better or different than using robots with a surgeon's help, especially regarding costs and patient recovery.
Canada - recruiting
Bronchoscopic Microwave Ablation of Lung Tissue in Surgical Candidates - UK
This study is testing a new way to treat lung cancer using heat to destroy cancer cells, called microwave ablation. It hopes to see if this treatment could help patients avoid major surgery for lung tumours, improving recovery and reducing complications in the future.
Italy · United Kingdom - ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase II, two-arm study to investigate tepotinib combined with osimertinib in MET amplified, advanced or metastatic non-small cell lung cancer (NSCLC) harboring activating EGFR mutations and having acquired resistance to prior osimertinib therapy (INSIGHT 2 Study)
This study is for people with a certain type of advanced lung cancer that has stopped responding to a previous treatment called osimertinib. It tests a new combination of two drugs, tepotinib and osimertinib, to see if it can shrink tumours.
Italy · France · Belgium - active not recruiting
The SUMMIT Study: A Cancer Screening Study
The SUMMIT study is looking at better ways to find cancer early. It will test a blood test for many cancers and offer special lung scans to people at higher risk in London who have smoked. The goal is to improve how we check for cancer.
United Kingdom - active not recruitingPHASE2
Study of Novel Treatment Combinations in Patients With Lung Cancer
This study looks at new drug combinations to treat lung cancer. It has three parts: for cancer that has spread, cancer that has grown despite previous treatment, and earlier-stage cancer that can be removed by surgery.
United States · Brazil · Hong Kong - recruiting
Rapid Absorbance-based Detection of Inner Cheek Cell Abnormalities Using Light Spectroscopy for Risk Evaluation of Lung Cancer to Enable Critical Decision Support in Targeted Patient Populations
This study is testing a new, simple cheek swab test called AIR-DS to help find lung cancer early. It looks for tiny changes in cells that might show lung cancer before it's severe. This could make detecting lung cancer easier and quicker.
United Kingdom - recruiting
CMR Right Ventricular Contractile Reserve Following Lung Resection
This study looks at how lung surgery affects heart health. We're using special heart scans to see if removing part of a lung changes how the heart's right side works, and if this affects how well people can do daily activities.
United Kingdom - recruiting
Assessment of Novel Biomarkers in Participants Undergoing Targeted Lung Health Checks
This study looks for new ways to spot lung cancer early in people having NHS lung health checks. Researchers are collecting samples like blood or spit to see if these can help find cancer better, especially when X-rays aren't clear. The goal is to improve how we find and treat lung cancer.
United Kingdom - recruitingNot Applicable
APPLIED-LUNG: Transforming lung cancer screening
This study is looking into a new blood test called OXcan. It aims to see if this blood test can accurately find lung cancer and help decide who truly needs a CT scan as part of NHS lung cancer screening.
United Kingdom · England - ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase II, single-arm trial to investigate tepotinib in advanced (locally advanced or metastatic) non-small cell lung cancer with MET exon 14 (METex14) skipping alterations or MET amplification (VISION)
This study is looking at a new medicine called tepotinib for certain types of advanced lung cancer. It aims to see how well it shrinks tumours in people with specific changes in their cancer cells (METex14 skipping or MET amplification).
Belgium · France · Poland - active not recruiting
Tissue Engineering Approaches to Treat COPD
This study is looking at lung tissue from people with and without COPD to understand the disease better. Researchers are also trying to create new lab-grown lung tissue to help treat lung damage, specifically focusing on how it might work with existing lung tissue.
United Kingdom - active not recruitingPHASE3
A Study to Assess the Efficacy and Safety of Zipalertinib Versus Placebo for Adjuvant Treatment in Participants With Stage IB-IIIA NSCLC With Uncommon EGFR Mutations, Following Complete Tumor Resection
This study is looking into a new drug, zipalertinib, for people with a certain type of lung cancer (NSCLC) in its early stages. It compares zipalertinib with standard chemotherapy to a dummy pill (placebo) with standard chemotherapy after surgery.
United States · Argentina · Australia - recruitingNA
Reducing Chronic Breathlessness in Adults by Following a Self-guided, Internet Based Supportive Intervention (SELF-BREATHE)
This study looks at how a self-guided online tool called SELF-BREATHE helps adults with long-term breathlessness. It aims to see if using this website improves their breathing and quality of life, and if it could be used more widely in the NHS.
United Kingdom - active not recruitingPHASE1, PHASE2
Study of EOS-448 With Standard of Care and/or Investigational Therapies in Participants With Advanced Solid Tumors
This study is testing different combinations of new drugs, including EOS-448, with or without standard treatments for advanced cancers like lung and head & neck cancer, and melanoma. Researchers want to see if these combinations are safe and effective.
United States · Belgium · France - recruiting
Testing whether adding a quick tummy scan to routine lung cancer screening can help detect other serious illnesses earlier
This study looks at adding a quick tummy scan to routine lung cancer checks for ever-smokers aged 55-70. It aims to see if this helps find other serious conditions, like kidney cancer, earlier. Researchers want to make sure it's practical and doesn't add too much time.
United Kingdom · England - recruitingPHASE2
Diagnostic Accuracy Study for OWL-EVO1 As a Lung Cancer EVOC® Probe (Evolution Phase 2)
This study is testing a new breath test called OWL-EVO1 to see if it can accurately find lung cancer. It involves comparing people with lung cancer to those without, to make sure the test works well and is easy to use.
Czechia · Hungary · United Kingdom - authorisedPhase II and Phase III (Integrated)
Test-Retest Evaluation of [18F]F-AraG in Lung Tumors (TREAT)
This study, called TREAT, is looking at a new way to check how lung tumours respond to treatment. It uses a special scan with a substance called [18F]F-AraG. The aim is to see if this scan can reliably measure changes in tumour activity, which could help doctors understand if a treatment is working.
Netherlands