Lung Cancer research hub

A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study Comparing Niraparib Plus Pembrolizumab Versus Placebo Plus Pembrolizumab as Maintenance Therapy in Participants Whose Disease has Remained Stable or Responded to First-Line Platinum Based Chemotherapy with Pembrolizumab for Stage IIIB/IIIC or IV Non-Small Cell Lung Cancer (ZEAL 1L)

This study looks at a new combination treatment for advanced lung cancer (non-small cell lung cancer). It compares two medicines, Niraparib and Pembrolizumab, with Pembrolizumab alone, to see if the combination helps people live longer or keeps their cancer from growing for longer.

A RANDOMIZED, PHASE 2, DOUBLE-BLIND STUDY TO EVALUATE THE EFFICACY OF DOSTARLIMAB PLUS CHEMOTHERAPY VERSUS PEMBROLIZUMAB PLUS CHEMOTHERAPY IN METASTATIC NON-SQUAMOUS NON-SMALL CELL LUNG CANCER

This study looks at new treatments for a type of lung cancer that has spread. It compares two different drug combinations, both including chemotherapy, to see which works better at shrinking tumours and helping people live longer. It's a key step in finding improved care.

A Phase II, two-arm study to investigate tepotinib combined with osimertinib in MET amplified, advanced or metastatic non-small cell lung cancer (NSCLC) harboring activating EGFR mutations and having acquired resistance to prior osimertinib therapy (INSIGHT 2 Study)

This study is for people with a certain type of advanced lung cancer that has stopped responding to a previous treatment called osimertinib. It tests a new combination of two drugs, tepotinib and osimertinib, to see if it can shrink tumours.

A Phase II, single-arm trial to investigate tepotinib in advanced (locally advanced or metastatic) non-small cell lung cancer with MET exon 14 (METex14) skipping alterations or MET amplification (VISION)

This study is looking at a new medicine called tepotinib for certain types of advanced lung cancer. It aims to see how well it shrinks tumours in people with specific changes in their cancer cells (METex14 skipping or MET amplification).

Phase Ib/II trial of the combination of atezolizumab with dendritic cell vaccination as maintenance treatment in patients with extensive stage small cell lung cancer (ES-SCLC) after induction treatment.

This study is looking at a new way to treat extensive small cell lung cancer. It combines a drug called atezolizumab with a special vaccine made from your own cells. The aim is to see if this combination can help people live longer without their cancer growing after initial treatment.

A multicentre phase II, open-label, non-randomized study evaluating Platinum-Pemetrexed-Atezolizumab ( Bevacizumab) for patients with stage IIIB/IV non-squamous non-small cell lung cancer with EGFR mutations, ALK rearrangement or ROS1 fusion progressing after Targeted therapies

This study looks at a new combination of existing medicines for a type of lung cancer (NSCLC) that has worsened after previous treatments. It aims to see how many patients respond positively to this new treatment approach.

Development of the Drug and Alcohol Respiratory Health Test

This study is creating a simple test to check lung health in adults who use certain substances. Many people with substance use disorder have breathing problems that often go unnoticed. This new test aims to find these issues early so people can get the right help.

A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors

This study is looking at new combinations of medicines for advanced lung or breast cancer. We want to see if they are safe, how much medicine gets into the body, and if they show early signs of working. It's for adults with certain types of advanced cancer.

A Study to Assess the Efficacy and Safety of Zipalertinib Versus Placebo for Adjuvant Treatment in Participants With Stage IB-IIIA NSCLC With Uncommon EGFR Mutations, Following Complete Tumor Resection

This study is looking into a new drug, zipalertinib, for people with a certain type of lung cancer (NSCLC) in its early stages. It compares zipalertinib with standard chemotherapy to a dummy pill (placebo) with standard chemotherapy after surgery.

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

This study is looking at a new treatment called HER3-DXd for people with certain advanced solid tumours that haven't responded to other treatments. It aims to see how well it works and if it's safe for different types of cancer, like melanoma, lung cancer, and breast cancer.

Assessment of Novel Biomarkers in Participants Undergoing Targeted Lung Health Checks

This study looks for new ways to spot lung cancer early in people having NHS lung health checks. Researchers are collecting samples like blood or spit to see if these can help find cancer better, especially when X-rays aren't clear. The goal is to improve how we find and treat lung cancer.

Study of Novel Treatment Combinations in Patients With Lung Cancer

This study looks at new drug combinations to treat lung cancer. It has three parts: for cancer that has spread, cancer that has grown despite previous treatment, and earlier-stage cancer that can be removed by surgery.

Analysis of Screen-detected Lung Cancers' Genomic Traits

This study looks at lung cancers found through screening to understand their unique features. Researchers want to learn more about these cancers to find better ways to check for them without needing surgery, making screening safer and more effective for everyone.

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

This study is testing a new drug, rezatapopt, for advanced cancers with a specific gene change (TP53 Y220C). It's also looking at rezatapopt with another drug, pembrolizumab, to see how safe and effective they are. It’s for people who have already had cancer treatment.

European Real-World Registry for Use of the Ion Endoluminal System

This study looks at how well a device called the Ion Endoluminal System works in real patients. It's for people having tests for lung growths (nodules) to see if they're cancerous or to help locate them for treatment.

A Clinical Study of Pembrolizumab (+) Berahyaluronidase Alfa (MK-3475A) to Treat Newly-diagnosed Metastatic Non-small Cell Lung Cancer (MK-3475A-F84)

This study looks at a new way to give a lung cancer medicine called pembrolizumab. It compares giving it through a drip in your arm (IV) versus a new injection under the skin (SC) for people with advanced non-small cell lung cancer. Researchers want to see how the injection works.

APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors

This study is testing a new oral medicine, APL-101, for people with advanced cancers. It focuses on lung cancer and other solid tumours where specific genetic changes linked to a protein called MET are found. Researchers want to see how well it works and if it's safe.

First in Human Study for the Assessment of Safety and Initial Performance of the EAS1 System

This study is testing a new system called EAS1 to treat lung cancer. It's the first time this system is being used in humans. Doctors want to see if it's safe and if it works well for people with early-stage lung cancer who could also have surgery.

The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study

The MOMENTUM Study is tracking how a new type of advanced radiotherapy, called MR-Linac, works for people with different cancers. It aims to see if this treatment improves survival, controls cancer better, and enhances quality of life by using highly precise radiation guidance.

Radiograph Accelerated Detection and Identification of Cancer in the Lung

This study looks at how a new computer program called qXR, which uses artificial intelligence (AI), can help doctors find lung cancer earlier. It checks chest X-rays to spot possible problems, aiming to improve diagnosis and treatment for people in the UK.

Study of EOS-448 With Standard of Care and/or Investigational Therapies in Participants With Advanced Solid Tumors

This study is testing different combinations of new drugs, including EOS-448, with or without standard treatments for advanced cancers like lung and head & neck cancer, and melanoma. Researchers want to see if these combinations are safe and effective.

An Observational Study of Predictors and Outcomes of Lung Cancer in Never-smokers in the UK

This study looks at lung cancer in people in the UK who have never smoked. Researchers want to understand why non-smokers get lung cancer and find ways to diagnose it earlier and improve treatment. Taking part won't change your usual medical care.

Bronchoscopic Microwave Ablation of Lung Tissue

This study looks at a new way to treat lung cancer using a special tool to heat and remove small growths (nodules) in the lungs. It aims to see how safe and effective this treatment is for patients.

Nodule IMmunophenotyping Biomarker for Lung Cancer Early Diagnosis Study

This study, called NIMBLE, uses AI to look at blood tests and CT scans to better tell the difference between harmless lung growths (nodules) and lung cancer. It aims to improve early diagnosis, especially for people with a history of cancer.

Reducing Chronic Breathlessness in Adults by Following a Self-guided, Internet Based Supportive Intervention (SELF-BREATHE)

This study looks at how a self-guided online tool called SELF-BREATHE helps adults with long-term breathlessness. It aims to see if using this website improves their breathing and quality of life, and if it could be used more widely in the NHS.

Rapid Absorbance-based Detection of Inner Cheek Cell Abnormalities Using Light Spectroscopy for Risk Evaluation of Lung Cancer to Enable Critical Decision Support in Targeted Patient Populations

This study is testing a new, simple cheek swab test called AIR-DS to help find lung cancer early. It looks for tiny changes in cells that might show lung cancer before it's severe. This could make detecting lung cancer easier and quicker.

DOLCE: Determining the Impact of Optellum's Lung Cancer Prediction Solution

This study checks if an AI tool helps doctors decide the best care for lung lumps. It aims to see if using AI improves patient health and saves money compared to current methods for managing these lumps.

AI & Radiomics for Stratification of Lung Nodules After Radically Treated Cancer

This study uses computers to analyse scans of new lung spots in people who've had cancer. It aims to help doctors tell if these spots are harmless, a new cancer, or cancer spread, to improve diagnosis and care.

The SUMMIT Study: A Cancer Screening Study

The SUMMIT study is looking at better ways to find cancer early. It will test a blood test for many cancers and offer special lung scans to people at higher risk in London who have smoked. The goal is to improve how we check for cancer.

A Feasibility Study of MRI Guided Stereotactic Ablative Radiotherapy (MIDSECTION)

This study looks at treating abdominal and lung cancers using a new type of radiotherapy machine, called an MR-Linac. It aims to see if this machine can deliver very precise radiation to tumours while better protecting healthy tissues, and how it affects the patient experience.

CMR Right Ventricular Contractile Reserve Following Lung Resection

This study looks at how lung surgery affects heart health. We're using special heart scans to see if removing part of a lung changes how the heart's right side works, and if this affects how well people can do daily activities.

Bronchoscopic Microwave Ablation of Lung Tissue in Surgical Candidates - UK

This study is testing a new way to treat lung cancer using heat to destroy cancer cells, called microwave ablation. It hopes to see if this treatment could help patients avoid major surgery for lung tumours, improving recovery and reducing complications in the future.

Clinical Investigation Evaluating the Performance, Safety and Clinical Benefit of the Endowave FlexAblate™ Microwave Ablation System in Patients Undergoing Lung Ablation Procedures.

This study looks at a new way to treat lung cancer called microwave ablation. It's for people with lung nodules who can't have surgery or choose not to. The study will check if the treatment works and is safe.

SCOOT: Sample Collection for DART

This study helps find lung health problems, especially lung cancer, earlier. We use a blood sample to create new computer tools. These tools aim to speed up diagnosis and help doctors choose the best treatment faster for people aged 55-75 with certain lung findings.

Test-Retest Evaluation of [18F]F-AraG in Lung Tumors (TREAT)

This study, called TREAT, is looking at a new way to check how lung tumours respond to treatment. It uses a special scan with a substance called [18F]F-AraG. The aim is to see if this scan can reliably measure changes in tumour activity, which could help doctors understand if a treatment is working.

Understanding the Feasibility of a Co-designed Pre-radiotherapy Exercise Programme - A Single-arm Study

This study looks at a new exercise plan for people with lung cancer having radiotherapy. Participants cycle for 20 minutes before treatment to see if it's helpful and safe. The goal is to make treatment easier for future patients.

Lung cAncer Robotic Comparative Study

This study compares two keyhole surgeries for early lung cancer: robotic-assisted and video-assisted. It aims to see which method works best, helps recovery, and improves patients' quality of life when treating small lung cancers.

Diagnostic Accuracy Study for OWL-EVO1 As a Lung Cancer EVOC® Probe (Evolution Phase 2)

This study is testing a new breath test called OWL-EVO1 to see if it can accurately find lung cancer. It involves comparing people with lung cancer to those without, to make sure the test works well and is easy to use.

CA209-8KX Phase I/II pharmacokinetic multi-tumor study of subcutaneous formulation of nivolumab monotherapy

A Phase 3 Study to Evaluate Zimberelimab (AB122) Combined with Domvanalimab (AB154) Compared to Pembrolizumab in Front-Line, PD-L1-High, Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Oxford Pleural Embolisation Trial

This study looks at a simple way to prevent a common side effect, a 'collapsed lung' (pneumothorax), after lung cancer treatment called thermal ablation. It tests if injecting a patient's own blood around the lung helps seal tiny air leaks, potentially making recovery quicker and safer.

Tissue Engineering Approaches to Treat COPD

This study is looking at lung tissue from people with and without COPD to understand the disease better. Researchers are also trying to create new lab-grown lung tissue to help treat lung damage, specifically focusing on how it might work with existing lung tissue.