Assessment of Novel Biomarkers in Participants Undergoing Targeted Lung Health Checks
This study, called ALPINE, is helping us understand lung cancer better. It focuses on people in North Central London who are already having NHS lung health checks, which use special X-rays called low-dose CT scans. These scans are good at finding problems, but sometimes it's hard to tell if a spot on the lung is serious or not. The researchers want to collect small samples, like blood or spit, from participants to look for ‘biomarkers’. These are tiny signals in the body that could help tell us more about lung changes. By combining these samples with scan results, the study hopes to find more accurate ways to identify lung cancers that need treatment, and avoid unnecessary worry or procedures for harmless spots. This could lead to better and more personalised care for everyone.
At a glance
What is this study about?
The ALPINE study is all about improving how we find lung cancer early. Currently, the NHS offers Lung Health Checks to people at higher risk, using a special type of X-ray called a low-dose CT scan. These scans are really good at spotting early signs of lung cancer, which can help save lives. However, sometimes these scans show small spots in the lungs that are hard to tell apart – are they a serious cancer that needs treatment, or just something harmless? This can cause worry and sometimes lead to more tests that might not be needed.
Researchers are very interested in finding new ways to get clearer answers. One promising idea is to look for 'biomarkers' – these are like unique chemical signals that our bodies produce. They can be found in simple samples like blood or saliva (spit). The ALPINE study aims to collect these types of samples from people who are already having a Lung Health Check in North Central London. By comparing what they find in these samples with the CT scan results and the patient's health information, they hope to discover biomarkers that can help doctors make more accurate decisions.
Ultimately, the goal is to make lung cancer screening even better. If we can use these biomarkers alongside CT scans, it might become easier to tell the difference between serious cancers and harmless spots. This could help doctors recommend the right treatment at the right time, prevent unnecessary worry or procedures, and improve the chances of successful treatment for those who need it.
Key takeaways
- It's about finding better ways to detect lung cancer early.
- The study uses samples like blood or spit alongside current X-ray scans.
- You must be between 55 and 74 and already in an NHS Lung Health Check.
- Participation involves giving samples during your usual health check visits.
- This research aims to improve lung cancer screening for future patients.
Who may be eligible?
This study is open to people who are already taking part in the NHS Lung Health Check programme in North Central London. You need to be between 55 and 74 years old (up to your 75th birthday).
It's important that you are able to understand what the study involves and can give your written permission to take part. Your doctor will also need to agree that joining the study is suitable for you.
If you don't want to be involved, you won't be able to join. Also, if for any reason you can't understand or give your permission, or if your doctor advises against it, then you won't be able to take part.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you between 55 and 74 years old?
- Are you already attending an NHS Lung Health Check in North Central London?
- Can you understand what the study involves and agree to take part?
- Has your doctor confirmed you are suitable for the study?
What does participation involve?
If you decide to take part in the ALPINE study, it will run alongside your regular NHS Lung Health Check appointments. You won't have to visit the clinic more often than planned for your health check. The main thing you'll be asked to do is provide some small, simple samples, such as blood or saliva (spit), during one of your existing health check visits. These samples will then be stored and analysed by the research team to look for new markers for lung cancer.
You won't be given any new medications as part of this study. The researchers will also use information from your CT scans and your general health records, but all your personal details will be kept private. The study is collecting information over time to help future research, so there isn't a specific 'end date' for your individual participation beyond providing the samples and allowing your health information to be used for the study.
Potential risks and benefits
Locations (1)
- University College London Hospitals NHS Foundation TrustVerified postcodeLondon, United Kingdom· Recruiting
Common questions
What is a 'biomarker'?
A biomarker is like a tiny signal in your body, found in samples like blood or saliva, that can tell us about your health or if a disease is present.
Will taking part affect my NHS Lung Health Check appointments?
No, taking part in the study will happen alongside your planned NHS Lung Health Check appointments and won't change them.
Do I have to take any new medicine for this study?
No, you will not receive any new medications as part of the ALPINE study.
What kind of samples will be collected?
The study aims to collect simple samples, such as blood or saliva (spit), during your health check visit.
Can I change my mind after joining the study?
Yes, you can withdraw from the study at any time, and it won't affect your medical care.
How to find out more
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
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