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An Observational Study of Predictors and Outcomes of Lung Cancer in Never-smokers in the UK

This important UK study is investigating lung cancer in adults who have never smoked, meaning they've smoked fewer than 100 cigarettes in their lives. The main goal is to understand more about people who get lung cancer without having smoked, to help find it earlier and improve outcomes. Researchers will look at things like people's backgrounds, health conditions, and environment. They will also study how people found out they had lung cancer, their symptoms, and the treatments they received. This information could help doctors identify lung cancer sooner in non-smokers. During the study, your usual medical care will not change.

At a glance

Status
Recruiting
Sponsor
University College London Hospitals
Enrolment target
225
Start
17 Sep 2024
Estimated completion
01 Sep 2029

What is this study about?

Lung cancer is often linked with smoking, but unfortunately, some people who have never smoked can also develop it. This study is specifically for adults in the UK who have lung cancer but have never smoked cigarettes or tobacco. The main purpose is to learn more about why these individuals get lung cancer and how their illness progresses.

Researchers want to gather information about people's health history, symptoms they experienced, and how their lung cancer was diagnosed. They will also look at the different treatments individuals received and how these affected them. By understanding these stories, the study hopes to find patterns that could lead to earlier diagnosis for other non-smokers in the future.

Ultimately, the project aims to identify any factors – both things we can change and things we can't – that might be linked to lung cancer in non-smokers. This includes looking at things like environmental factors, blood tests, and even genetic information. All this information will help doctors and researchers understand the disease better and hopefully find ways to improve care and save lives.

Key takeaways

  • The study focuses on lung cancer in UK adults who have never smoked.
  • It aims to understand why non-smokers get lung cancer and identify early diagnosis signs.
  • Your medical treatment will not change if you participate.
  • Information will be collected from your medical records; no extra tests or visits are needed.
  • Your contribution helps improve future care for other non-smoking lung cancer patients.
  • You can stop participating at any time without affecting your care.

Who may be eligible?

To be able to join this study, you must be an adult aged 18 or older and have already been diagnosed with primary lung cancer. This diagnosis would have been confirmed by scans or tissue samples at one of the hospitals taking part in the study.

A very important rule for this study is that you must have *never* smoked cigarettes or tobacco. This means you must have smoked fewer than 100 cigarettes in your whole life, or less than 75 grams of tobacco. If you have ever been prescribed nicotine replacement therapy, you would also not be able to join.

Also, if you are being considered for the study, you must be able to understand what is being asked of you and give your full permission to take part.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

  1. Are you an adult aged 18 or over?
  2. Have you been diagnosed with primary lung cancer?
  3. Have you smoked fewer than 100 cigarettes in your whole life? (This means 'never-smoker' for the study)
  4. Have you *never* received a prescription for nicotine replacement therapy?
  5. Are you able to understand the study and give your permission to take part?
Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, your involvement won't change your standard medical care for your lung cancer. You won't be given any new treatments or procedures because of the study. The researchers will simply be collecting information about your diagnosis, symptoms, previous health, and the treatments you receive as part of your normal care. This information will come from your medical records. You won't need to visit extra clinics or have additional tests specifically for this study. The study involves collecting this information over time, but it won't impact your daily life or treatment schedule.

Potential risks and benefits

Taking part in this study is considered very low risk because it mainly involves looking at information from your medical records and does not change your treatment or add any procedures. The main benefit is that your information will help doctors understand lung cancer in non-smokers better, potentially leading to earlier diagnosis and improved care for others in the future. You have the right to withdraw from the study at any time without giving a reason, and this will not affect your medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.
  • University College London Hospital
    Verified postcode
    London, United Kingdom· Recruiting

Common questions

What is a 'never-smoker' in this study?

In this study, a 'never-smoker' means someone who has smoked fewer than 100 cigarettes or less than 75 grams of tobacco in their entire life.

Will my treatment change if I join this study?

No, your medical care and treatment will not change at all if you take part. The study just collects information about your existing care.

What kind of information will the study collect about me?

The study will collect details about your background, other health conditions, how your lung cancer was diagnosed, your symptoms, and the treatments you receive.

Do I need to visit the hospital more often for this study?

No, there are no extra hospital visits required specifically for this study. All information will be gathered from your existing medical records.

Why is this study important?

It's important because it helps doctors learn more about lung cancer in people who have never smoked, which can lead to better ways to find the disease earlier and improve care for others.

How to find out more

Neal Navani, PhD

Always speak to your GP or specialist before deciding to take part in a study.

Interested in taking part?

Register your interest

Share your details and the research team for "An Observational Study of Predictors and Outcomes of Lung Ca…" will contact you if you may be eligible. Always speak to your GP before agreeing to take part.

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