A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease

To join this study, you must have been officially diagnosed with Crohn's disease, and your condition needs to be moderately to severely active – meaning you're experiencing noticeable symptoms. You also need to weigh at least 40 kilograms (about 6 stone 4 pounds) and be between 16 and 80 years old. An important point is that previous treatments for your Crohn's disease must not have worked well for you, or you couldn't tolerate them.

There are certain reasons why you might not be able to join. For example, if you have other specific gut conditions like ulcerative colitis or have had many past operations on your bowel. You also can't take part if you have certain severe bowel problems like a completely blocked bowel, bad infections (like C. difficile or tuberculosis that isn't fully treated), or some serious liver problems.

Women who are pregnant, breastfeeding, or planning to become pregnant during the study cannot participate. Also, if you have or have had certain cancers, you might not be eligible. These rules help make sure the study is safe for everyone involved and that the results are clear.

If you decide to take part in this study, you will receive either the new medicine, Afimkibart, or a dummy medicine called a placebo. You won't know which one you're getting, and neither will your study doctor. This is standard practice in medical research to ensure fair and accurate results. You'll need to attend regular visits to the hospital or clinic so the study team can monitor your health, check your symptoms, and see how you're responding to the treatment.

During these visits, you can expect to have various assessments, which might include blood tests, stool (poo) samples, physical examinations, and possibly some scans or scopes to look inside your bowel. You will also be asked to keep track of your symptoms and any side effects you experience. The medicine itself will likely be given over a period to see its full effect. You'll be closely supported by the study team throughout the whole process. The total time you'd be involved in the study would depend on the study design, but generally, these types of studies involve several months of treatment and follow-up.