RecruitingOBSERVATIONAL

Myeloma Novel Drug Discovery Ver 1.2

This study, called 'Myeloma Novel Drug Discovery', aims to improve our understanding of myeloma, a cancer affecting the bone marrow. Every year, over 5,000 people in the UK are diagnosed with myeloma. Researchers want to better understand this condition and find more effective treatments with fewer side effects. To do this, we are collecting small samples of blood and bone marrow. These samples will be used in the laboratory to test possible new treatments and to figure out why some existing treatments might not always work as well as hoped. Taking part means giving an extra small sample during a routine procedure.

At a glance

Status

Recruiting

Sponsor

Institute of Cancer Research, United Kingdom

Enrolment target

250

Start

22 Jul 2020

Estimated completion

28 Feb 2035

Multiple Myeloma

What is this study about?

Myeloma is a type of cancer that starts in the bone marrow, the soft tissue inside our bones. Here in the UK, more than 5,000 new cases are found each year. This study, called 'Myeloma Novel Drug Discovery', is all about helping scientists learn more about myeloma. Their main goal is to find better ways to treat this cancer, hoping to make treatments more effective and cause fewer unwanted side effects, ultimately improving the lives of patients.

To achieve this, researchers need to understand more about how myeloma works and why treatments succeed or fail. They are doing this by collecting samples of blood and bone marrow. These samples are really important because they allow scientists to test new possible treatments in the lab. They can also use them to figure out why some treatments might not work for certain people, which is a big step towards developing more personalised care.

This study is unique because it's an 'observational study'. This means you won't be given any new medicines or treatments as part of the study itself. Instead, it carefully watches and collects information from samples that are already being taken as part of your normal medical care. The information gathered from these samples could lead to breakthroughs in how myeloma is treated in the future.

Key takeaways

This study helps scientists learn more about myeloma.
It collects extra blood and bone marrow samples during routine procedures.
No new treatments or extra appointments are involved.
Your samples help find better treatments for myeloma patients.
You can stop taking part at any time without it affecting your care.

Who may be eligible?

This study is looking for adults aged 18 or over who either have myeloma, or who doctors think might have it, or a related condition affecting the plasma cells. You can be at any stage of your diagnosis, treatment, or follow-up.

To be able to take part, you would already be having a routine blood test or bone marrow sample taken by your medical team for your diagnosis, to check how you're doing, or for follow-up. We would then ask if you would be willing to provide a small extra sample at the same time as this planned procedure.

However, you won't be able to join if you can't give your agreement to take part, or if you have certain active infections like HIV, Hepatitis B/C, or COVID that could make your sample unsafe for laboratory use by the research team.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Do you have, or might you have, myeloma or a similar condition?
Are you already scheduled for a blood test or bone marrow sample?
Are you willing to give an extra small sample during that procedure?
Are you able to agree to take part in the study?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, your involvement would be very simple. It means that when you are already having a routine blood test or a bone marrow sample taken for your diagnosis, staging, or follow-up, an additional small sample would be collected at the same time. You won't need any extra visits to the hospital or clinic specifically for this study. There are no new medications to take as part of the study, and no extra tests or follow-up appointments beyond your usual medical care. The total duration of your participation would only be the time it takes to collect that extra sample during your planned procedure.

Potential risks and benefits

The main benefit of taking part is that your small sample could greatly contribute to advancing our understanding of myeloma and help develop new, more effective treatments for future patients. There are very few risks, as the extra sample would be taken during a procedure you're already having, meaning no additional discomfort beyond what you would experience normally. Your health information would be kept private. You are free to change your mind and withdraw from the study at any time without affecting your medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

The Royal Marsden NHS Foundation Trust
Verified postcode
Sutton, United Kingdom· Recruiting

Common questions

What is myeloma?

Myeloma is a type of cancer that starts in the bone marrow, which is the soft tissue inside your bones that makes blood cells.

Will I receive new treatment in this study?

No, this is an observational study, meaning you won't be given any new medicines or treatments as part of the research itself.

How long will my involvement in the study last?

Your involvement is very brief – it only takes place during a routine blood test or bone marrow sample you're already having.

Will taking part affect my regular medical care?

No, taking part in this study will not affect your usual medical care or treatment plan in any way.

What happens to my samples?

Your samples will be used in the laboratory to help scientists test new treatments and better understand myeloma, to benefit future patients.

How to find out more

Disco Team

Disco.iras263630@nhs.net 020 3186 5275 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.