RecruitingNAINTERVENTIONAL

Evaluation of a PREHABilitation Protocol Using Adapted Physical Activity (APA) for Multiple Myeloma Patients Eligible for Intensive Autologous Stem Cell Transplantation Treatment

This study is exploring whether specially designed exercise programmes, known as 'adapted physical activity' (APA), can benefit people with multiple myeloma who are expecting to have a stem cell transplant. Previous research on exercise programmes for cancer patients has had mixed results, with some showing good effects on quality of life, tiredness, and physical fitness, while others have shown little improvement. This might be because the exercise plans weren't quite right or people found them hard to stick to. This new study aims to create an exercise programme that is not only effective but also enjoyable and easy for patients to continue. The main goal is to find a programme that improves how patients feel, reduces fatigue, and boosts their physical condition before their transplant, making sure it can work for as many people as possible, regardless of their age or current fitness level.

At a glance

Status

Recruiting

Phase

Sponsor

Centre Hospitalier Henri Duffaut - Avignon

Enrolment target

120

Start

10 Feb 2025

Estimated completion

28 Feb 2028

Multiple Myeloma

What is this study about?

Imagine you're getting ready for a big challenge, like a very important medical procedure. Wouldn't it be great to feel as strong and ready as possible beforehand? That's exactly what this study is trying to achieve for people with multiple myeloma who are going to have a stem cell transplant. Multiple myeloma is a type of cancer that affects cells in your bone marrow. A stem cell transplant is a treatment that can help, but it can be quite demanding on your body.

Researchers want to see if specific exercise programmes, called 'adapted physical activity' (APA), can help patients feel better and stronger before their transplant. Think of APA as exercise tailored just for you and your health needs. While some studies have shown that exercise can really help people with cancer feel less tired and improve their quality of life, others haven't seen the same clear benefits. One of the reasons for this might be that some exercise plans are difficult for patients to keep up with, or they just don't enjoy them.

This study aims to design an exercise programme that not only works well but is also appealing and easy for patients to stick with. The ultimate goal is to find the best way to use exercise to improve patients' energy levels, physical fitness, and overall well-being. This will allow them to go into their stem cell transplant feeling as healthy and prepared as possible, and importantly, the programme will be suitable for many people, no matter their age or how fit they are currently.

Key takeaways

This study evaluates tailored exercise for multiple myeloma patients.
It aims to improve quality of life, fatigue, and physical health before a stem cell transplant.
The goal is to create an effective and easy-to-stick-with exercise plan.
It will consider patients' individual needs, age, and fitness level.
Participation involves adapted exercises and completing questionnaires.

Who may be eligible?

To join this study, participants need to be at least 18 years old and have been diagnosed with multiple myeloma. It's important that they are also candidates for a specific type of stem cell transplant, known as an autologous stem cell transplant. Participants should also be able to read and understand French, as they'll need to complete questionnaires in this language.

There are also some reasons why someone might not be able to join. For example, if you've had another type of cancer in the last three years (with some exceptions like very common skin cancers), or if you have certain heart conditions or severe bone problems that would make exercise unsafe, you might not be eligible. They also can't include individuals who have significant nerve damage affecting their senses or movement, or those under legal guardianship.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years or older?
Do you have multiple myeloma and are you eligible for an autologous stem cell transplant?
Can you read and complete questionnaires in French?
Do you have a doctor's prescription for adapted physical activity?
Have you discussed any other recent cancer diagnoses or serious health conditions with your doctor?

Answer every question to see your result.

What does participation involve?

The study aims to understand how specially designed exercise sessions can help you. The details of what taking part involves aren't fully described in the summary provided, but typically in similar studies, you might:

* Attend regular exercise sessions, which could be supervised or given as a plan to follow at home. * Fill out questionnaires about your quality of life, how tired you feel, and your usual physical activity levels. * Have your physical condition assessed at different times during the study.

The overall duration of your participation would depend on the specific programme length, often lasting several weeks or months leading up to your transplant.

Potential risks and benefits

Taking part in this study could potentially offer several benefits, such as improving your energy levels, physical fitness, and overall well-being before your stem cell transplant. The exercises are designed to be adapted to your needs, aiming to be safe and effective. However, some risks associated with physical activity can include muscle soreness or, rarely, injuries. It's also possible that the exercise programme might not help everyone. You have the right to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Centre Hospitalier d'Avignon, Hôpital Henri Duffaut
Verified postcode
Avignon, France· Recruiting

Common questions

What is 'Adapted Physical Activity' (APA)?

APA is an exercise programme specifically designed and adjusted for your individual health condition and abilities, making it safe and beneficial for you.

Who is this study for?

This study is for adults (18 years or older) in France who have multiple myeloma and are preparing for an autologous stem cell transplant.

What does the study hope to achieve?

It aims to find the most effective and user-friendly exercise programme to improve quality of life, reduce tiredness, and boost physical fitness for patients before their transplant.

Will the exercise programme be difficult?

The programme will be adapted to your individual pace and physical condition, so it should be manageable and safe for you.

Do I have to speak French to participate?

Yes, you need to be able to read, understand, and complete questionnaires in French.

How to find out more

Marilyne Grinand, PhD

grinand.marilyne@ch-avignon.fr (+33)432759392 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.