A study investigating the effect of curcumin on the absorption and elimination of IMU 838, a new compound that may potentially be used in the treatment of multiple sclerosis, and the effect of IMU 838 on the absorption and elimination of rosuvastatin.
This study is focused on understanding how a new medicine called IMU 838 moves through your body – how it's taken in and how it's removed. IMU 838 is being developed as a possible new treatment for multiple sclerosis, a condition that affects your brain and spinal cord. Researchers will also look at how IMU 838 interacts with curcumin, a natural substance found in turmeric. Additionally, they will observe if IMU 838 affects how another common medicine, rosuvastatin (used for lowering cholesterol), works in the body. This is an early-stage study, meaning it's one of the first times this drug is being tested in humans to see how it behaves, rather than testing its effectiveness as a treatment.
At a glance
What is this study about?
This study is a very early step in understanding a new medicine called IMU 838, which could one day help people with multiple sclerosis (MS). When a new medicine is developed, scientists first need to understand exactly what happens to it inside the human body. This includes looking at how much of the medicine gets absorbed into the bloodstream, how it travels around, and how quickly it's removed from the body. This information is really important for working out the right dose and how often a medicine should be taken.
Another key part of this research is to see if IMU 838 interacts with other common substances. Specifically, the study will look at how IMU 838 behaves when curcumin is also present. Curcumin is a natural compound found in turmeric, which some people take as a supplement. It's important to know if taking IMU 838 alongside curcumin changes how either substance works in the body. The study will also investigate if IMU 838 affects how a widely used cholesterol-lowering medicine, called rosuvastatin, is processed by the body.
Understanding these interactions is vital for patient safety and for doctors to know if they need to adjust doses of other medications when someone is taking IMU 838. Because this is a very early-stage study, it's not looking at whether IMU 838 can treat MS yet. Instead, it's focused purely on the 'body science' part – how the medicine moves in and out of people. This kind of research helps ensure that if the drug moves to later stages of testing, we already have a good understanding of its basic behaviour.
Key takeaways
- This study looks at how a new drug for MS, called IMU 838, acts in the body.
- It checks how IMU 838 interacts with curcumin and rosuvastatin.
- It's an early safety and 'how it works' study, not a treatment trial.
- Open to healthy adults aged 18 and over, both men and women.
- Your participation helps advance medical understanding.
Who may be eligible?
This study is looking for healthy adult volunteers. To take part, you must be at least 18 years old. There is no upper age limit, meaning older adults can also participate.
Both men and women are welcome to join this study. The researchers need to understand how the new medicine behaves in a broad range of people.
Further details about whether you are suitable for the study would be discussed in more detail if you were interested in taking part. They would look at your overall health to make sure it's safe for you to participate.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you at least 18 years old?
- Are you generally healthy?
- Are you comfortable completing multiple clinic visits?
- Are you willing to have regular blood and urine tests?
- Are you able to follow study instructions carefully?
What does participation involve?
Taking part in this study would involve a series of visits to a clinic. You would likely need to take the study medication (IMU 838) and potentially curcumin or rosuvastatin, depending on which group you are in. Researchers will take blood and urine samples regularly to measure how the drugs are absorbed and eliminated from your body. You might also have other health checks like blood pressure measurements or heart rate monitoring. The total duration of your participation would be explained fully before you decide to join, including how many visits are needed and how long each visit might last.
Potential risks and benefits
Locations (1)
- —UnverifiedNetherlands
Common questions
What is multiple sclerosis (MS)?
MS is a condition that affects your brain and spinal cord, leading to a range of symptoms like tiredness, walking difficulties, and vision problems.
What is IMU 838?
IMU 838 is a new medicine being studied as a possible future treatment for multiple sclerosis.
What is curcumin?
Curcumin is a natural substance found in turmeric, a spice often used in cooking and sometimes taken as a supplement.
What is rosuvastatin?
Rosuvastatin is a common medicine prescribed by doctors to help lower high cholesterol levels.
Will this study help my MS?
This is an early study to understand how IMU 838 works in the body, not to test if it treats MS. So, it's unlikely to directly help your symptoms.
How to find out more
Always speak to your GP or specialist before deciding to take part in a study.
Discussion
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