REFUEL-MS: Clinical and Cost-Effectiveness RCT

Many people living with Multiple Sclerosis (MS) find that tiredness, or fatigue, is a big problem for them. However, not everyone gets help for it as part of their routine care. This study is about testing a new app called REFUEL-MS, which was created with input from people with MS themselves. The app is designed to help reduce that feeling of extreme tiredness. It offers different tools like physical activities, balance exercises, and ways to manage thoughts and feelings (similar to a technique called Cognitive Behavioural Therapy, or CBT). Past research suggests these types of approaches can be helpful for MS fatigue.

The main goal of this study is to see how well the REFUEL-MS app works to reduce MS-related fatigue compared to the usual care you might receive. We also want to make sure it's safe to use. The app is a bit special because it's 'patient-led'. This means you can choose what parts of the app are most helpful for you, like focusing on physical exercise or coping strategies. You can also set your own goals and keep track of your progress. Plus, a healthcare professional will be there to support you through virtual appointments and messages in the app. It's important to remember that the REFUEL-MS app is meant to be an extra tool and won't replace any medical care you’re already getting for your MS.

We are looking for 378 people with MS from across the UK to take part. We're particularly interested in including people who might not usually get involved in MS research, such as older people, men, those from LGBTQ+ communities, different ethnic backgrounds, or those with varying levels of disability or digital experience. If you don't have a suitable smartphone or tablet, we can lend you one for the study. By taking part, you could help us find new ways to improve treatment for MS fatigue and contribute to future research.