AuthorisedPhase III and phase IV (Integrated)Interventional

Antibiotic Treatment Trial in Acute Coronary Syndrome

This research, called the 'Antibiotic Treatment Trial in Acute Coronary Syndrome', is investigating if certain antibiotics might help people who have recently experienced a heart attack. The doctors want to see if these medications, specifically Ceftriaxon and Amoxin, can prevent serious health issues like another heart attack, heart failure, or a stroke in the 12 months after the first event. This is a large study (Phase III and IV) meaning it's building on earlier research. It will follow participants for up to five years to understand the longer-term effects. Anyone aged 18 or older can be considered for this trial.

At a glance

Status

Authorised

Phase

Phase III and phase IV (Integrated)

Sponsor

TAYS Sydaenkeskus Oy

Enrolment target

1,070

Start

27 Aug 2025

non-ST-elevation myocardial infarction (NSTEMI)ST-elevation myocardial infarction (STEMI)coronary artery disease

What is this study about?

Imagine you've had a heart attack – a serious event where blood flow to your heart is suddenly blocked. Doctors are always looking for new ways to help people recover and prevent future problems. This study is exploring a really interesting idea: could common antibiotics, medicines usually used to fight infections, also help protect your heart and brain after a heart attack?

Specifically, the trial is looking at two antibiotics, Ceftriaxon and Amoxin. The main goal is to see if, one year after a heart attack, people taking these antibiotics have fewer serious health issues. These serious issues include things like having another heart attack, developing severe heart failure (meaning your heart struggles to pump blood), or experiencing a stroke or a 'mini-stroke' (TIA). The researchers will also be checking on these health issues at 3 months, 2 years, and even 5 years to get a full picture of the long-term effects.

This is an important piece of research because if antibiotics are found to be helpful, it could offer a new and simple way to improve the health of many people who have had a heart attack. It builds on what we already know about how our bodies react to a heart attack, and whether reducing inflammation or fighting certain hidden infections might play a role in recovery.

Key takeaways

Tests if antibiotics can prevent serious health problems after a heart attack.
Specifically looks at preventing heart attacks, strokes, or severe heart failure.
Involves two common antibiotics: Ceftriaxon and Amoxin.
Follows participants for up to 5 years to see long-term effects.
Open to adults aged 18 and over who have recently had a heart attack.

Who may be eligible?

To be able to join this study, there are a few main things the doctors will be looking for. Firstly, you must be an adult – meaning you are 18 years old or older. There is no upper age limit, so people of all adult ages can be considered.

Secondly, the study is for people who have recently experienced a specific type of heart attack. This includes those who have had what doctors call a 'non-ST-elevation myocardial infarction' (NSTEMI) or an 'ST-elevation myocardial infarction' (STEMI). These are simply different ways doctors describe heart attacks that show up differently on an ECG test. People with coronary artery disease, which is a common cause of heart attacks, may also be suitable.

Both men and women are welcome to take part in this research. The study team will review your full medical history and current health carefully to make sure the trial is safe and appropriate for you.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Have you recently had a heart attack (NSTEMI or STEMI)?
Are you willing to potentially receive an antibiotic or a dummy pill?
Are you able to attend follow-up appointments for up to 5 years?
Are you happy for your health information to be used for research?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, you might receive one of the antibiotics (Ceftriaxon or Amoxin) or a placebo (a dummy pill with no active medicine, which looks the same). You wouldn't know which one you are getting, and neither would your study doctor, as this helps make the results fair and accurate.

You would need to have several check-ups and assessments over a period of time. This includes visits at 3 months, 12 months, 2 years, and 5 years after joining the study. These visits usually involve talking to the study team about your health, checking your heart, and possibly having some blood tests. The total duration of your participation, including follow-up, could be up to five years.

Potential risks and benefits

Participating in a study means you might receive a new treatment that could potentially help your heart health, but there's no guarantee. You might also receive a placebo. Like all medicines, antibiotics can have side effects, and the study team will explain these in detail. There might also be risks or discomforts from the tests and procedures involved. It's important to remember that you are free to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
Finland

Common questions

What is a 'heart attack' in this study?

It refers to a serious event where blood flow to your heart is blocked, specifically NSTEMI or STEMI, which doctors diagnose.

What are the antibiotics being tested?

The study is testing Ceftriaxon and Amoxin, which are common medicines used to fight infections.

Will I know if I'm getting an antibiotic or a dummy pill?

No, neither you nor your study doctor will know. This is to ensure the results are unbiased.

How long will I be involved in the study?

You'll be followed for up to 5 years, with check-ups at specific times throughout this period.

Can I stop being part of the study once I've started?

Yes, you can choose to leave the study at any time, for any reason, without it affecting your usual medical care.