AuthorisedHuman Pharmacology (Phase I)- OtherInterventional

A research study to see how NNC0487-0111 affects the body’s energy use after a weight loss in adults living with obesity, compared to a low-calorie diet or placebo

If you've lost weight but are still living with obesity, your body might try to put that weight back on. This study is testing a new medicine, called NNC0487-0111, to see if it can help prevent this by affecting how your body uses energy. Researchers want to compare the effects of this new medicine with a low-calorie diet or a placebo (a dummy medicine with no active ingredients). This is a very early-stage study, meaning it's primarily focused on understanding how the new medicine works in the body and if it's safe. It's for adults aged 18 and over, of any gender. The goal is to find better ways to support people in managing their weight over the long term.

At a glance

Status

Authorised

Phase

Human Pharmacology (Phase I)- Other

Sponsor

Novo Nordisk A/S

Enrolment target

120

Start

11 May 2026

Obesity

What is this study about?

When people lose weight, their body often tries to get back to its original weight. This can make it hard to keep the weight off in the long run. Scientists are trying to understand why this happens and develop new ways to help. This research study is looking at a new treatment called NNC0487-0111. The main aim is to see how this new medicine affects the way your body burns energy after you’ve lost weight. This is important because how your body uses energy plays a big role in maintaining your weight.

The study will compare the effects of NNC0487-0111 with two other approaches: a low-calorie diet and a placebo. A placebo is a dummy medicine that looks just like the real medicine but contains no active ingredients. This helps researchers understand if any changes are truly due to the new medicine or just other factors, like the expectation of feeling better. By comparing these groups, scientists hope to learn if NNC0487-0111 could be a helpful tool for people who are managing their weight.

This is a very early stage of research, sometimes called a Phase I study. This means the main focus is on how the new medicine works in the human body and to check its safety. It's not about whether it can cure a condition, but rather to gather important information that will help decide if it should be studied further in larger groups of people. Participants will be carefully monitored throughout the study to ensure their well-being.

Key takeaways

This study is testing a new medicine, NNC0487-0111, for adults managing obesity after weight loss.
It aims to understand how the medicine affects the body's energy use.
The study compares the medicine to a low-calorie diet or a dummy medicine (placebo).
It's an early-stage study (Phase I) focusing on safety and how the medicine works.
Participants must be adults aged 18 or older, of any gender.
Your participation could help researchers find new ways to support weight management.

Who may be eligible?

To be considered for this study, you must be an adult aged 18 or older. The study is open to both men and women.

More detailed information about who can and cannot join a study is usually provided by the research team. This often includes specific health conditions, medications you might be taking, or other factors. These rules are in place to keep you safe and to make sure the study results are clear and accurate.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Are you an adult living with obesity who has experienced weight loss?
Are you comfortable potentially receiving a new medicine, a low-calorie diet, or a placebo?
Are you able to attend regular clinic visits and follow study instructions?

Answer every question to see your result.

What does participation involve?

If you choose to take part in this study, you will have several visits to the clinic. These visits will involve various assessments, such as health checks, blood tests, and possibly measurements of your body's energy use. You would be given either the new medicine (NNC0487-0111), instructions for a low-calorie diet, or a placebo to take as directed. You would need to follow these instructions carefully. The research team will regularly check on your health and any side effects you might experience. After the main treatment period, there will likely be follow-up visits to see how you are doing. The total duration of your participation in the study, including all visits and follow-ups, would be explained to you in detail by the research team.

Potential risks and benefits

Taking part in a research study has potential benefits and risks. You might gain access to a new treatment before it's widely available, and your participation could help others in the future by advancing medical knowledge. However, there's no guarantee the new medicine will work for you, and you might experience side effects. It's also possible you could be in the group receiving a placebo, meaning you wouldn’t get the active treatment. All potential risks and side effects will be fully explained to you. Remember, joining a study is always voluntary, and you have the right to withdraw at any time, for any reason, without it affecting your usual medical care.

Locations (2)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
Netherlands
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Unverified
Denmark

Common questions

What is a 'human pharmacology (Phase I) study'?

This is an early-stage study that mainly checks how a new medicine works in the body, how much is safe, and if it causes any serious side effects. It's not designed to see if it cures a condition.

What is a placebo?

A placebo is a 'dummy' medicine that looks like the real treatment but doesn’t contain any active ingredients. It helps researchers compare the effects of the new medicine.

Can I still get my usual medical care if I join?

Yes, joining a study should not affect your ability to receive your standard medical care from your doctor.

Will I know if I'm getting the new medicine or a placebo?

Often in studies like this, you won't know which group you are in until after the study is finished. This helps make the results fairer.

What does 'obesity' mean in this study?

In this context, it refers to adults who have experienced weight loss but are still classified as living with obesity based on standard medical guidelines.