AuthorisedTherapeutic use (Phase IV)Interventional

Efficacy and safety of pharmacological therapy of obesity in liver transplant candidates

This ongoing study is investigating a medicine called Mounjaro for adults who have obesity and are on the waiting list for a liver transplant. The main goal is to see how much people's weight, body mass index (BMI), and body fat change while taking the medicine. Researchers will also be checking very carefully for any side effects and making sure the treatment is safe. They're also looking at how patients fare before and after their liver transplant, including any health problems, how long they live, and how well their new liver works. This helps understand if the medicine can improve health outcomes for this group of patients.

At a glance

Status

Authorised

Phase

Therapeutic use (Phase IV)

Sponsor

Institute For Clinical And Experimental Medicine

Enrolment target

Start

18 Mar 2026

Obesity

What is this study about?

This study is exploring a new way to help people who have obesity and are waiting for a liver transplant. Obesity can sometimes make liver transplant surgery more complicated, and this study is trying to find out if a medicine called Mounjaro can help manage weight for these patients. Mounjaro is already approved for other uses, and this study is looking at how it works in this specific group.

The main thing researchers want to find out is whether Mounjaro helps people lose weight, reduce their body mass index (BMI), and change their body fat over time. They will carefully measure these changes. But it's not just about weight loss; they also want to make sure the medicine is safe. They will be watching closely for any side effects or health problems that might come up during the treatment.

Beyond weight and safety, the study will also track important health outcomes. This includes looking at any complications patients might have while waiting for their transplant, problems after the transplant itself (like infections or issues with the new liver), and how long patients and their new livers survive after the operation. This information will help doctors understand if Mounjaro can make a positive difference for people in this difficult situation.

Key takeaways

This study evaluates Mounjaro for weight management in liver transplant candidates.
It aims to see how much weight, BMI, and body fat change.
Safety is a key focus, with close monitoring for side effects.
The study tracks health outcomes both before and after a liver transplant.
Participants must be adults (18+) with obesity on a liver transplant waiting list.

Who may be eligible?

To be part of this study, you must be an adult, at least 18 years old. Both men and women can take part. You also need to have obesity and be on the waiting list for a liver transplant.

The doctors running the study will check if your specific health situation makes you a good fit. They will review your medical history to make sure that taking part is safe for you and that you meet all the necessary requirements for the study.

It's important to remember that even if you meet these general criteria, there might be other reasons why the study doctors decide you can't join, specific to your health. This is to ensure the study is suitable and safe for everyone involved.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Do you have obesity?
Are you currently on the waiting list for a liver transplant?
Are you able to attend regular clinic appointments for check-ups?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, you would receive the study medicine, Mounjaro, which is given as an injection using a pre-filled pen. You would typically give yourself this injection, guided by the study team. You would have regular visits to the clinic so the doctors can monitor your health, take measurements like weight and BMI, and check for any side effects. You'll also have blood tests and other examinations.

The study involves follow-up appointments both while you are waiting for your transplant and after the transplant, if you receive one during the study period. These follow-up appointments will continue for several months after your transplant to check on your recovery, health, and how well the new liver is doing. The full duration of your participation would depend on when you receive a transplant and how long the post-transplant follow-up period is for you, but it would involve regular commitments over an extended period.

Potential risks and benefits

Taking part in a study like this might offer potential benefits, such as potentially helping with weight management, which could improve aspects of your health while waiting for a liver transplant. However, there's no guarantee you will experience these benefits. As with any medicine, Mounjaro can have side effects, which could range from mild to more serious. The study team will explain all known risks and carefully monitor you. You are free to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
Czechia

Common questions

What is Mounjaro?

Mounjaro is a medicine given as an injection to help manage weight. This study is looking at how it works for people waiting for a liver transplant.

Why is this study important?

This study is important because it could help doctors find better ways to support people with obesity who are waiting for a liver transplant, potentially improving their health.

Are there different doses of Mounjaro in the study?

Yes, the study is using two different doses: 2.5 mg and 5 mg, both given as an injection in a pre-filled pen.

How long will I be in the study?

The study involves regular check-ups while you're waiting for a transplant and for several months after, if you have one. The total time depends on your personal situation within the study period.

What kind of checks will I have?

You'll have regular weigh-ins, measurements of your body (like BMI), blood tests, and health checks to see how you're doing and if there are any side effects.