A Study of Retatrutide (LY3437943) in the Maintenance of Weight Reduction in Individuals With Obesity

To join this study, you must be an adult aged 18 or older and be living with obesity. You should also have tried to lose weight through diet at least once before, without lasting success.

There are several reasons why you might not be able to participate. For example, if your weight has changed by more than 5 kilograms (about 11 pounds) in the 90 days before the study starts, or if you've already had or are planning to have weight-loss surgery or certain other procedures for obesity, you wouldn't be eligible. Also, if you have types 1 or 2 diabetes, or certain heart conditions, you wouldn't be able to join. Your doctor will carefully check your medical history to ensure your safety and suitability for the study.

Additionally, if you have a family history of medullary thyroid cancer or certain related genetic conditions, or if you've had specific serious heart problems or inflammation of the pancreas recently, you wouldn't be able to take part. This also applies if you've used any weight-loss medications, even over-the-counter ones, within the 90 days before screening.

If you decide to take part, you'll be involved in the study for approximately 125 weeks, which is about two and a half years. The study has two main treatment phases. For the first 80 weeks, everyone receives the same dose of Retatrutide. After this initial period, you'll be randomly assigned to one of three groups for the next 36 weeks: either you'll continue with the same dose of Retatrutide, switch to a different dose, or receive a placebo (a dummy treatment without any active medication). This assignment is 'double-blinded', meaning neither you nor your study doctor will know which group you are in. Throughout the study, you will have regular visits to the clinic for health checks, assessments, and to receive your medication. The research team will explain all the visits and procedures in detail before you agree to participate.