A Two-year Prospective, Observational Study of Wegovy in Real-world Clinical Practice
This study is checking how a weight-loss medicine called Wegovy (semaglutide) works for people with obesity in everyday healthcare. It's an observational study, meaning researchers will simply watch and record what happens as people take Wegovy as prescribed by their own doctor. They want to see how it affects things like weight, body mass index (BMI), waist size, and how people feel about their quality of life. The study will follow people for about two years to get a good picture of its real-world impact. It aims to understand how Wegovy helps with weight management when used as part of regular medical care.
At a glance
What is this study about?
This study is looking at a medicine called Wegovy, which is used to help people manage their weight if they have obesity. Instead of testing a new treatment, this study wants to understand how Wegovy is used in real life by patients and doctors, outside of a strict clinical trial setting. Think of it like watching how a car performs on everyday roads, rather than on a special test track.
Participants in this study will be taking Wegovy as part of their normal medical care, prescribed by their own doctor. The researchers will then collect information over about two years to see how the medicine affects things like a person's weight, their body size (like waist measurement), and how they feel about their general health and well-being. They'll also look at how doctors decide to prescribe Wegovy and how patients use it.
The main goal is to get a clearer picture of Wegovy's effects when used in typical doctor's offices and clinics. This information is really important because it helps us understand the medicine's impact on a larger group of people and in more everyday situations than standard drug trials usually cover.
Key takeaways
- This study looks at Wegovy (semaglutide) used in everyday healthcare for obesity.
- It's an 'observational study' – you'll take Wegovy as your doctor prescribes.
- Researchers will track weight, body size, and quality of life over two years.
- You'll complete questionnaires on a device with internet access.
- Your participation helps understand real-world effects of Wegovy in the UK.
- Participation is voluntary, and you can withdraw at any time.
Who may be eligible?
To join this study, you need to be an adult (18 years or older) and ready to start taking Wegovy for the first time. The decision to take Wegovy must have been made by you and your doctor independently, before you even consider joining this study. You also need to have at least one weight measurement recorded recently, before the study starts.
You'll need to be able to fill out questionnaires on an electronic device with internet access. Also, your doctor must confirm that you meet the criteria for Wegovy to be covered by insurance or the NHS in the UK.
You wouldn't be able to join if you've been in this study before, or if you've recently taken other weight-loss medications or similar types of drugs within the last 90 days. Pregnant women or women who could become pregnant and are not using effective birth control methods cannot participate. Also, if you have certain medical conditions like a personal or family history of a specific type of thyroid cancer (medullary thyroid carcinoma) or Multiple Endocrine Neoplasia syndrome, you would not be able to join. Anyone planning to move out of the area within the next year would also be excluded.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you 18 years old or older?
- Are you about to start Wegovy for the first time?
- Has your doctor already prescribed Wegovy to you, purely for your medical care?
- Are you able to use an electronic device with internet to fill out questionnaires?
- Have you been free from other weight-loss injections (like GLP-1s) for the last 3 months?
- Do you have a personal or family history of medullary thyroid cancer or MEN2?
What does participation involve?
If you decide to take part, you'll continue to take Wegovy as prescribed by your own doctor, just as you normally would. The study itself won't change how you receive your medicine or what your doctor recommends. Researchers will simply collect information from your medical records and you'll be asked to complete some questionnaires on an electronic device about your health and how you're feeling. There aren't any extra clinic visits required just for the study – the information will be gathered during your regular appointments. The study will last for about two years, during which your progress will be monitored.
Potential risks and benefits
Locations (30)
- CAP SarriàVerified postcodeBarcelona, Spain
- CAP SantsVerified postcodeBarcelona, Spain
- Hospital Vall d'HebronVerified postcodeBarcelona, Spain
- Centro de Salud Cartagena Casco AntiguoVerified postcodeCartagena, Spain
- Hospital Vithas SevillaVerified postcodeCastilleja de la Cuesta, Spain
- Hospital Univ. Virgen de la ArrixacaVerified postcodeEl Palmar (Murcia), Spain
- Clínica de Endocrinología y Nutrición Dr. BellidoVerified postcodeFerrol, Spain
- Ginegetafe S.L.Verified postcodeGetafe (Madrid), Spain
- Centro de Salud La CuestaVerified postcodeLa Cuesta (Santa Cruz de Tenerife), Spain
- Hospital Univ. de Gran Canaria Doctor NegrínVerified postcodeLas Palmas de Gran Canaria, Spain
- Hospital Universitario Sanitas Virgen del MarVerified postcodeMadrid, Spain
- Hospital Quirónsalud MálagaVerified postcodeMálaga, Spain
Common questions
What is an 'observational study'?
It means the researchers are just watching and recording what happens as you take your medication normally. They aren't asking you to try anything new or different.
Will I get free medication if I join?
No, this study doesn't provide the medication. You will be taking Wegovy as prescribed and paid for through your normal healthcare plan (e.g., NHS or private prescription).
How long will I be in the study?
The study will follow you for about two years.
Will joining change my medical treatment?
No, your doctor will continue to treat you as they normally would. The study just collects information about that treatment.
What if I decide I don't want to be in the study anymore?
You can leave the study at any time without needing to give a reason, and it won't affect your medical care.
How to find out more
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
Discussion
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